{
  "_id": "6a1afe8d1d7bb097a09fe796",
  "Package": "SpliceImpactR",
  "Type": "Package",
  "Title": "An R package to identify functional impacts due to alternative\nRNA processing events",
  "Version": "1.1.0",
  "Authors@R": "c(person(given=\"Zachary\", family=\"Wakefield\",\nemail = \"zachpw@bu.edu\",\nrole = c(\"cre\", \"aut\"),\ncomment = c(ORCID = \"0000-0002-9104-0934\")),\nperson(given=\"Ana\", family=\"Fiszbein\",\nemail = \"anafisz@bu.edu\",\nrole = c(\"aut\")))",
  "Description": "Works by taking in processed data from the HIT Index\nand/or rMATS and identifying how differentially used\nalternative RNA processing events lead to changes in protein\nfunction through various means. Primarily this is done through\nprotein similarity, functional protein domain analysis, and\ndomain-domain interaction changes. Notably, we both identify\nalterantive RNA processing event 'swaps' across condition and\nare able to perform holistic analyses regarding the impact of\ndifferent RNA processing events.",
  "License": "GPL-3",
  "Encoding": "UTF-8",
  "RoxygenNote": "7.3.3",
  "biocViews": "AlternativeSplicing, DifferentialSplicing,\nStatisticalMethod, Alignment",
  "VignetteBuilder": "knitr",
  "Config/testthat/edition": "3",
  "BugReports": "https://github.com/fiszbein-lab/SpliceImpactR/issues",
  "Config/pak/sysreqs": "cmake make libbz2-dev libicu-dev liblzma-dev\nlibpng-dev libxml2-dev libssl-dev xz-utils zlib1g-dev",
  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 13:06:51 UTC",
  "RemoteUrl": "https://github.com/bioc/SpliceImpactR",
  "RemoteRef": "HEAD",
  "RemoteSha": "64b59abd29e1fab8340fd18f9bd4a9090606507f",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-05-30 09:52:45 UTC",
    "User": "root"
  },
  "Author": "Zachary Wakefield [cre, aut] (ORCID:\n<https://orcid.org/0000-0002-9104-0934>),\nAna Fiszbein [aut]",
  "Maintainer": "Zachary Wakefield <zachpw@bu.edu>",
  "MD5sum": "468b2adc9496005a51b7af45659d03bc",
  "_user": "bioc",
  "_type": "src",
  "_file": "SpliceImpactR_1.1.0.tar.gz",
  "_fileid": "1ef8721989818e5bfdbb79403fba3851e122ba17419b0abde69198381379fc30",
  "_filesize": 6376572,
  "_sha256": "1ef8721989818e5bfdbb79403fba3851e122ba17419b0abde69198381379fc30",
  "_created": "2026-05-30T09:52:45.000Z",
  "_published": "2026-05-30T15:13:17.481Z",
  "_jobs": [
    {
      "job": 78640930416,
      "time": 325,
      "config": "bioc-checks",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7307584569"
    },
    {
      "job": 78640930421,
      "time": 601,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "7307612170"
    },
    {
      "job": 78640930426,
      "time": 645,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7307616510"
    },
    {
      "job": 78640930429,
      "time": 323,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "7309151725"
    },
    {
      "job": 78640930435,
      "time": 297,
      "config": "macos-release-arm64",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7309149603"
    },
    {
      "job": 78639958947,
      "time": 495,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7307326535"
    },
    {
      "job": 78640930425,
      "time": 255,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7307577319"
    },
    {
      "job": 78640930484,
      "time": 529,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "ERROR",
      "artifact": "7307605875"
    },
    {
      "job": 78640930459,
      "time": 426,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "ERROR",
      "artifact": "7307596107"
    },
    {
      "job": 78640930465,
      "time": 422,
      "config": "windows-release",
      "r": "4.6.0",
      "check": "ERROR",
      "artifact": "7307596203"
    }
  ],
  "_bioccheck": {
    "error": 0,
    "warning": 0,
    "note": 12
  },
  "_buildurl": "https://github.com/r-universe/bioc/actions/runs/26676931306",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/bioc/SpliceImpactR",
