{
  "_id": "6a1ad4801d7bb097a09e4263",
  "Package": "drugTargetInteractions",
  "Type": "Package",
  "Title": "Drug-Target Interactions",
  "Version": "1.21.0",
  "Date": "2023-10-24",
  "Authors@R": "person(\"Thomas\", \"Girke\", email=\"thomas.girke@ucr.edu\", role=c(\"cre\", \"aut\"))",
  "Description": "Provides utilities for identifying drug-target\ninteractions for sets of small molecule or gene/protein\nidentifiers. The required drug-target interaction information\nis obained from a local SQLite instance of the ChEMBL database.\nChEMBL has been chosen for this purpose, because it provides\none of the most comprehensive and best annotatated knowledge\nresources for drug-target information available in the public\ndomain.",
  "VignetteBuilder": "knitr",
  "License": "Artistic-2.0",
  "NeedsCompilation": "no",
  "URL": "https://github.com/girke-lab/drugTargetInteractions",
  "biocViews": "Cheminformatics, BiomedicalInformatics, Pharmacogenetics,\nPharmacogenomics, Proteomics, Metabolomics",
  "RoxygenNote": "7.1.1",
  "BugReports": "https://github.com/girke-lab/drugTargetInteractions",
  "Config/pak/sysreqs": "make libbz2-dev libicu-dev liblzma-dev libpng-dev\nlibxml2-dev libssl-dev xz-utils zlib1g-dev",
  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 12:55:28 UTC",
  "RemoteUrl": "https://github.com/bioc/drugTargetInteractions",
  "RemoteRef": "HEAD",
  "RemoteSha": "6fc4a01259286b77d98a4a2cc05e579d495a3573",
  "Packaged": {
    "Date": "2026-05-30 08:39:51 UTC",
    "User": "root"
  },
  "Author": "Thomas Girke [cre, aut]",
  "Maintainer": "Thomas Girke <thomas.girke@ucr.edu>",
  "MD5sum": "05e1e80ed98f8d1752fb6e5e4196913c",
  "_user": "bioc",
  "_type": "src",
  "_file": "drugTargetInteractions_1.21.0.tar.gz",
  "_fileid": "0597d900f1b64dc4889761fd63dee4ec2273f425f9a621ade41e4d33087e4723",
  "_filesize": 753509,
  "_sha256": "0597d900f1b64dc4889761fd63dee4ec2273f425f9a621ade41e4d33087e4723",
  "_created": "2026-05-30T08:39:51.000Z",
  "_published": "2026-05-30T12:13:52.702Z",
  "_jobs": [
    {
      "job": 78637182723,
      "time": 247,
      "config": "bioc-checks",
      "r": "4.6.0",
      "check": "WARNING",
      "artifact": "7306921574"
    },
    {
      "job": 78637182736,
      "time": 501,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "7306945855"
    },
    {
      "job": 78637182735,
      "time": 488,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7306944788"
    },
    {
      "job": 78637182744,
      "time": 321,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "7308084992"
    },
    {
      "job": 78637182739,
      "time": 276,
      "config": "macos-release-arm64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7308080763"
    },
    {
      "job": 78636882616,
      "time": 378,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7306897332"
    },
    {
      "job": 78637182750,
      "time": 199,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7306917266"
    },
    {
      "job": 78637182743,
      "time": 410,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "7306937183"
    },
    {
      "job": 78637182740,
      "time": 377,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "7306934025"
    },
    {
      "job": 78637182741,
      "time": 392,
      "config": "windows-release",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7306935468"
    }
  ],
  "_bioccheck": {
    "error": 0,
    "warning": 1,
    "note": 12
  },
  "_buildurl": "https://github.com/r-universe/bioc/actions/runs/26679353298",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/bioc/drugTargetInteractions",
  "_commit": {
    "id": "6fc4a01259286b77d98a4a2cc05e579d495a3573",
    "author": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "committer": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "message": "bump x.y.z version to odd y following creation of RELEASE_3_23 branch\n",
