{
  "_id": "6a197148acfb0bcc41deda92",
  "Package": "airpart",
  "Title": "Differential cell-type-specific allelic imbalance",
  "Version": "1.21.0",
  "Authors@R": "c(person(given = \"Wancen\",\nfamily = \"Mu\",\nrole = c(\"aut\", \"cre\"),\nemail = \"wancen@live.unc.edu\",\ncomment = c(ORCID = \"0000-0002-5061-7581\")),\nperson(given = \"Michael\",\nfamily = \"Love\",\nrole = c(\"aut\", \"ctb\"),\ncomment = c(ORCID = \"0000-0001-8401-0545\")))",
  "Description": "Airpart identifies sets of genes displaying differential\ncell-type-specific allelic imbalance across cell types or\nstates, utilizing single-cell allelic counts. It makes use of a\ngeneralized fused lasso with binomial observations of allelic\ncounts to partition cell types by their allelic imbalance.\nAlternatively, a nonparametric method for partitioning cell\ntypes is offered. The package includes a number of\nvisualizations and quality control functions for examining\nsingle cell allelic imbalance datasets.",
  "License": "GPL-2",
  "VignetteBuilder": "knitr",
  "biocViews": "SingleCell, RNASeq, ATACSeq, ChIPSeq, Sequencing,\nGeneRegulation, GeneExpression, Transcription,\nTranscriptomeVariant, CellBiology, FunctionalGenomics,\nDifferentialExpression, GraphAndNetwork, Regression,\nClustering, QualityControl",
  "Encoding": "UTF-8",
  "BugReports": "https://github.com/Wancen/airpart/issues",
  "URL": "https://github.com/Wancen/airpart",
  "RoxygenNote": "7.2.3",
  "Config/testthat/edition": "3",
  "Config/pak/sysreqs": "libcairo2-dev libfontconfig1-dev libfreetype6-dev\nlibfribidi-dev libharfbuzz-dev libicu-dev libjpeg-dev\nlibpng-dev libtiff-dev libwebp-dev perl zlib1g-dev",
  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 12:55:30 UTC",
  "RemoteUrl": "https://github.com/bioc/airpart",
  "RemoteRef": "HEAD",
  "RemoteSha": "8e271c382d5aac8a6125e0558389063bb759c149",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-05-29 08:49:29 UTC",
    "User": "root"
  },
  "Author": "Wancen Mu [aut, cre] (ORCID: <https://orcid.org/0000-0002-5061-7581>),\nMichael Love [aut, ctb] (ORCID:\n<https://orcid.org/0000-0001-8401-0545>)",
  "Maintainer": "Wancen Mu <wancen@live.unc.edu>",
  "MD5sum": "7b60ce15906552fb060657f753a4422a",
  "_user": "bioc",
  "_type": "src",
  "_file": "airpart_1.21.0.tar.gz",
  "_fileid": "7d660d99e40e2f00bd5ab9127bda29110772c4b24325e6600ffce238395643b3",
  "_filesize": 1198824,
  "_sha256": "7d660d99e40e2f00bd5ab9127bda29110772c4b24325e6600ffce238395643b3",
  "_created": "2026-05-29T08:49:29.000Z",
  "_published": "2026-05-29T10:58:16.625Z",
  "_jobs": [
    {
      "job": 78468786474,
      "time": 209,
      "config": "bioc-checks",
      "r": "4.6.0",
      "check": "WARNING",
      "artifact": "7286875945"
    },
    {
      "job": 78468786488,
      "time": 469,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "7286955570"
    },
    {
      "job": 78468786469,
      "time": 420,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7286941567"
    },
    {
      "job": 78468786510,
      "time": 218,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "7289064596"
    },
    {
      "job": 78468786478,
      "time": 246,
      "config": "macos-release-arm64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7289072931"
    },
    {
      "job": 78467882781,
      "time": 348,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7286811034"
    },
    {
      "job": 78468786718,
      "time": 172,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7286864222"
    },
    {
      "job": 78468786581,
      "time": 357,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "7286922575"
    },
    {
      "job": 78468786496,
      "time": 335,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "7286915845"
    },
    {
      "job": 78468786518,
      "time": 334,
      "config": "windows-release",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7286915135"
    }
  ],
  "_bioccheck": {
    "error": 0,
    "warning": 1,
    "note": 9
  },
  "_buildurl": "https://github.com/r-universe/bioc/actions/runs/26627531263",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/bioc/airpart",
  "_commit": {
    "id": "8e271c382d5aac8a6125e0558389063bb759c149",
    "author": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "committer": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "message": "bump x.y.z version to odd y following creation of RELEASE_3_23 branch\n",
