{
  "_id": "6a212cb4cd65a98ecbd23a3d",
  "Package": "methylumi",
  "Type": "Package",
  "Title": "Handle Illumina methylation data",
  "Version": "2.59.0",
  "Date": "2021-10-27",
  "Author": "Sean Davis, Pan Du, Sven Bilke, Tim Triche, Jr., Moiz Bootwalla",
  "biocViews": "DNAMethylation, TwoChannel, Preprocessing, QualityControl,\nCpGIsland",
  "Maintainer": "Sean Davis <seandavi@gmail.com>",
  "Description": "This package provides classes for holding and manipulating\nIllumina methylation data.  Based on eSet, it can contain MIAME\ninformation, sample information, feature information, and\nmultiple matrices of data.  An \"intelligent\" import function,\nmethylumiR can read the Illumina text files and create a\nMethyLumiSet. methylumIDAT can directly read raw IDAT files\nfrom HumanMethylation27 and HumanMethylation450 microarrays.\nNormalization, background correction, and quality control\nfeatures for GoldenGate, Infinium, and Infinium HD arrays are\nalso included.",
  "Collate": "AllGenerics.R MethyLumiSet-class.R MethyLumiM-class.R\nMoreGenerics.R Methods.R bgcorr.R coercions.R detectionpval.R\nfeatureFilter.R mclapply_replace.R methylData-class.R\nmethylumIDAT.R methylumiCSV.R methylumiR.R normalization.R\nplotNegOob.R qc.probe.plot.R readIDAT2.R stripMethyLumiSet.R\nutilities.R varFilter.R",
  "VignetteBuilder": "knitr",
  "BugReports": "https://github.com/seandavi/methylumi/issues/new",
  "License": "GPL-2",
  "Encoding": "UTF-8",
  "RoxygenNote": "7.1.2",
  "Config/pak/sysreqs": "make libbz2-dev libicu-dev liblzma-dev libpng-dev\nlibxml2-dev libssl-dev libx11-dev xz-utils zlib1g-dev",
  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 12:33:56 UTC",
  "RemoteUrl": "https://github.com/bioc/methylumi",
  "RemoteRef": "HEAD",
  "RemoteSha": "57b4be3912704138b56d0a1b248c2f5482c3e5c0",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-06-04 07:29:36 UTC",
    "User": "root"
  },
  "MD5sum": "b2690ab190ec0d6a4b2a84953f491016",
  "_user": "bioc",
  "_type": "src",
  "_file": "methylumi_2.59.0.tar.gz",
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  "_sha256": "be9b5e98821412e8e40918abae2d7960b3b3087402b8a70fbb9c73dd7be15cc5",
  "_created": "2026-06-04T07:29:36.000Z",
  "_published": "2026-06-04T07:43:48.303Z",
  "_jobs": [
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  "_bioccheck": {
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    "warning": 7,
    "note": 18
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  "_buildurl": "https://github.com/r-universe/bioc/actions/runs/26937047620",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/bioc/methylumi",
  "_commit": {
    "id": "57b4be3912704138b56d0a1b248c2f5482c3e5c0",
    "author": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "committer": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "message": "bump x.y.z version to odd y following creation of RELEASE_3_23 branch\n",
    "time": 1777379636
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  "_maintainer": {
    "name": "Sean Davis",
    "email": "seandavi@gmail.com",
    "login": "seandavi",
    "description": "Software developer, Pediatric oncologist, Cancer researcher, Data scientist and engineer, Community organizer",
    "uuid": 92435
  },
  "_distro": "noble",
  "_registered": true,
  "_dependencies": [
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      "package": "FDb.InfiniumMethylation.hg19",
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      "package": "minfi",
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    {
      "package": "BiocGenerics",
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    {
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    {
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    },
    {