    "time": 1777380928
  },
  "_maintainer": {
    "name": "Thomas Girke",
    "email": "thomas.girke@ucr.edu",
    "login": "tgirke",
    "description": "",
    "uuid": 1336916
  },
  "_distro": "noble",
  "_registered": true,
  "_dependencies": [
    {
      "package": "methods",
      "role": "Depends"
    },
    {
      "package": "R",
      "version": ">= 4.1",
      "role": "Depends"
    },
    {
      "package": "utils",
      "role": "Imports"
    },
    {
      "package": "RSQLite",
      "role": "Imports"
    },
    {
      "package": "UniProt.ws",
      "role": "Imports"
    },
    {
      "package": "biomaRt",
      "role": "Imports"
    },
    {
      "package": "ensembldb",
      "role": "Imports"
    },
    {
      "package": "BiocFileCache",
      "role": "Imports"
    },
    {
      "package": "dplyr",
      "role": "Imports"
    },
    {
      "package": "rappdirs",
      "role": "Imports"
    },
    {
      "package": "AnnotationFilter",
      "role": "Imports"
    },
    {
      "package": "S4Vectors",
      "role": "Imports"
    },
    {
      "package": "RUnit",
      "role": "Suggests"
    },
    {
      "package": "BiocStyle",
      "role": "Suggests"
    },
    {
      "package": "knitr",
      "role": "Suggests"
    },
    {
      "package": "rmarkdown",
      "role": "Suggests"
    },
    {
      "package": "ggplot2",
      "role": "Suggests"
    },
    {
      "package": "reshape2",
      "role": "Suggests"
    },
    {
      "package": "DT",
      "role": "Suggests"
    },
    {
      "package": "EnsDb.Hsapiens.v86",
      "role": "Suggests"
    }
  ],
  "_owner": "bioc",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [
    {
      "week": "2025-44",
      "n": 2
    },
    {
      "week": "2026-18",
      "n": 2
    }
  ],
  "_tags": [],
  "_bioc": [
    {
      "branch": "devel",
      "version": "1.21.0",
      "bioc": "3.24"
    },
    {
      "branch": "release",
      "version": "1.20.0",
      "bioc": "3.23"
    }
  ],
  "_topics": [
    "cheminformatics",
    "biomedicalinformatics",
    "pharmacogenetics",
    "pharmacogenomics",
    "proteomics",
    "metabolomics"
  ],
  "_stars": 1,
  "_contributors": [
    {
      "user": "khoran",
      "count": 17,
      "uuid": 1340344
    },
    {
      "user": "tgirke",
      "count": 9,
      "uuid": 1336916
    },
    {
      "user": "nturaga",
      "count": 6,
      "uuid": 2746443
    }
  ],
  "_userbio": {
    "uuid": 2286807,
    "type": "organization",
    "name": "Bioconductor",
    "description": "Software for the analysis and comprehension of high-throughput genomic data"
  },
  "_downloads": {
    "count": 338,
    "source": "https://www.bioconductor.org/packages/stats/bioc/drugTargetInteractions"
  },
  "_devurl": "https://github.com/girke-lab/drugtargetinteractions",
  "_searchresults": 15,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/drugTargetInteractions.html",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md",
    "manual.pdf"
  ],
  "_homeurl": "https://github.com/girke-lab/drugtargetinteractions",
  "_realowner": "bioc",
  "_cranurl": false,
  "_exports": [
    "cmpIdMapping",
    "downloadChemblDb",
    "downloadUniChem",
    "drugTargetAnnot",
    "drugTargetAnnotTable",
    "drugTargetBioactivity",
    "genConfig",
    "getDrugTarget",
    "getParalogs",
    "getSymEnsUp",
    "getUniprotIDs",
    "processDrugage",
    "runDrugTarget_Annot_Bioassay",
    "transformTTD"
  ],
  "_help": [
    {
      "page": "drugTargetInteraction-package",
      "title": "Drug-Target Interactions",
      "topics": [
        "drugTargetInteractions-package",
        "drugTargetInteractions"
      ]
    },
    {
      "page": "cmpIdMapping",