  "_commit": {
    "id": "64b59abd29e1fab8340fd18f9bd4a9090606507f",
    "author": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "committer": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "message": "bump x.y.z version to odd y following creation of RELEASE_3_23 branch\n",
    "time": 1777381611
  },
  "_maintainer": {
    "name": "Zachary Wakefield",
    "email": "zachpw@bu.edu",
    "login": "zachpwakefield",
    "description": "",
    "uuid": 59847937,
    "orcid": "0000-0002-9104-0934"
  },
  "_distro": "noble",
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 3.5.0",
      "role": "Depends"
    },
    {
      "package": "data.table",
      "role": "Imports"
    },
    {
      "package": "BiocFileCache",
      "role": "Imports"
    },
    {
      "package": "BiocParallel",
      "role": "Imports"
    },
    {
      "package": "Biostrings",
      "role": "Imports"
    },
    {
      "package": "GenomicRanges",
      "role": "Imports"
    },
    {
      "package": "SummarizedExperiment",
      "role": "Imports"
    },
    {
      "package": "biomaRt",
      "role": "Imports"
    },
    {
      "package": "IRanges",
      "role": "Imports"
    },
    {
      "package": "PFAM.db",
      "role": "Imports"
    },
    {
      "package": "dplyr",
      "role": "Imports"
    },
    {
      "package": "ggplot2",
      "role": "Imports"
    },
    {
      "package": "ggpubr",
      "role": "Imports"
    },
    {
      "package": "patchwork",
      "role": "Imports"
    },
    {
      "package": "pwalign",
      "role": "Imports"
    },
    {
      "package": "rtracklayer",
      "role": "Imports"
    },
    {
      "package": "scales",
      "role": "Imports"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "tidyr",
      "role": "Imports"
    },
    {
      "package": "tools",
      "role": "Imports"
    },
    {
      "package": "utils",
      "role": "Imports"
    },
    {
      "package": "magrittr",
      "role": "Imports"
    },
    {
      "package": "methods",
      "role": "Imports"
    },
    {
      "package": "S4Vectors",
      "role": "Imports"
    },
    {
      "package": "devtools",
      "role": "Suggests"
    },
    {
      "package": "testthat",
      "version": ">= 3.0.0",
      "role": "Suggests"
    },
    {
      "package": "knitr",
      "role": "Suggests"
    },
    {
      "package": "rmarkdown",
      "role": "Suggests"
    },
    {
      "package": "cowplot",
      "role": "Suggests"
    },
    {
      "package": "stringr",
      "role": "Suggests"
    },
    {
      "package": "readr",
      "role": "Suggests"
    },
    {
      "package": "tibble",
      "role": "Suggests"
    },
    {
      "package": "BiocStyle",
      "role": "Suggests"
    },
    {
      "package": "clusterProfiler",
      "role": "Suggests"
    },
    {
      "package": "AnnotationDbi",
      "role": "Suggests"
    },
    {
      "package": "msigdbr",
      "role": "Suggests"
    },
    {
      "package": "org.Hs.eg.db",
      "role": "Suggests"
    },
    {
      "package": "org.Mm.eg.db",
      "role": "Suggests"
    }
  ],
  "_owner": "bioc",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [
    {
      "week": "2025-46",
      "n": 5
    },
    {
      "week": "2026-13",
      "n": 2
    },
    {
      "week": "2026-18",
      "n": 2
    }
  ],
  "_tags": [],
  "_bioc": [
    {
      "branch": "devel",
      "version": "1.1.0",
      "bioc": "3.24"
    },
    {
      "branch": "release",
      "version": "1.0.0",
      "bioc": "3.23"
    }
  ],
  "_topics": [
    "alternativesplicing",
    "differentialsplicing",
    "statisticalmethod",
    "alignment"
  ],
  "_stars": 2,
  "_contributors": [
    {
      "user": "zachpwakefield",
      "count": 34,
      "uuid": 59847937
    }
  ],
  "_userbio": {
    "uuid": 2286807,
