{
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  "Package": "methylumi",
  "Type": "Package",
  "Title": "Handle Illumina methylation data",
  "Version": "2.59.3",
  "Date": "2026-08-14",
  "Author": "Sean Davis, Pan Du, Sven Bilke, Tim Triche, Jr., Moiz Bootwalla",
  "biocViews": "DNAMethylation, TwoChannel, Preprocessing, QualityControl,\nCpGIsland",
  "Maintainer": "Sean Davis <seandavi@gmail.com>",
  "Description": "This package provides classes for holding and manipulating\nIllumina methylation data.  Based on eSet, it can contain MIAME\ninformation, sample information, feature information, and\nmultiple matrices of data.  An \"intelligent\" import function,\nmethylumiR can read the Illumina text files and create a\nMethyLumiSet. methylumIDAT can directly read raw IDAT files\nfrom HumanMethylation27 and HumanMethylation450 microarrays.\nNormalization, background correction, and quality control\nfeatures for GoldenGate, Infinium, and Infinium HD arrays are\nalso included.",
  "Collate": "AllGenerics.R MethyLumiSet-class.R MethyLumiM-class.R\nMoreGenerics.R Methods.R bgcorr.R coercions.R data.R\ndetectionpval.R featureFilter.R mclapply_replace.R\nmethylData-class.R methylumIDAT.R methylumiCSV.R methylumiR.R\nnormalization.R plotNegOob.R qc.probe.plot.R readIDAT2.R\nstripMethyLumiSet.R utilities.R varFilter.R",
  "VignetteBuilder": "quarto",
  "URL": "https://seandavi.github.io/methylumi/,\nhttps://github.com/seandavi/methylumi",
  "BugReports": "https://github.com/seandavi/methylumi/issues",
  "License": "GPL-2",
  "Encoding": "UTF-8",
  "Config/testthat/edition": "3",
  "Config/roxygen2/version": "8.1.0",
  "Config/pak/sysreqs": "make libbz2-dev libicu-dev liblzma-dev libpng-dev\nlibxml2-dev libssl-dev libx11-dev xz-utils zlib1g-dev",
  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-08-14 16:33:14 UTC",
  "RemoteUrl": "https://github.com/bioc/methylumi",
  "RemoteRef": "HEAD",
  "RemoteSha": "4232eaf043694b8b8e2bfe1095f03185be39a8af",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-11-01 13:00:32 UTC",
    "User": "root"
  },
  "_user": "bioc",
  "_type": "src",
  "_file": "methylumi_2.59.3.tar.gz",
  "_fileid": "https://r2.ropensci.org/860b50952eb94affbd45e6fbee8ae779c111fd6ad5ab344a861510936dbff015",
  "_filesize": 6745391,
  "_sha256": "860b50952eb94affbd45e6fbee8ae779c111fd6ad5ab344a861510936dbff015",
  "_expires": "2027-02-09T14:19:14.000Z",
  "_created": "2026-11-01T13:00:32.000Z",
  "_published": "2026-11-01T14:19:16.806Z",
  "_upstream": "https://github.com/bioc/methylumi",
  "_status": "success",
  "_maintainer": {
    "name": "Sean Davis",
    "email": "seandavi@gmail.com",
    "login": "seandavi",
    "description": "Software developer, Pediatric oncologist, Cancer researcher, Data scientist and engineer, Community organizer",
    "uuid": 92435
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  "_jobs": [
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      "config": "bioc-checks",
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    "error": 2,
    "warning": 5,
    "note": 14
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  "_buildurl": "https://github.com/r-universe/bioc/actions/runs/41308361725",
  "_commit": {
    "id": "4232eaf043694b8b8e2bfe1095f03185be39a8af",
    "author": "Sean Davis <seandavi@gmail.com>",
    "committer": "GitHub <noreply@github.com>",
    "message": "Install methylumi into the real library before building the pkgdown site (#52)\n\npkgdown::build_site(install = TRUE) installs the package into a temporary\nlibrary that exists only on the calling R process's .libPaths(). The articles\nare .qmd, so pkgdown renders them by shelling out to the Quarto CLI, which\nstarts a fresh R session per file -- and that session inherits none of the\ntemporary library. library(methylumi) in the vignettes therefore resolved\nagainst the stale methylumi already in the container's site-library, and the\nbuild died with the long-fixed defunct import from #28:\n\n  ! package or namespace load failed for 'methylumi':\n   object 'parallel' is not exported by 'namespace:lattice'\n  Quitting from methylumi.qmd:83-93 [load]\n\nbuild_site() renders articles with quiet = TRUE, which is why the log showed\nonly 'Error returned by quarto CLI'.\n\nInstall into site-library ourselves and pass install = FALSE, so the child\nQuarto sessions see the package being documented.\n\nCo-authored-by: Claude Opus 5 <noreply@anthropic.com>",
