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  "Title": "Computation of Gene Expression-Based Signatures in Breast Cancer",
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      "rows": 21,
      "table": true,
      "tojson": true
    },
    {
      "name": "sig.pik3cags",
      "title": "Gene expression Grade Index (GGI) as published in Sotiriou et al. 2006",
      "object": "sig.pik3cags",
      "file": "sig.pik3cags.rda",
      "class": [
        "data.frame"
      ],
      "fields": [
        "probe",
        "EntrezGene.ID",
        "coefficient"
      ],
      "rows": 278,
      "table": true,
      "tojson": true
    },
    {
      "name": "sig.tamr13",
      "title": "Tamoxifen Resistance signature composed of 13 gene clusters (TAMR13) as published by Loi et al. 2008.",
      "object": "sig.tamr13",
      "file": "sig.tamr13.rda",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "sigOvcAngiogenic",
      "title": "sigOvcAngiogenic dataset",
      "object": "sigOvcAngiogenic",
      "file": "sigOvcAngiogenic.rda",
      "class": [
        "data.frame"
      ],
      "fields": [
        "probe",
        "illumina_humanwg_6_v2",
        "entrezgene",
        "ensembl_gene_id",
        "hgnc_symbol",
        "unigene",
        "description",
        "chromosome_name",
        "start_position",
        "end_position",
        "strand",
        "band",
        "weight"
      ],
      "rows": 100,
      "table": true,
      "tojson": true
    },
    {
      "name": "sigOvcCrijns",
      "title": "sigOvcCrijns dataset",
      "object": "sigOvcCrijns",
      "file": "sigOvcCrijns.rda",
      "class": [
        "data.frame"
      ],
      "fields": [
        "probe",
        "hgnc_symbol",
        "entrezgene",
        "ensembl_gene_id",
        "unigene",
        "description",
        "chromosome_name",
        "start_position",
        "end_position",
        "strand",
        "band",
        "weight"
      ],
      "rows": 86,
      "table": true,
      "tojson": true
    },
    {
      "name": "sigOvcSpentzos",
      "title": "sigOcvSpentzos dataset",
      "object": "sigOvcSpentzos",
      "file": "sigOvcSpentzos.rda",
      "class": [
        "data.frame"
      ],
      "fields": [
        "probe",
        "affy_hg_u133a",
        "entrezgene",
        "hgnc_symbol",
        "ensembl_gene_id",
        "unigene",
        "description",
        "chromosome_name",
        "start_position",
        "end_position",
        "strand",
        "band",
        "weight"
      ],
      "rows": 17,
      "table": true,
      "tojson": true
    },
    {
      "name": "sigOvcTCGA",
      "title": "sigOvcTCGA dataset",
      "object": "sigOvcTCGA",
      "file": "sigOvcTCGA.rda",
      "class": [
        "data.frame"
      ],
      "fields": [
        "probe",
        "entrezgene",
        "hgnc_symbol",
        "ensembl_gene_id",
        "unigene",
        "description",
        "chromosome_name",
        "start_position",
        "end_position",
        "strand",
        "band",
        "Gene.set",
        "beta",
        "p.value"
      ],
      "rows": 193,
      "table": true,
      "tojson": true
    },
    {
      "name": "sigOvcYoshihara",
      "title": "sigOvcYoshihara dataset",
      "object": "sigOvcYoshihara",
      "file": "sigOvcYoshihara.rda",
      "class": [
        "data.frame"
      ],
      "fields": [
        "probe",
        "hgnc_symbol",
        "refseq_mrna",
        "entrezgene",
        "ensembl_gene_id",
        "unigene",
        "description",
        "chromosome_name",
        "start_position",
        "end_position",
        "strand",
        "band",
        "weight"
      ],
      "rows": 88,
      "table": true,
      "tojson": true
    },
    {
      "name": "ssp2003",
      "title": "SSP2003 classifier for identification of breast cancer molecular subtypes (Sorlie et al 2003)",
      "object": "ssp2003",
      "file": "ssp2003.rda",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "ssp2003.robust",
      "title": "SSP2003 classifier for identification of breast cancer molecular subtypes (Sorlie et al 2003)",
      "object": "ssp2003.robust",
      "file": "ssp2003.robust.rda",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "ssp2003.scale",
