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    {
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        "aol_rfs_10y"
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        "list"
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    {
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      "object": "scmod2.robust",
      "file": "scmod2.robust.rda",
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      "tojson": true
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      "name": "sig.endoPredict",
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      "object": "sig.endoPredict",
      "file": "sig.endoPredict.rda",
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        "a",
        "b"
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      "table": true,
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    {
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      "title": "Signature used to compute the 70 genes prognosis profile (GENE70) as published by van't Veer et al. 2002",
      "object": "sig.gene70",
      "file": "sig.gene70.rda",
      "class": [
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      "fields": [
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      "rows": 70,
      "table": true,
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    {
      "name": "sig.gene76",
      "title": "Signature used to compute the Relapse Score (GENE76) as published in Wang et al. 2005",
      "object": "sig.gene76",
      "file": "sig.gene76.rda",
      "class": [
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      "fields": [
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        "EntrezGene.ID",
        "NCBI.gene.symbol",
        "HUGO.gene.symbol",
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        "Alternative.symbols",
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      ],
      "rows": 76,
      "table": true,
      "tojson": true
    },
    {
      "name": "sig.genius",
      "title": "Gene Expression progNostic Index Using Subtypes (GENIUS) as published by Haibe-Kains et al. 2010.",
      "object": "sig.genius",
      "file": "sig.genius.rda",
      "class": [
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      ],
      "fields": [],
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    {
      "name": "sig.ggi",
      "title": "Gene expression Grade Index (GGI) as published in Sotiriou et al. 2006",
      "object": "sig.ggi",
      "file": "sig.ggi.rda",
      "class": [
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        "EntrezGene.ID",
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        "HUGO.gene.symbol",
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        "Description"
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      "rows": 128,
      "table": true,
      "tojson": true
    },
    {
      "name": "sig.oncotypedx",
      "title": "Signature used to compute the OncotypeDX signature as published by Paik et al 2004",
      "object": "sig.oncotypedx",
      "file": "sig.oncotypedx.rda",
      "class": [
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      "fields": [
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        "EntrezGene.ID",
        "group",
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      "tojson": true
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    {
      "name": "sig.pik3cags",
      "title": "Gene expression Grade Index (GGI) as published in Sotiriou et al. 2006",
      "object": "sig.pik3cags",
      "file": "sig.pik3cags.rda",
      "class": [
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      "fields": [
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        "EntrezGene.ID",
        "coefficient"
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      "table": true,
      "tojson": true
    },
    {
      "name": "sig.tamr13",
      "title": "Tamoxifen Resistance signature composed of 13 gene clusters (TAMR13) as published by Loi et al. 2008.",
      "object": "sig.tamr13",
      "file": "sig.tamr13.rda",
      "class": [
        "list"
      ],
      "fields": [],
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      "tojson": true
    },
    {
      "name": "sigOvcAngiogenic",
      "title": "sigOvcAngiogenic dataset",
      "object": "sigOvcAngiogenic",
      "file": "sigOvcAngiogenic.rda",
      "class": [
        "data.frame"
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      "fields": [
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        "illumina_humanwg_6_v2",
        "entrezgene",
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        "hgnc_symbol",
        "unigene",
        "description",
        "chromosome_name",
        "start_position",
        "end_position",
        "strand",
        "band",
        "weight"
      ],
      "rows": 100,
      "table": true,
      "tojson": true
    },
    {
      "name": "sigOvcCrijns",
