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  "_rbuild": "4.6.2",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/manual.pdf",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/VariantAnnotation.html"
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  "_realowner": "bioc",
  "_cranurl": false,
  "_exports": [
    "AllVariants",
    "alt",
    "alt<-",
    "altDepth",
    "altDepth<-",
    "altFraction",
    "asVCF",
    "called",
    "cbind",
    "CodingVariants",
    "columns",
    "downstream",
    "downstream<-",
    "duplicateRSID",
    "expand",
    "filt",
    "filt<-",
    "filterVcf",
    "FiveUTRVariants",
    "fixed",
    "fixed<-",
    "geno",
    "geno<-",
    "genome",
    "genotypeCodesToNucleotides",
    "genotypeToSnpMatrix",
    "getSeq",
    "getTranscriptSeqs",
    "GLtoGP",
    "hardFilters",
    "hardFilters<-",
    "header",
    "header<-",
    "idType",
    "idType<-",
    "import",
    "indexVcf",
    "info",
    "info<-",
    "intergenic",
    "intergenic<-",
    "IntergenicVariants",
    "IntronVariants",
    "isDeletion",
    "isDelins",
    "isIndel",
    "isInsertion",
    "isSNV",
    "isSubstitution",
    "isTransition",
    "keys",
    "keytypes",
    "locateVariants",
    "makeVRangesFromGRanges",
    "mcols<-",
    "meta",
    "meta<-",
    "PLtoGP",
    "post_Hs_region",
    "predictCoding",
    "probabilityToSnpMatrix",
    "promoter",
    "promoter<-",
    "PromoterVariants",
    "qual",
    "qual<-",
    "rbind",
    "readGeno",
    "readGT",
    "readInfo",
    "readVcf",
    "readVcfAsVRanges",
    "ref",
    "ref<-",
    "refDepth",
    "refDepth<-",
    "reference",
    "resetFilter",
    "sampleNames",
    "sampleNames<-",
    "samples",
    "scanVcf",
    "scanVcfHeader",
    "ScanVcfParam",
    "select",
    "seqinfo",
    "seqlevels",
    "snpSummary",
    "softFilter",
    "softFilterMatrix",
    "softFilterMatrix<-",
    "SpliceSiteVariants",
    "stackSamples",
    "strand",
    "strand<-",
    "subset",
    "summarizeVariants",
    "tabulate",
    "ThreeUTRVariants",
    "totalDepth",
    "totalDepth<-",
    "updateObject",
    "upstream",
    "upstream<-",
    "VCF",
    "vcfFields",
    "VcfFile",
    "VcfFileList",
    "vcfFixed",
    "vcfFixed<-",
    "vcfGeno",
    "vcfGeno<-",
    "VCFHeader",
    "vcfInfo",
    "vcfInfo<-",
    "vcfSamples",
    "vcfSamples<-",
    "vcfTrimEmpty",
    "vcfTrimEmpty<-",
    "vcfWhich",
    "vcfWhich<-",
    "vep_by_region",
    "VRanges",
    "VRangesList",
    "VRangesScanVcfParam",
    "writeVcf"
  ],
  "_help": [
    {
      "page": "filterVcf-methods",
      "title": "Filter VCF files",
      "topics": [
        "filterVcf",
        "filterVcf,character-method",
        "filterVcf,TabixFile-method"
      ]
    },
    {
      "page": "genotypeToSnpMatrix-methods",
      "title": "Convert genotype calls from a VCF file to a SnpMatrix object",
      "topics": [
        "genotypeToSnpMatrix",
        "genotypeToSnpMatrix,array-method",
        "genotypeToSnpMatrix,CollapsedVCF-method"
      ]
    },
    {
      "page": "getTranscriptSeqs-methods",
      "title": "Get transcript sequences",
      "topics": [
        "getTranscriptSeqs",
        "getTranscriptSeqs,GRanges,FaFile-method",
        "getTranscriptSeqs,GRangesList,ANY-method",
        "getTranscriptSeqs,GRangesList,BSgenome-method",
        "getTranscriptSeqs,GRangesList,FaFile-method"
      ]
    },
    {