    "time": 1777380930
  },
  "_maintainer": {
    "name": "Wancen Mu",
    "email": "wancen@live.unc.edu",
    "orcid": "0000-0002-5061-7581"
  },
  "_distro": "noble",
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 4.1",
      "role": "Depends"
    },
    {
      "package": "SingleCellExperiment",
      "role": "Imports"
    },
    {
      "package": "SummarizedExperiment",
      "role": "Imports"
    },
    {
      "package": "S4Vectors",
      "role": "Imports"
    },
    {
      "package": "scater",
      "role": "Imports"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "smurf",
      "role": "Imports"
    },
    {
      "package": "apeglm",
      "version": ">= 1.13.3",
      "role": "Imports"
    },
    {
      "package": "emdbook",
      "role": "Imports"
    },
    {
      "package": "mclust",
      "role": "Imports"
    },
    {
      "package": "clue",
      "role": "Imports"
    },
    {
      "package": "dynamicTreeCut",
      "role": "Imports"
    },
    {
      "package": "matrixStats",
      "role": "Imports"
    },
    {
      "package": "dplyr",
      "role": "Imports"
    },
    {
      "package": "plyr",
      "role": "Imports"
    },
    {
      "package": "ggplot2",
      "role": "Imports"
    },
    {
      "package": "ComplexHeatmap",
      "role": "Imports"
    },
    {
      "package": "forestplot",
      "role": "Imports"
    },
    {
      "package": "RColorBrewer",
      "role": "Imports"
    },
    {
      "package": "rlang",
      "role": "Imports"
    },
    {
      "package": "lpSolve",
      "role": "Imports"
    },
    {
      "package": "grid",
      "role": "Imports"
    },
    {
      "package": "grDevices",
      "role": "Imports"
    },
    {
      "package": "graphics",
      "role": "Imports"
    },
    {
      "package": "utils",
      "role": "Imports"
    },
    {
      "package": "pbapply",
      "role": "Imports"
    },
    {
      "package": "knitr",
      "role": "Suggests"
    },
    {
      "package": "rmarkdown",
      "role": "Suggests"
    },
    {
      "package": "roxygen2",
      "version": ">= 6.0.0",
      "role": "Suggests"
    },
    {
      "package": "testthat",
      "version": ">= 3.0.0",
      "role": "Suggests"
    },
    {
      "package": "gplots",
      "role": "Suggests"
    },
    {
      "package": "tidyr",
      "role": "Suggests"
    }
  ],
  "_owner": "bioc",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [
    {
      "week": "2025-44",
      "n": 2
    },
    {
      "week": "2026-18",
      "n": 2
    }
  ],
  "_tags": [],
  "_bioc": [
    {
      "branch": "devel",
      "version": "1.21.0",
      "bioc": "3.24"
    },
    {
      "branch": "release",
      "version": "1.20.0",
      "bioc": "3.23"
    }
  ],
  "_topics": [
    "singlecell",
    "rnaseq",
    "atacseq",
    "chipseq",
    "sequencing",
    "generegulation",
    "geneexpression",
    "transcription",
    "transcriptomevariant",
    "cellbiology",
    "functionalgenomics",
    "differentialexpression",
    "graphandnetwork",
    "regression",
    "clustering",
    "qualitycontrol"
  ],
  "_stars": 2,
  "_contributors": [
    {
      "user": "wancen",
      "count": 124,
      "uuid": 42752661
    },
    {
      "user": "mikelove",
      "count": 57,
      "uuid": 69203
    },
    {
      "user": "nturaga",
      "count": 6,
      "uuid": 2746443
    },
    {
      "user": "jwokaty",
      "count": 2,
      "uuid": 1744257
    }
  ],
  "_userbio": {
    "uuid": 2286807,
    "type": "organization",
    "name": "Bioconductor",
    "description": "Software for the analysis and comprehension of high-throughput genomic data"
  },
  "_downloads": {
    "count": 431,
    "source": "https://www.bioconductor.org/packages/stats/bioc/airpart"
  },
  "_devurl": "https://github.com/wancen/airpart",
  "_searchresults": 2,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/airpart.html",
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md",
    "manual.pdf"
  ],
  "_homeurl": "https://github.com/wancen/airpart",
  "_realowner": "bioc",
  "_cranurl": false,
  "_exports": [
    "allelicRatio",
    "cellQC",
    "consensusPart",
    "estDisp",
    "extractResult",
    "featureQC",
    "fusedLasso",
    "geneCluster",
    "makeForest",
    "makeHeatmap",
    "makeOffByOneAdjMat",