      "title": "sigOvcCrijns dataset",
      "object": "sigOvcCrijns",
      "file": "sigOvcCrijns.rda",
      "class": [
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      ],
      "fields": [
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        "hgnc_symbol",
        "entrezgene",
        "ensembl_gene_id",
        "unigene",
        "description",
        "chromosome_name",
        "start_position",
        "end_position",
        "strand",
        "band",
        "weight"
      ],
      "rows": 86,
      "table": true,
      "tojson": true
    },
    {
      "name": "sigOvcSpentzos",
      "title": "sigOcvSpentzos dataset",
      "object": "sigOvcSpentzos",
      "file": "sigOvcSpentzos.rda",
      "class": [
        "data.frame"
      ],
      "fields": [
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        "affy_hg_u133a",
        "entrezgene",
        "hgnc_symbol",
        "ensembl_gene_id",
        "unigene",
        "description",
        "chromosome_name",
        "start_position",
        "end_position",
        "strand",
        "band",
        "weight"
      ],
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      "table": true,
      "tojson": true
    },
    {
      "name": "sigOvcTCGA",
      "title": "sigOvcTCGA dataset",
      "object": "sigOvcTCGA",
      "file": "sigOvcTCGA.rda",
      "class": [
        "data.frame"
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      "fields": [
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        "entrezgene",
        "hgnc_symbol",
        "ensembl_gene_id",
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        "chromosome_name",
        "start_position",
        "end_position",
        "strand",
        "band",
        "Gene.set",
        "beta",
        "p.value"
      ],
      "rows": 193,
      "table": true,
      "tojson": true
    },
    {
      "name": "sigOvcYoshihara",
      "title": "sigOvcYoshihara dataset",
      "object": "sigOvcYoshihara",
      "file": "sigOvcYoshihara.rda",
      "class": [
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        "entrezgene",
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        "start_position",
        "end_position",
        "strand",
        "band",
        "weight"
      ],
      "rows": 88,
      "table": true,
      "tojson": true
    },
    {
      "name": "ssp2003",
      "title": "SSP2003 classifier for identification of breast cancer molecular subtypes (Sorlie et al 2003)",
      "object": "ssp2003",
      "file": "ssp2003.rda",
      "class": [
        "list"
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      "fields": [],
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      "tojson": true
    },
    {
      "name": "ssp2003.robust",
      "title": "SSP2003 classifier for identification of breast cancer molecular subtypes (Sorlie et al 2003)",
      "object": "ssp2003.robust",
      "file": "ssp2003.robust.rda",
      "class": [
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      "fields": [],
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      "tojson": true
    },
    {
      "name": "ssp2003.scale",
      "title": "SSP2003 classifier for identification of breast cancer molecular subtypes (Sorlie et al 2003)",
      "object": "ssp2003.scale",
      "file": "ssp2003.scale.rda",
      "class": [
        "list"
      ],
      "fields": [],
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      "tojson": true
    },
    {
      "name": "ssp2006",
      "title": "SSP2006 classifier for identification of breast cancer molecular subtypes (Hu et al 2006)",
      "object": "ssp2006",
      "file": "ssp2006.rda",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "ssp2006.robust",
      "title": "SSP2006 classifier for identification of breast cancer molecular subtypes (Hu et al 2006)",
      "object": "ssp2006.robust",
      "file": "ssp2006.robust.rda",
      "class": [
        "list"
      ],
      "fields": [],
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      "tojson": true
    },
    {
      "name": "ssp2006.scale",
      "title": "SSP2006 classifier for identification of breast cancer molecular subtypes (Hu et al 2006)",
      "object": "ssp2006.scale",
      "file": "ssp2006.scale.rda",
      "class": [
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      ],
      "fields": [],
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      "tojson": true
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  ],
  "_help": [
    {
      "page": "bimod",
      "title": "Function to identify bimodality for gene expression or signature score",
      "topics": [
        "bimod"
      ]
    },
    {
      "page": "boxplotplus2",
      "title": "Box plot of group of values with corresponding jittered points",
      "topics": [
        "boxplotplus2"
      ]
    },
    {
      "page": "claudinLow",
      "title": "Claudin-low classification for Breast Cancer Data",
