{ "_id": "6a103b6aacfb0bcc41c9b7b0", "Package": "SEMPLR", "Title": "SNP Effect Matrix Pipeline in R", "Version": "1.1.1", "Authors@R": "c(\nperson(\"Grace\", \"Kenney\",\nemail = \"kenney.grace6@gmail.com\",\nrole = c(\"aut\", \"cre\"),\ncomment = c(ORCID = \"0009-0009-6308-3150\")),\nperson(\"Douglas\", \"Phanstiel\",\nrole = c(\"aut\")),\nperson(\"NIH NIGMS\", role = \"fnd\"),\nperson(\"NSF GRFP\", role = \"fnd\"))", "Description": "SEMPLR computes transcription factor binding affinity\nscores for genomic positions and genetic variants. Scores are\ncomputed from SNP Effect Matrices (SEMs) produced by SEMpl. 223\npre-computed SEMs are included with the package or custom sets\ncan be provided. Enrichment can be tested among sets of genomic\npositions to determine if transcription factor binding events\noccur more often than expected. Comparing binding affinity\nscores between alleles can reveal differences in transcription\nfactor binding with genetic variation. This package also\nincludes several visualization functions to view scores both on\nthe motif and variant/position level.", "Encoding": "UTF-8", "Roxygen": "list(markdown = TRUE)", "RoxygenNote": "7.3.3", "VignetteBuilder": "knitr", "License": "MIT + file LICENSE", "Config/testthat/edition": "3", "URL": "https://github.com/grkenney/SEMPLR,\nhttps://grkenney.github.io/SEMPLR", "BugReports": "https://www.github.com/grkenney/SEMPLR/issues", "biocViews": "MotifAnnotation, Transcription, SNP, GenomicVariation", "LazyData": "true", "Config/pak/sysreqs": "libcairo2-dev cmake libfontconfig1-dev\nlibfreetype6-dev make libbz2-dev libicu-dev liblzma-dev\nlibpng-dev libuv1-dev libxml2-dev libssl-dev xz-utils\nzlib1g-dev", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-05-11 18:37:02 UTC", "RemoteUrl": "https://github.com/bioc/SEMPLR", "RemoteRef": "HEAD", "RemoteSha": "0bc12fab3869811db4427761f5c5fbafd5ab72db", "NeedsCompilation": "yes", "Packaged": { "Date": "2026-05-11 22:11:35 UTC", "User": "root" }, "Author": "Grace Kenney [aut, cre] (ORCID:\n),\nDouglas Phanstiel [aut],\nNIH NIGMS [fnd],\nNSF GRFP [fnd]", "Maintainer": "Grace Kenney ", "MD5sum": "fb7535646849040d9c687f9d0469442e", "_user": "bioc", "_type": "src", "_file": "SEMPLR_1.1.1.tar.gz", "_fileid": "c37e74c9669db66170b9481a20b29c88037f2d15e60c8be50cf94533a9d460d9", "_filesize": 1995347, "_sha256": "c37e74c9669db66170b9481a20b29c88037f2d15e60c8be50cf94533a9d460d9", "_created": "2026-05-11T22:11:35.000Z", "_published": "2026-05-22T11:18:02.515Z", "_jobs": [ { "job": 77368398146, "time": 383, "config": "bioc-checks", "r": "4.6.0", "check": "NOTE", "artifact": "6931185871" }, { "job": 77368398385, "time": 561, "config": "linux-devel-arm64", "r": "4.7.0", "check": "OK", "artifact": "6931232186" }, { "job": 77368398304, "time": 669, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "6931261395" }, { "job": 77368398825, "time": 561, "config": "linux-release-arm64", "r": 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