{
  "_id": "6a481981e06c18f0a652c6fa",
  "Package": "epimutacions",
  "Title": "Robust outlier identification for DNA methylation data",
  "Version": "1.17.0",
  "Authors@R": "c(person(\"Dolors\", \"Pelegri-Siso\", ,\"dolors.pelegri@isglobal.org\", role = c(\"aut\", \"cre\"),comment = c(ORCID = \"0000-0002-5993-3003\")),\nperson(\"Juan R.\", \"Gonzalez\", ,\"juanr.gonzalez@isglobal.org\", role = \"aut\", comment = c(ORCID = \"0000-0003-3267-2146\")),\nperson(\"Carlos\", \"Ruiz-Arenas\", ,\"carlos.ruiza@upf.edu\", role = \"aut\", comment = c(ORCID = \"0000-0002-6014-3498\")),\nperson(\"Carles\", \"Hernandez-Ferrer\", ,\"carles.hernandez@cnag.crg.eu\", role = \"aut\", comment = c(ORCID = \"0000-0002-8029-7160\")),\nperson(\"Leire\",family = \"Abarrategui\",role = c(\"aut\"),email = \"abarrategui.leire@gmail.com\", comment = c(ORCID = \"0000-0002-1175-038X\")))",
  "Description": "The package includes some statistical outlier detection\nmethods for epimutations detection in DNA methylation data. The\nmethods included in the package are MANOVA, Multivariate linear\nmodels, isolation forest, robust mahalanobis distance, quantile\nand beta. The methods compare a case sample with a suspected\ndisease against a reference panel (composed of healthy\nindividuals) to identify epimutations in the given case sample.\nIt also contains functions to annotate and visualize the\nidentified epimutations.",
  "biocViews": "DNAMethylation, BiologicalQuestion, Preprocessing,\nStatisticalMethod, Normalization",
  "License": "MIT + file LICENSE",
  "VignetteBuilder": "knitr",
  "Encoding": "UTF-8",
  "Roxygen": "list(markdown = TRUE)",
  "URL": "https://github.com/isglobal-brge/epimutacions",
  "BugReports": "https://github.com/isglobal-brge/epimutacions/issues",
  "RoxygenNote": "7.2.3",
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  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 12:58:12 UTC",
  "RemoteUrl": "https://github.com/bioc/epimutacions",
  "RemoteRef": "HEAD",
  "RemoteSha": "8f3f289ee5e72c8bc2dad13e35071e2dab32fcad",
  "NeedsCompilation": "yes",
  "Packaged": {
    "Date": "2026-07-03 20:04:15 UTC",
    "User": "root"
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  "Author": "Dolors Pelegri-Siso [aut, cre] (ORCID:\n<https://orcid.org/0000-0002-5993-3003>),\nJuan R. Gonzalez [aut] (ORCID: <https://orcid.org/0000-0003-3267-2146>),\nCarlos Ruiz-Arenas [aut] (ORCID:\n<https://orcid.org/0000-0002-6014-3498>),\nCarles Hernandez-Ferrer [aut] (ORCID:\n<https://orcid.org/0000-0002-8029-7160>),\nLeire Abarrategui [aut] (ORCID:\n<https://orcid.org/0000-0002-1175-038X>)",
  "Maintainer": "Dolors Pelegri-Siso <dolors.pelegri@isglobal.org>",
  "MD5sum": "d5416920d5ad1b157912afb67e4f1422",
  "_user": "bioc",
  "_type": "src",
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  "_created": "2026-07-03T20:04:15.000Z",
  "_published": "2026-07-03T20:20:17.858Z",
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      "page": "add_ensemble_regulatory",
      "title": "Add ENSEMBL regulatory regions to epimutations",
      "topics": [
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      "page": "annotate_cpg",
      "title": "Annotate the DMR resulting from epimutacions package",
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      "page": "annotate_epimutations",
      "title": "Annotate the results of epimutations or epimutations_one_leave_out functions",
      "topics": [
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      ]
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      "page": "betas_from_bump",
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      "topics": [
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      "page": "betas_sd_mean",
      "title": "Computes beta values, standard deviation and mean to plot the epimutation",
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      "title": "Generates a GRanges object",
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      "page": "epi_beta",
      "title": "Identifies epimutations based on a beta distribution.",
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      "page": "epi_iForest",
      "title": "Identifies epimutations using Isolation Forest",
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      "title": "Identifies epimutations using Robust Mahalanobis distance",
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      "title": "Identifies epimutations using MANOVA",
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      "page": "epi_parameters",
      "title": "Settings for parameters of 'epimutations' and 'epimutations_one_leave_out' functions",
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      "page": "epi_preprocess",
      "title": "Preprocess methylation array",
      "topics": [
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      "page": "epi_quantile",
      "title": "Identifies epimutations using quantile distribution",
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      "page": "epimutations",
      "title": "Epimutations analysis based on outlier detection methods",
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      "page": "epimutations_one_leave_out",
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      "page": "get_candRegsGR",
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