      "title": "cmpIdMapping",
      "topics": [
        "cmpIdMapping"
      ]
    },
    {
      "page": "downloadChemblDb",
      "title": "downloadChemblDb",
      "topics": [
        "downloadChemblDb"
      ]
    },
    {
      "page": "downloadUniChem",
      "title": "downloadUniChem",
      "topics": [
        "downloadUniChem"
      ]
    },
    {
      "page": "drugTargetAnnot",
      "title": "drugTargetAnnot",
      "topics": [
        "drugTargetAnnot",
        "queryBy"
      ]
    },
    {
      "page": "drugTargetAnnotTable",
      "title": "drugTargetAnnotTable",
      "topics": [
        "drugTargetAnnotTable"
      ]
    },
    {
      "page": "drugTargetBioactivity",
      "title": "drugTargetBioactivity",
      "topics": [
        "drugTargetBioactivity"
      ]
    },
    {
      "page": "genConfig",
      "title": "genConfig",
      "topics": [
        "genConfig"
      ]
    },
    {
      "page": "getDrugTarget",
      "title": "getDrugTarget",
      "topics": [
        "getDrugTarget"
      ]
    },
    {
      "page": "getParalogs",
      "title": "getParalogs",
      "topics": [
        "getParalogs"
      ]
    },
    {
      "page": "getSymEnsUp",
      "title": "Gene to Protein ID Mappings",
      "topics": [
        "getSymEnsUp"
      ]
    },
    {
      "page": "getUniprotIDs",
      "title": "Retrieve UniProt IDs via ID and Cluster Mappings",
      "topics": [
        "getUniprotIDs"
      ]
    },
    {
      "page": "processDrugage",
      "title": "processDrugage",
      "topics": [
        "processDrugage"
      ]
    },
    {
      "page": "runDrugTarget_Annot_Bioassay",
      "title": "runDrugTarget_Annot_Bioassay",
      "topics": [
        "runDrugTarget_Annot_Bioassay"
      ]
    },
    {
      "page": "transformTTD",
      "title": "transformTTD",
      "topics": [
        "transformTTD"
      ]
    }
  ],
  "_readme": "https://github.com/bioc/drugTargetInteractions/raw/HEAD/README.md",
  "_rundeps": [
    "abind",
    "AnnotationDbi",
    "AnnotationFilter",
    "askpass",
    "BH",
    "Biobase",
    "BiocBaseUtils",
    "BiocFileCache",
    "BiocGenerics",
    "BiocIO",
    "BiocParallel",
    "biomaRt",
    "Biostrings",
    "bit",
    "bit64",
    "bitops",
    "blob",
    "cachem",
    "cigarillo",
    "cli",
    "codetools",
    "cpp11",
    "crayon",
    "curl",
    "DBI",
    "dbplyr",
    "DelayedArray",
    "dplyr",
    "ensembldb",
    "fastmap",
    "filelock",
    "formatR",
    "futile.logger",
    "futile.options",
    "generics",
    "GenomeInfoDb",
    "GenomicAlignments",
    "GenomicFeatures",
    "GenomicRanges",
    "glue",
    "hms",
    "httr",
    "httr2",
    "IRanges",
    "jsonlite",
    "KEGGREST",
    "lambda.r",
    "lattice",
    "lazyeval",
    "lifecycle",
    "magrittr",
    "Matrix",
    "MatrixGenerics",
    "matrixStats",
    "memoise",
    "mime",
    "openssl",
    "pillar",
    "pkgconfig",
    "png",
    "prettyunits",
    "progress",
    "ProtGenerics",
    "purrr",
    "R6",
    "rappdirs",
    "RCurl",
    "restfulr",
    "Rhtslib",
    "rjson",
    "rjsoncons",
    "rlang",
    "Rsamtools",
    "RSQLite",
    "rtracklayer",
    "S4Arrays",
    "S4Vectors",
    "Seqinfo",
    "snow",
    "SparseArray",
    "stringi",
    "stringr",
    "SummarizedExperiment",
    "sys",
    "tibble",
    "tidyr",
    "tidyselect",
    "UCSC.utils",
    "UniProt.ws",
    "utf8",
    "vctrs",
    "withr",
    "XML",
    "xml2",
    "XVector",
    "yaml"
  ],
  "_vignettes": [
    {
      "source": "drugTargetInteractions.Rmd",
      "filename": "drugTargetInteractions.html",
      "title": "Drug-Target Interactions",
      "author": "Authors: Kevin Horan, Yuzhu Duan, Austin Leong, Dan Evans, Jamison McCorrison, Nicholas Schork and Thomas Girke",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "Overview",
