{ "_id": "6a1af9421d7bb097a09fb5c9", "Package": "SimFFPE", "Type": "Package", "Title": "NGS Read Simulator for FFPE Tissue", "Version": "1.25.0", "Authors@R": "person(\"Lanying\", \"Wei\", email=\"lanying.wei@uni-muenster.de\",\nrole = c(\"aut\", \"cre\"), comment = c(ORCID = \"0000-0002-4281-8017\"))", "Description": "The NGS (Next-Generation Sequencing) reads from FFPE\n(Formalin-Fixed Paraffin-Embedded) samples contain numerous\nartifact chimeric reads (ACRS), which can lead to false\npositive structural variant calls. These ACRs are derived from\nthe combination of two single-stranded DNA (ss-DNA) fragments\nwith short reverse complementary regions (SRCRs). 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