    "type": "organization",
    "name": "Bioconductor",
    "description": "Software for the analysis and comprehension of high-throughput genomic data"
  },
  "_downloads": {
    "count": 235,
    "source": "https://www.bioconductor.org/packages/stats/bioc/SpliceImpactR"
  },
  "_devurl": "https://github.com/fiszbein-lab/spliceimpactr",
  "_searchresults": 3,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md",
    "extra/SpliceImpactR.html",
    "manual.pdf"
  ],
  "_homeurl": "https://github.com/fiszbein-lab/spliceimpactr",
  "_realowner": "bioc",
  "_cranurl": false,
  "_exports": [
    "add_splice_part",
    "as_dt_from_s4",
    "as_splice_impact_result",
    "attach_sequences",
    "compare_hit_index",
    "compare_sequence_frame",
    "compare_sequences_alignment",
    "compare_transcript_pairs",
    "enrich_by_db",
    "enrich_by_event",
    "enrich_domains_hypergeo",
    "filter_spliceimpact_hits",
    "get_annotation",
    "get_background",
    "get_comprehensive_annotations",
    "get_di_gene_enrichment",
    "get_differential_inclusion",
    "get_domain_gene_for_enrichment",
    "get_domains",
    "get_enrichment",
    "get_exon_features",
    "get_gene_enrichment",
    "get_hitindex",
    "get_hits_core",
    "get_hits_domain",
    "get_hits_final_view",
    "get_hits_ppi",
    "get_hits_sequence",
    "get_manual_features",
    "get_matched_events_chunked",
    "get_pairs",
    "get_ppi_gene_enrichment",
    "get_ppi_interactions",
    "get_ppi_switches",
    "get_protein_features",
    "get_proximal_shift_from_hits",
    "get_rmats",
    "get_rmats_hit",
    "get_rmats_post_di",
    "get_splicing_impact",
    "get_user_data",
    "get_user_data_post_di",
    "import_di_table",
    "integrated_event_summary",
    "keep_sig_pairs",
    "load_example_data",
    "load_rmats",
    "overview_spicing_comparison",
    "plot_alignment_summary",
    "plot_di_volcano_dt",
    "plot_enriched_domains_counts",
    "plot_length_comparison",
    "plot_ppi_summary",
    "plot_two_transcripts_with_domains_unified",
    "probe_individual_event",
    "spliceimpact_s4_guide",
    "spliceimpact_s4_schema"
  ],
  "_help": [
    {
      "page": "add_splice_part",
      "title": "Add one part to an existing SpliceImpactResult",
      "topics": [
        "add_splice_part"
      ]
    },
    {
      "page": "as_dt_from_s4",
      "title": "Convert S4 slots back to data.table",
      "topics": [
        "as_dt_from_s4"
      ]
    },
    {
      "page": "as_splice_impact_result",
      "title": "Build S4 SpliceImpact container",
      "topics": [
        "as_splice_impact_result"
      ]
    },
    {
      "page": "attach_sequences",
      "title": "Attach transcript and protein sequences to an event or annotation table",
      "topics": [
        "attach_sequences"
      ]
    },
    {
      "page": "compare_hit_index",
      "title": "Compare HIT index values between conditions",
      "topics": [
        "compare_hit_index"
      ]
    },
    {
      "page": "compare_sequence_frame",
      "title": "Compare frame states after sequence alignment",
      "topics": [
        "compare_sequence_frame"
      ]
    },
    {
      "page": "compare_sequences_alignment",
      "title": "Compare isoform nucleotide and protein sequences by pairwise alignment",
      "topics": [
        "compare_sequences_alignment"
      ]
    },
    {
      "page": "compare_transcript_pairs",
      "title": "Compare user-selected transcript pairs",
      "topics": [
        "compare_transcript_pairs"
      ]
    },
    {
      "page": "enrich_by_db",
      "title": "Run domain enrichment by database",
      "topics": [
        "enrich_by_db"
      ]
    },
    {
      "page": "enrich_by_event",
      "title": "Run domain enrichment by event type",
      "topics": [
        "enrich_by_event"
      ]
    },
    {