      "topics": [
        "claudinLow"
      ]
    },
    {
      "page": "claudinLowData",
      "title": "claudinLowData for use in the claudinLow classifier. Data generously provided by Aleix Prat.",
      "topics": [
        "claudinLowData"
      ]
    },
    {
      "page": "collapseIDs",
      "title": "Utility function to collapse IDs",
      "topics": [
        "collapseIDs"
      ]
    },
    {
      "page": "compareProtoCor",
      "title": "Function to statistically compare correlation to prototypes",
      "topics": [
        "compareProtoCor"
      ]
    },
    {
      "page": "compute.pairw.cor.meta",
      "title": "Function to compute pairwise correlations in a meta-analytical framework",
      "topics": [
        "compute.pairw.cor.meta"
      ]
    },
    {
      "page": "compute.pairw.cor.z",
      "title": "Function to compute the Z transformation of the pairwise correlations for a list of datasets",
      "topics": [
        "compute.pairw.cor.z"
      ]
    },
    {
      "page": "compute.proto.cor.meta",
      "title": "Function to compute correlations to prototypes in a meta-analytical framework",
      "topics": [
        "compute.proto.cor.meta"
      ]
    },
    {
      "page": "cordiff.dep",
      "title": "Function to estimate whether two dependent correlations differ",
      "topics": [
        "cordiff.dep"
      ]
    },
    {
      "page": "endoPredict",
      "title": "Function to compute the endoPredict signature as published by Filipits et al 2011",
      "topics": [
        "endoPredict"
      ]
    },
    {
      "page": "expos",
      "title": "Gene expression, annotations and clinical data from the International Genomics Consortium",
      "topics": [
        "annot.expos",
        "data.expos",
        "demo.expos",
        "expos"
      ]
    },
    {
      "page": "fuzzy.ttest",
      "title": "Function to compute the fuzzy Student t test based on weighted mean and weighted variance",
      "topics": [
        "fuzzy.ttest"
      ]
    },
    {
      "page": "gene70",
      "title": "Function to compute the 70 genes prognosis profile (GENE70) as published by van't Veer et al. 2002",
      "topics": [
        "gene70"
      ]
    },
    {
      "page": "gene76",
      "title": "Function to compute the Relapse Score as published by Wang et al. 2005",
      "topics": [
        "gene76"
      ]
    },
    {
      "page": "geneid.map",
      "title": "Function to find the common genes between two datasets or a dataset and a gene list",
      "topics": [
        "geneid.map"
      ]
    },
    {
      "page": "genius",
      "title": "Function to compute the Gene Expression progNostic Index Using Subtypes (GENIUS) as published by Haibe-Kains et al. 2010",
      "topics": [
        "genius"
      ]
    },
    {
      "page": "ggi",
      "title": "Function to compute the raw and scaled Gene expression Grade Index (GGI)",
      "topics": [
        "ggi"
      ]
    },
    {
      "page": "ihc4",
      "title": "Function to compute the IHC4 prognostic score as published by Paik et al. in 2004.",
      "topics": [
        "ihc4"
      ]
    },
    {
      "page": "intrinsic.cluster",
      "title": "Function to fit a Single Sample Predictor (SSP) as in Perou, Sorlie, Hu, and Parker publications",
      "topics": [
        "intrinsic.cluster"
      ]
    },
    {
      "page": "intrinsic.cluster.predict",
      "title": "Function to identify breast cancer molecular subtypes using the Single Sample Predictor (SSP)",
      "topics": [
        "intrinsic.cluster.predict"
      ]
    },
    {
      "page": "map.datasets",
      "title": "Function to map a list of datasets through EntrezGene IDs in order to get the union of the genes",
      "topics": [
        "map.datasets"
      ]
    },
    {
      "page": "medianCtr",
      "title": "Center around the median",
      "topics": [
        "medianCtr"
      ]
    },
    {
      "page": "mod1",
      "title": "Gene modules published in Desmedt et al. 2008",
      "topics": [
        "mod1"
      ]
    },
    {
      "page": "mod2",
      "title": "Gene modules published in Wirapati et al. 2008",
      "topics": [
        "mod2"
      ]
    },
    {
      "page": "modelOvcAngiogenic",
      "title": "Model used to classify ovarian tumors into Angiogenic and NonAngiogenic subtypes.",
      "topics": [
        "modelOvcAngiogenic"
      ]
    },
    {
      "page": "molecular.subtyping",
      "title": "Function to identify breast cancer molecular subtypes using the Subtype Clustering Model",
      "topics": [
        "molecular.subtyping"
      ]
    },
    {
      "page": "nkis",
      "title": "Gene expression, annotations and clinical data from van de Vijver et al. 2002",
      "topics": [
        "annot.nkis",
        "data.nkis",
        "demo.nkis",
        "nkis"
      ]
    },
    {
      "page": "npi",
      "title": "Function to compute the Nottingham Prognostic Index",
      "topics": [
