{
  "_id": "6ace3ba9a14063b82c3b1a80",
  "Package": "methylumi",
  "Type": "Package",
  "Title": "Handle Illumina methylation data",
  "Version": "2.59.3",
  "Date": "2026-08-14",
  "Author": "Sean Davis, Pan Du, Sven Bilke, Tim Triche, Jr., Moiz Bootwalla",
  "biocViews": "DNAMethylation, TwoChannel, Preprocessing, QualityControl,\nCpGIsland",
  "Maintainer": "Sean Davis <seandavi@gmail.com>",
  "Description": "This package provides classes for holding and manipulating\nIllumina methylation data.  Based on eSet, it can contain MIAME\ninformation, sample information, feature information, and\nmultiple matrices of data.  An \"intelligent\" import function,\nmethylumiR can read the Illumina text files and create a\nMethyLumiSet. methylumIDAT can directly read raw IDAT files\nfrom HumanMethylation27 and HumanMethylation450 microarrays.\nNormalization, background correction, and quality control\nfeatures for GoldenGate, Infinium, and Infinium HD arrays are\nalso included.",
  "Collate": "AllGenerics.R MethyLumiSet-class.R MethyLumiM-class.R\nMoreGenerics.R Methods.R bgcorr.R coercions.R data.R\ndetectionpval.R featureFilter.R mclapply_replace.R\nmethylData-class.R methylumIDAT.R methylumiCSV.R methylumiR.R\nnormalization.R plotNegOob.R qc.probe.plot.R readIDAT2.R\nstripMethyLumiSet.R utilities.R varFilter.R",
  "VignetteBuilder": "quarto",
  "URL": "https://seandavi.github.io/methylumi/,\nhttps://github.com/seandavi/methylumi",
  "BugReports": "https://github.com/seandavi/methylumi/issues",
  "License": "GPL-2",
  "Encoding": "UTF-8",
  "Config/testthat/edition": "3",
  "Config/roxygen2/version": "8.1.0",
  "Config/pak/sysreqs": "make libbz2-dev libicu-dev liblzma-dev libpng-dev\nlibxml2-dev libssl-dev libx11-dev xz-utils zlib1g-dev",
  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-08-14 16:33:14 UTC",
  "RemoteUrl": "https://github.com/bioc/methylumi",
  "RemoteRef": "HEAD",
  "RemoteSha": "4232eaf043694b8b8e2bfe1095f03185be39a8af",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-10-13 13:31:33 UTC",
    "User": "root"
  },
  "_user": "bioc",
  "_type": "src",
  "_file": "methylumi_2.59.3.tar.gz",
  "_fileid": "https://r2.ropensci.org/b654cbe801d302f930fe3cca282553da15ab44281fb3e516a0e4bb55de54c360",
  "_filesize": 6740553,
  "_sha256": "b654cbe801d302f930fe3cca282553da15ab44281fb3e516a0e4bb55de54c360",
  "_expires": "2027-01-21T14:09:41.000Z",
  "_created": "2026-10-13T13:31:33.000Z",
  "_published": "2026-10-13T14:09:45.791Z",
  "_buildurl": "https://github.com/r-universe/bioc/actions/runs/38404543783",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_bioccheck": {
    "error": 2,
    "warning": 5,
    "note": 14
  },
  "_upstream": "https://github.com/bioc/methylumi",
  "_commit": {
    "id": "4232eaf043694b8b8e2bfe1095f03185be39a8af",
    "author": "Sean Davis <seandavi@gmail.com>",
    "committer": "GitHub <noreply@github.com>",
    "message": "Install methylumi into the real library before building the pkgdown site (#52)\n\npkgdown::build_site(install = TRUE) installs the package into a temporary\nlibrary that exists only on the calling R process's .libPaths(). The articles\nare .qmd, so pkgdown renders them by shelling out to the Quarto CLI, which\nstarts a fresh R session per file -- and that session inherits none of the\ntemporary library. library(methylumi) in the vignettes therefore resolved\nagainst the stale methylumi already in the container's site-library, and the\nbuild died with the long-fixed defunct import from #28:\n\n  ! package or namespace load failed for 'methylumi':\n   object 'parallel' is not exported by 'namespace:lattice'\n  Quitting from methylumi.qmd:83-93 [load]\n\nbuild_site() renders articles with quiet = TRUE, which is why the log showed\nonly 'Error returned by quarto CLI'.\n\nInstall into site-library ourselves and pass install = FALSE, so the child\nQuarto sessions see the package being documented.\n\nCo-authored-by: Claude Opus 5 <noreply@anthropic.com>",