      "page": "GLtoGP",
      "title": "Convert genotype likelihoods to genotype probabilities",
      "topics": [
        "GLtoGP",
        "PLtoGP"
      ]
    },
    {
      "page": "indexVcf-method",
      "title": "Create index files for VCF files",
      "topics": [
        "indexVcf",
        "indexVcf,character-method",
        "indexVcf,VcfFile-method",
        "indexVcf,VcfFileList-method"
      ]
    },
    {
      "page": "isSNV-methods",
      "title": "Identification of genomic variant types.",
      "topics": [
        "isDeletion",
        "isDeletion,CollapsedVCF-method",
        "isDeletion,ExpandedVCF-method",
        "isDeletion,VRanges-method",
        "isDelins",
        "isDelins,CollapsedVCF-method",
        "isDelins,ExpandedVCF-method",
        "isDelins,VRanges-method",
        "isIndel",
        "isIndel,CollapsedVCF-method",
        "isIndel,ExpandedVCF-method",
        "isIndel,VRanges-method",
        "isInsertion",
        "isInsertion,CollapsedVCF-method",
        "isInsertion,ExpandedVCF-method",
        "isInsertion,VRanges-method",
        "isSNV",
        "isSNV,CollapsedVCF-method",
        "isSNV,ExpandedVCF-method",
        "isSNV,VRanges-method",
        "isSubstitution",
        "isSubstitution,CollapsedVCF-method",
        "isSubstitution,ExpandedVCF-method",
        "isSubstitution,VRanges-method",
        "isTransition",
        "isTransition,CollapsedVCF-method",
        "isTransition,ExpandedVCF-method",
        "isTransition,VRanges-method"
      ]
    },
    {
      "page": "locateVariants-methods",
      "title": "Locate variants",
      "topics": [
        "locateVariants",
        "locateVariants,GRanges,GRangesList,AllVariants-method",
        "locateVariants,GRanges,GRangesList,CodingVariants-method",
        "locateVariants,GRanges,GRangesList,FiveUTRVariants-method",
        "locateVariants,GRanges,GRangesList,IntergenicVariants-method",
        "locateVariants,GRanges,GRangesList,IntronVariants-method",
        "locateVariants,GRanges,GRangesList,PromoterVariants-method",
        "locateVariants,GRanges,GRangesList,SpliceSiteVariants-method",
        "locateVariants,GRanges,GRangesList,ThreeUTRVariants-method",
        "locateVariants,GRanges,GRangesList,VariantType-method",
        "locateVariants,GRanges,TxDb,AllVariants-method",
        "locateVariants,GRanges,TxDb,CodingVariants-method",
        "locateVariants,GRanges,TxDb,FiveUTRVariants-method",
        "locateVariants,GRanges,TxDb,IntergenicVariants-method",
        "locateVariants,GRanges,TxDb,IntronVariants-method",
        "locateVariants,GRanges,TxDb,PromoterVariants-method",
        "locateVariants,GRanges,TxDb,SpliceSiteVariants-method",
        "locateVariants,GRanges,TxDb,ThreeUTRVariants-method",
        "locateVariants,GRanges,TxDb,VariantType-method",
        "locateVariants,IntegerRanges,GRangesList,VariantType-method",
        "locateVariants,IntegerRanges,TxDb,VariantType-method",
        "locateVariants,VCF,GRangesList,VariantType-method",
        "locateVariants,VCF,TxDb,VariantType-method"
      ]
    },
    {
      "page": "PolyPhenDb-class",
      "title": "PolyPhenDb objects",
      "topics": [
        "class:PolyPhenDb",
        "columns,PolyPhenDb-method",
        "duplicateRSID",
        "keys,PolyPhenDb-method",
        "metadata,PolyPhenDb-method",
        "PolyPhen",
        "PolyPhenDb",
        "PolyPhenDb-class",
        "select,PolyPhenDb-method"
