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The method is based on comparing detected\nregions to a pooled null distribution, that can be implemented\neven when as few as two samples per population are available.\nRegion-level statistics are obtained by fitting a generalized\nleast squares (GLS) regression model with a nested\nautoregressive correlated error structure for the effect of\ninterest on transformed methylation proportions.", "License": "MIT + file LICENSE", "biocViews": "ImmunoOncology, DNAMethylation, Epigenetics,\nMultipleComparison, Software, Sequencing,\nDifferentialMethylation, WholeGenome, Regression,\nFunctionalGenomics", "LazyData": "true", "VignetteBuilder": "knitr", "RoxygenNote": "7.2.3", "Config/pak/sysreqs": "make libbz2-dev libicu-dev liblzma-dev libpng-dev\nlibxml2-dev libssl-dev libx11-dev xz-utils zlib1g-dev", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-04-28 12:47:22 UTC", "RemoteUrl": "https://github.com/bioc/dmrseq", "RemoteRef": "HEAD", "RemoteSha": 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