{
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  "Package": "SynMut",
  "Type": "Package",
  "Title": "SynMut: Designing Synonymously Mutated Sequences with Different\nGenomic Signatures",
  "Version": "1.29.0",
  "Authors@R": "c(person(\"Haogao\", \"Gu\", email = \"hggu@connect.hku.hk\", role = c(\"aut\", \"cre\")),\nperson(\"Leo L.M.\", \"Poon\", email = \"llmpoon@hku.hk\", role = \"led\"))",
  "Description": "There are increasing demands on designing virus mutants\nwith specific dinucleotide or codon composition. This tool can\ntake both dinucleotide preference and/or codon usage bias into\naccount while designing mutants. It is a powerful tool for in\nsilico designs of DNA sequence mutants.",
  "License": "GPL-2",
  "Encoding": "UTF-8",
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  "biocViews": "SequenceMatching, ExperimentalDesign, Preprocessing",
  "BugReports": "https://github.com/Koohoko/SynMut/issues",
  "URL": "https://github.com/Koohoko/SynMut",
  "Config/pak/sysreqs": "libicu-dev zlib1g-dev",
  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 12:50:09 UTC",
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    "Date": "2026-05-30 09:44:06 UTC",
    "User": "root"
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  "Author": "Haogao Gu [aut, cre],\nLeo L.M. Poon [led]",
  "Maintainer": "Haogao Gu <hggu@connect.hku.hk>",
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    "twitter": "@GuHaogao",
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  "_selfowned": true,
  "_usedby": 0,
  "_updates": [
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      "n": 2
    },
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    "type": "organization",
    "name": "Bioconductor",
    "description": "Software for the analysis and comprehension of high-throughput genomic data"
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    "count": 348,
    "source": "https://www.bioconductor.org/packages/stats/bioc/SynMut"
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  "_assets": [
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    "extra/citation.html",
    "extra/citation.json",
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    "manual.pdf"
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  "_homeurl": "https://github.com/koohoko/synmut",
  "_realowner": "bioc",
  "_cranurl": false,
  "_exports": [
    "codon_dist",
    "codon_mimic",
    "codon_random",
    "codon_to",
    "dinu_dist",
    "dinu_to",
    "get_cu",
    "get_dna",
    "get_du",
    "get_freq",
    "get_nu",
    "get_region",
    "get_rscu",
    "input_seq",
    "seq_random"
  ],
  "_help": [
    {
      "page": "codon_dist-methods",
      "title": "Calculating the codon usage difference between sequences",
      "topics": [
        "codon_dist",
        "codon_dist,ANY-method"
      ]
    },
    {
      "page": "codon_mimic-methods",
      "title": "Mimic a target codon usage bias",
      "topics": [
        "codon_mimic",
        "codon_mimic,DNAStringSet,DNAStringSet-method",
        "codon_mimic,regioned_dna,DNAStringSet-method",
        "codon_mimic,regioned_dna,vector-method"
      ]
    },
    {
      "page": "codon_random-methods",
      "title": "Generate random synonymous mutations",
      "topics": [
        "codon_random",
        "codon_random,DNAStringSet-method",
        "codon_random,regioned_dna-method"
      ]
    },
    {
      "page": "codon_to-methods",
      "title": "Maximize or minimize the usage of certain codon.",
      "topics": [
        "codon_to",
        "codon_to,regioned_dna-method"
      ]
    },
    {
      "page": "dinu_dist-methods",
      "title": "Calculating the dinucleotide usage difference between sequences",
      "topics": [
        "dinu_dist",
        "dinu_dist,ANY-method"
      ]
    },
    {
      "page": "dinu_to-methods",
      "title": "Maximize or minimize the usage of certain dinucleotide.",
      "topics": [
        "dinu_to",
        "dinu_to,regioned_dna-method"
      ]
    },
    {
      "page": "get_cu-methods",
      "title": "Get codon usage matrix",
      "topics": [
        "get_cu",
        "get_cu,DNAStringSet-method",
        "get_cu,regioned_dna-method"
      ]
    },
    {
      "page": "get_dna-methods",
      "title": "Get the DNAStringSet data",
      "topics": [
        "get_dna",
        "get_dna,regioned_dna-method"
      ]
    },
    {
      "page": "get_du-methods",
      "title": "Get dinucleotide usage matrix",
      "topics": [
        "get_du",
        "get_du,DNAStringSet-method",
        "get_du,regioned_dna-method"
      ]
    },
    {
      "page": "get_freq-methods",
      "title": "Get codon usage frequency of synonymous codons",
      "topics": [
        "get_freq",
        "get_freq,DNAStringSet-method",
        "get_freq,matrix-method",
        "get_freq,regioned_dna-method",
        "get_freq,vector-method"
      ]
    },
    {
      "page": "get_nu-methods",
      "title": "Get nucleotide usage matrix",
      "topics": [
        "get_nu",
        "get_nu,DNAStringSet-method",
        "get_nu,regioned_dna-method"
      ]
    },
    {
      "page": "get_region-methods",
      "title": "Get the variable region",
      "topics": [
        "get_region",
        "get_region,regioned_dna-method"
      ]
    },
    {
      "page": "get_rscu-methods",
      "title": "Get Relative Synonymous Codon Usage (rscu) of synonymous codons",
      "topics": [
        "get_rscu",
        "get_rscu,DNAStringSet-method",
        "get_rscu,regioned_dna-method"
      ]
    },
    {
      "page": "input_seq-methods",
      "title": "Import region / constructing regioned_dna object",
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        "input_seq",
        "input_seq,character-method",
        "input_seq,DNAString-method",
        "input_seq,DNAStringSet-method"
      ]
    },
    {
      "page": "regioned_dna-class",
      "title": "An S4 class to record DNA sequences and variable regions for mutations",
      "topics": [
        "regioned_dna-class"
      ]
    },
    {
      "page": "seq_random-methods",
      "title": "Generate 'n' random DNA sequnces of length 'm'",
      "topics": [
        "seq_random",
        "seq_random,numeric,numeric-method"
      ]
    }
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      "filename": "SynMut.html",
      "title": "SynMut: Tools for Designing Synonymously Mutated Sequences",
      "author": "Haogao Gu, Leo L.M. Poon, School of Public Health, The University of Hong Kong",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "Getting started",
        "Installation",
        "Input data",
        "Access the data",
        "Generating mutations",
        "Random synonymous mutants",
        "Synonymous mutants with maximal/minimal usage of specific codon",
        "Synonymous mutants with maximal/minimal usage of specific dinucleotide",
        "Synonymous mutants mimicking a specific codon usage pattern",
        "Output the results",
        "Session information"
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      "created": "2019-04-23 08:43:34",
      "modified": "2019-04-29 07:33:48",
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