      "title": "SSP2003 classifier for identification of breast cancer molecular subtypes (Sorlie et al 2003)",
      "object": "ssp2003.scale",
      "file": "ssp2003.scale.rda",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "ssp2006",
      "title": "SSP2006 classifier for identification of breast cancer molecular subtypes (Hu et al 2006)",
      "object": "ssp2006",
      "file": "ssp2006.rda",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "ssp2006.robust",
      "title": "SSP2006 classifier for identification of breast cancer molecular subtypes (Hu et al 2006)",
      "object": "ssp2006.robust",
      "file": "ssp2006.robust.rda",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "ssp2006.scale",
      "title": "SSP2006 classifier for identification of breast cancer molecular subtypes (Hu et al 2006)",
      "object": "ssp2006.scale",
      "file": "ssp2006.scale.rda",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "bimod",
      "title": "Function to identify bimodality for gene expression or signature score",
      "topics": [
        "bimod"
      ]
    },
    {
      "page": "boxplotplus2",
      "title": "Box plot of group of values with corresponding jittered points",
      "topics": [
        "boxplotplus2"
      ]
    },
    {
      "page": "claudinLow",
      "title": "Claudin-low classification for Breast Cancer Data",
      "topics": [
        "claudinLow"
      ]
    },
    {
      "page": "claudinLowData",
      "title": "claudinLowData for use in the claudinLow classifier. Data generously provided by Aleix Prat.",
      "topics": [
        "claudinLowData"
      ]
    },
    {
      "page": "collapseIDs",
      "title": "Utility function to collapse IDs",
      "topics": [
        "collapseIDs"
      ]
    },
    {
      "page": "compareProtoCor",
      "title": "Function to statistically compare correlation to prototypes",
      "topics": [
        "compareProtoCor"
      ]
    },
    {
      "page": "compute.pairw.cor.meta",
      "title": "Function to compute pairwise correlations in a meta-analytical framework",
      "topics": [
        "compute.pairw.cor.meta"
      ]
    },
    {
      "page": "compute.pairw.cor.z",
      "title": "Function to compute the Z transformation of the pairwise correlations for a list of datasets",
      "topics": [
        "compute.pairw.cor.z"
      ]
    },
    {
      "page": "compute.proto.cor.meta",
      "title": "Function to compute correlations to prototypes in a meta-analytical framework",
      "topics": [
        "compute.proto.cor.meta"
      ]
    },
    {
      "page": "cordiff.dep",
      "title": "Function to estimate whether two dependent correlations differ",
      "topics": [
        "cordiff.dep"
      ]
    },
    {
      "page": "endoPredict",
      "title": "Function to compute the endoPredict signature as published by Filipits et al 2011",
      "topics": [
        "endoPredict"
      ]
    },
    {
      "page": "expos",
      "title": "Gene expression, annotations and clinical data from the International Genomics Consortium",
      "topics": [
        "annot.expos",
        "data.expos",
        "demo.expos",
        "expos"
      ]
    },
    {
      "page": "fuzzy.ttest",
      "title": "Function to compute the fuzzy Student t test based on weighted mean and weighted variance",
      "topics": [
        "fuzzy.ttest"
      ]
    },
    {
      "page": "gene70",
      "title": "Function to compute the 70 genes prognosis profile (GENE70) as published by van't Veer et al. 2002",
      "topics": [
        "gene70"
      ]
    },
    {
      "page": "gene76",
      "title": "Function to compute the Relapse Score as published by Wang et al. 2005",
      "topics": [
        "gene76"
      ]
    },
    {
      "page": "geneid.map",
      "title": "Function to find the common genes between two datasets or a dataset and a gene list",
      "topics": [
        "geneid.map"
      ]
    },
    {
      "page": "genius",
      "title": "Function to compute the Gene Expression progNostic Index Using Subtypes (GENIUS) as published by Haibe-Kains et al. 2010",
      "topics": [
        "genius"
      ]
    },
    {
      "page": "ggi",
      "title": "Function to compute the raw and scaled Gene expression Grade Index (GGI)",
      "topics": [
        "ggi"
      ]
    },
    {
      "page": "ihc4",