      ]
    },
    {
      "page": "PolyPhenDbColumns",
      "title": "PolyPhenDb Columns",
      "topics": [
        "PolyPhenDbColumns"
      ]
    },
    {
      "page": "post_Hs_region",
      "title": "elementary vep/homo_sapiens/region call to ensembl VEP REST API",
      "topics": [
        "post_Hs_region"
      ]
    },
    {
      "page": "predictCoding-methods",
      "title": "Predict amino acid coding changes for variants",
      "topics": [
        "predictCoding",
        "predictCoding,CollapsedVCF,TxDb,ANY,missing-method",
        "predictCoding,ExpandedVCF,TxDb,ANY,missing-method",
        "predictCoding,GRanges,TxDb,ANY,DNAStringSet-method",
        "predictCoding,IntegerRanges,TxDb,ANY,DNAStringSet-method",
        "predictCoding,VRanges,TxDb,ANY,missing-method"
      ]
    },
    {
      "page": "probabilityToSnpMatrix",
      "title": "Convert posterior genotype probability to a SnpMatrix object",
      "topics": [
        "probabilityToSnpMatrix"
      ]
    },
    {
      "page": "PROVEANDb-class",
      "title": "PROVEANDb objects",
      "topics": [
        "class:PROVEANDb",
        "columns,PROVEANDb-method",
        "keys,PROVEANDb-method",
        "keytypes,PROVEANDb-method",
        "PROVEAN",
        "PROVEANDb",
        "PROVEANDb-class",
        "select,PROVEANDb-method"
      ]
    },
    {
      "page": "readVcf-methods",
      "title": "Read VCF files",
      "topics": [
        "import,VcfFile,ANY,ANY-method",
        "readGeno",
        "readGT",
        "readInfo",
        "readVcf",
        "readVcf,character,ANY-method",
        "readVcf,character,missing-method",
        "readVcf,TabixFile,GRanges-method",
        "readVcf,TabixFile,GRangesList-method",
        "readVcf,TabixFile,IntegerRangesList-method",
        "readVcf,TabixFile,missing-method",
        "readVcf,TabixFile,ScanVcfParam-method"
      ]
    },
    {
      "page": "scanVcf-methods",
      "title": "Import VCF files",
      "topics": [
        "scanVcf",
        "scanVcf,character,missing-method",
        "scanVcf,character,ScanVcfParam-method",
        "scanVcf,connection,missing-method",
        "scanVcf,TabixFile,GRanges-method",
        "scanVcf,TabixFile,IntegerRangesList-method",
        "scanVcf,TabixFile,missing-method",
        "scanVcf,TabixFile,ScanVcfParam-method",
        "scanVcfHeader",
        "scanVcfHeader,character-method",
        "scanVcfHeader,missing-method",
        "scanVcfHeader,TabixFile-method"
      ]
    },
    {
      "page": "ScanVcfParam-class",
      "title": "Parameters for scanning VCF files",
      "topics": [
        "ScanVcfParam",
        "ScanVcfParam,ANY-method",
        "ScanVcfParam,missing-method",
        "ScanVcfParam-class",
        "vcfFixed",
        "vcfFixed<-",
        "vcfGeno",
        "vcfGeno<-",
        "vcfInfo",
        "vcfInfo<-",
        "vcfSamples",
        "vcfSamples<-",
        "vcfTrimEmpty",
        "vcfTrimEmpty<-",
        "vcfWhich",
        "vcfWhich<-"
      ]
    },
    {
      "page": "seqinfo-method",
      "title": "Get seqinfo for VCF file",
      "topics": [
        "seqinfo",
        "seqinfo,VcfFile-method",
        "seqinfo,VcfFileList-method"
      ]
    },
    {
      "page": "SIFTDb-class",
      "title": "SIFTDb objects",
      "topics": [
        "class:SIFTDb",
        "columns,SIFTDb-method",
        "keys,SIFTDb-method",
        "metadata,SIFTDb-method",
        "select,SIFTDb-method",
