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  "Package": "maftools",
  "Title": "Summarize, Analyze and Visualize MAF Files",
  "Version": "2.29.0",
  "Date": "2021-04-30",
  "Authors@R": "person(given = \"Anand\",\nfamily = \"Mayakonda\",\nrole = c(\"aut\", \"cre\"),\nemail = \"anand_mt@hotmail.com\",\ncomment = c(ORCID = \"0000-0003-1162-687X\"))",
  "Maintainer": "Anand Mayakonda <anand_mt@hotmail.com>",
  "Description": "Analyze and visualize Mutation Annotation Format (MAF)\nfiles from large scale sequencing studies. This package\nprovides various functions to perform most commonly used\nanalyses in cancer genomics and to create feature rich\ncustomizable visualzations with minimal effort.",
  "License": "MIT + file LICENSE",
  "URL": "https://github.com/PoisonAlien/maftools",
  "BugReports": "https://github.com/PoisonAlien/maftools/issues",
  "VignetteBuilder": "knitr",
  "biocViews": "DataRepresentation, DNASeq, Visualization, DriverMutation,\nVariantAnnotation, FeatureExtraction, Classification,\nSomaticMutation, Sequencing, FunctionalGenomics, Survival",
  "Encoding": "UTF-8",
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  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 12:43:52 UTC",
  "RemoteUrl": "https://github.com/bioc/maftools",
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  "Author": "Anand Mayakonda [aut, cre] (ORCID:\n<https://orcid.org/0000-0003-1162-687X>)",
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  "_exports": [
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    "bamreadcounts",
    "cancerhotspots",
    "cancerhotspotsAggr",
    "clinicalEnrichment",
    "coBarplot",
    "coGisticChromPlot",
    "compareSignatures",
    "coOncoplot",
    "drugInteractions",
    "estimateSignatures",
    "extractSignatures",
    "filterMaf",
    "forestPlot",
    "genesToBarcodes",
    "genotypeMatrix",
    "getClinicalData",
    "getCytobandSummary",
    "getFields",
    "getGeneSummary",
    "getSampleSummary",
    "gisticBubblePlot",
    "gisticChromPlot",
    "gisticCompare",
    "gisticOncoPlot",
    "gtMarkers",
    "icgcSimpleMutationToMAF",
    "inferHeterogeneity",
    "intersectMAF",
    "lollipopPlot",
    "lollipopPlot2",
    "MAF",
    "maf2mae",
    "mafbarplot",
    "mafCompare",
    "mafSummary",
    "mafSurvGroup",
    "mafSurvival",
    "math.score",
    "merge_mafs",
    "mutCountMatrix",
    "oncodrive",
    "oncoplot",
    "oncostrip",
    "pathways",
    "pfamDomains",
    "plotApobecDiff",
    "plotCBSsegments",
    "plotClusters",
    "plotCophenetic",
    "plotEnrichmentResults",
    "plotmafSummary",
    "plotMosdepth",
    "plotMosdepth_t",
    "plotOncodrive",
    "plotPathways",
    "plotProtein",
    "plotSignatures",
    "plotTiTv",
    "plotVaf",
    "prepareMutSig",
    "prepAscat",
    "prepAscat_t",
    "rainfallPlot",
    "read.maf",
    "readGistic",
    "sampleSwaps",
    "segmentLogR",
    "segSummarize",
    "setdiffMAF",
    "signatureEnrichment",
    "somaticInteractions",
    "subsetMaf",
    "survGroup",
    "tcgaAvailable",
    "tcgaCompare",
    "tcgaLoad",
    "titv",
    "tmb",
    "trinucleotideMatrix",
    "vafCompare",
    "write.GisticSummary",
    "write.mafSummary"
  ],
  "_help": [
    {
      "page": "annovarToMaf",
      "title": "Converts annovar annotations into MAF.",
      "topics": [
        "annovarToMaf"
      ]
    },
    {
      "page": "bamreadcounts",
      "title": "extract nucleotide counts for targeted variants from the BAM file.",
      "topics": [
        "bamreadcounts"
      ]
    },
    {
      "page": "cancerhotspots",
      "title": "Genotype known cancer hotspots from the tumor BAM file",
      "topics": [
        "cancerhotspots"
      ]
    },
    {
      "page": "cancerhotspotsAggr",
      "title": "Aggregate cancerhotspots reports",
      "topics": [
        "cancerhotspotsAggr"
      ]
    },
    {
      "page": "clinicalEnrichment",