        "npi"
      ]
    },
    {
      "page": "oncotypedx",
      "title": "Function to compute the OncotypeDX signature as published by Paik et al. in 2004.",
      "topics": [
        "oncotypedx"
      ]
    },
    {
      "page": "ovcAngiogenic",
      "title": "Function to compute the subtype scores and risk classifications for the angiogenic molecular subtype in ovarian cancer",
      "topics": [
        "ovcAngiogenic"
      ]
    },
    {
      "page": "ovcCrijns",
      "title": "Function to compute the subtype scores and risk classifications for the prognostic signature published by Crinjs et al.",
      "topics": [
        "ovcCrijns"
      ]
    },
    {
      "page": "ovcTCGA",
      "title": "Function to compute the prediction scores and risk classifications for the ovarian cancer TCGA signature",
      "topics": [
        "ovcTCGA"
      ]
    },
    {
      "page": "ovcYoshihara",
      "title": "Function to compute the subtype scores and risk classifications for the prognostic signature published by Yoshihara et al.",
      "topics": [
        "ovcYoshihara"
      ]
    },
    {
      "page": "overlapSets",
      "title": "Overlap two datasets",
      "topics": [
        "overlapSets"
      ]
    },
    {
      "page": "pam50",
      "title": "PAM50 classifier for identification of breast cancer molecular subtypes (Parker et al 2009)",
      "topics": [
        "pam50",
        "pam50.robust",
        "pam50.scale"
      ]
    },
    {
      "page": "pik3cags",
      "title": "Function to compute the PIK3CA gene signature (PIK3CA-GS)",
      "topics": [
        "pik3cags"
      ]
    },
    {
      "page": "power.cor",
      "title": "Function for sample size calculation for correlation coefficients",
      "topics": [
        "power.cor"
      ]
    },
    {
      "page": "ps.cluster",
      "title": "Function to compute the prediction strength of a clustering model",
      "topics": [
        "ps.cluster"
      ]
    },
    {
      "page": "read.m.file",
      "title": "Function to read a 'csv' file containing gene lists (aka gene signatures)",
      "topics": [
        "read.m.file"
      ]
    },
    {
      "page": "readArray",
      "title": "Overlap two datasets",
      "topics": [
        "readArray"
      ]
    },
    {
      "page": "rename.duplicate",
      "title": "Function to rename duplicated strings",
      "topics": [
        "rename.duplicate"
      ]
    },
    {
      "page": "rescale",
      "title": "Function to rescale values based on quantiles",
      "topics": [
        "rescale"
      ]
    },
    {
      "page": "rorS",
      "title": "Function to compute the rorS signature as published by Parker et al 2009",
      "topics": [
        "rorS"
      ]
    },
    {
      "page": "scmgene.robust",
      "title": "Subtype Clustering Model using only ESR1, ERBB2 and AURKA genes for identification of breast cancer molecular subtypes",
      "topics": [
        "scmgene.robust"
      ]
    },
    {
      "page": "scmod1.robust",
      "title": "Subtype Clustering Model using ESR1, ERBB2 and AURKA modules for identification of breast cancer molecular subtypes (Desmedt et al 2008)",
      "topics": [
        "scmod1.robust"
      ]
    },
    {
      "page": "scmod2.robust",
      "title": "Subtype Clustering Model using ESR1, ERBB2 and AURKA modules for identification of breast cancer molecular subtypes (Desmedt et al 2008)",
      "topics": [
        "scmod2.robust"
      ]
    },
    {
      "page": "setcolclass.df",
      "title": "Function to set the class of columns in a data.frame",
      "topics": [
        "setcolclass.df"
      ]
    },
    {
      "page": "sig.endoPredict",
      "title": "Signature used to compute the endoPredict signature as published by Filipits et al 2011",
      "topics": [
        "sig.endoPredict"
      ]
    },
    {
      "page": "sig.gene70",
      "title": "Signature used to compute the 70 genes prognosis profile (GENE70) as published by van't Veer et al. 2002",
      "topics": [
        "sig.gene70"
      ]
    },
    {
      "page": "sig.gene76",
      "title": "Signature used to compute the Relapse Score (GENE76) as published in Wang et al. 2005",
      "topics": [
        "sig.gene76"
      ]
    },
    {
      "page": "sig.genius",
      "title": "Gene Expression progNostic Index Using Subtypes (GENIUS) as published by Haibe-Kains et al. 2010.",
      "topics": [
        "sig.genius"
      ]
    },
    {
      "page": "sig.ggi",
      "title": "Gene expression Grade Index (GGI) as published in Sotiriou et al. 2006",
      "topics": [
        "sig.ggi"
      ]
    },
    {
      "page": "sig.oncotypedx",
      "title": "Signature used to compute the OncotypeDX signature as published by Paik et al 2004",
      "topics": [
        "sig.oncotypedx"
      ]
    },
    {
      "page": "sig.pik3cags",
      "title": "Gene expression Grade Index (GGI) as published in Sotiriou et al. 2006",
      "topics": [