    "time": 1786725194
  },
  "_maintainer": {
    "name": "Sean Davis",
    "email": "seandavi@gmail.com",
    "login": "seandavi",
    "description": "Software developer, Pediatric oncologist, Cancer researcher, Data scientist and engineer, Community organizer",
    "uuid": 92435
  },
  "_distro": "resolute",
  "_jobs": [
    {
      "job": 115325008401,
      "time": 452,
      "config": "bioc-checks",
      "r": "4.6.1",
      "check": "ERROR",
      "artifact": "11818428862"
    },
    {
      "job": 115325008650,
      "time": 627,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "11818304026"
    },
    {
      "job": 115325009331,
      "time": 797,
      "config": "linux-release-x86_64",
      "r": "4.6.1",
      "check": "NOTE",
      "artifact": "11819765772"
    },
    {
      "job": 115325008543,
      "time": 579,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "11821451486"
    },
    {
      "job": 115325008608,
      "time": 604,
      "config": "macos-release-arm64",
      "r": "4.6.1",
      "check": "NOTE",
      "artifact": "11821501175"
    },
    {
      "job": 115320764899,
      "time": 535,
      "config": "source",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11818736974"
    },
    {
      "job": 115325008546,
      "time": 345,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "11817219412"
    },
    {
      "job": 115325008416,
      "time": 699,
      "config": "windows-devel-x86_64",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "11818724052"
    },
    {
      "job": 115325008624,
      "time": 704,
      "config": "windows-oldrel-x86_64",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "11819243963"
    },
    {
      "job": 115325008877,
      "time": 701,
      "config": "windows-release-x86_64",
      "r": "4.6.1",
      "check": "NOTE",
      "artifact": "11818379765"
    }
  ],
  "_registered": true,
  "_dependencies": [
    {
      "package": "Biobase",
      "role": "Depends"
    },
    {
      "package": "methods",
      "role": "Depends"
    },
    {
      "package": "R",
      "version": ">= 4.0",
      "role": "Depends"
    },
    {
      "package": "scales",
      "role": "Depends"
    },
    {
      "package": "reshape2",
      "role": "Depends"
    },
    {
      "package": "ggplot2",
      "role": "Depends"
    },
    {
      "package": "matrixStats",
      "role": "Depends"
    },
    {
      "package": "FDb.InfiniumMethylation.hg19",
      "version": ">= 2.2.0",
      "role": "Depends"
    },
    {
      "package": "minfi",
      "role": "Depends"
    },
    {
      "package": "BiocGenerics",
      "role": "Imports"
    },
    {
      "package": "S4Vectors",
      "role": "Imports"
    },
    {
      "package": "IRanges",
      "role": "Imports"
    },
    {
      "package": "GenomeInfoDb",
      "role": "Imports"
    },
    {
      "package": "GenomicRanges",
      "role": "Imports"
    },
    {
      "package": "SummarizedExperiment",
      "role": "Imports"
    },
    {
      "package": "Biobase",
      "role": "Imports"
    },
    {
      "package": "graphics",
      "role": "Imports"
    },
    {
      "package": "grDevices",
      "role": "Imports"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "utils",
      "role": "Imports"
    },
    {
      "package": "lattice",
      "role": "Imports"
    },
    {
      "package": "annotate",
      "role": "Imports"
    },
    {
      "package": "genefilter",
      "role": "Imports"
    },
    {
      "package": "AnnotationDbi",
      "role": "Imports"
    },
    {
      "package": "minfi",
      "role": "Imports"
    },
    {
      "package": "stats4",
      "role": "Imports"
    },
    {
      "package": "illuminaio",
