{ "_id": "6a129d7eacfb0bcc41d0f51b", "Package": "compSPOT", "Type": "Package", "Title": "compSPOT: Tool for identifying and comparing significantly\nmutated genomic hotspots", "Version": "1.11.0", "Authors@R": "c(\nperson(\"Sydney\", \"Grant\", email = \"Sydney.Grant@roswellpark.org\",\nrole = c(\"aut\", \"cre\"),\ncomment = c(ORCID = \"0000-0003-1849-5921\")),\nperson(\"Ella\", \"Sampson\", email = \"ellasamp@buffalo.edu\", role = c(\"aut\")),\nperson(\"Rhea\", \"Rodrigues\",\nemail = \"RheaCarmelGlen.Rodrigues@roswellpark.org\",\nrole = c(\"aut\"), comment = c(ORCID = \"0000-0002-8573-8658\")),\nperson(\"Gyorgy\", \"Paragh\", email = \"Gyorgy.Paragh@roswellpark.org\",\nrole = c(\"aut\"), comment = c(ORCID = \"0000-0002-6612-9267\")))", "Description": "Clonal cell groups share common mutations within cancer,\nprecancer, and even clinically normal appearing tissues. The\nfrequency and location of these mutations may predict prognosis\nand cancer risk. It has also been well established that certain\ngenomic regions have increased sensitivity to acquiring\nmutations. Mutation-sensitive genomic regions may therefore\nserve as markers for predicting cancer risk. This package\ncontains multiple functions to establish significantly mutated\nhotspots, compare hotspot mutation burden between samples, and\nperform exploratory data analysis of the correlation between\nhotspot mutation burden and personal risk factors for cancer,\nsuch as age, gender, and history of carcinogen exposure. This\npackage allows users to identify robust genomic markers to help\nestablish cancer risk.", "License": "Artistic-2.0", "Encoding": "UTF-8", "LazyData": "FALSE", "Roxygen": "list(markdown = TRUE)", "RoxygenNote": "7.2.3", "biocViews": "Software, Technology, Sequencing, DNASeq, WholeGenome,\nClassification, SingleCell, Survival, MultipleComparison", "VignetteBuilder": "knitr", "URL": "https://github.com/sydney-grant/compSPOT", "BugReports": "https://github.com/sydney-grant/compSPOT/issues", "Config/testthat/edition": "3", "Config/pak/sysreqs": "cmake make libicu-dev libuv1-dev libssl-dev", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-04-28 13:01:21 UTC", "RemoteUrl": "https://github.com/bioc/compSPOT", "RemoteRef": "HEAD", "RemoteSha": "0f916bfbe403adbe8a74217893cad8fa3fff54e2", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-24 06:34:41 UTC", "User": "root" }, "Author": "Sydney Grant [aut, cre] (ORCID:\n),\nElla Sampson [aut],\nRhea Rodrigues [aut] 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