      "page": "enrich_domains_hypergeo",
      "title": "Domain-level enrichment via hypergeometric test",
      "topics": [
        "enrich_domains_hypergeo"
      ]
    },
    {
      "page": "filter_spliceimpact_hits",
      "title": "Filter a SpliceImpactResult by arbitrary paired-hit columns",
      "topics": [
        "filter_spliceimpact_hits"
      ]
    },
    {
      "page": "get_annotation",
      "title": "Load and cache GENCODE annotations, sequences, and hybrid exon annotations",
      "topics": [
        "get_annotation"
      ]
    },
    {
      "page": "get_background",
      "title": "Build a transcript-pair background with domain and length annotations",
      "topics": [
        "get_background"
      ]
    },
    {
      "page": "get_comprehensive_annotations",
      "title": "Combine multiple sources of protein feature annotations",
      "topics": [
        "get_comprehensive_annotations"
      ]
    },
    {
      "page": "get_di_gene_enrichment",
      "title": "Extract Differential-Inclusion Genes for Enrichment",
      "topics": [
        "get_di_gene_enrichment"
      ]
    },
    {
      "page": "get_differential_inclusion",
      "title": "Differential Inclusion Analysis from Hit Index Tables",
      "topics": [
        "get_differential_inclusion"
      ]
    },
    {
      "page": "get_domain_gene_for_enrichment",
      "title": "Extract Domain-Altering Genes for Enrichment",
      "topics": [
        "get_domain_gene_for_enrichment"
      ]
    },
    {
      "page": "get_domains",
      "title": "Add protein domain annotations to splicing events",
      "topics": [
        "get_domains"
      ]
    },
    {
      "page": "get_enrichment",
      "title": "Gene Set Enrichment for Splicing-Linked Gene Lists",
      "topics": [
        "get_enrichment"
      ]
    },
    {
      "page": "get_exon_features",
      "title": "Map protein features to coding exons",
      "topics": [
        "get_exon_features"
      ]
    },
    {
      "page": "get_gene_enrichment",
      "title": "Unified gene selector for enrichment foregrounds",
      "topics": [
        "get_gene_enrichment"
      ]
    },
    {
      "page": "get_hitindex",
      "title": "Load HIT index PSI files for one or more samples/conditions.",
      "topics": [
        "get_hitindex"
      ]
    },
    {
      "page": "get_hits_core",
      "title": "Convenience accessor for core paired-hit columns",
      "topics": [
        "get_hits_core"
      ]
    },
    {
      "page": "get_hits_domain",
      "title": "Convenience accessor for domain-focused paired-hit columns",
      "topics": [
        "get_hits_domain"
      ]
    },
    {
      "page": "get_hits_final_view",
      "title": "Access paired-hits as compact data.table subsets",
      "topics": [
        "get_hits_final_view"
      ]
    },
    {
      "page": "get_hits_ppi",
      "title": "Convenience accessor for PPI-focused paired-hit columns",
      "topics": [
        "get_hits_ppi"
      ]
    },
    {
      "page": "get_hits_sequence",
      "title": "Convenience accessor for sequence/frame-focused paired-hit columns",
      "topics": [
        "get_hits_sequence"
      ]
    },
    {
      "page": "get_manual_features",
      "title": "Incorporate user-supplied protein features",
      "topics": [
        "get_manual_features"
      ]
    },
    {
      "page": "get_matched_events_chunked",
      "title": "Match splicing events to transcript annotations in chunks",
      "topics": [
        "get_matched_events_chunked"
      ]
    },
    {
      "page": "get_pairs",
      "title": "Pair inclusion and exclusion forms of splicing events",
      "topics": [
        "get_pairs"
      ]
    },
    {
      "page": "get_ppi_gene_enrichment",
      "title": "Extract Protein-Interaction-Affected Genes for Enrichment",
      "topics": [
        "get_ppi_gene_enrichment"
      ]