    "time": 1786725194
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  "_host": "GitHub-Actions",
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    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md"
  ],
  "_homeurl": "https://github.com/seandavi/methylumi",
  "_realowner": "bioc",
  "_cranurl": false,
  "_exports": [
    ".mclapply",
    "betas",
    "betas<-",
    "combine",
    "combine27k450k",
    "controlData",
    "controlData<-",
    "controlTypes",
    "corplot",
    "cy3",
    "Cy3.N",
    "Cy3<-",
    "cy5",
    "Cy5.N",
    "Cy5<-",
    "dataType",
    "dataType<-",
    "designIItoMandU",
    "designItoMandU",
    "detection",
    "detection<-",
    "diagnostics",
    "estimateM",
    "exprs",
    "exprs<-",
    "extractBarcodeAndPosition",
    "featureFilter",
    "getAssayDataNameSubstitutions",
    "getBarcodes",
    "getHistory",
    "hist",
    "IDATsToMatrices",
    "IDATtoMatrix",
    "intensities.IB",
    "intensities.M",
    "intensities.OOB",
    "intensities.OOB.allelic",
    "intensities.U",
    "intensitiesByChannel",
    "lumiCSV",
    "lumIDAT",
    "mergeProbeDesigns",
    "methylated",
    "methylated.N",
    "methylated.N<-",
    "methylated<-",
    "methylumi.bgcorr",
    "methylumi.diagnostics",
    "methylumiCSV",
    "methylumIDAT",
    "methylumiR",
    "NChannelSetToMethyLumiSet",
    "negctls",
    "negctls.stderr",
    "negnorm",
    "normalizeMethyLumiSet",
    "normctls",
    "pairs",
    "plotNAs",
    "plotNegOob",
    "plotSampleIntensities",
    "probeNAs",
    "psummary",
    "pval.detect",
    "pval.detect<-",
    "pvals",
    "pvals<-",
    "qc.probe.plot",
    "QCdata",
    "QCdata<-",
    "qcplot",
    "sampleNAs",
    "show",
    "stripBeadNs",
    "stripBeadSDs",
    "stripMethyLumiSet",
    "stripOOB",
    "summary",
    "tcgaPipeline",
    "total.intensity",
    "unmethylated",
    "unmethylated.N",
    "unmethylated.N<-",
    "unmethylated<-",
    "varFilter"
  ],
  "_datasets": [
    {
      "name": "CpGs",
      "title": "Data frame describing loci on the 27 and 450k arrays",
      "object": "CpGs",
      "file": "CpGs.rda",
      "class": [
        "data.frame"
      ],
      "fields": [
        "CpGs",
        "design.27k",
        "design.450k",
        "type",
        "random"
      ],
      "rows": 487177,
      "table": true,
      "tojson": true
    },
    {
      "name": "mldat",
      "title": "Example SAM format Illumina methylation dataset",
      "object": "mldat",
      "file": "mldat.rda",
      "class": [
        "MethyLumiSet"
      ],
      "fields": [],
      "table": false,
      "tojson": false
    }
  ],
  "_help": [
    {
      "page": "methylumi-package",
      "title": "Handle Illumina methylation data",
      "topics": [
        "methylumi-package",
        "methylumi"
      ]
    },
    {
      "page": "CpGs",
      "title": "Data frame describing loci on the 27 and 450k arrays",
      "topics": [
        "CpGs"
      ]
    },
    {
      "page": "estimateM",
      "title": "Estimate methylation M-value matrix",
      "topics": [
        "estimateM"
      ]
    },
    {
      "page": "extractBarcodeAndPosition",
      "title": "Extract the barcode and position information from a Sentrix ID",
      "topics": [
        "extractBarcodeAndPosition"
      ]
    },
    {
      "page": "featureFilter",
      "title": "Annotation-based filtering of features (CpG sites) in a MethyLumiSet or MethyLumiM object",
      "topics": [
        "featureFilter",