      "role": "Imports"
    },
    {
      "package": "GenomicFeatures",
      "role": "Imports"
    },
    {
      "package": "BiocParallel",
      "role": "Imports"
    },
    {
      "package": "lumi",
      "role": "Suggests"
    },
    {
      "package": "limma",
      "role": "Suggests"
    },
    {
      "package": "SQN",
      "role": "Suggests"
    },
    {
      "package": "MASS",
      "role": "Suggests"
    },
    {
      "package": "rtracklayer",
      "role": "Suggests"
    },
    {
      "package": "Biostrings",
      "role": "Suggests"
    },
    {
      "package": "quarto",
      "role": "Suggests"
    },
    {
      "package": "TCGAMethylation450k",
      "role": "Suggests"
    },
    {
      "package": "IlluminaHumanMethylation450kanno.ilmn12.hg19",
      "role": "Suggests"
    },
    {
      "package": "FDb.InfiniumMethylation.hg18",
      "version": ">= 2.2.0",
      "role": "Suggests"
    },
    {
      "package": "Homo.sapiens",
      "role": "Suggests"
    },
    {
      "package": "TxDb.Hsapiens.UCSC.hg19.knownGene",
      "role": "Suggests"
    },
    {
      "package": "knitr",
      "role": "Suggests"
    },
    {
      "package": "testthat",
      "version": ">= 3.0.0",
      "role": "Suggests"
    }
  ],
  "_owner": "bioc",
  "_selfowned": true,
  "_usedby": 22,
  "_updates": [
    {
      "week": "2026-33",
      "n": 15
    }
  ],
  "_tags": [],
  "_bioc": [
    {
      "branch": "devel",
      "version": "2.59.3",
      "bioc": "3.24",
      "repository": "bioc"
    },
    {
      "branch": "release",
      "version": "2.58.1",
      "bioc": "3.23",
      "repository": "bioc"
    }
  ],
  "_topics": [
    "dnamethylation",
    "twochannel",
    "preprocessing",
    "qualitycontrol",
    "cpgisland",
    "quarto"
  ],
  "_stars": 9,
  "_contributors": [
    {
      "user": "seandavi",
      "count": 242,
      "uuid": 92435
    },
    {
      "user": "dtenenba",
      "count": 50,
      "uuid": 2286826
    },
    {
      "user": "ttriche",
      "count": 42,
      "uuid": 4386
    },
    {
      "user": "nturaga",
      "count": 24,
      "uuid": 2746443
    },
    {
      "user": "jwokaty",
      "count": 16,
      "uuid": 1744257
    },
    {
      "user": "vobencha",
      "count": 4,
      "uuid": 2466173
    },
    {
      "user": "alanocallaghan",
      "count": 2,
      "uuid": 10779688
    },
    {
      "user": "hpages",
      "count": 2,
      "uuid": 8810451
    },
    {
      "user": "mbootwalla",
      "count": 1,
      "uuid": 851911
    }
  ],
  "_userbio": {
    "uuid": 2286807,
    "type": "organization",
    "name": "Bioconductor",
    "followers": 476,
    "description": "Software for the analysis and comprehension of high-throughput genomic data"
  },
  "_downloads": {
    "count": 2880,
    "source": "https://www.bioconductor.org/packages/stats/bioc/methylumi"
  },
  "_mentions": 75,
  "_devurl": "https://github.com/seandavi/methylumi",
  "_searchresults": 108,
  "_quarto": true,
  "_rbuild": "4.6.1",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/manual.pdf",
    "extra/methylumi.html",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md"
  ],
  "_homeurl": "https://github.com/seandavi/methylumi",
  "_realowner": "bioc",
  "_cranurl": false,
  "_exports": [
    ".mclapply",
    "betas",
    "betas<-",
    "combine",
    "combine27k450k",
    "controlData",
    "controlData<-",
    "controlTypes",
    "corplot",
    "cy3",
    "Cy3.N",
    "Cy3<-",
    "cy5",
    "Cy5.N",
    "Cy5<-",
    "dataType",
    "dataType<-",
    "designIItoMandU",
    "designItoMandU",
    "detection",
    "detection<-",
    "diagnostics",
    "estimateM",
    "exprs",
    "exprs<-",
    "extractBarcodeAndPosition",
    "featureFilter",
    "getAssayDataNameSubstitutions",
    "getBarcodes",
    "getHistory",
    "hist",
    "IDATsToMatrices",
    "IDATtoMatrix",