      "title": "Function to compute the IHC4 prognostic score as published by Paik et al. in 2004.",
      "topics": [
        "ihc4"
      ]
    },
    {
      "page": "intrinsic.cluster",
      "title": "Function to fit a Single Sample Predictor (SSP) as in Perou, Sorlie, Hu, and Parker publications",
      "topics": [
        "intrinsic.cluster"
      ]
    },
    {
      "page": "intrinsic.cluster.predict",
      "title": "Function to identify breast cancer molecular subtypes using the Single Sample Predictor (SSP)",
      "topics": [
        "intrinsic.cluster.predict"
      ]
    },
    {
      "page": "map.datasets",
      "title": "Function to map a list of datasets through EntrezGene IDs in order to get the union of the genes",
      "topics": [
        "map.datasets"
      ]
    },
    {
      "page": "medianCtr",
      "title": "Center around the median",
      "topics": [
        "medianCtr"
      ]
    },
    {
      "page": "mod1",
      "title": "Gene modules published in Desmedt et al. 2008",
      "topics": [
        "mod1"
      ]
    },
    {
      "page": "mod2",
      "title": "Gene modules published in Wirapati et al. 2008",
      "topics": [
        "mod2"
      ]
    },
    {
      "page": "modelOvcAngiogenic",
      "title": "Model used to classify ovarian tumors into Angiogenic and NonAngiogenic subtypes.",
      "topics": [
        "modelOvcAngiogenic"
      ]
    },
    {
      "page": "molecular.subtyping",
      "title": "Function to identify breast cancer molecular subtypes using the Subtype Clustering Model",
      "topics": [
        "molecular.subtyping"
      ]
    },
    {
      "page": "nkis",
      "title": "Gene expression, annotations and clinical data from van de Vijver et al. 2002",
      "topics": [
        "annot.nkis",
        "data.nkis",
        "demo.nkis",
        "nkis"
      ]
    },
    {
      "page": "npi",
      "title": "Function to compute the Nottingham Prognostic Index",
      "topics": [
        "npi"
      ]
    },
    {
      "page": "oncotypedx",
      "title": "Function to compute the OncotypeDX signature as published by Paik et al. in 2004.",
      "topics": [
        "oncotypedx"
      ]
    },
    {
      "page": "ovcAngiogenic",
      "title": "Function to compute the subtype scores and risk classifications for the angiogenic molecular subtype in ovarian cancer",
      "topics": [
        "ovcAngiogenic"
      ]
    },
    {
      "page": "ovcCrijns",
      "title": "Function to compute the subtype scores and risk classifications for the prognostic signature published by Crinjs et al.",
      "topics": [
        "ovcCrijns"
      ]
    },
    {
      "page": "ovcTCGA",
      "title": "Function to compute the prediction scores and risk classifications for the ovarian cancer TCGA signature",
      "topics": [
        "ovcTCGA"
      ]
    },
    {
      "page": "ovcYoshihara",
      "title": "Function to compute the subtype scores and risk classifications for the prognostic signature published by Yoshihara et al.",
      "topics": [
        "ovcYoshihara"
      ]
    },
    {
      "page": "overlapSets",
      "title": "Overlap two datasets",
      "topics": [
        "overlapSets"
      ]
    },
    {
      "page": "pam50",
      "title": "PAM50 classifier for identification of breast cancer molecular subtypes (Parker et al 2009)",
      "topics": [
        "pam50",
        "pam50.robust",
        "pam50.scale"
      ]
    },
    {
      "page": "pik3cags",
      "title": "Function to compute the PIK3CA gene signature (PIK3CA-GS)",
      "topics": [
        "pik3cags"
      ]
    },
    {
      "page": "power.cor",
      "title": "Function for sample size calculation for correlation coefficients",
      "topics": [
        "power.cor"
      ]
    },
    {
      "page": "ps.cluster",
      "title": "Function to compute the prediction strength of a clustering model",
      "topics": [
        "ps.cluster"
      ]
    },
    {
      "page": "read.m.file",
      "title": "Function to read a 'csv' file containing gene lists (aka gene signatures)",
      "topics": [
        "read.m.file"
      ]
    },
    {
      "page": "readArray",
      "title": "Overlap two datasets",
      "topics": [
        "readArray"
      ]
    },
    {
      "page": "rename.duplicate",
      "title": "Function to rename duplicated strings",
