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  "Package": "RCAS",
  "Type": "Package",
  "Title": "RNA Centric Annotation System",
  "Version": "1.39.0",
  "Date": "2024-03-19",
  "Authors@R": "c(person(\"Bora\", \"Uyar\", email='bora.uyar@mdc-berlin.de', role=c(\"aut\", \"cre\")),\nperson(\"Dilmurat\", \"Yusuf\", role=c(\"aut\")),\nperson(\"Ricardo\", \"Wurmus\", role=c(\"aut\")),\nperson(\"Altuna\", \"Akalin\", role=c(\"aut\")))",
  "Description": "RCAS is an R/Bioconductor package designed as a generic\nreporting tool for the functional analysis of\ntranscriptome-wide regions of interest detected by\nhigh-throughput experiments. Such transcriptomic regions could\nbe, for instance, signal peaks detected by CLIP-Seq analysis\nfor protein-RNA interaction sites, RNA modification sites\n(alias the epitranscriptome), CAGE-tag locations, or any other\ncollection of query regions at the level of the transcriptome.\nRCAS produces in-depth annotation summaries and coverage\nprofiles based on the distribution of the query regions with\nrespect to transcript features (exons, introns, 5'/3' UTR\nregions, exon-intron boundaries, promoter regions). Moreover,\nRCAS can carry out functional enrichment analyses and\ndiscriminative motif discovery.",
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  "Repository": "https://bioc.r-universe.dev",
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  "Author": "Bora Uyar [aut, cre],\nDilmurat Yusuf [aut],\nRicardo Wurmus [aut],\nAltuna Akalin [aut]",
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    "deleteSampleDataFromDB",
    "discoverFeatureSpecificMotifs",
    "extractSequences",
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    "findEnrichedFunctions",
    "generateKmers",
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    "getFeatureBoundaryCoverageMulti",
    "getIntervalOverlapMatrix",
    "getMotifSummaryTable",
    "getPWM",
    "getTargetedGenesTable",
    "getTxdbFeatures",
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    "importBed",
    "importBedFiles",
    "importGtf",
    "parseMsigdb",
    "plotFeatureBoundaryCoverage",
    "printMsigdbDataset",
    "queryGff",
    "retrieveOrthologs",
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    "runTopGO",
    "summarizeDatabaseContent",
    "summarizeQueryRegions",
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      "title": "Sample GFF file imported as a GRanges object",
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      "class": [
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      ],
      "fields": [],
      "table": false,
      "tojson": false
    },
    {
      "name": "queryRegions",
      "title": "Sample BED file imported as a GRanges object",
      "object": "queryRegions",
      "class": [
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      ],
      "fields": [],
      "table": false,
      "tojson": false
    }
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      "title": "calculateCoverageProfile",
      "topics": [
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      ]
    },
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      "page": "calculateCoverageProfileFromTxdb",
      "title": "calculateCoverageProfileFromTxdb",
      "topics": [
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      ]
    },
    {
      "page": "calculateCoverageProfileList",
      "title": "calculateCoverageProfileList",
      "topics": [
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      ]
    },
    {
      "page": "calculateCoverageProfileListFromTxdb",
      "title": "calculateCoverageProfileListFromTxdb",
      "topics": [
        "calculateCoverageProfileListFromTxdb"
      ]
    },
    {
      "page": "checkSeqDb",
      "title": "checkSeqDb",
      "topics": [
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      ]
    },
    {
      "page": "createControlRegions",
      "title": "createControlRegions",
      "topics": [
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      ]
    },
    {
      "page": "createDB",
      "title": "createDB",
      "topics": [
        "createDB"
      ]
    },
    {
      "page": "createOrthologousGeneSetList",
      "title": "createOrthologousMsigdbDataset This function is deprecated. For functional enrichment analysis, use findEnrichedFunctions.",
      "topics": [
        "createOrthologousGeneSetList"
      ]
    },
    {
      "page": "deleteSampleDataFromDB",
      "title": "deleteSampleDataFromDB",
      "topics": [
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      ]
    },
    {
      "page": "discoverFeatureSpecificMotifs",
      "title": "discoverFeatureSpecificMotifs",
      "topics": [
        "discoverFeatureSpecificMotifs"
      ]
    },
    {
      "page": "extractSequences",
