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At Step 2,\nRNA-sense outputs the groups of differentially expressed\ntranscripts, which are up- or downregulated in the mutant\ncompared to the wild-type at each time point. At Step 3,\nCorrelations (Fisher's exact test) between the outputs of Step\n1 (switch up- and switch down- time profile groups) and the\noutputs of Step2 (differentially expressed transcript groups)\nare calculated. 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