      "topics": [
        "rename.duplicate"
      ]
    },
    {
      "page": "rescale",
      "title": "Function to rescale values based on quantiles",
      "topics": [
        "rescale"
      ]
    },
    {
      "page": "rorS",
      "title": "Function to compute the rorS signature as published by Parker et al 2009",
      "topics": [
        "rorS"
      ]
    },
    {
      "page": "scmgene.robust",
      "title": "Subtype Clustering Model using only ESR1, ERBB2 and AURKA genes for identification of breast cancer molecular subtypes",
      "topics": [
        "scmgene.robust"
      ]
    },
    {
      "page": "scmod1.robust",
      "title": "Subtype Clustering Model using ESR1, ERBB2 and AURKA modules for identification of breast cancer molecular subtypes (Desmedt et al 2008)",
      "topics": [
        "scmod1.robust"
      ]
    },
    {
      "page": "scmod2.robust",
      "title": "Subtype Clustering Model using ESR1, ERBB2 and AURKA modules for identification of breast cancer molecular subtypes (Desmedt et al 2008)",
      "topics": [
        "scmod2.robust"
      ]
    },
    {
      "page": "setcolclass.df",
      "title": "Function to set the class of columns in a data.frame",
      "topics": [
        "setcolclass.df"
      ]
    },
    {
      "page": "sig.endoPredict",
      "title": "Signature used to compute the endoPredict signature as published by Filipits et al 2011",
      "topics": [
        "sig.endoPredict"
      ]
    },
    {
      "page": "sig.gene70",
      "title": "Signature used to compute the 70 genes prognosis profile (GENE70) as published by van't Veer et al. 2002",
      "topics": [
        "sig.gene70"
      ]
    },
    {
      "page": "sig.gene76",
      "title": "Signature used to compute the Relapse Score (GENE76) as published in Wang et al. 2005",
      "topics": [
        "sig.gene76"
      ]
    },
    {
      "page": "sig.genius",
      "title": "Gene Expression progNostic Index Using Subtypes (GENIUS) as published by Haibe-Kains et al. 2010.",
      "topics": [
        "sig.genius"
      ]
    },
    {
      "page": "sig.ggi",
      "title": "Gene expression Grade Index (GGI) as published in Sotiriou et al. 2006",
      "topics": [
        "sig.ggi"
      ]
    },
    {
      "page": "sig.oncotypedx",
      "title": "Signature used to compute the OncotypeDX signature as published by Paik et al 2004",
      "topics": [
        "sig.oncotypedx"
      ]
    },
    {
      "page": "sig.pik3cags",
      "title": "Gene expression Grade Index (GGI) as published in Sotiriou et al. 2006",
      "topics": [
        "sig.pik3cags"
      ]
    },
    {
      "page": "sig.score",
      "title": "Function to compute signature scores as linear combination of gene expressions",
      "topics": [
        "sig.score"
      ]
    },
    {
      "page": "sig.tamr13",
      "title": "Tamoxifen Resistance signature composed of 13 gene clusters (TAMR13) as published by Loi et al. 2008.",
      "topics": [
        "sig.tamr13"
      ]
    },
    {
      "page": "sigOvcAngiogenic",
      "title": "sigOvcAngiogenic dataset",
      "topics": [
        "sigOvcAngiogenic"
      ]
    },
    {
      "page": "sigOvcCrijns",
      "title": "sigOvcCrijns dataset",
      "topics": [
        "sigOvcCrijns"
      ]
    },
    {
      "page": "sigOvcSpentzos",
      "title": "sigOcvSpentzos dataset",
      "topics": [
        "sigOvcSpentzos"
      ]
    },
    {
      "page": "sigOvcTCGA",
      "title": "sigOvcTCGA dataset",
      "topics": [
        "sigOvcTCGA"
      ]
    },
    {
      "page": "sigOvcYoshihara",
      "title": "sigOvcYoshihara dataset",
      "topics": [
        "sigOvcYoshihara"
      ]
    },
    {
      "page": "spearmanCI",
      "title": "Function to compute the confidence interval for the Spearman correelation coefficient",
      "topics": [
        "spearmanCI"
      ]
    },
    {
      "page": "ssp2003",
      "title": "SSP2003 classifier for identification of breast cancer molecular subtypes (Sorlie et al 2003)",
      "topics": [
        "ssp2003",
        "ssp2003.robust",
        "ssp2003.scale"
      ]
    },
    {
      "page": "ssp2006",
      "title": "SSP2006 classifier for identification of breast cancer molecular subtypes (Hu et al 2006)",
      "topics": [
        "ssp2006",