      "package": "GenomeInfoDb",
      "role": "Imports"
    },
    {
      "package": "GenomicRanges",
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    {
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  "_owner": "bioc",
  "_selfowned": true,
  "_usedby": 17,
  "_updates": [
    {
      "week": "2025-44",
      "n": 2
    },
    {
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  "_tags": [],
  "_bioc": [
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      "bioc": "3.24"
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    {
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      "version": "2.58.0",
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  ],
  "_topics": [
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    "twochannel",
    "preprocessing",
    "qualitycontrol",
    "cpgisland"
  ],
  "_stars": 9,
  "_contributors": [
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      "uuid": 92435
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    "type": "organization",
    "name": "Bioconductor",
    "description": "Software for the analysis and comprehension of high-throughput genomic data"
  },
  "_downloads": {
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    "source": "https://www.bioconductor.org/packages/stats/bioc/methylumi"
  },
  "_mentions": 75,
  "_devurl": "https://github.com/seandavi/methylumi",
  "_searchresults": 100,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/methylumi.html",
    "extra/readme.html",
    "extra/readme.md",
    "manual.pdf"
  ],
  "_homeurl": "https://github.com/seandavi/methylumi",
  "_realowner": "bioc",
  "_cranurl": false,
  "_exports": [
    ".mclapply",
    "betas",
    "betas<-",
    "combine",
    "combine27k450k",
    "controlData",
    "controlData<-",
    "controlTypes",
    "corplot",
    "cy3",
    "Cy3.N",
    "Cy3<-",
    "cy5",
    "Cy5.N",
    "Cy5<-",
    "dataType",
    "dataType<-",
    "designIItoMandU",
    "designItoMandU",
    "detection",
    "detection<-",
    "diagnostics",
    "estimateM",
    "exprs",
    "exprs<-",
    "extractBarcodeAndPosition",
    "featureFilter",
    "getAssayDataNameSubstitutions",
    "getBarcodes",
    "getHistory",
    "hist",
    "IDATsToMatrices",
    "IDATtoMatrix",
    "intensities.IB",
    "intensities.M",
    "intensities.OOB",
    "intensities.OOB.allelic",
    "intensities.U",
    "intensitiesByChannel",
    "lumiCSV",
    "lumIDAT",
    "mergeProbeDesigns",
    "methylated",
    "methylated.N",
    "methylated.N<-",
    "methylated<-",
    "methylumi.bgcorr",
    "methylumi.diagnostics",
    "methylumiCSV",
    "methylumIDAT",
    "methylumiR",
    "NChannelSetToMethyLumiSet",
    "negctls",
    "negctls.stderr",
    "negnorm",
    "normalizeMethyLumiSet",
    "normctls",
    "pairs",
    "plotNAs",
    "plotNegOob",
    "plotSampleIntensities",
    "probeNAs",
    "psummary",
    "pval.detect",
    "pval.detect<-",
    "pvals",
    "pvals<-",
    "qc.probe.plot",
    "QCdata",
    "QCdata<-",
    "qcplot",
    "sampleNAs",
    "show",
    "stripBeadNs",
    "stripBeadSDs",
    "stripMethyLumiSet",
    "stripOOB",
    "summary",
    "tcgaPipeline",
    "total.intensity",
    "unmethylated",
    "unmethylated.N",
    "unmethylated.N<-",
    "unmethylated<-",
    "varFilter"
  ],
  "_datasets": [
    {
      "name": "CpGs",
      "title": "Data frame describing loci on the 27 and 450k arrays.",
      "object": "CpGs",
      "file": "CpGs.rda",
      "class": [
        "data.frame"
      ],
      "fields": [
        "CpGs",
        "design.27k",
        "design.450k",
        "type",
        "random"
      ],
      "rows": 487177,
      "table": true,
      "tojson": true
    },
    {
      "name": "mldat",
      "title": "Example SAM format Illumina methylation dataset",