        "SIFT",
        "SIFTDb",
        "SIFTDb-class"
      ]
    },
    {
      "page": "SIFTDbColumns",
      "title": "SIFTDb Columns",
      "topics": [
        "SIFTDbColumns"
      ]
    },
    {
      "page": "snpSummary",
      "title": "Counts and distribution statistics for SNPs in a VCF object",
      "topics": [
        "snpSummary",
        "snpSummary,CollapsedVCF-method"
      ]
    },
    {
      "page": "summarizeVariants-methods",
      "title": "Summarize variants by sample",
      "topics": [
        "summarizeVariants",
        "summarizeVariants,GRangesList,VCF,function-method",
        "summarizeVariants,GRangesList,VCF,VariantType-method",
        "summarizeVariants,TxDb,VCF,CodingVariants-method",
        "summarizeVariants,TxDb,VCF,FiveUTRVariants-method",
        "summarizeVariants,TxDb,VCF,IntronVariants-method",
        "summarizeVariants,TxDb,VCF,PromoterVariants-method",
        "summarizeVariants,TxDb,VCF,SpliceSiteVariants-method",
        "summarizeVariants,TxDb,VCF,ThreeUTRVariants-method"
      ]
    },
    {
      "page": "variant_body",
      "title": "helper function to construct inputs for VEP REST API",
      "topics": [
        "variant_body"
      ]
    },
    {
      "page": "defunct",
      "title": "Defunct Functions in Package 'VariantAnnotation'",
      "topics": [
        "dbSNPFilter",
        "MatrixToSnpMatrix",
        "readVcfLongForm",
        "readVcfLongForm,character,character,missing-method",
        "readVcfLongForm,character,character,ScanVcfParam-method",
        "readVcfLongForm,character,missing,missing-method",
        "readVcfLongForm,TabixFile,character,GRanges-method",
        "readVcfLongForm,TabixFile,character,IntegerRangesList-method",
        "readVcfLongForm,TabixFile,character,missing-method",
        "readVcfLongForm,TabixFile,character,ScanVcfParam-method",
        "refLocsToLocalLocs",
        "refLocsToLocalLocs,GRanges,missing,GRangesList-method",
        "refLocsToLocalLocs,GRanges,TxDb,missing-method",
        "regionFilter",
        "restrictToSNV",
        "VariantAnnotation-defunct",
        "VRangesScanVcfParam"
      ]
    },
    {
      "page": "VariantType-class",
      "title": "VariantType subclasses",
      "topics": [
        "AllVariants",
        "AllVariants-class",
        "CodingVariants",
        "CodingVariants-class",
        "downstream",
        "downstream,AllVariants-method",
        "downstream,IntergenicVariants-method",
        "downstream,PromoterVariants-method",
        "downstream<-",
        "downstream<-,AllVariants-method",
        "downstream<-,IntergenicVariants-method",
        "downstream<-,PromoterVariants-method",
        "FiveUTRVariants",
        "FiveUTRVariants-class",
        "idType",
        "idType,IntergenicVariants-method",
        "idType<-",
        "idType<-,IntergenicVariants-method",
        "intergenic",
        "intergenic,AllVariants-method",
        "intergenic<-",
        "intergenic<-,AllVariants-method",
        "IntergenicVariants",
        "IntergenicVariants-class",
        "IntronVariants",
        "IntronVariants-class",
        "promoter",
        "promoter,AllVariants-method",
        "promoter<-",
        "promoter<-,AllVariants-method",
        "PromoterVariants",
        "PromoterVariants-class",
        "show,AllVariants-method",
        "show,PromoterVariants-method",
        "show,VariantType-method",