    "intensities.IB",
    "intensities.M",
    "intensities.OOB",
    "intensities.OOB.allelic",
    "intensities.U",
    "intensitiesByChannel",
    "lumiCSV",
    "lumIDAT",
    "mergeProbeDesigns",
    "methylated",
    "methylated.N",
    "methylated.N<-",
    "methylated<-",
    "methylumi.bgcorr",
    "methylumi.diagnostics",
    "methylumiCSV",
    "methylumIDAT",
    "methylumiR",
    "NChannelSetToMethyLumiSet",
    "negctls",
    "negctls.stderr",
    "negnorm",
    "normalizeMethyLumiSet",
    "normctls",
    "pairs",
    "plotNAs",
    "plotNegOob",
    "plotSampleIntensities",
    "probeNAs",
    "psummary",
    "pval.detect",
    "pval.detect<-",
    "pvals",
    "pvals<-",
    "qc.probe.plot",
    "QCdata",
    "QCdata<-",
    "qcplot",
    "sampleNAs",
    "show",
    "stripBeadNs",
    "stripBeadSDs",
    "stripMethyLumiSet",
    "stripOOB",
    "summary",
    "tcgaPipeline",
    "total.intensity",
    "unmethylated",
    "unmethylated.N",
    "unmethylated.N<-",
    "unmethylated<-",
    "varFilter"
  ],
  "_datasets": [
    {
      "name": "CpGs",
      "title": "Data frame describing loci on the 27 and 450k arrays",
      "object": "CpGs",
      "file": "CpGs.rda",
      "class": [
        "data.frame"
      ],
      "fields": [
        "CpGs",
        "design.27k",
        "design.450k",
        "type",
        "random"
      ],
      "rows": 487177,
      "table": true,
      "tojson": true
    },
    {
      "name": "mldat",
      "title": "Example SAM format Illumina methylation dataset",
      "object": "mldat",
      "file": "mldat.rda",
      "class": [
        "MethyLumiSet"
      ],
      "fields": [],
      "table": false,
      "tojson": false
    }
  ],
  "_help": [
    {
      "page": "methylumi-package",
      "title": "Handle Illumina methylation data",
      "topics": [
        "methylumi-package",
        "methylumi"
      ]
    },
    {
      "page": "CpGs",
      "title": "Data frame describing loci on the 27 and 450k arrays",
      "topics": [
        "CpGs"
      ]
    },
    {
      "page": "estimateM",
      "title": "Estimate methylation M-value matrix",
      "topics": [
        "estimateM"
      ]
    },
    {
      "page": "extractBarcodeAndPosition",
      "title": "Extract the barcode and position information from a Sentrix ID",
      "topics": [
        "extractBarcodeAndPosition"
      ]
    },
    {
      "page": "featureFilter",
      "title": "Annotation-based filtering of features (CpG sites) in a MethyLumiSet or MethyLumiM object",
      "topics": [
        "featureFilter",
        "featureFilter,MethyLumiM-method",
        "featureFilter,MethyLumiSet-method"
      ]
    },
    {
      "page": "getAssayDataNameSubstitutions",
      "title": "Return a data.frame of AssayData name substitutions",
      "topics": [
        "getAssayDataNameSubstitutions"
      ]
    },
    {
      "page": "IDATsToMatrices",
      "title": "convert multiple idats to matrices",
      "topics": [
        "IDATsToMatrices"
      ]
    },
    {
      "page": "IDATtoMatrix",
      "title": "process a single IDAT (just the mean intensities)",
      "topics": [
        "IDATtoMatrix"
      ]
    },
    {
      "page": "methylData-class",
      "title": "Class '\"methylData\"', superclass for MethyLumiSet and MethyLumiM",
      "topics": [
        "diagnostics,methylData-method",
        "methylated.N,methylData-method",
        "methylated.N<-,methylData,matrix-method",
        "methylData-class",
        "plotNAs,methylData-method",
        "pval.detect,methylData-method",
        "pval.detect<-,methylData,numeric-method",
        "unmethylated.N,methylData-method",
        "unmethylated.N<-,methylData,matrix-method"
      ]
    },
    {
      "page": "generics",
      "title": "methylumi accessors",
      "topics": [
        "betas",
        "betas<-",
