{ "_id": "6a1bce9c1d7bb097a0a13ee3", "Package": "biotmle", "Title": "Targeted Learning with Moderated Statistics for Biomarker\nDiscovery", "Version": "1.37.0", "Authors@R": "c(\nperson(\"Nima\", \"Hejazi\", email = \"nh@nimahejazi.org\",\nrole = c(\"aut\", \"cre\", \"cph\"),\ncomment = c(ORCID = \"0000-0002-7127-2789\")),\nperson(\"Alan\", \"Hubbard\", email = \"hubbard@berkeley.edu\",\nrole = c(\"aut\", \"ths\"),\ncomment = c(ORCID = \"0000-0002-3769-0127\")),\nperson(\"Mark\", \"van der Laan\", email = \"laan@stat.berkeley.edu\",\nrole = c(\"aut\", \"ths\"),\ncomment = c(ORCID = \"0000-0003-1432-5511\")),\nperson(\"Weixin\", \"Cai\", email = \"wcai@berkeley.edu\",\nrole = \"ctb\",\ncomment = c(ORCID = \"0000-0003-2680-3066\")),\nperson(\"Philippe\", \"Boileau\", email = \"philippe_boileau@berkeley.edu\",\nrole = \"ctb\",\ncomment = c(ORCID = \"0000-0002-4850-2507\"))\n)", "Description": "Tools for differential expression biomarker discovery\nbased on microarray and next-generation sequencing data that\nleverage efficient semiparametric estimators of the average\ntreatment effect for variable importance analysis. Estimation\nand inference of the (marginal) average treatment effects of\npotential biomarkers are computed by targeted minimum\nloss-based estimation, with joint, stable inference constructed\nacross all biomarkers using a generalization of moderated\nstatistics for use with the estimated efficient influence\nfunction. The procedure accommodates the use of ensemble\nmachine learning for the estimation of nuisance functions.", "License": "MIT + file LICENSE", "URL": "https://code.nimahejazi.org/biotmle", "BugReports": "https://github.com/nhejazi/biotmle/issues", "Encoding": "UTF-8", "VignetteBuilder": "knitr", "RoxygenNote": "7.1.2", "biocViews": "Regression, GeneExpression, DifferentialExpression,\nSequencing, Microarray, RNASeq, ImmunoOncology", "Config/pak/sysreqs": "make zlib1g-dev", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-04-28 12:45:34 UTC", "RemoteUrl": "https://github.com/bioc/biotmle", "RemoteRef": "HEAD", "RemoteSha": "637bce4128bc312b8c73484dbf8387eba1ee1a6e", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-29 08:35:26 UTC", "User": "root" }, "Author": "Nima Hejazi [aut, cre, cph] (ORCID:\n),\nAlan Hubbard [aut, ths] (ORCID:\n),\nMark van der Laan [aut, ths] (ORCID:\n),\nWeixin Cai [ctb] (ORCID: ),\nPhilippe Boileau [ctb] (ORCID: )", "Maintainer": 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