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  "Title": "Calculates cell type specificity from single cell data",
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  "Description": "SPICEY (SPecificity Index for Coding and Epigenetic\nactivitY) is an R package designed to quantify cell-type\nspecificity in single-cell transcriptomic and epigenomic data,\nparticularly scRNA-seq and scATAC-seq. It introduces two\ncomplementary indices: the Gene Expression Tissue Specificity\nIndex (GETSI) and the Regulatory Element Tissue Specificity\nIndex (RETSI), both based on entropy to provide continuous,\ninterpretable measures of specificity. By integrating gene\nexpression and chromatin accessibility, SPICEY enables\nstandardized analysis of cell-type-specific regulatory programs\nacross diverse tissues and conditions.",
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  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 13:05:27 UTC",
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  "Author": "Georgina Fuentes-Páez [aut, cre] (ORCID:\n<https://orcid.org/0009-0003-9417-7148>),\nNacho Molina [aut],\nMireia Ramos-Rodriguez [aut],\nLorenzo Pasquali [aut],\nMinisterio de Ciencia e Innovación Spain [fnd] (program: FPI\nFellowship)",
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      "topics": [
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      ]
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      "title": "Calculate normalized Shannon-entropy of specificity scores",
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      "title": "SPICEY: Tissue specificity analysis for single-cell data The SPICEY package provides a user-friendly pipeline for quantifying and visualizing tissue specificity specificity from single-cell ATAC-seq and/or single cell RNA-seq datasets, typically processed with tools such as Seurat or Signac. The core outputs of SPICEY are two tissue specific metrics, combined with entropy-based measures.",
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      "source": "SPICEY.Rmd",
      "filename": "SPICEY.html",
      "title": "Measuring tissue specificity from single cell data with SPICEY",
      "author": "Georgina Fuentes-Páez",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "Preamble",
        "Cell-Type Specificity Indices: RETSI and GETSI",
        "Entropy-based Specificity Indices",
        "Installation",
        "Input Requirements",
        "Single-cell ATAC-seq Data",
        "Single-cell RNA-seq Data",
        "Co-accessibility Links (Optional for Region-to-Gene Linking)",
        "Quick example",
        "Example: Step-by-Step SPICEY Workflow",
        "Computing RETSI",
        "Computing GETSI",
        "Computing SPICEY",
        "Building Tissue-Specific Regulatory Networks",
        "Annotating Regions to Putative Target Genes (Optional)",
        "Nearest Gene Annotation",
        "Required inputs:",
        "Optional parameters:",
        "Annotate to co-accessible Genes",
        "Using custom region-to-gene annotation",
        "Integrating SPICEY measures to build tissue-specific networks",
        "Output Description",
        "SPICEY Measures",
        "Linked SPICEY Measures",
        "Visualizing cell-type specificity",
        "Arguments",
        "References",
        "SessionInfo"
      ],
      "created": "2025-06-03 12:47:54",
      "modified": "2025-10-08 14:54:37",
      "commits": 35
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