        "corplot",
        "getHistory",
        "methylated",
        "methylated<-",
        "pvals",
        "pvals<-",
        "QCdata",
        "QCdata<-",
        "unmethylated",
        "unmethylated<-"
      ]
    },
    {
      "page": "MethyLumi-class",
      "title": "The base class for storing Illumina Methylation data",
      "topics": [
        "methylated,MethyLumi-method",
        "methylated<-,MethyLumi,matrix-method",
        "MethyLumi-class",
        "pvals,MethyLumi-method",
        "pvals<-,MethyLumi,matrix-method",
        "qcplot,Methylumi-method",
        "summary,MethyLumi-method",
        "unmethylated,MethyLumi-method",
        "unmethylated<-,MethyLumi,matrix-method"
      ]
    },
    {
      "page": "MethyLumi-strippers",
      "title": "Strip excessive probe-level data from MethyLumiSets",
      "topics": [
        "MethyLumi-strippers",
        "stripBeadNs",
        "stripBeadSDs",
        "stripMethyLumiSet",
        "stripOOB"
      ]
    },
    {
      "page": "methylumIDAT",
      "title": "methylumIDAT",
      "topics": [
        "methylumIDAT"
      ]
    },
    {
      "page": "methylumiGenerics",
      "title": "Generics defined in methylumi",
      "topics": [
        "betas,GenomicMethylSet-method",
        "betas,MethylSet-method",
        "betas,RangedSummarizedExperiment-method",
        "combine27k450k",
        "controlData",
        "controlData<-",
        "cy3",
        "Cy3.N",
        "Cy3<-",
        "cy5",
        "Cy5.N",
        "Cy5<-",
        "dataType",
        "dataType<-",
        "designIItoMandU",
        "designItoMandU",
        "detection",
        "detection<-",
        "diagnostics",
        "getBarcodes",
        "getProtocolData",
        "IDATsToDFs",
        "IDATtoDF",
        "intensities.IB",
        "intensities.M",
        "intensities.OOB",
        "intensities.OOB.allelic",
        "intensities.U",
        "intensitiesByChannel",
        "lumiCSV",
        "lumIDAT",
        "mergeProbeDesigns",
        "methylated,MethylSet-method",
        "methylated.N",
        "methylated.N<-",
        "methylumi.bgcorr",
        "methylumi.diagnostics",
        "methylumiCSV",
        "NChannelSetToMethyLumiSet",
        "negctls",
        "negctls.stderr",
        "negnorm",
        "normctls",
        "plotNAs",
        "plotNegOob",
        "probeNAs",
        "psummary",
        "pval.detect",
        "pval.detect<-",
        "qc.probe.plot",
        "sampleNAs",
        "total.intensity",
        "unmethylated,MethylSet-method",
        "unmethylated.N",
        "unmethylated.N<-"
      ]
    },
    {
      "page": "MethyLumiM-class",
      "title": "Class \"MethyLumiM\": for Illumina Methylation microarray data using logRatios",
      "topics": [
        "betas,MethyLumiM-method",
        "combine,MethyLumiM,MethyLumiM-method",
        "controlData,MethyLumiM-method",
        "controlData<-,MethyLumiM,ANY-method",
        "controlTypes,MethyLumiM-method",
        "dataType,MethyLumiM-method",
        "dataType<-,MethyLumiM,ANY-method",
        "dataType<-,MethyLumiM-method",
        "detection,MethyLumiM-method",
        "detection<-,MethyLumiM-method",
        "getHistory,MethyLumiM-method",
        "intensitiesByChannel,MethyLumiM-method",
        "methylated,MethyLumiM-method",
        "methylated.N,MethyLumiM-method",
        "methylated.N<-,MethyLumiM,ANY-method",
        "methylated<-,MethyLumiM,ANY-method",
        "MethyLumiM",
        "MethyLumiM-class",
        "negctls,MethyLumiM,character-method",
        "negctls,MethyLumiM,missing-method",
        "negnorm,MethyLumiM,character-method",
        "negnorm,MethyLumiM,missing-method",
        "normctls,MethyLumiM-method",
        "probeNAs,MethyLumiM-method",
        "pvals,MethyLumiM-method",
        "QCdata,MethyLumiM-method",