    },
    {
      "page": "get_ppi_interactions",
      "title": "Pull PPI from SpliceImpactR's data",
      "topics": [
        "get_ppi_interactions"
      ]
    },
    {
      "page": "get_ppi_switches",
      "title": "Annotate hits_domain with PPI changes for inclusion vs exclusion forms",
      "topics": [
        "get_ppi_switches"
      ]
    },
    {
      "page": "get_protein_features",
      "title": "External function to fetch protein features from biomaRt",
      "topics": [
        "get_protein_features"
      ]
    },
    {
      "page": "get_proximal_shift_from_hits",
      "title": "Classify splicing events as proximal or distal",
      "topics": [
        "get_proximal_shift_from_hits"
      ]
    },
    {
      "page": "get_rmats",
      "title": "Expand rMATS event tables into scalar exon inclusion/exclusion coordinates.",
      "topics": [
        "get_rmats"
      ]
    },
    {
      "page": "get_rmats_hit",
      "title": "Wrapper function to get both rmats and hit index cleanly",
      "topics": [
        "get_rmats_hit"
      ]
    },
    {
      "page": "get_rmats_post_di",
      "title": "Import post-differential-inclusion rMATS results",
      "topics": [
        "get_rmats_post_di"
      ]
    },
    {
      "page": "get_splicing_impact",
      "title": "End-to-end SpliceImpactR wrapper with selectable output class",
      "topics": [
        "get_splicing_impact"
      ]
    },
    {
      "page": "get_user_data",
      "title": "Get User-Supplied Splicing Event Data",
      "topics": [
        "get_user_data"
      ]
    },
    {
      "page": "get_user_data_post_di",
      "title": "Format user-supplied post-DI (post-differential-inclusion) splicing results",
      "topics": [
        "get_user_data_post_di"
      ]
    },
    {
      "page": "import_di_table",
      "title": "Standardize a differential inclusion (DI) result table",
      "topics": [
        "import_di_table"
      ]
    },
    {
      "page": "integrated_event_summary",
      "title": "Integrated summary of event classification, alignment, and domain changes",
      "topics": [
        "integrated_event_summary"
      ]
    },
    {
      "page": "keep_sig_pairs",
      "title": "Filter event pairs by significance and deltaPSI thresholds",
      "topics": [
        "keep_sig_pairs"
      ]
    },
    {
      "page": "load_example_data",
      "title": "Load bundled example inputs for documentation",
      "topics": [
        "load_example_data"
      ]
    },
    {
      "page": "load_rmats",
      "title": "Load rMATS event files into standardized data.tables",
      "topics": [
        "load_rmats"
      ]
    },
    {
      "page": "overview_spicing_comparison",
      "title": "Overview of global splicing event distributions between conditions",
      "topics": [
        "overview_spicing_comparison"
      ]
    },
    {
      "page": "plot_alignment_summary",
      "title": "Plot alignment score distribution and coding summary",
      "topics": [
        "plot_alignment_summary"
      ]
    },
    {
      "page": "plot_di_volcano_dt",
      "title": "Volcano plot for differential inclusion results",
      "topics": [
        "plot_di_volcano_dt"
      ]
    },
    {
      "page": "plot_enriched_domains_counts",
      "title": "Plot enriched domains by associated event count",
      "topics": [
        "plot_enriched_domains_counts"
      ]
    },
    {
      "page": "plot_length_comparison",
      "title": "Compare inclusion vs. exclusion isoform lengths",
      "topics": [
        "plot_length_comparison"
      ]
    },
    {
      "page": "plot_ppi_summary",
      "title": "Plot summary of altered PPI interactions",
      "topics": [
        "plot_ppi_summary"
      ]
    },
    {
      "page": "plot_two_transcripts_with_domains_unified",
      "title": "Plot two transcripts with exon structure and protein feature tracks (unified view)",