      "title": "extractSequences",
      "topics": [
        "extractSequences"
      ]
    },
    {
      "page": "findDifferentialMotifs",
      "title": "Find Differential Motifs",
      "topics": [
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      ]
    },
    {
      "page": "findEnrichedFunctions",
      "title": "findEnrichedFunctions",
      "topics": [
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      ]
    },
    {
      "page": "generateKmers",
      "title": "Generate K-mers",
      "topics": [
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      ]
    },
    {
      "page": "getFeatureBoundaryCoverage",
      "title": "getFeatureBoundaryCoverage",
      "topics": [
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    {
      "page": "getFeatureBoundaryCoverageBin",
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    },
    {
      "page": "getFeatureBoundaryCoverageMulti",
      "title": "getFeatureBoundaryCoverageMulti",
      "topics": [
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      ]
    },
    {
      "page": "getIntervalOverlapMatrix",
      "title": "getIntervalOverlapMatrix",
      "topics": [
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      ]
    },
    {
      "page": "getMotifSummaryTable",
      "title": "getMotifSummaryTable",
      "topics": [
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      ]
    },
    {
      "page": "getPWM",
      "title": "getPWM",
      "topics": [
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      ]
    },
    {
      "page": "getTargetedGenesTable",
      "title": "getTargetedGenesTable",
      "topics": [
        "getTargetedGenesTable"
      ]
    },
    {
      "page": "getTxdbFeatures",
      "title": "getTxdbFeatures",
      "topics": [
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    },
    {
      "page": "getTxdbFeaturesFromGRanges",
      "title": "getTxdbFeaturesFromGRanges",
      "topics": [
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      ]
    },
    {
      "page": "gff",
      "title": "Sample GFF file imported as a GRanges object",
      "topics": [
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    },
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    },
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      "title": "Sample BED file imported as a GRanges object",
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      "page": "retrieveOrthologs",
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      "source": "RCAS.metaAnalysis.vignette.Rmd",
      "filename": "RCAS.metaAnalysis.vignette.html",
      "title": "How to do meta-analysis of CLIP-seq peaks from multiple samples with RCAS",
      "author": "Bora Uyar, Ricardo Wurmus, Altuna Akalin",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "Preparing the inputs",
        "Project Data File",
        "GTF File (genome annotations)",
        "Creating a RSQLite database",
        "Generating a meta-analysis report",
        "Acknowledgements"
      ],
      "created": "2018-02-26 16:04:31",
      "modified": "2024-02-04 19:50:03",
      "commits": 4
    },
    {
      "source": "RCAS.vignette.Rmd",
      "filename": "RCAS.vignette.html",
      "title": "The RNA Centric Analysis System Report",
      "author": "Bora Uyar, Dilmurat Yusuf, Ricardo Wurmus, Altuna Akalin",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "Data input",
        "Importing sample data",
        "Importing custom data",
        "Summarizing Overlaps of Query Regions with Genomic Annotation Features",
        "Querying the annotation file",
        "Finding targeted gene types",
        "Extending the annotation feature space",
        "Plotting overlap counts between query regions and transcript features",
        "Obtaining a table of overlap counts between query regions and genes",
        "Profiling the coverage of query regions across transcript features",
        "Coverage profile of query regions at feature boundaries",
        "Coverage profile of query regions for all transcript features",
        "Discriminative Motif Discovery",
        "Calculating enriched motifs",
        "motif analysis: getting motif summary statistics",
        "Functional enrichment  analysis",
        "Generating a full report",
        "A test run for human",
        "A custom run for human",
        "To turn off certain modules of the report",
        "To run the pipeline for species other than human",
        "To turn off verbose output and progress bars",
        "Printing raw data generated by the runReport function",
        "Acknowledgements"
      ],
      "created": "2016-04-19 06:35:51",
      "modified": "2024-03-20 01:54:05",
      "commits": 17
    }
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