        "sig.pik3cags"
      ]
    },
    {
      "page": "sig.score",
      "title": "Function to compute signature scores as linear combination of gene expressions",
      "topics": [
        "sig.score"
      ]
    },
    {
      "page": "sig.tamr13",
      "title": "Tamoxifen Resistance signature composed of 13 gene clusters (TAMR13) as published by Loi et al. 2008.",
      "topics": [
        "sig.tamr13"
      ]
    },
    {
      "page": "sigOvcAngiogenic",
      "title": "sigOvcAngiogenic dataset",
      "topics": [
        "sigOvcAngiogenic"
      ]
    },
    {
      "page": "sigOvcCrijns",
      "title": "sigOvcCrijns dataset",
      "topics": [
        "sigOvcCrijns"
      ]
    },
    {
      "page": "sigOvcSpentzos",
      "title": "sigOcvSpentzos dataset",
      "topics": [
        "sigOvcSpentzos"
      ]
    },
    {
      "page": "sigOvcTCGA",
      "title": "sigOvcTCGA dataset",
      "topics": [
        "sigOvcTCGA"
      ]
    },
    {
      "page": "sigOvcYoshihara",
      "title": "sigOvcYoshihara dataset",
      "topics": [
        "sigOvcYoshihara"
      ]
    },
    {
      "page": "spearmanCI",
      "title": "Function to compute the confidence interval for the Spearman correelation coefficient",
      "topics": [
        "spearmanCI"
      ]
    },
    {
      "page": "ssp2003",
      "title": "SSP2003 classifier for identification of breast cancer molecular subtypes (Sorlie et al 2003)",
      "topics": [
        "ssp2003",
        "ssp2003.robust",
        "ssp2003.scale"
      ]
    },
    {
      "page": "ssp2006",
      "title": "SSP2006 classifier for identification of breast cancer molecular subtypes (Hu et al 2006)",
      "topics": [
        "ssp2006",
        "ssp2006.robust",
        "ssp2006.scale"
      ]
    },
    {
      "page": "st.gallen",
      "title": "Function to compute the St Gallen consensus criterion for prognostication",
      "topics": [
        "st.gallen"
      ]
    },
    {
      "page": "stab.fs",
      "title": "Function to quantify stability of feature selection",
      "topics": [
        "stab.fs"
      ]
    },
    {
      "page": "stab.fs.ranking",
      "title": "Function to quantify stability of feature ranking",
      "topics": [
        "stab.fs.ranking"
      ]
    },
    {
      "page": "strescR",
      "title": "Utility function to escape LaTeX special characters present in a string",
      "topics": [
        "strescR"
      ]
    },
    {
      "page": "subtype.cluster",
      "title": "Function to fit the Subtype Clustering Model",
      "topics": [
        "subtype.cluster"
      ]
    },
    {
      "page": "subtype.cluster.predict",
      "title": "Function to identify breast cancer molecular subtypes using the Subtype Clustering Model",
      "topics": [
        "subtype.cluster.predict"
      ]
    },
    {
      "page": "tamr13",
      "title": "Function to compute the risk scores of the tamoxifen resistance signature (TAMR13)",
      "topics": [
        "tamr13"
      ]
    },
    {
      "page": "tbrm",
      "title": "Function to compute Tukey's Biweight Robust Mean",
      "topics": [
        "tbrm"
      ]
    },
    {
      "page": "vdxs",
      "title": "Gene expression, annotations and clinical data from Wang et al. 2005 and Minn et al 2007",
      "topics": [
        "annot.vdxs",
        "data.vdxs",
        "demo.vdxs",
        "vdxs"
      ]
    },
    {
      "page": "weighted.meanvar",
      "title": "Function to compute the weighted mean and weighted variance of 'x'",
      "topics": [
        "weighted.meanvar"
      ]
    },
    {
      "page": "write.m.file",
      "title": "Function to write a 'csv' file containing gene lists (aka gene signatures)",
      "topics": [
        "write.m.file"
      ]
    }
  ],
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    "sys",
    "tibble",
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  "_vignettes": [
    {
      "source": "genefu.Rmd",
      "filename": "genefu.html",
      "title": "genefu: A Package for Breast Cancer Gene Expression Analysis",
      "author": "Deena M.A. Gendoo, Natchar Ratanasirigulchai, Markus Schröder, Laia Pare, Joel S.Parker - &nc Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC27599, USA, Aleix Prat, Benjamin Haibe-Kains",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "Loading Package for Case Studies",
        "Load Datasets and Packages for Case Studies",
        "Case Studies",
        "Compare Molecular Subtype Classifications",
        "Comparing Risk Prediction Models",
        "References",
        "Where genefu was used in subtyping",
        "Where genefu was used in Comparing Subtyping Schemes",
        "Where genefu was used to Compute Prognostic gene signature scores",
        "As well as other publications",
        "SessionInfo"
      ],
      "created": "2021-01-12 18:25:26",
      "modified": "2021-05-21 19:12:20",
      "commits": 3
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