        "ssp2006.robust",
        "ssp2006.scale"
      ]
    },
    {
      "page": "st.gallen",
      "title": "Function to compute the St Gallen consensus criterion for prognostication",
      "topics": [
        "st.gallen"
      ]
    },
    {
      "page": "stab.fs",
      "title": "Function to quantify stability of feature selection",
      "topics": [
        "stab.fs"
      ]
    },
    {
      "page": "stab.fs.ranking",
      "title": "Function to quantify stability of feature ranking",
      "topics": [
        "stab.fs.ranking"
      ]
    },
    {
      "page": "strescR",
      "title": "Utility function to escape LaTeX special characters present in a string",
      "topics": [
        "strescR"
      ]
    },
    {
      "page": "subtype.cluster",
      "title": "Function to fit the Subtype Clustering Model",
      "topics": [
        "subtype.cluster"
      ]
    },
    {
      "page": "subtype.cluster.predict",
      "title": "Function to identify breast cancer molecular subtypes using the Subtype Clustering Model",
      "topics": [
        "subtype.cluster.predict"
      ]
    },
    {
      "page": "tamr13",
      "title": "Function to compute the risk scores of the tamoxifen resistance signature (TAMR13)",
      "topics": [
        "tamr13"
      ]
    },
    {
      "page": "tbrm",
      "title": "Function to compute Tukey's Biweight Robust Mean",
      "topics": [
        "tbrm"
      ]
    },
    {
      "page": "vdxs",
      "title": "Gene expression, annotations and clinical data from Wang et al. 2005 and Minn et al 2007",
      "topics": [
        "annot.vdxs",
        "data.vdxs",
        "demo.vdxs",
        "vdxs"
      ]
    },
    {
      "page": "weighted.meanvar",
      "title": "Function to compute the weighted mean and weighted variance of 'x'",
      "topics": [
        "weighted.meanvar"
      ]
    },
    {
      "page": "write.m.file",
      "title": "Function to write a 'csv' file containing gene lists (aka gene signatures)",
      "topics": [
        "write.m.file"
      ]
    }
  ],
  "_readme": "https://github.com/bioc/genefu/raw/HEAD/README.md",
  "_rundeps": [
    "AIMS",
    "amap",
    "AnnotationDbi",
    "askpass",
    "Biobase",
    "BiocBaseUtils",
    "BiocFileCache",
    "BiocGenerics",
    "biomaRt",
    "Biostrings",
    "bit",
    "bit64",
    "blob",
    "bootstrap",
    "cachem",
    "class",
    "cli",
    "cluster",
    "codetools",
    "cpp11",
    "crayon",
    "curl",
    "data.table",
    "DBI",
    "dbplyr",
    "diagram",
    "digest",
    "dplyr",
    "e1071",
    "farver",
    "fastmap",
    "filelock",
    "future",
    "future.apply",
    "generics",
    "ggplot2",
    "globals",
    "glue",
    "gtable",
    "hms",
    "httr",
    "httr2",
    "iC10",
    "iC10TrainingData",
    "impute",
    "ipred",
    "IRanges",
    "isoband",
    "jsonlite",
    "KEGGREST",
    "KernSmooth",
    "labeling",
    "lattice",
    "lava",
    "lifecycle",
    "limma",
    "listenv",
    "magrittr",
    "MASS",
    "Matrix",
    "mclust",
    "memoise",
    "mime",
    "nnet",
    "numDeriv",
    "openssl",
    "pamr",
    "parallelly",
    "pillar",
    "pkgconfig",
    "png",
    "prettyunits",
    "prodlim",
    "progress",
    "progressr",
    "proxy",
    "purrr",
    "R6",
    "RColorBrewer",
    "Rcpp",
    "rlang",
    "rmeta",
    "rpart",
    "RSQLite",
    "S4Vectors",
    "S7",
    "scales",
    "Seqinfo",
    "shape",
    "SQUAREM",
    "statmod",
    "stringi",
    "stringr",
    "SuppDists",
    "survcomp",
    "survival",
    "survivalROC",
    "sys",
    "tibble",
    "tidyr",
    "tidyselect",
    "utf8",
    "vctrs",
    "viridisLite",
    "withr",
    "xml2",
    "XVector"
  ],
  "_vignettes": [
    {
      "source": "genefu.Rmd",
      "filename": "genefu.html",
      "title": "genefu: A Package for Breast Cancer Gene Expression Analysis",
      "author": "Deena M.A. Gendoo, Natchar Ratanasirigulchai, Markus Schröder, Laia Pare, Joel S.Parker - &nc Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC27599, USA, Aleix Prat, Benjamin Haibe-Kains",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "Loading Package for Case Studies",
        "Load Datasets and Packages for Case Studies",
        "Case Studies",
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