      "title": "Performs mutational enrichment analysis for a given clinical feature.",
      "topics": [
        "clinicalEnrichment"
      ]
    },
    {
      "page": "coBarplot",
      "title": "Draw two barplots side by side for cohort comparision.",
      "topics": [
        "coBarplot"
      ]
    },
    {
      "page": "coGisticChromPlot",
      "title": "Co-plot version of gisticChromPlot()",
      "topics": [
        "coGisticChromPlot"
      ]
    },
    {
      "page": "compareSignatures",
      "title": "Compares identified denovo mutational signatures to known COSMIC signatures",
      "topics": [
        "compareSignatures"
      ]
    },
    {
      "page": "coOncoplot",
      "title": "Draw two oncoplots side by side for cohort comparision.",
      "topics": [
        "coOncoplot"
      ]
    },
    {
      "page": "drugInteractions",
      "title": "Drug-Gene Interactions",
      "topics": [
        "drugInteractions"
      ]
    },
    {
      "page": "estimateSignatures",
      "title": "Estimate number of signatures based on cophenetic correlation metric",
      "topics": [
        "estimateSignatures"
      ]
    },
    {
      "page": "extractSignatures",
      "title": "Extract mutational signatures from trinucleotide context.",
      "topics": [
        "extractSignatures"
      ]
    },
    {
      "page": "filterMaf",
      "title": "Filter MAF objects",
      "topics": [
        "filterMaf"
      ]
    },
    {
      "page": "forestPlot",
      "title": "Draw forest plot for differences betweeen cohorts.",
      "topics": [
        "forestPlot"
      ]
    },
    {
      "page": "genesToBarcodes",
      "title": "Extracts Tumor Sample Barcodes where the given genes are mutated.",
      "topics": [
        "genesToBarcodes"
      ]
    },
    {
      "page": "genotypeMatrix",
      "title": "Creates a Genotype Matrix for every variant",
      "topics": [
        "genotypeMatrix"
      ]
    },
    {
      "page": "getClinicalData",
      "title": "extract annotations from MAF object",
      "topics": [
        "getClinicalData",
        "getClinicalData,MAF-method"
      ]
    },
    {
      "page": "getCytobandSummary",
      "title": "extract cytoband summary from GISTIC object",
      "topics": [
        "getCytobandSummary",
        "getCytobandSummary,GISTIC-method"
      ]
    },
    {
      "page": "getFields",
      "title": "extract available fields from MAF object",
      "topics": [
        "getFields",
        "getFields,MAF-method"
      ]
    },
    {
      "page": "getGeneSummary",
      "title": "extract gene summary from MAF or GISTIC object",
      "topics": [
        "getGeneSummary",
        "getGeneSummary,GISTIC-method",
        "getGeneSummary,MAF-method"
      ]
    },
    {
      "page": "getSampleSummary",
      "title": "extract sample summary from MAF or GISTIC object",
      "topics": [
        "getSampleSummary",
        "getSampleSummary,GISTIC-method",
        "getSampleSummary,MAF-method"
      ]
    },
    {
      "page": "GISTIC-class",
      "title": "Class GISTIC",
      "topics": [
        "GISTIC",
        "GISTIC-class"
      ]
    },
    {
      "page": "gisticBubblePlot",
      "title": "Plot gistic results as a bubble plot",
      "topics": [
        "gisticBubblePlot"
      ]
    },
    {
      "page": "gisticChromPlot",
      "title": "Plot gistic results along linearized chromosome",
      "topics": [
        "gisticChromPlot"
      ]
    },
    {
      "page": "gisticCompare",
      "title": "compare two GISTIC objects",
      "topics": [
        "gisticCompare"
      ]
    },
    {
      "page": "gisticOncoPlot",
      "title": "Plot gistic results.",
      "topics": [
        "gisticOncoPlot"
      ]
    },
    {
      "page": "gtMarkers",
      "title": "Extract read counts from genetic markers for ASCAT analysis",
      "topics": [
        "gtMarkers"
      ]
    },
    {
      "page": "icgcSimpleMutationToMAF",