      "topics": [
        "plot_two_transcripts_with_domains_unified"
      ]
    },
    {
      "page": "probe_individual_event",
      "title": "Visualize PSI values for a single splicing event",
      "topics": [
        "probe_individual_event"
      ]
    },
    {
      "page": "spliceimpact_s4_guide",
      "title": "Detailed guide for using SpliceImpactResult",
      "topics": [
        "spliceimpact_s4_guide"
      ]
    },
    {
      "page": "spliceimpact_s4_schema",
      "title": "S4 slot and key schema for SpliceImpactResult",
      "topics": [
        "spliceimpact_s4_schema"
      ]
    },
    {
      "page": "SpliceImpactResult-class",
      "title": "SpliceImpact result container (S4)",
      "topics": [
        "SpliceImpactResult-class"
      ]
    }
  ],
  "_readme": "https://github.com/bioc/SpliceImpactR/raw/HEAD/README.md",
  "_rundeps": [
    "abind",
    "AnnotationDbi",
    "askpass",
    "backports",
    "BH",
    "Biobase",
    "BiocBaseUtils",
    "BiocFileCache",
    "BiocGenerics",
    "BiocIO",
    "BiocParallel",
    "biomaRt",
    "Biostrings",
    "bit",
    "bit64",
    "bitops",
    "blob",
    "boot",
    "broom",
    "cachem",
    "car",
    "carData",
    "cigarillo",
    "cli",
    "codetools",
    "colorspace",
    "corrplot",
    "cowplot",
    "cpp11",
    "crayon",
    "curl",
    "data.table",
    "DBI",
    "dbplyr",
    "DelayedArray",
    "Deriv",
    "doBy",
    "dplyr",
    "farver",
    "fastmap",
    "filelock",
    "forecast",
    "formatR",
    "Formula",
    "fracdiff",
    "futile.logger",
    "futile.options",
    "generics",
    "GenomicAlignments",
    "GenomicRanges",
    "ggplot2",
    "ggpubr",
    "ggrepel",
    "ggsci",
    "ggsignif",
    "glue",
    "gridExtra",
    "gtable",
    "hms",
    "httr",
    "httr2",
    "IRanges",
    "isoband",
    "jsonlite",
    "KEGGREST",
    "labeling",
    "lambda.r",
    "lattice",
    "lifecycle",
    "lme4",
    "lmtest",
    "magrittr",
    "MASS",
    "Matrix",
    "MatrixGenerics",
    "MatrixModels",
    "matrixStats",
    "memoise",
    "mgcv",
    "microbenchmark",
    "mime",
    "minqa",
    "modelr",
    "nlme",
    "nloptr",
    "nnet",
    "numDeriv",
    "openssl",
    "patchwork",
    "pbkrtest",
    "PFAM.db",
    "pillar",
    "pkgconfig",
    "png",
    "polynom",
    "prettyunits",
    "progress",
    "purrr",
    "pwalign",
    "quantreg",
    "R6",
    "rappdirs",
    "rbibutils",
    "RColorBrewer",
    "Rcpp",
    "RcppArmadillo",
    "RcppEigen",
    "RCurl",
    "Rdpack",
    "reformulas",
    "restfulr",
    "Rhtslib",
    "rjson",
    "rlang",
    "Rsamtools",
    "RSQLite",
    "rstatix",
    "rtracklayer",
    "S4Arrays",
    "S4Vectors",
    "S7",
    "scales",
    "Seqinfo",
    "snow",
    "SparseArray",
    "SparseM",
    "stringi",
    "stringr",
    "SummarizedExperiment",
    "survival",
    "sys",
    "tibble",
    "tidyr",
    "tidyselect",
    "timeDate",
    "urca",
    "utf8",
    "vctrs",
    "viridisLite",
    "withr",
    "XML",
    "xml2",
    "XVector",
    "yaml",
    "zoo"
  ],
  "_vignettes": [
    {
      "source": "SpliceImpactR.Rmd",
      "filename": "SpliceImpactR.html",
      "title": "SpliceImpactR",
      "author": "Zachary Wakefield, Ana Fiszbein",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Overview",
        "Installation",
        "Option 1: BiocManager",
        "Option 2: devtools (GitHub)",
        "External tools and acronyms",
        "Workflow map",
        "Load Reference Resources",
        "Build Sample Manifest",
        "Quick start wrapper (get_splicing_impact)",
        "Read Splicing Events",
        "Sample-Level QC and Exploration",
        "Compare HITindex Between Conditions",
        "PSI Distribution Overview",
        "Differential Inclusion (DI)",
