{ "_id": "6acb6b05fe5cc25786e8fb5b", "Package": "dinoR", "Title": "Differential NOMe-seq analysis", "Version": "1.9.1", "Authors@R": "person(\"Michaela\", \"Schwaiger\",, \"michaela.schwaiger@fmi.ch\",\nrole = c(\"aut\", \"cre\"),\ncomment = c(ORCID = \"0000-0002-4522-7810\"))", "Description": "dinoR tests for significant differences in NOMe-seq\nfootprints between two conditions, using genomic regions of\ninterest (ROI) centered around a landmark, for example a\ntranscription factor (TF) motif. This package takes NOMe-seq\ndata (GCH methylation/protection) in the form of a Ranged\nSummarized Experiment as input. dinoR can be used to group\nsequencing fragments into 3 or 5 categories representing\ncharacteristic footprints (TF bound, nculeosome bound, open\nchromatin), plot the percentage of fragments in each category\nin a heatmap, or averaged across different ROI groups, for\nexample, containing a common TF motif. It is designed to\ncompare footprints between two sample groups, using edgeR's\nquasi-likelihood methods on the total fragment counts per ROI,\nsample, and footprint category.", "License": "MIT + file LICENSE", "Encoding": "UTF-8", "Roxygen": "list(markdown = TRUE)", "Config/testthat/edition": "3", "VignetteBuilder": "knitr", "LazyData": "false", "biocViews": "NucleosomePositioning, Epigenetics, MethylSeq,\nDifferentialMethylation, Coverage, Transcription, Sequencing,\nSoftware", "URL": "https://github.com/xxxmichixxx/dinoR", "BugReports": "https://github.com/xxxmichixxx/dinoR/issues", "Config/roxygen2/version": "8.1.0", "Config/pak/sysreqs": "libicu-dev libpng-dev perl zlib1g-dev", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-09-11 09:04:28 UTC", "RemoteUrl": "https://github.com/bioc/dinoR", "RemoteRef": "HEAD", "RemoteSha": "3ddf4a8c7ff1eb285985d163ee577ba91cf57480", "NeedsCompilation": "no", "Packaged": { "Date": "2026-10-11 10:29:32 UTC", "User": "root" }, "Author": "Michaela Schwaiger [aut, cre] (ORCID:\n)", "Maintainer": "Michaela Schwaiger ", "_user": "bioc", "_type": "src", "_file": "dinoR_1.9.1.tar.gz", "_fileid": "https://r2.ropensci.org/0d994d0bc5997d7b471cde358357faed2bd1568c01e040600fe93a4406f044bf", "_filesize": 4258882, "_sha256": "0d994d0bc5997d7b471cde358357faed2bd1568c01e040600fe93a4406f044bf", "_expires": "2027-01-19T10:54:59.000Z", "_created": "2026-10-11T10:29:32.000Z", "_published": "2026-10-11T10:55:01.628Z", "_buildurl": "https://github.com/r-universe/bioc/actions/runs/38131875354", "_status": "success", "_host": "GitHub-Actions", "_bioccheck": { "error": 0, "warning": 0, "note": 4 }, "_upstream": "https://github.com/bioc/dinoR", "_commit": { "id": "3ddf4a8c7ff1eb285985d163ee577ba91cf57480", "author": "xxxmichixxx ", "committer": "xxxmichixxx ", "message": "Removed the prior.count option from diNOMeTest since edgeR does not support this anymore.\n", "time": 1789117468 }, "_maintainer": { "name": "Michaela Schwaiger", 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