        "featureFilter,MethyLumiM-method",
        "featureFilter,MethyLumiSet-method"
      ]
    },
    {
      "page": "getAssayDataNameSubstitutions",
      "title": "Return a data.frame of AssayData name substitutions",
      "topics": [
        "getAssayDataNameSubstitutions"
      ]
    },
    {
      "page": "IDATsToMatrices",
      "title": "convert multiple idats to matrices",
      "topics": [
        "IDATsToMatrices"
      ]
    },
    {
      "page": "IDATtoMatrix",
      "title": "process a single IDAT (just the mean intensities)",
      "topics": [
        "IDATtoMatrix"
      ]
    },
    {
      "page": "methylData-class",
      "title": "Class '\"methylData\"', superclass for MethyLumiSet and MethyLumiM",
      "topics": [
        "diagnostics,methylData-method",
        "methylated.N,methylData-method",
        "methylated.N<-,methylData,matrix-method",
        "methylData-class",
        "plotNAs,methylData-method",
        "pval.detect,methylData-method",
        "pval.detect<-,methylData,numeric-method",
        "unmethylated.N,methylData-method",
        "unmethylated.N<-,methylData,matrix-method"
      ]
    },
    {
      "page": "generics",
      "title": "methylumi accessors",
      "topics": [
        "betas",
        "betas<-",
        "corplot",
        "getHistory",
        "methylated",
        "methylated<-",
        "pvals",
        "pvals<-",
        "QCdata",
        "QCdata<-",
        "unmethylated",
        "unmethylated<-"
      ]
    },
    {
      "page": "MethyLumi-class",
      "title": "The base class for storing Illumina Methylation data",
      "topics": [
        "methylated,MethyLumi-method",
        "methylated<-,MethyLumi,matrix-method",
        "MethyLumi-class",
        "pvals,MethyLumi-method",
        "pvals<-,MethyLumi,matrix-method",
        "qcplot,Methylumi-method",
        "summary,MethyLumi-method",
        "unmethylated,MethyLumi-method",
        "unmethylated<-,MethyLumi,matrix-method"
      ]
    },
    {
      "page": "MethyLumi-strippers",
      "title": "Strip excessive probe-level data from MethyLumiSets",
      "topics": [
        "MethyLumi-strippers",
        "stripBeadNs",
        "stripBeadSDs",
        "stripMethyLumiSet",
        "stripOOB"
      ]
    },
    {
      "page": "methylumIDAT",
      "title": "methylumIDAT",
      "topics": [
        "methylumIDAT"
      ]
    },
    {
      "page": "methylumiGenerics",
      "title": "Generics defined in methylumi",
      "topics": [
        "betas,GenomicMethylSet-method",
        "betas,MethylSet-method",
        "betas,RangedSummarizedExperiment-method",
        "combine27k450k",
        "controlData",
        "controlData<-",
        "cy3",
        "Cy3.N",
        "Cy3<-",
        "cy5",
        "Cy5.N",
        "Cy5<-",
        "dataType",
        "dataType<-",
        "designIItoMandU",
        "designItoMandU",
        "detection",
        "detection<-",
        "diagnostics",
        "getBarcodes",
        "getProtocolData",
        "IDATsToDFs",
        "IDATtoDF",
        "intensities.IB",
        "intensities.M",
        "intensities.OOB",
        "intensities.OOB.allelic",
        "intensities.U",
        "intensitiesByChannel",
        "lumiCSV",
        "lumIDAT",
        "mergeProbeDesigns",
        "methylated,MethylSet-method",
        "methylated.N",
        "methylated.N<-",
        "methylumi.bgcorr",
        "methylumi.diagnostics",
        "methylumiCSV",
        "NChannelSetToMethyLumiSet",
        "negctls",
        "negctls.stderr",
        "negnorm",
        "normctls",
        "plotNAs",
        "plotNegOob",
        "probeNAs",
        "psummary",
        "pval.detect",
        "pval.detect<-",
        "qc.probe.plot",
        "sampleNAs",
        "total.intensity",
        "unmethylated,MethylSet-method",
        "unmethylated.N",
        "unmethylated.N<-"
      ]
    },
    {
      "page": "MethyLumiM-class",
      "title": "Class \"MethyLumiM\": for Illumina Methylation microarray data using logRatios",
