{ "_id": "6a1f2c0ab401979e73425a02", "Package": "immunotation", "Type": "Package", "Title": "Tools for working with diverse immune genes", "Version": "1.21.0", "Date": "2021-08-09", "Authors@R": "c(\nperson(\"Katharina\", \"Imkeller\", email = \"ag.imkeller@gmail.com\", role = c(\"cre\", \"aut\")))", "Description": "MHC (major histocompatibility complex) molecules are cell\nsurface complexes that present antigens to T cells. The\nrepertoire of antigens presented in a given genetic background\nlargely depends on the sequence of the encoded MHC molecules,\nand thus, in humans, on the highly variable HLA (human\nleukocyte antigen) genes of the hyperpolymorphic HLA locus.\nMore than 28,000 different HLA alleles have been reported, with\nsignificant differences in allele frequencies between human\npopulations worldwide. Reproducible and consistent annotation\nof HLA alleles in large-scale bioinformatics workflows remains\nchallenging, because the available reference databases and\nsoftware tools often use different HLA naming schemes. The\npackage immunotation provides tools for consistent annotation\nof HLA genes in typical immunoinformatics workflows such as for\nexample the prediction of MHC-presented peptides in different\nhuman donors. Converter functions that provide mappings between\ndifferent HLA naming schemes are based on the MHC restriction\nontology (MRO). The package also provides automated access to\nHLA alleles frequencies in worldwide human reference\npopulations stored in the Allele Frequency Net Database.", "License": "GPL-3", "Encoding": "UTF-8", "Collate": "'external_resources_input.R' 'AFND_interface.R'\n'MRO_interface_helper.R' 'MRO_interface.R' 'MACUI_interface.R'\n'nomenclature_queries.R' 'AFND_queries.R' 'visualization.R'", "VignetteBuilder": "knitr", "RoxygenNote": "7.1.1", "biocViews": "Software, ImmunoOncology, BiomedicalInformatics, Genetics,\nAnnotation", "BugReports": "https://github.com/imkeller/immunotation/issues", "Config/pak/sysreqs": "libicu-dev libxml2-dev libssl-dev libx11-dev", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-04-28 12:55:54 UTC", "RemoteUrl": "https://github.com/bioc/immunotation", "RemoteRef": "HEAD", "RemoteSha": "1396b68259b8e483f531930cdde437cc8a6d7a70", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-15 10:11:37 UTC", "User": "root" }, "Author": "Katharina 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