        "SpliceSiteVariants",
        "SpliceSiteVariants-class",
        "ThreeUTRVariants",
        "ThreeUTRVariants-class",
        "upstream",
        "upstream,AllVariants-method",
        "upstream,IntergenicVariants-method",
        "upstream,PromoterVariants-method",
        "upstream<-",
        "upstream<-,AllVariants-method",
        "upstream<-,IntergenicVariants-method",
        "upstream<-,PromoterVariants-method",
        "VariantType-class"
      ]
    },
    {
      "page": "VCF-class",
      "title": "VCF class objects",
      "topics": [
        "alt",
        "alt,VCF-method",
        "alt<-",
        "alt<-,CollapsedVCF,CharacterList-method",
        "alt<-,CollapsedVCF,DNAStringSetList-method",
        "alt<-,ExpandedVCF,character-method",
        "alt<-,ExpandedVCF,DNAStringSet-method",
        "cbind,VCF-method",
        "class:CollapsedVCF",
        "class:ExpandedVCF",
        "class:VCF",
        "CollapsedVCF",
        "CollapsedVCF-class",
        "dimnames<-,VCF,list-method",
        "expand,CollapsedVCF-method",
        "expand,ExpandedVCF-method",
        "ExpandedVCF",
        "ExpandedVCF-class",
        "filt",
        "filt,VCF-method",
        "filt<-",
        "filt<-,VCF,character-method",
        "fixed",
        "fixed,VCF-method",
        "fixed<-",
        "fixed<-,VCF,DataFrame-method",
        "geno",
        "geno,VCF,ANY-method",
        "geno,VCF,character-method",
        "geno,VCF,numeric-method",
        "geno,VCF-method",
        "geno,VCFHeader,ANY-method",
        "geno<-",
        "geno<-,VCF,character,matrix-method",
        "geno<-,VCF,missing,matrix-method",
        "geno<-,VCF,missing,SimpleList-method",
        "geno<-,VCF,numeric,matrix-method",
        "genome,VCF-method",
        "genotypeCodesToNucleotides",
        "header,VCF-method",
        "header<-",
        "header<-,VCF,VCFHeader-method",
        "info",
        "info,VCF-method",
        "info<-",
        "info<-,VCF,DataFrame-method",
        "mcols<-,VCF,ANY-method",
        "mcols<-,VCF-method",
        "qual",
        "qual,VCF-method",
        "qual<-",
        "qual<-,VCF,numeric-method",
        "rbind,VCF-method",
        "ref",
        "ref,VCF-method",
        "ref<-",
        "ref<-,VCF,DNAStringSet-method",
        "rowRanges,VCF-method",
        "rowRanges<-,VCF,GRanges-method",
        "seqlevels,VCF-method",
        "show,CollapsedVCF-method",
        "show,ExpandedVCF-method",
        "show,VCF-method",
        "SnpMatrixToVCF",
        "strand,VCF-method",
        "strand<-,VCF,ANY-method",
        "subset,VCF-method",
        "updateObject,VCF-method",
        "VCF",
        "VCF-class",
        "vcfFields,VCF-method",
        "[,VCF,ANY,ANY,ANY-method",
        "[,VCF,ANY,ANY-method",
        "[,VCF-method",
        "[<-,VCF,ANY,ANY,VCF-method"
      ]
    },
    {
      "page": "VcfFile-class",
      "title": "Manipulate Variant Call Format (Vcf) files.",
      "topics": [
        "vcfFields,character-method",
        "vcfFields,missing-method",
        "vcfFields,VcfFile-method",
        "vcfFields,VcfFileList-method",
        "VcfFile",
        "VcfFile-class",
        "VcfFileList",
        "VcfFileList-class"
      ]
    },
    {
      "page": "VCFHeader-class",
      "title": "VCFHeader instances",
      "topics": [
        "contig",
        "contig,VCFHeader-method",
        "fixed,VCFHeader-method",
        "fixed<-,VCFHeader,DataFrameList-method",
