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  "Title": "Discovering genomic regions where methylation is strongly\nassociated with transcriptional activity",
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  "Description": "DNA methylation is generally considered to be associated\nwith transcriptional silencing. However, comprehensive,\ngenome-wide investigation of this relationship requires the\nevaluation of potentially millions of correlation values\nbetween the methylation of individual genomic loci and\nexpression of associated transcripts in a relatively large\nnumbers of samples. Methodical makes this process quick and\neasy while keeping a low memory footprint. It also provides a\nnovel method for identifying regions where a number of\nmethylation sites are consistently strongly associated with\ntranscriptional expression. In addition, Methodical enables\nhousing DNA methylation data from diverse sources (e.g. WGBS,\nRRBS and methylation arrays) with a common framework, lifting\nover DNA methylation data between different genome builds and\ncreating base-resolution plots of the association between DNA\nmethylation and transcriptional activity at transcriptional\nstart sites.",
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