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For example,\nthe user can input the most highly expressed genes from RNA-Seq\ndata, or gene co-expression modules to determine which\ntissue-specific genes are enriched in those datasets.\nTissue-specific genes were defined by processing RNA-Seq data\nfrom the Human Protein Atlas (HPA) (Uhlén et al. 2015), GTEx\n(Ardlie et al. 2015), and mouse ENCODE (Shen et al. 2012) using\nthe algorithm from the HPA (Uhlén et al. 2015).The\nhypergeometric test is being used to determine if the\ntissue-specific genes are enriched among the input genes. Along\nwith tissue-specific gene enrichment, the TissueEnrich package\ncan also be used to define tissue-specific genes from\nexpression datasets provided by the user, which can then be\nused to calculate tissue-specific gene enrichments.", "License": "MIT + file LICENSE", "VignetteBuilder": "knitr", "Encoding": "UTF-8", "RoxygenNote": "7.3.1", "biocViews": "GeneSetEnrichment, GeneExpression, Sequencing", "Config/pak/sysreqs": "libicu-dev libpng-dev libxml2-dev libssl-dev\nzlib1g-dev", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-04-28 12:47:36 UTC", "RemoteUrl": "https://github.com/bioc/TissueEnrich", "RemoteRef": "HEAD", "RemoteSha": "7a20771e07e76d27a76371c0dc802aa330d1a04c", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-30 09:41:43 UTC", "User": "root" }, "Author": "Ashish Jain [aut, cre],\nGeetu Tuteja [aut]", "Maintainer": "Ashish Jain ", "MD5sum": "b85fdb5c67d9df29562678f6cc4f9dba", "_user": "bioc", "_type": "src", "_file": 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