        "geno,VCFHeader-method",
        "geno<-,VCFHeader,missing,DataFrame-method",
        "header",
        "header,VCFHeader-method",
        "info,VCFHeader-method",
        "info<-,VCFHeader,DataFrame-method",
        "meta",
        "meta,VCFHeader-method",
        "meta<-",
        "meta<-,VCFHeader,DataFrame-method",
        "meta<-,VCFHeader,DataFrameList-method",
        "reference",
        "reference,VCFHeader-method",
        "samples",
        "samples,VCFHeader-method",
        "seqinfo,VCFHeader-method",
        "show,VCFHeader-method",
        "vcfFields",
        "vcfFields,VCFHeader-method",
        "VCFHeader",
        "VCFHeader-class"
      ]
    },
    {
      "page": "vep_by_region",
      "title": "Use the VEP region API on variant information in a VCF object as defined in VariantAnnotation.",
      "topics": [
        "vep_by_region"
      ]
    },
    {
      "page": "VRanges-class",
      "title": "VRanges objects",
      "topics": [
        "alt,VRanges-method",
        "alt<-,VRanges,ANY-method",
        "altDepth",
        "altDepth,VRanges-method",
        "altDepth<-",
        "altDepth<-,VRanges-method",
        "altFraction",
        "altFraction,VRanges-method",
        "asVCF",
        "asVCF,VRanges-method",
        "called",
        "called,VRanges-method",
        "characterOrRle-class",
        "characterRle-class",
        "class:VRanges",
        "coerce,GRanges,VRanges-method",
        "coerce,VCF,VRanges-method",
        "coerce,VRanges,VCF-method",
        "complexRle-class",
        "factorOrRle-class",
        "factorRle-class",
        "hardFilters",
        "hardFilters,VRanges-method",
        "hardFilters<-",
        "hardFilters<-,VRanges-method",
        "integerOrRle-class",
        "integerRle-class",
        "logicalRle-class",
        "makeVRangesFromGRanges",
        "match,VRanges,VRanges-method",
        "numericRle-class",
        "rawRle-class",
        "readVcfAsVRanges",
        "ref,VRanges-method",
        "ref<-,VRanges,ANY-method",
        "refDepth",
        "refDepth,VRanges-method",
        "refDepth<-",
        "refDepth<-,VRanges-method",
        "resetFilter",
        "sampleNames,VRanges-method",
        "sampleNames<-,VRanges,ANY-method",
        "softFilter",
        "softFilterMatrix",
        "softFilterMatrix,VRanges-method",
        "softFilterMatrix<-",
        "softFilterMatrix<-,VRanges-method",
        "tabulate",
        "tabulate,VRanges-method",
        "totalDepth",
        "totalDepth,VRanges-method",
        "totalDepth<-",
        "totalDepth<-,VRanges-method",
        "VRanges",
        "VRanges-class",
        "writeVcf,VRanges,ANY-method"
      ]
    },
    {
      "page": "VRangesList-class",
      "title": "VRangesList objects",
      "topics": [
        "alt,VRangesList-method",
        "class:CompressedVRangesList",
        "class:SimpleVRangesList",
        "class:VRangesList",
        "CompressedVRangesList-class",
        "ref,VRangesList-method",
        "SimpleVRangesList-class",
        "stackSamples",
        "stackSamples,VRangesList-method",
        "VRangesList",
        "VRangesList-class"
      ]
    },
    {
      "page": "writeVcf-methods",
      "title": "Write VCF files",
      "topics": [
        "writeVcf",
        "writeVcf,VCF,character-method",
        "writeVcf,VCF,connection-method"
      ]
    }
  ],
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