        "sampleNAs,MethyLumiM-method",
        "total.intensity,MethyLumiM-method",
        "unmethylated,MethyLumiM-method",
        "unmethylated.N,MethyLumiM-method",
        "unmethylated.N<-,MethyLumiM,ANY-method",
        "unmethylated<-,MethyLumiM,ANY-method",
        "[,MethyLumiM,ANY,ANY,ANY-method",
        "[,MethyLumiM,ANY-method"
      ]
    },
    {
      "page": "MethyLumiQC-class",
      "title": "Class '\"MethyLumiQC\"' for holding Illumina methylation QC data",
      "topics": [
        "combine,MethyLumiQC,MethyLumiQC-method",
        "controlData<-,MethyLumiSet,MethyLumiQC-method",
        "controlTypes,MethyLumiQC-method",
        "Cy3.N,MethyLumiQC-method",
        "Cy3<-,MethyLumiQC,matrix-method",
        "Cy5.N,MethyLumiQC-method",
        "Cy5<-,MethyLumiQC,matrix-method",
        "hist,MethyLumiQC-method",
        "intensitiesByChannel,MethyLumiQC-method",
        "methylated,MethyLumiQC-method",
        "MethyLumiQC-class",
        "negctls,MethyLumiQC,character-method",
        "negctls,MethyLumiQC,missing-method",
        "negctls.stderr,MethyLumiQC,character-method",
        "negctls.stderr,MethyLumiQC,missing-method",
        "negnorm,MethyLumiQC,character-method",
        "negnorm,MethyLumiQC,missing-method",
        "normctls,MethyLumiQC-method",
        "QCdata<-,MethyLumiSet,MethyLumiQC-method",
        "qcplot,MethyLumiQC-method",
        "unmethylated,MethyLumiQC-method"
      ]
    },
    {
      "page": "methylumiR",
      "title": "Load data from an Illumina methylation platform",
      "topics": [
        "methylumiR"
      ]
    },
    {
      "page": "MethyLumiSet-class",
      "title": "Class '\"MethyLumiSet\"' for containing Illumina methylation data",
      "topics": [
        "betas,MethyLumiSet-method",
        "betas<-,MethyLumiSet,matrix-method",
        "boxplot,MethyLumiSet-method",
        "combine,MethyLumiSet,MethyLumiSet-method",
        "combine27k450k,MethyLumiSet,MethyLumiSet-method",
        "controlData,MethyLumiSet-method",
        "controlData<-,MethyLumiSet",
        "controlTypes,MethyLumiSet-method",
        "corplot,MethyLumiSet-method",
        "Cy3.N,MethyLumiSet-method",
        "Cy5.N,MethyLumiSet-method",
        "exprs,MethyLumiSet-method",
        "getHistory,MethyLumiSet-method",
        "hist,MethyLumiSet-method",
        "intensities.IB,MethyLumiSet,character-method",
        "intensities.IB,MethyLumiSet,missing-method",
        "intensities.M,MethyLumiSet,character-method",
        "intensities.M,MethyLumiSet,missing-method",
        "intensities.OOB,MethyLumiSet,character-method",
        "intensities.OOB,MethyLumiSet,missing-method",
        "intensities.OOB.allelic,MethyLumiSet,character,character-method",
        "intensities.OOB.allelic,MethyLumiSet,missing,missing-method",
        "intensities.U,MethyLumiSet,character-method",
        "intensities.U,MethyLumiSet,missing-method",
        "intensitiesByChannel,MethyLumiSet-method",
        "methylated,MethyLumiSet-method",
        "methylated<-,MethyLumiSet,matrix-method",
        "MethyLumiSet-class",
        "negctls,MethyLumiSet,character-method",
        "negctls,MethyLumiSet,missing-method",
        "negctls.stderr,MethyLumiSet,character-method",
        "negctls.stderr,MethyLumiSet,missing-method",
        "negnorm,MethyLumiSet,character-method",
        "negnorm,MethyLumiSet,missing-method",
        "normctls,MethyLumiSet-method",
        "pairs,MethyLumiSet-method",
        "plotSampleIntensities,MethyLumiSet-method",
        "probeNAs,MethyLumiSet-method",
        "QCdata,MethyLumiSet-method",
        "QCdata<-,MethyLumiSet",
        "qcplot,MethyLumiSet-method",
        "sampleNAs,MethyLumiSet-method",
        "show,MethyLumiSet-method",
        "total.intensity,MethyLumiSet-method",
        "unmethylated,MethyLumiSet-method",