      "topics": [
        "betas,MethyLumiM-method",
        "combine,MethyLumiM,MethyLumiM-method",
        "controlData,MethyLumiM-method",
        "controlData<-,MethyLumiM,ANY-method",
        "controlTypes,MethyLumiM-method",
        "dataType,MethyLumiM-method",
        "dataType<-,MethyLumiM,ANY-method",
        "dataType<-,MethyLumiM-method",
        "detection,MethyLumiM-method",
        "detection<-,MethyLumiM-method",
        "getHistory,MethyLumiM-method",
        "intensitiesByChannel,MethyLumiM-method",
        "methylated,MethyLumiM-method",
        "methylated.N,MethyLumiM-method",
        "methylated.N<-,MethyLumiM,ANY-method",
        "methylated<-,MethyLumiM,ANY-method",
        "MethyLumiM",
        "MethyLumiM-class",
        "negctls,MethyLumiM,character-method",
        "negctls,MethyLumiM,missing-method",
        "negnorm,MethyLumiM,character-method",
        "negnorm,MethyLumiM,missing-method",
        "normctls,MethyLumiM-method",
        "probeNAs,MethyLumiM-method",
        "pvals,MethyLumiM-method",
        "QCdata,MethyLumiM-method",
        "sampleNAs,MethyLumiM-method",
        "total.intensity,MethyLumiM-method",
        "unmethylated,MethyLumiM-method",
        "unmethylated.N,MethyLumiM-method",
        "unmethylated.N<-,MethyLumiM,ANY-method",
        "unmethylated<-,MethyLumiM,ANY-method",
        "[,MethyLumiM,ANY,ANY,ANY-method",
        "[,MethyLumiM,ANY-method"
      ]
    },
    {
      "page": "MethyLumiQC-class",
      "title": "Class '\"MethyLumiQC\"' for holding Illumina methylation QC data",
      "topics": [
        "combine,MethyLumiQC,MethyLumiQC-method",
        "controlData<-,MethyLumiSet,MethyLumiQC-method",
        "controlTypes,MethyLumiQC-method",
        "Cy3.N,MethyLumiQC-method",
        "Cy3<-,MethyLumiQC,matrix-method",
        "Cy5.N,MethyLumiQC-method",
        "Cy5<-,MethyLumiQC,matrix-method",
        "hist,MethyLumiQC-method",
        "intensitiesByChannel,MethyLumiQC-method",
        "methylated,MethyLumiQC-method",
        "MethyLumiQC-class",
        "negctls,MethyLumiQC,character-method",
        "negctls,MethyLumiQC,missing-method",
        "negctls.stderr,MethyLumiQC,character-method",
        "negctls.stderr,MethyLumiQC,missing-method",
        "negnorm,MethyLumiQC,character-method",
        "negnorm,MethyLumiQC,missing-method",
        "normctls,MethyLumiQC-method",
        "QCdata<-,MethyLumiSet,MethyLumiQC-method",
        "qcplot,MethyLumiQC-method",
        "unmethylated,MethyLumiQC-method"
      ]
    },
    {
      "page": "methylumiR",
      "title": "Load data from an Illumina methylation platform",
      "topics": [
        "methylumiR"
      ]
    },
    {
      "page": "MethyLumiSet-class",
      "title": "Class '\"MethyLumiSet\"' for containing Illumina methylation data",
      "topics": [
        "betas,MethyLumiSet-method",
        "betas<-,MethyLumiSet,matrix-method",
        "boxplot,MethyLumiSet-method",
        "combine,MethyLumiSet,MethyLumiSet-method",
        "combine27k450k,MethyLumiSet,MethyLumiSet-method",
        "controlData,MethyLumiSet-method",
        "controlData<-,MethyLumiSet",
        "controlTypes,MethyLumiSet-method",
        "corplot,MethyLumiSet-method",
        "Cy3.N,MethyLumiSet-method",
        "Cy5.N,MethyLumiSet-method",
        "exprs,MethyLumiSet-method",
        "getHistory,MethyLumiSet-method",
        "hist,MethyLumiSet-method",
        "intensities.IB,MethyLumiSet,character-method",
        "intensities.IB,MethyLumiSet,missing-method",
        "intensities.M,MethyLumiSet,character-method",
        "intensities.M,MethyLumiSet,missing-method",
        "intensities.OOB,MethyLumiSet,character-method",
        "intensities.OOB,MethyLumiSet,missing-method",
        "intensities.OOB.allelic,MethyLumiSet,character,character-method",
        "intensities.OOB.allelic,MethyLumiSet,missing,missing-method",
        "intensities.U,MethyLumiSet,character-method",