        "Install Package",
        "Load Package and Access Help",
        "Working Environment",
        "Required Files and Directories",
        "Produce Results Quickly",
        "Retrieve UniProt IDs",
        "UniProt's UNIREF Clusters",
        "BioMart's Paralogs",
        "Query Drug-Target Annotations",
        "Using drugTargetAnnot",
        "Query with Compound IDs",
        "Query with Protein IDs",
        "Query with Gene IDs",
        "Using getDrugTarget",
        "Query Bioassay Data",
        "Workflow to Run Everything",
        "ID mapping",
        "Query with Gene Names",
        "Query with ENSEBML Gene IDs",
        "Query with UniProt IDs",
        "UNIREF Cluster",
        "BioMart Parlogs",
        "Drug-Target Data",
        "Drug-Target Frequency",
        "Write Results to Tabular Files",
        "Session Info",
        "References"
      ],
      "created": "2020-11-30 16:24:41",
      "modified": "2021-08-26 17:17:11",
      "commits": 7
    }
  ],
  "_score": 4.477121254719663,
  "_indexed": true,
  "_nocasepkg": "drugtargetinteractions",
  "_universes": [
    "bioc",
    "tgirke",
    "girke-lab"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.21.0",
      "date": "2026-05-30T08:44:08.000Z",
      "distro": "noble",
      "commit": "6fc4a01259286b77d98a4a2cc05e579d495a3573",
      "fileid": "e9f184b67d10c35d08d5d2987bf0e2cfe719a05ed8e6d065a8452317ed85784f",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26679353298"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "1.21.0",
      "date": "2026-05-30T08:44:08.000Z",
      "distro": "noble",
      "commit": "6fc4a01259286b77d98a4a2cc05e579d495a3573",
      "fileid": "c6a526f2129620c7f34226ad33e67d2cbbb211ce24634f1f2fdcf4b433305a7b",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26679353298"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.21.0",
      "date": "2026-05-30T12:10:11.000Z",
      "commit": "6fc4a01259286b77d98a4a2cc05e579d495a3573",
      "fileid": "976062cefd86e86396eea263c760c5dbab917abece8d4950382adea91add475a",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26679353298"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "1.21.0",
      "date": "2026-05-30T12:09:50.000Z",
      "commit": "6fc4a01259286b77d98a4a2cc05e579d495a3573",
      "fileid": "5a4df6e176fb5a8f8fe42316515886389e7884dc6fafb428b918a387ac7206cd",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26679353298"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "1.21.0",
      "date": "2026-05-30T08:43:53.000Z",
      "commit": "6fc4a01259286b77d98a4a2cc05e579d495a3573",
      "fileid": "bd1696ac74bec47170ed140f122248420b7e732f592a9f23eee34c4dd6160a95",
      "status": "success",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26679353298"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "1.21.0",
      "date": "2026-05-30T08:42:45.000Z",
      "commit": "6fc4a01259286b77d98a4a2cc05e579d495a3573",
      "fileid": "8fe40c19d9672b9272c8e6b5c9fedb509a6f585dd7a7b523459b7288537e2649",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26679353298"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "1.21.0",
      "date": "2026-05-30T08:42:36.000Z",
      "commit": "6fc4a01259286b77d98a4a2cc05e579d495a3573",
      "fileid": "443c2a1838ff5ccaefb7bd2eaa128a8f71eae489577f56bed80bd72de5d16c5e",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26679353298"
    },
    {
      "r": "4.6.0",
      "os": "win",
      "version": "1.21.0",
      "date": "2026-05-30T08:42:50.000Z",
      "commit": "6fc4a01259286b77d98a4a2cc05e579d495a3573",
      "fileid": "9ca457122ae930f5026e1941f0efe9c699172b8b711b733681c65616678ac3e9",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26679353298"
    }
  ]
}