        "Match Events to Sequences and Build Transcript Pairs",
        "Sequence-Level Consequences",
        "Domain-Level Changes and Domain Enrichment",
        "PPI Rewiring",
        "Gene Enrichment Foreground Probes",
        "Visualize Transcript and Protein Consequences",
        "Inspect a Single Event",
        "Integrative Visualization",
        "Output Description (hits_final, data, res)",
        "hits_final (integrated event-level output)",
        "data (raw sample-level input table)",
        "res (differential inclusion output)",
        "S4 Applications and Accessors",
        "S4-first Main Workflow (Code Only)",
        "Custom Input Entry Points",
        "Add Manual Protein Features",
        "Pre-DI Custom Table",
        "Post-DI Custom Table",
        "Post-DI rMATS Import",
        "Transcript-Pair Entry Point",
        "Session Info"
      ],
      "created": "2025-11-11 18:26:47",
      "modified": "2026-03-23 17:18:10",
      "commits": 2
    }
  ],
  "_score": 4.477121254719663,
  "_indexed": true,
  "_nocasepkg": "spliceimpactr",
  "_universes": [
    "bioc",
    "zachpwakefield",
    "fiszbein-lab"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.1.0",
      "date": "2026-05-30T10:40:20.000Z",
      "distro": "noble",
      "commit": "64b59abd29e1fab8340fd18f9bd4a9090606507f",
      "fileid": "8e25914645bbde00390d194f3cc34195bff99d39c6eadb67216202752d130e7e",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26676931306"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "1.1.0",
      "date": "2026-05-30T10:40:24.000Z",
      "distro": "noble",
      "commit": "64b59abd29e1fab8340fd18f9bd4a9090606507f",
      "fileid": "4f4086eea59dc62c9d24a3d3f8de6704d32c1f12c7af4b8f5e0e971ef00d1b08",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26676931306"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.1.0",
      "date": "2026-05-30T15:09:37.000Z",
      "commit": "64b59abd29e1fab8340fd18f9bd4a9090606507f",
      "fileid": "e72c3dd2fe01706a6b11acbaaa1b65a7eea56270cfb5850edbb788e4f555c76c",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26676931306"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "1.1.0",
      "date": "2026-05-30T15:09:23.000Z",
      "commit": "64b59abd29e1fab8340fd18f9bd4a9090606507f",
      "fileid": "604cd24ba9420ad84d2396868df45e3181c56b1f9769b0efc679b0fd6f1de689",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26676931306"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "1.1.0",
      "date": "2026-05-30T10:39:44.000Z",
      "commit": "64b59abd29e1fab8340fd18f9bd4a9090606507f",
      "fileid": "9b0a8ec0a0e1e79353fbb520e9e3f85160d1872f766f7649bba7f4629656bc8c",
      "status": "success",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26676931306"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "1.1.0",
      "date": "2026-05-30T10:38:31.000Z",
      "commit": "64b59abd29e1fab8340fd18f9bd4a9090606507f",
      "fileid": "6cbea8aaf46515db0fc396ee80861e596118c6639d552e86910739ca2d6bd1ff",
      "status": "failure",
      "check": "ERROR",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26676931306"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "1.1.0",
      "date": "2026-05-30T10:38:20.000Z",
      "commit": "64b59abd29e1fab8340fd18f9bd4a9090606507f",
      "fileid": "360036d4a54aaa856ad54629bb0bbc0d9c408402875c785746c10e35d8694f7d",
      "status": "failure",
      "check": "ERROR",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26676931306"
    },
    {
      "r": "4.6.0",
      "os": "win",
      "version": "1.1.0",
      "date": "2026-05-30T10:38:18.000Z",
      "commit": "64b59abd29e1fab8340fd18f9bd4a9090606507f",
      "fileid": "7c000cb665bba1ef9505ff884306dae638d8dec7fcd20d7890ef2bfcb66846ce",
      "status": "failure",
      "check": "ERROR",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/26676931306"
    }
  ]
}