      "object": "mldat",
      "file": "mldat.rda",
      "class": [
        "MethyLumiSet"
      ],
      "fields": [],
      "table": false,
      "tojson": false
    }
  ],
  "_help": [
    {
      "page": "methylumi-package",
      "title": "Handle Illumina methylation data",
      "topics": [
        "methylumi-package",
        "methylumi"
      ]
    },
    {
      "page": "CpGs",
      "title": "Data frame describing loci on the 27 and 450k arrays.",
      "topics": [
        "CpGs"
      ]
    },
    {
      "page": "estimateM",
      "title": "Estimate methylation M-value matrix",
      "topics": [
        "estimateM"
      ]
    },
    {
      "page": "extractBarcodeAndPosition",
      "title": "Extract the Barcode and Position Information from Sentrix ID",
      "topics": [
        "extractBarcodeAndPosition"
      ]
    },
    {
      "page": "featureFilter",
      "title": "Annotation-based Filtering of Features (CpG sites) in a MethyLumiSet or MethyLumiM object",
      "topics": [
        "featureFilter",
        "featureFilter,MethyLumiM-method",
        "featureFilter,MethyLumiSet-method"
      ]
    },
    {
      "page": "getAssayDataNameSubstitutions",
      "title": "Return a data.frame of AssayData name substitutions.",
      "topics": [
        "getAssayDataNameSubstitutions"
      ]
    },
    {
      "page": "IDATsToMatrices",
      "title": "convert multiple idats to matrices",
      "topics": [
        "IDATsToMatrices"
      ]
    },
    {
      "page": "IDATtoMatrix",
      "title": "process a single IDAT (just the mean intensities)",
      "topics": [
        "IDATtoMatrix"
      ]
    },
    {
      "page": "methylData-class",
      "title": "Class '\"methylData\"', superclass for MethyLumiSet and MethyLumiM",
      "topics": [
        "diagnostics,methylData-method",
        "methylated.N,methylData-method",
        "methylated.N<-,methylData,matrix-method",
        "methylData-class",
        "plotNAs,methylData-method",
        "pval.detect,methylData-method",
        "pval.detect<-,methylData,numeric-method",
        "unmethylated.N,methylData-method",
        "unmethylated.N<-,methylData,matrix-method"
      ]
    },
    {
      "page": "generics",
      "title": "methylumi accessors",
      "topics": [
        "betas",
        "betas<-",
        "corplot",
        "getHistory",
        "methylated",
        "methylated<-",
        "pvals",
        "pvals<-",
        "QCdata",
        "QCdata<-",
        "unmethylated",
        "unmethylated<-"
      ]
    },
    {
      "page": "MethyLumi-class",
      "title": "The base class for storing Illumina Methylation data",
      "topics": [
        "methylated,MethyLumi-method",
        "methylated<-,MethyLumi,matrix-method",
        "MethyLumi-class",
        "pvals,MethyLumi-method",
        "pvals<-,MethyLumi,matrix-method",
        "qcplot,Methylumi-method",
        "summary,MethyLumi-method",
        "unmethylated,MethyLumi-method",
        "unmethylated<-,MethyLumi,matrix-method"
      ]
    },
    {
      "page": "stripBeadExtras",
      "title": "Strip excessive probe-level data from MethyLumiSets",
      "topics": [
        "stripBeadNs",
        "stripBeadSDs",
        "stripMethyLumiSet",
        "stripOOB"
      ]
    },
    {
      "page": "methylumIDAT",
      "title": "methylumIDAT",
      "topics": [
        "methylumIDAT"
      ]
    },
    {
      "page": "methylumiGenerics",
      "title": "Generics defined in methylumi",
      "topics": [
        "betas,GenomicMethylSet-method",
        "betas,MethylSet-method",
        "betas,RangedSummarizedExperiment-method",
        "combine27k450k",
        "controlData",
        "controlData<-",
        "cy3",
        "Cy3.N",
        "Cy3<-",
        "cy5",