    "makeSimulatedData",
    "makeStep",
    "makeViolin",
    "preprocess",
    "summaryAllelicRatio",
    "wilcoxExt"
  ],
  "_help": [
    {
      "page": "allelicRatio",
      "title": "Fit beta-binomial across cell types",
      "topics": [
        "allelicRatio"
      ]
    },
    {
      "page": "cellQC",
      "title": "Quality control on cells",
      "topics": [
        "cellQC"
      ]
    },
    {
      "page": "consensusPart",
      "title": "Consensus Partitions",
      "topics": [
        "consensusPart"
      ]
    },
    {
      "page": "estDisp",
      "title": "Estimate overdispersion parameter of a beta-binomial",
      "topics": [
        "estDisp"
      ]
    },
    {
      "page": "extractResult",
      "title": "Extract results from an airpart analysis",
      "topics": [
        "extractResult"
      ]
    },
    {
      "page": "featureQC",
      "title": "Quality control on features",
      "topics": [
        "featureQC"
      ]
    },
    {
      "page": "fusedLasso",
      "title": "Generalized fused lasso to partition cell types by allelic imbalance",
      "topics": [
        "fusedLasso"
      ]
    },
    {
      "page": "geneCluster",
      "title": "Gene clustering based on allelic ratio matrix with pseudo-count",
      "topics": [
        "geneCluster"
      ]
    },
    {
      "page": "makeForest",
      "title": "Plot allelic ratio result as forest",
      "topics": [
        "makeForest"
      ]
    },
    {
      "page": "makeHeatmap",
      "title": "Plot allelic ratio as heatmap",
      "topics": [
        "makeHeatmap"
      ]
    },
    {
      "page": "makeOffByOneAdjMat",
      "title": "Generating adjancy matrix for neighboring cell states.",
      "topics": [
        "makeOffByOneAdjMat"
      ]
    },
    {
      "page": "makeSimulatedData",
      "title": "Make simulated data for airpart",
      "topics": [
        "makeSimulatedData"
      ]
    },
    {
      "page": "makeStep",
      "title": "Plot group partition and posterior allelic ratio estimates by step",
      "topics": [
        "makeStep"
      ]
    },
    {
      "page": "makeViolin",
      "title": "Posterior mean allelic ratio estimates in violin plots",
      "topics": [
        "makeViolin"
      ]
    },
    {
      "page": "preprocess",
      "title": "Preprocess the SingleCellExperiment",
      "topics": [
        "preprocess"
      ]
    },
    {
      "page": "summaryAllelicRatio",
      "title": "Allelic ratio summary",
      "topics": [
        "summaryAllelicRatio"
      ]
    },
    {
      "page": "wilcoxExt",
      "title": "Extension on Pairwise Mann Whitney Wilcoxon Test for partitioning",
      "topics": [
        "wilcoxExt"
      ]
    }
  ],
  "_readme": "https://github.com/bioc/airpart/raw/HEAD/README.md",
  "_rundeps": [
    "abind",
    "apeglm",
    "assorthead",
    "backports",
    "base64enc",
    "bbmle",
    "bdsmatrix",
    "beachmat",
    "beeswarm",
    "BH",
    "Biobase",
    "BiocGenerics",
    "BiocNeighbors",
    "BiocParallel",
    "BiocSingular",
    "Cairo",
    "catdata",
    "checkmate",
    "circlize",
    "cli",
    "clue",
    "cluster",
    "coda",
    "codetools",
    "colorspace",
    "ComplexHeatmap",
    "cpp11",
    "crayon",
    "DelayedArray",
    "digest",
    "doParallel",
    "dplyr",
    "dqrng",
    "dynamicTreeCut",
    "emdbook",
    "farver",
    "FNN",
    "foreach",
    "forestplot",
    "formatR",
    "futile.logger",
    "futile.options",
    "generics",
    "GenomicRanges",
    "GetoptLong",
    "ggbeeswarm",
    "ggplot2",
    "ggrastr",
    "ggrepel",
    "glmnet",
    "GlobalOptions",
    "glue",
    "gridExtra",
    "gtable",
    "IRanges",
    "irlba",
    "isoband",
    "iterators",
    "jsonlite",
    "labeling",
    "lambda.r",
    "lattice",
    "lifecycle",
    "lpSolve",
    "magrittr",
    "MASS",
    "Matrix",
    "MatrixGenerics",
    "matrixStats",
    "mclust",
    "mgcv",
    "mvtnorm",
    "nlme",
    "numDeriv",
    "pbapply",
    "pheatmap",
    "pillar",
    "pkgconfig",
    "plyr",
    "png",
    "R6",
    "ragg",
    "RColorBrewer",
    "Rcpp",
    "RcppAnnoy",
    "RcppArmadillo",
    "RcppEigen",
    "RcppML",
    "RcppNumerical",
    "RcppProgress",
    "rjson",
    "rlang",
    "RSpectra",
    "rsvd",
    "Rtsne",
    "S4Arrays",
    "S4Vectors",
    "S7",
    "ScaledMatrix",
