{ "_id": "6a197657acfb0bcc41df1e41", "Package": "ZygosityPredictor", "Type": "Package", "Title": "Package for prediction of zygosity for variants/genes in NGS\ndata", "Version": "1.13.0", "Date": "2025-07-28", "Authors@R": "c(\nperson(\"Marco\", \"Rheinnecker\",\nemail=\"marco.rheinnecker@dkfz-heidelberg.de\",\nrole = c(\"aut\", \"cre\"),\ncomment=c(ORCID=\"0009-0009-7181-3977\")),\nperson(\"Marc\", \"Ruebsam\",\nrole = c(\"aut\")),\nperson(\"Daniel\", \"Huebschmann\",\nrole = c(\"aut\")),\nperson(\"Martina\", \"Froehlich\",\nrole = c(\"aut\")),\nperson(\"Barbara\", \"Hutter\",\nrole = c(\"aut\"))\n)", "License": "GPL-2", "Description": "The ZygosityPredictor allows to predict how many copies of\na gene are affected by small variants. In addition to the basic\ncalculations of the affected copy number of a variant, the\nZygosity-Predictor can integrate the influence of several\nvariants on a gene and ultimately make a statement if and how\nmany wild-type copies of the gene are left. This information\nproves to be of particular use in the context of translational\nmedicine. For example, in cancer genomes, the\nZygosity-Predictor can address whether unmutated copies of\ntumor-suppressor genes are present. Beyond this, it is possible\nto make this statement for all genes of an organism. The\nZygosity-Predictor was primarily developed to handle SNVs and\nINDELs (later addressed as small-variants) of somatic and\ngermline origin. In order not to overlook severe effects\noutside of the small-variant context, it has been extended with\nthe assessment of large scale deletions, which cause losses of\nwhole genes or parts of them.", "RoxygenNote": "7.2.3", "Encoding": "UTF-8", "biocViews": "BiomedicalInformatics, FunctionalPrediction,\nSomaticMutation, GenePrediction", "LazyData": "false", "VignetteBuilder": "knitr", "Config/pak/sysreqs": "libglpk-dev make libbz2-dev libicu-dev liblzma-dev\nlibpng-dev libxml2-dev libssl-dev libx11-dev xz-utils\nzlib1g-dev", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-04-28 13:00:21 UTC", "RemoteUrl": "https://github.com/bioc/ZygosityPredictor", "RemoteRef": "HEAD", "RemoteSha": "207b3746d0eb02b1a8715b49245a07c705b4f0ab", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-29 09:32:50 UTC", "User": "root" }, "Author": "Marco Rheinnecker [aut, cre] (ORCID:\n),\nMarc Ruebsam [aut],\nDaniel Huebschmann [aut],\nMartina Froehlich [aut],\nBarbara Hutter 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