        "unmethylated<-,MethyLumiSet,matrix-method",
        "[,MethyLumiSet,ANY,ANY,ANY-method",
        "[,MethyLumiSet,ANY-method"
      ]
    },
    {
      "page": "mldat",
      "title": "Example SAM format Illumina methylation dataset",
      "topics": [
        "mldat"
      ]
    },
    {
      "page": "normalizeMethyLumiSet",
      "title": "Normalize a MethyLumiSet, accounting for dye bias",
      "topics": [
        "normalizeMethyLumiSet"
      ]
    },
    {
      "page": "plotSampleIntensities",
      "title": "Plot the sample intensities",
      "topics": [
        "plotSampleIntensities"
      ]
    },
    {
      "page": "qcplot",
      "title": "Methods for dealing with control data for Illumina methylation data",
      "topics": [
        "controlTypes",
        "qcplot"
      ]
    },
    {
      "page": "tcgaPipeline",
      "title": "Total convenience function for processing IDATs like tcga",
      "topics": [
        "tcgaPipeline"
      ]
    },
    {
      "page": "varFilter",
      "title": "Variation-based filtering of features (CpG sites) in a MethyLumiSet or MethyLumiM object",
      "topics": [
        "varFilter",
        "varFilter,MethyLumiM-method",
        "varFilter,MethyLumiSet-method"
      ]
    }
  ],
  "_readme": "https://github.com/bioc/methylumi/raw/HEAD/README.md",
  "_rundeps": [
    "abind",
    "annotate",
    "AnnotationDbi",
    "askpass",
    "base64",
    "beanplot",
    "BH",
    "Biobase",
    "BiocBaseUtils",
    "BiocFileCache",
    "BiocGenerics",
    "BiocIO",
    "biocmake",
    "BiocParallel",
    "Biostrings",
    "bit",
    "bit64",
    "bitops",
    "blob",
    "bumphunter",
    "cachem",
    "cigarillo",
    "cli",
    "clipr",
    "codetools",
    "cpp11",
    "crayon",
    "curl",
    "data.table",
    "DBI",
    "dbplyr",
    "DelayedArray",
    "DelayedMatrixStats",
    "digest",
    "dir.expiry",
    "doRNG",
    "dplyr",
    "farver",
    "fastmap",
    "FDb.InfiniumMethylation.hg19",
    "filelock",
    "foreach",
    "formatR",
    "futile.logger",
    "futile.options",
    "genefilter",
    "generics",
    "GenomeInfoDb",
    "GenomicAlignments",
    "GenomicFeatures",
    "GenomicRanges",
    "GEOquery",
    "ggplot2",
    "glue",
    "gtable",
    "h5mread",
    "HDF5Array",
    "hms",
    "httr",
    "httr2",
    "illuminaio",
    "IRanges",
    "isoband",
    "iterators",
    "jsonlite",
    "KEGGREST",
    "labeling",
    "lambda.r",
    "lattice",
    "lifecycle",
    "limma",
    "locfit",
    "magrittr",
    "MASS",
    "Matrix",
    "MatrixGenerics",
    "matrixStats",
    "mclust",
    "memoise",
    "mime",
    "minfi",
    "multtest",
    "nlme",
    "nor1mix",
    "openssl",
    "org.Hs.eg.db",
    "pillar",
    "pkgconfig",
    "plyr",
    "png",
    "preprocessCore",
    "prettyunits",
    "progress",
    "purrr",
    "quadprog",
    "R.methodsS3",
    "R.oo",
    "R.utils",
    "R6",
    "RColorBrewer",
    "Rcpp",
    "RCurl",
    "readr",
    "rentrez",
    "reshape",
    "reshape2",
    "restfulr",
    "rhdf5",
    "rhdf5filters",
    "Rhdf5lib",
    "Rhtslib",
    "rjson",
    "rlang",
    "rngtools",
    "Rsamtools",
    "RSQLite",
    "rtracklayer",
    "rvest",
    "S4Arrays",
    "S4Vectors",
    "S7",
    "scales",
    "scrime",
    "selectr",
    "Seqinfo",
    "siggenes",
    "snow",
    "SparseArray",
    "sparseMatrixStats",
    "statmod",
    "stringi",
    "stringr",
    "SummarizedExperiment",
    "survival",
    "sys",
    "tibble",
    "tidyr",
    "tidyselect",
    "TxDb.Hsapiens.UCSC.hg19.knownGene",
    "tzdb",
    "UCSC.utils",
    "utf8",
    "vctrs",
    "viridisLite",
    "vroom",
    "withr",
    "XML",
    "xml2",
    "xtable",
    "XVector",
    "yaml"
  ],
  "_vignettes": [
    {
      "source": "methylumi.qmd",
      "filename": "methylumi.html",
      "title": "An Introduction to the methylumi package",