        "intensities.U,MethyLumiSet,missing-method",
        "intensitiesByChannel,MethyLumiSet-method",
        "methylated,MethyLumiSet-method",
        "methylated<-,MethyLumiSet,matrix-method",
        "MethyLumiSet-class",
        "negctls,MethyLumiSet,character-method",
        "negctls,MethyLumiSet,missing-method",
        "negctls.stderr,MethyLumiSet,character-method",
        "negctls.stderr,MethyLumiSet,missing-method",
        "negnorm,MethyLumiSet,character-method",
        "negnorm,MethyLumiSet,missing-method",
        "normctls,MethyLumiSet-method",
        "pairs,MethyLumiSet-method",
        "plotSampleIntensities,MethyLumiSet-method",
        "probeNAs,MethyLumiSet-method",
        "QCdata,MethyLumiSet-method",
        "QCdata<-,MethyLumiSet",
        "qcplot,MethyLumiSet-method",
        "sampleNAs,MethyLumiSet-method",
        "show,MethyLumiSet-method",
        "total.intensity,MethyLumiSet-method",
        "unmethylated,MethyLumiSet-method",
        "unmethylated<-,MethyLumiSet,matrix-method",
        "[,MethyLumiSet,ANY,ANY,ANY-method",
        "[,MethyLumiSet,ANY-method"
      ]
    },
    {
      "page": "mldat",
      "title": "Example SAM format Illumina methylation dataset",
      "topics": [
        "mldat"
      ]
    },
    {
      "page": "normalizeMethyLumiSet",
      "title": "Normalize a MethyLumiSet, accounting for dye bias",
      "topics": [
        "normalizeMethyLumiSet"
      ]
    },
    {
      "page": "plotSampleIntensities",
      "title": "Plot the sample intensities",
      "topics": [
        "plotSampleIntensities"
      ]
    },
    {
      "page": "qcplot",
      "title": "Methods for dealing with control data for Illumina methylation data",
      "topics": [
        "controlTypes",
        "qcplot"
      ]
    },
    {
      "page": "tcgaPipeline",
      "title": "Total convenience function for processing IDATs like tcga",
      "topics": [
        "tcgaPipeline"
      ]
    },
    {
      "page": "varFilter",
      "title": "Variation-based filtering of features (CpG sites) in a MethyLumiSet or MethyLumiM object",
      "topics": [
        "varFilter",
        "varFilter,MethyLumiM-method",
        "varFilter,MethyLumiSet-method"
      ]
    }
  ],
  "_readme": "https://github.com/bioc/methylumi/raw/HEAD/README.md",
  "_rundeps": [
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    "askpass",
    "base64",
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    "BH",
    "Biobase",
    "BiocBaseUtils",
    "BiocFileCache",
    "BiocGenerics",
    "BiocIO",
    "biocmake",
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    "Biostrings",
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    "SummarizedExperiment",
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    "yaml"
  ],
  "_vignettes": [
    {
      "source": "methylumi.qmd",
      "filename": "methylumi.html",
      "title": "An Introduction to the methylumi package",
      "engine": "quarto::html",
      "headings": [
        "Introduction",
        "Loading data",
        "Quality control",
        "Normalization",
        "Example analysis",
        "Session information"
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      "created": "2026-08-14 10:54:19",
      "modified": "2026-08-14 10:54:19",
      "commits": 1
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    {
      "source": "methylumi450k.qmd",
      "filename": "methylumi450k.html",
      "title": "Working with Illumina 450k Arrays using methylumi",
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      "headings": [
        "Creating a MethyLumiSet object from IDATs",
        "Negative and normalization controls",
        "Preprocessing the raw data",
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        "Session information"
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      "created": "2026-08-14 10:54:19",
      "modified": "2026-08-14 10:54:19",
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