{
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  "Package": "doubletrouble",
  "Title": "Identification and classification of duplicated genes",
  "Version": "1.13.0",
  "Date": "2024-03-19",
  "Authors@R": "c(\nperson(given = \"Fabrício\",\nfamily = \"Almeida-Silva\",\nrole = c(\"aut\", \"cre\"),\nemail = \"fabricio_almeidasilva@hotmail.com\",\ncomment = c(ORCID = \"0000-0002-5314-2964\")),\nperson(given = \"Yves\",\nfamily = \"Van de Peer\",\nrole = \"aut\",\nemail = \"yves.vandepeer@psb.vib-ugent.be\",\ncomment = c(ORCID = \"0000-0003-4327-3730\"))\n)",
  "Description": "doubletrouble aims to identify duplicated genes from\nwhole-genome protein sequences and classify them based on their\nmodes of duplication. The duplication modes are i. segmental\nduplication (SD); ii. tandem duplication (TD); iii. proximal\nduplication (PD); iv. transposed duplication (TRD) and; v.\ndispersed duplication (DD). Transposon-derived duplicates (TRD)\ncan be further subdivided into rTRD (retrotransposon-derived\nduplication) and dTRD (DNA transposon-derived duplication). If\nusers want a simpler classification scheme, duplicates can also\nbe classified into SD- and SSD-derived (small-scale\nduplication) gene pairs. Besides classifying gene pairs, users\ncan also classify genes, so that each gene is assigned a unique\nmode of duplication. Users can also calculate substitution\nrates per substitution site (i.e., Ka and Ks) from duplicate\npairs, find peaks in Ks distributions with Gaussian Mixture\nModels (GMMs), and classify gene pairs into age groups based on\nKs peaks.",
  "License": "GPL-3",
  "URL": "https://github.com/almeidasilvaf/doubletrouble",
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  "Date/Publication": "2026-04-28 12:59:27 UTC",
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  "Author": "Fabrício Almeida-Silva [aut, cre] (ORCID:\n<https://orcid.org/0000-0002-5314-2964>),\nYves Van de Peer [aut] (ORCID: <https://orcid.org/0000-0003-4327-3730>)",
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      "source": "doubletrouble_vignette.Rmd",
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      "title": "Identification and classification of duplicated genes",
      "author": "Fabricio Almeida-Silva, Yves Van de Peer",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "Installation",
        "Input data",
        "Getting to know the example data sets",
        "Data preparation",
        "Classifying duplicated gene pairs and genes",
        "The binary scheme (SD vs SSD)",
        "The standard scheme (SSD → TD, PD, DD)",
        "The extended scheme (SSD → TD, PD, TRD, DD)",
        "The full scheme (SSD → TD, PD, rTRD, dTRD, DD)",
        "Classifying genes into unique modes of duplication",
        "Calculating substitution rates for duplicated gene pairs",
        "Identifying and visualizing $K_s$ peaks",
        "Classifying genes by age groups",
        "Data visualization",
        "Visualizing the frequency of duplicates per mode",
        "Visualizing $K_s$ distributions",
        "Visualizing substitution rates by species",
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