    "scales",
    "scater",
    "scuttle",
    "Seqinfo",
    "shape",
    "SingleCellExperiment",
    "sitmo",
    "smurf",
    "snow",
    "SparseArray",
    "stringi",
    "SummarizedExperiment",
    "survival",
    "systemfonts",
    "textshaping",
    "tibble",
    "tidyselect",
    "utf8",
    "uwot",
    "vctrs",
    "vipor",
    "viridis",
    "viridisLite",
    "withr",
    "XVector"
  ],
  "_vignettes": [
    {
      "source": "airpart.Rmd",
      "filename": "airpart.html",
      "title": "Differential cell-type-specific allelic imbalance with airpart",
      "author": "Wancen Mu, Hirak Sarkar, Avi Srivastava, Kwangbom Choi, Rob Patro, Michael I. Love",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Real data example",
        "Simulated data example I",
        "Simulation set-up",
        "Required input data",
        "Create allelic ratio matrix",
        "Quality control steps",
        "QC on cells",
        "QC on genes",
        "Gene clustering",
        "Running airpart for allelic imbalance across groups of cells",
        "Simple summary table of allelic ratio",
        "Experiment-wide beta-binomial over-dispersion",
        "Modeling using fused lasso with binomial likelihood",
        "Consensus partition",
        "Modeling using pairwise Mann-Whitney-Wilcoxon extension",
        "Calculating allelic ratio estimates via beta-binomial model",
        "Derive statistical inference",
        "Allelic ratio partition and posterior inference, example II",
        "Session Info"
      ],
      "created": "2021-04-01 16:35:49",
      "modified": "2023-03-04 15:32:48",
      "commits": 28
    }
  ],
  "_score": 4.778151250383644,
  "_indexed": true,
  "_nocasepkg": "airpart",
  "_universes": [
    "bioc",
    "wancen"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.21.0",
      "date": "2026-05-29T08:54:38.000Z",
      "distro": "noble",
      "commit": "8e271c382d5aac8a6125e0558389063bb759c149",
      "fileid": "3ff90d197ce0b13a661013ead45b10f838afc5b1f686c41bc75d4ef474e045c3",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26627531263"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "1.21.0",
      "date": "2026-05-29T08:53:55.000Z",
      "distro": "noble",
      "commit": "8e271c382d5aac8a6125e0558389063bb759c149",
      "fileid": "cbb8204e8326d3a7b421f46157102f491da1a69965c0bc426f59c17e199e0e0a",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26627531263"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.21.0",
      "date": "2026-05-29T10:55:16.000Z",
      "commit": "8e271c382d5aac8a6125e0558389063bb759c149",
      "fileid": "1ac9a48811b9b590f4768cb9142756161c6e779a758de81d7506db88363748d5",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26627531263"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "1.21.0",
      "date": "2026-05-29T10:55:21.000Z",
      "commit": "8e271c382d5aac8a6125e0558389063bb759c149",
      "fileid": "bd74ffdf76f8aa7eb92b05176987a03eca4ad881ebeaa1dfaa82359f68bffd89",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26627531263"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "1.21.0",
      "date": "2026-05-29T08:53:05.000Z",
      "commit": "8e271c382d5aac8a6125e0558389063bb759c149",
      "fileid": "3f464615692663238c7212f6fc4f13884546c12189d6421324b8ee745a3bb864",
      "status": "success",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26627531263"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "1.21.0",
      "date": "2026-05-29T08:51:45.000Z",
      "commit": "8e271c382d5aac8a6125e0558389063bb759c149",
      "fileid": "fd001303e5eb2a98b7691535941e26b320bfdf1a419d01e3c56f3baaab7a7590",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26627531263"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "1.21.0",
      "date": "2026-05-29T08:51:37.000Z",
      "commit": "8e271c382d5aac8a6125e0558389063bb759c149",
      "fileid": "4edd11229c7b59f550c85ad227e50faede53834a6eb15d73513f90f73a09be36",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26627531263"
    },
    {
      "r": "4.6.0",
      "os": "win",
      "version": "1.21.0",
      "date": "2026-05-29T08:51:48.000Z",
      "commit": "8e271c382d5aac8a6125e0558389063bb759c149",
      "fileid": "f9c17356498921666a55236976a569cb329472348181b35d6f52a1f98a645fd5",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26627531263"
    }
  ]
}