        "Cy5.N",
        "Cy5<-",
        "dataType",
        "dataType<-",
        "designIItoMandU",
        "designItoMandU",
        "detection",
        "detection<-",
        "diagnostics",
        "getBarcodes",
        "getProtocolData",
        "IDATsToDFs",
        "IDATtoDF",
        "intensities.IB",
        "intensities.M",
        "intensities.OOB",
        "intensities.OOB.allelic",
        "intensities.U",
        "intensitiesByChannel",
        "lumiCSV",
        "lumIDAT",
        "mergeProbeDesigns",
        "methylated,MethylSet-method",
        "methylated.N",
        "methylated.N<-",
        "methylumi.bgcorr",
        "methylumi.diagnostics",
        "methylumiCSV",
        "NChannelSetToMethyLumiSet",
        "negctls",
        "negctls.stderr",
        "negnorm",
        "normctls",
        "plotNAs",
        "plotNegOob",
        "probeNAs",
        "psummary",
        "pval.detect",
        "pval.detect<-",
        "qc.probe.plot",
        "sampleNAs",
        "total.intensity",
        "unmethylated,MethylSet-method",
        "unmethylated.N",
        "unmethylated.N<-"
      ]
    },
    {
      "page": "MethyLumiM-class",
      "title": "Class \"MethyLumiM\": for Illumina Methylation microarray data using logRatios",
      "topics": [
        "betas,MethyLumiM-method",
        "combine,MethyLumiM,MethyLumiM-method",
        "controlData,MethyLumiM-method",
        "controlData<-,MethyLumiM,ANY-method",
        "controlTypes,MethyLumiM-method",
        "dataType,MethyLumiM-method",
        "dataType<-,MethyLumiM,ANY-method",
        "dataType<-,MethyLumiM-method",
        "detection,MethyLumiM-method",
        "detection<-,MethyLumiM-method",
        "getHistory,MethyLumiM-method",
        "intensitiesByChannel,MethyLumiM-method",
        "methylated,MethyLumiM-method",
        "methylated.N,MethyLumiM-method",
        "methylated.N<-,MethyLumiM,ANY-method",
        "methylated<-,MethyLumiM,ANY-method",
        "MethyLumiM",
        "MethyLumiM-class",
        "negctls,MethyLumiM,character-method",
        "negctls,MethyLumiM,missing-method",
        "negnorm,MethyLumiM,character-method",
        "negnorm,MethyLumiM,missing-method",
        "normctls,MethyLumiM-method",
        "probeNAs,MethyLumiM-method",
        "pvals,MethyLumiM-method",
        "QCdata,MethyLumiM-method",
        "sampleNAs,MethyLumiM-method",
        "total.intensity,MethyLumiM-method",
        "unmethylated,MethyLumiM-method",
        "unmethylated.N,MethyLumiM-method",
        "unmethylated.N<-,MethyLumiM,ANY-method",
        "unmethylated<-,MethyLumiM,ANY-method",
        "[,MethyLumiM,ANY,ANY,ANY-method",
        "[,MethyLumiM,ANY-method"
      ]
    },
    {
      "page": "MethyLumiQC-class",
      "title": "Class '\"MethyLumiQC\"' for holding Illumina methylation QC data",
      "topics": [
        "combine,MethyLumiQC,MethyLumiQC-method",
        "controlData<-,MethyLumiSet,MethyLumiQC-method",
        "controlTypes,MethyLumiQC-method",
        "Cy3.N,MethyLumiQC-method",
        "Cy3<-,MethyLumiQC,matrix-method",
        "Cy5.N,MethyLumiQC-method",
        "Cy5<-,MethyLumiQC,matrix-method",
        "hist,MethyLumiQC-method",
        "intensitiesByChannel,MethyLumiQC-method",
        "methylated,MethyLumiQC-method",
        "MethyLumiQC-class",
        "negctls,MethyLumiQC,character-method",
        "negctls,MethyLumiQC,missing-method",
        "negctls.stderr,MethyLumiQC,character-method",
        "negctls.stderr,MethyLumiQC,missing-method",
        "negnorm,MethyLumiQC,character-method",
        "negnorm,MethyLumiQC,missing-method",
        "normctls,MethyLumiQC-method",
        "QCdata<-,MethyLumiSet,MethyLumiQC-method",
        "qcplot,MethyLumiQC-method",
        "unmethylated,MethyLumiQC-method"
      ]
