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  "_id": "6a1aaf911d7bb097a09d551c",
  "Package": "RAREsim",
  "Version": "1.17.0",
  "Date": "2020-08-01",
  "Title": "Simulation of Rare Variant Genetic Data",
  "Description": "Haplotype simulations of rare variant genetic data that\nemulates real data can be performed with RAREsim. RAREsim uses\nthe expected number of variants in MAC bins - either as\nprovided by default parameters or estimated from target data -\nand an abundance of rare variants as simulated HAPGEN2 to\nprobabilistically prune variants. RAREsim produces haplotypes\nthat emulate real sequencing data with respect to the total\nnumber of variants, allele frequency spectrum, haplotype\nstructure, and variant annotation.",
  "Authors@R": "c(person(given = \"Megan\", family = \"Null\", role = \"aut\", email = \"mnull@collegeofidaho.edu\"),\nperson(given = \"Ryan\", family = \"Barnard\", role = \"cre\", email = \"rbarnard1107@gmail.com\"))",
  "URL": "https://github.com/meganmichelle/RAREsim",
  "BugReports": "https://github.com/meganmichelle/RAREsim/issues",
  "License": "GPL-3",
  "LazyData": "FALSE",
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  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 12:58:22 UTC",
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  "Author": "Megan Null [aut],\nRyan Barnard [cre]",
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      "page": "afs",
      "title": "afs function - Calculates proportion of variants per rare MAC bins",
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      "title": "Given target data, fit the Number of Variants function",
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      "title": "Number of Variants function",
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        "nvariant"
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      "title": "African target data for the Number of Variants function from gnomADv2.1 (Karczewski, 2020)",
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      "headings": [
        "Overview of RAREsim",
        "Step (1): Simulate an abundance of rare variants",
        "Step (2): Estimate the expected number of rare variants",
        "Step (3): Probabilistically prune the rare variants",
        "Installing the RAREsim Package",
        "RAREsim R package: Estimate expected number of rare variants per MAC bin",
        "The Number of Variants function",
        "1) Fitting Target Data",
        "2) Using Default Parameters",
        "3) Directly Inputting Parameters",
        "Total Number of Variants in the Region",
        "The Allele Frequency Spectrum (AFS) Function",
        "Combining Funcitons to Get Expected Variants",
        "Session Info"
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      "created": "2020-12-28 14:48:02",
      "modified": "2022-04-22 19:43:43",
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