{ "_id": "6a1ae7dc1d7bb097a09f16e0", "Package": "SparseSignatures", "Version": "2.23.0", "Date": "2026-03-09", "Title": "SparseSignatures", "Authors@R": "c(\nperson(\"Daniele\", \"Ramazzotti\", role=c(\"aut\"),email=\"daniele.ramazzotti@unimib.it\",\ncomment = c(ORCID = \"0000-0002-6087-2666\")),\nperson(\"Avantika\", \"Lal\", role=c(\"aut\")),\nperson(\"Keli\", \"Liu\", role=c(\"ctb\")),\nperson(\"Luca\", \"De Sano\", role=c(\"cre\",\"aut\"), email=\"luca.desano@gmail.com\",\ncomment = c(ORCID = \"0000-0002-9618-3774\")),\nperson(\"Robert\", \"Tibshirani\", role=c(\"ctb\")),\nperson(\"Arend\", \"Sidow\", role=c(\"aut\")))", "Name": "An R package for the extraction of sparse mutational signatures\nfrom whole genome sequencing data", "Description": "Point mutations occurring in a genome can be divided into\n96 categories based on the base being mutated, the base it is\nmutated into and its two flanking bases. Therefore, for any\npatient, it is possible to represent all the point mutations\noccurring in that patient's tumor as a vector of length 96,\nwhere each element represents the count of mutations for a\ngiven category in the patient. A mutational signature\nrepresents the pattern of mutations produced by a mutagen or\nmutagenic process inside the cell. Each signature can also be\nrepresented by a vector of length 96, where each element\nrepresents the probability that this particular mutagenic\nprocess generates a mutation of the 96 above mentioned\ncategories. In this R package, we provide a set of functions to\nextract and visualize the mutational signatures that best\nexplain the mutation counts of a large number of patients.", "Encoding": "UTF-8", "License": "file LICENSE", "URL": "https://github.com/danro9685/SparseSignatures", "BugReports": "https://github.com/danro9685/SparseSignatures", "biocViews": "BiomedicalInformatics, SomaticMutation", "RoxygenNote": "7.3.3", "VignetteBuilder": "knitr", "Config/pak/sysreqs": "make libbz2-dev libicu-dev liblzma-dev libxml2-dev\nlibssl-dev xz-utils zlib1g-dev", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-04-28 12:47:45 UTC", "RemoteUrl": "https://github.com/bioc/SparseSignatures", "RemoteRef": "HEAD", "RemoteSha": "888f9fb0caa0ec9956cada4145adf99ef1042d31", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-30 09:36:25 UTC", "User": "root" }, "Author": "Daniele Ramazzotti [aut] (ORCID:\n),\nAvantika Lal [aut],\nKeli Liu [ctb],\nLuca De Sano [cre, aut] 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