    },
    {
      "page": "methylumiR",
      "title": "Load data from Illumina methylation platform",
      "topics": [
        "methylumiR"
      ]
    },
    {
      "page": "MethyLumiSet-class",
      "title": "Class '\"MethyLumiSet\"' for containing Illumina methylation data",
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        "betas,MethyLumiSet-method",
        "betas<-,MethyLumiSet,matrix-method",
        "boxplot,MethyLumiSet-method",
        "combine,MethyLumiSet,MethyLumiSet-method",
        "combine27k450k,MethyLumiSet,MethyLumiSet-method",
        "controlData,MethyLumiSet-method",
        "controlData<-,MethyLumiSet",
        "controlTypes,MethyLumiSet-method",
        "corplot,MethyLumiSet-method",
        "Cy3.N,MethyLumiSet-method",
        "Cy5.N,MethyLumiSet-method",
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        "getHistory,MethyLumiSet-method",
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        "intensities.IB,MethyLumiSet,missing-method",
        "intensities.M,MethyLumiSet,character-method",
        "intensities.M,MethyLumiSet,missing-method",
        "intensities.OOB,MethyLumiSet,character-method",
        "intensities.OOB,MethyLumiSet,missing-method",
        "intensities.OOB.allelic,MethyLumiSet,character,character-method",
        "intensities.OOB.allelic,MethyLumiSet,missing,missing-method",
        "intensities.U,MethyLumiSet,character-method",
        "intensities.U,MethyLumiSet,missing-method",
        "intensitiesByChannel,MethyLumiSet-method",
        "methylated,MethyLumiSet-method",
        "methylated<-,MethyLumiSet,matrix-method",
        "MethyLumiSet-class",
        "negctls,MethyLumiSet,character-method",
        "negctls,MethyLumiSet,missing-method",
        "negctls.stderr,MethyLumiSet,character-method",
        "negctls.stderr,MethyLumiSet,missing-method",
        "negnorm,MethyLumiSet,character-method",
        "negnorm,MethyLumiSet,missing-method",
        "normctls,MethyLumiSet-method",
        "pairs,MethyLumiSet-method",
        "plotSampleIntensities,MethyLumiSet-method",
        "probeNAs,MethyLumiSet-method",
        "QCdata,MethyLumiSet-method",
        "QCdata<-,MethyLumiSet",
        "qcplot,MethyLumiSet-method",
        "sampleNAs,MethyLumiSet-method",
        "show,MethyLumiSet-method",
        "total.intensity,MethyLumiSet-method",
        "unmethylated,MethyLumiSet-method",
        "unmethylated<-,MethyLumiSet,matrix-method",
        "[,MethyLumiSet,ANY,ANY,ANY-method",
        "[,MethyLumiSet,ANY-method"
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    {
      "page": "mldat",
      "title": "Example SAM format Illumina methylation dataset",
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    {
      "page": "normalizeMethyLumiSet",
      "title": "Normalize a MethyLumiSet, accounting for dye bias",
      "topics": [
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      "title": "Plot the sample intensities.",
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    {
      "page": "qcplot",
      "title": "Methods for dealing with control data for Illumina methylation data.",
      "topics": [
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        "qcplot"
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      "page": "tcgaPipeline",
      "title": "Total convenience function for processing IDATs like tcga",
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    {
      "page": "varFilter",
      "title": "Variation-based Filtering of Features (CpG sites) in a MethyLumiSet or MethyLumiM object",
      "topics": [
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        "varFilter,MethyLumiM-method",
        "varFilter,MethyLumiSet-method"
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