      "title": "Converts ICGC Simple Somatic Mutation format file to MAF",
      "topics": [
        "icgcSimpleMutationToMAF"
      ]
    },
    {
      "page": "inferHeterogeneity",
      "title": "Clusters variants based on Variant Allele Frequencies (VAF).",
      "topics": [
        "inferHeterogeneity"
      ]
    },
    {
      "page": "lollipopPlot",
      "title": "Draws lollipop plot of amino acid changes on to Protein structure.",
      "topics": [
        "lollipopPlot"
      ]
    },
    {
      "page": "lollipopPlot2",
      "title": "Compare two lollipop plots",
      "topics": [
        "lollipopPlot2"
      ]
    },
    {
      "page": "MAF",
      "title": "Construct an MAF object",
      "topics": [
        "MAF"
      ]
    },
    {
      "page": "MAF-class",
      "title": "Class MAF",
      "topics": [
        "MAF-class"
      ]
    },
    {
      "page": "maf2mae",
      "title": "Convert MAF to MultiAssayExperiment object",
      "topics": [
        "maf2mae"
      ]
    },
    {
      "page": "mafbarplot",
      "title": "Creates a bar plot",
      "topics": [
        "mafbarplot"
      ]
    },
    {
      "page": "mafCompare",
      "title": "compare two cohorts (MAF).",
      "topics": [
        "mafCompare"
      ]
    },
    {
      "page": "mafSummary",
      "title": "Summary statistics of MAF",
      "topics": [
        "mafSummary"
      ]
    },
    {
      "page": "mafSurvGroup",
      "title": "Performs survival analysis for a geneset",
      "topics": [
        "mafSurvGroup"
      ]
    },
    {
      "page": "mafSurvival",
      "title": "Performs survival analysis",
      "topics": [
        "mafSurvival"
      ]
    },
    {
      "page": "math.score",
      "title": "calculates MATH (Mutant-Allele Tumor Heterogeneity) score.",
      "topics": [
        "math.score"
      ]
    },
    {
      "page": "merge_mafs",
      "title": "Merge multiple mafs into single MAF",
      "topics": [
        "merge_mafs"
      ]
    },
    {
      "page": "mutCountMatrix",
      "title": "Generates count matrix of mutations.",
      "topics": [
        "mutCountMatrix"
      ]
    },
    {
      "page": "oncodrive",
      "title": "Detect cancer driver genes based on positional clustering of variants.",
      "topics": [
        "oncodrive"
      ]
    },
    {
      "page": "oncoplot",
      "title": "draw an oncoplot",
      "topics": [
        "oncoplot"
      ]
    },
    {
      "page": "oncostrip",
      "title": "draw an oncostrip similar to cBioportal oncoprinter output.",
      "topics": [
        "oncostrip"
      ]
    },
    {
      "page": "pathways",
      "title": "Enrichment of known oncogenic or custom pathways",
      "topics": [
        "pathways"
      ]
    },
    {
      "page": "pfamDomains",
      "title": "pfam domain annotation and summarization.",
      "topics": [
        "pfamDomains"
      ]
    },
    {
      "page": "plotApobecDiff",
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        "Installation",
        "Overview of the package",
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        "Reading MAF files.",
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        "APOBEC Enrichment estimation.",
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        "Changing colors for variant classifications",
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        "Bar plots",
        "Including annotations",
        "Highlighting samples",
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        "Oncogenic siganlling pathways",
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        "Tumor-Normal pair",
        "Tumor only",
        "CBS segmentation",
        "Processing Mosdepth output",
        "Pedersen BS, Quinlan AR. Mosdepth: quick coverage calculation for genomes and exomes. Bioinformatics. 2018;34(5):867-868. doi:10.1093/bioinformatics/btx699",
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