      "engine": "quarto::html",
      "headings": [
        "Introduction",
        "Loading data",
        "Quality control",
        "Normalization",
        "Example analysis",
        "Session information"
      ],
      "created": "2026-08-14 10:54:19",
      "modified": "2026-08-14 10:54:19",
      "commits": 1
    },
    {
      "source": "methylumi450k.qmd",
      "filename": "methylumi450k.html",
      "title": "Working with Illumina 450k Arrays using methylumi",
      "engine": "quarto::html",
      "headings": [
        "Creating a MethyLumiSet object from IDATs",
        "Negative and normalization controls",
        "Preprocessing the raw data",
        "Coercions to other data structures",
        "Session information"
      ],
      "created": "2026-08-14 10:54:19",
      "modified": "2026-08-14 10:54:19",
      "commits": 1
    }
  ],
  "_score": 10.169692675219318,
  "_indexed": true,
  "_nocasepkg": "methylumi",
  "_universes": [
    "bioc",
    "seandavi"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "2.59.3",
      "date": "2026-10-13T13:39:08.000Z",
      "distro": "resolute",
      "commit": "4232eaf043694b8b8e2bfe1095f03185be39a8af",
      "fileid": "https://r2.ropensci.org/dd1f417b28654a91a072511cddc704a9f279845f26884e29c8c32f35c8077929",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/38404543783"
    },
    {
      "r": "4.6.1",
      "os": "linux",
      "version": "2.59.3",
      "date": "2026-10-13T13:40:37.000Z",
      "distro": "resolute",
      "commit": "4232eaf043694b8b8e2bfe1095f03185be39a8af",
      "fileid": "https://r2.ropensci.org/a978850a0f805d5b05bfb1e27cf7984448af9b9e704d2467a0c7afb236d4d7e7",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/38404543783"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "2.59.3",
      "date": "2026-10-13T14:04:07.000Z",
      "commit": "4232eaf043694b8b8e2bfe1095f03185be39a8af",
      "fileid": "https://r2.ropensci.org/ec99f97c7028355b4d13933f6983984058cb8f30032b8f142ae8cbb0fa2f510b",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/38404543783"
    },
    {
      "r": "4.6.1",
      "os": "mac",
      "version": "2.59.3",
      "date": "2026-10-13T14:02:17.000Z",
      "commit": "4232eaf043694b8b8e2bfe1095f03185be39a8af",
      "fileid": "https://r2.ropensci.org/29b2595a416e08d5b1beecd1fc930e355ff5bdcd089a2d8dc73e0f9b274e9595",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/38404543783"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "2.59.3",
      "date": "2026-10-13T13:38:10.000Z",
      "commit": "4232eaf043694b8b8e2bfe1095f03185be39a8af",
      "fileid": "https://r2.ropensci.org/204ef83066c912ea07dd0366d6d573756db15e2029302f9915df1ac46a2e7b60",
      "status": "success",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/38404543783"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "2.59.3",
      "date": "2026-10-13T13:38:58.000Z",
      "commit": "4232eaf043694b8b8e2bfe1095f03185be39a8af",
      "fileid": "https://r2.ropensci.org/9b139d86727a2bba34a9b0c40f4251e94ad257da72c15bbbc962eaba1f756305",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/38404543783"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "2.59.3",
      "date": "2026-10-13T13:38:53.000Z",
      "commit": "4232eaf043694b8b8e2bfe1095f03185be39a8af",
      "fileid": "https://r2.ropensci.org/1a269ffe6a95453ccd18ed987c7105d0066af8ae77901d7d71d98ec40b5e835a",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/38404543783"
    },
    {
      "r": "4.6.1",
      "os": "win",
      "version": "2.59.3",
      "date": "2026-10-13T13:38:59.000Z",
      "commit": "4232eaf043694b8b8e2bfe1095f03185be39a8af",
      "fileid": "https://r2.ropensci.org/83823a8eda3769267d7007af5e4a3b752bf6fb850699eb140c53996028397e80",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/38404543783"
    }
  ]
}