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  "Title": "Quasispecies Diversity",
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  "Date": "2024-04-23",
  "Authors@R": "c(person(\"Mercedes\", \"Guerrero-Murillo\", email=\"mergumu@gmail.com\", role=c(\"cre\", \"aut\"), comment = c(ORCID = \"0000-0002-5556-2460\")),  person(\"Josep\", \"Gregori i Font\", role=c (\"aut\"), comment = c(ORCID = \"0000-0002-4253-8015\")))",
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  "Description": "Set of utility functions for viral quasispecies analysis\nwith NGS data. Most functions are equally useful for\nmetagenomic studies. There are three main types: (1) data\nmanipulation and exploration—functions useful for converting\nreads to haplotypes and frequencies, repairing reads,\nintersecting strand haplotypes, and visualizing haplotype\nalignments. (2) diversity indices—functions to compute\ndiversity and entropy, in which incidence, abundance, and\nfunctional indices are considered. (3) data\nsimulation—functions useful for generating random viral\nquasispecies data.",
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  "biocViews": "Software, Genetics, DNASeq, GeneticVariability, Sequencing,\nAlignment, SequenceMatching, DataImport",
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  "Author": "Mercedes Guerrero-Murillo [cre, aut] (ORCID:\n<https://orcid.org/0000-0002-5556-2460>),\nJosep Gregori i Font [aut] (ORCID:\n<https://orcid.org/0000-0002-4253-8015>)",
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    "SegSites",
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    "ShannonVar",
    "SortByMutations",
    "SummaryMuts",
    "TotalMutations",
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      "page": "QSutils-package",
      "title": "Quasispecies Diversity",
      "topics": [
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        "QSutils"
      ]
    },
    {
      "page": "Collapse",
      "title": "Collapse reads into haplotypes and frequencies",
      "topics": [
        "Collapse",
        "Recollapse"
      ]
    },
    {
      "page": "ConsSeq",
      "title": "Consensus sequence given an alignment and frequencies",
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        "ConsSeq"
      ]
    },
    {
      "page": "CorrectGapsAndNs",
      "title": "Function to correct an alignment with gaps and Ns",
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        "CorrectGapsAndNs"
      ]
    },
    {
      "page": "DBrule",
      "title": "Genotyping by the DB rule",
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      ]
    },
    {
      "page": "Diverge",
      "title": "Generate a set of diverging haplotypes",
      "topics": [
        "Diverge"
      ]
    },
    {
      "page": "DNA.dist",
      "title": "Matrix of DNA distances given an alignment",
      "topics": [
        "DNA.dist"
      ]
    },
    {
      "page": "DottedAlignment",
      "title": "Align haplotypes into a dotted alignment",
      "topics": [
        "DottedAlignment"
      ]
    },
    {
      "page": "DSFT",
      "title": "Downsampling followed by fringe trimming",
      "topics": [
        "DSFT"
      ]
    },
    {
      "page": "FAD",
      "title": "Functional attribute diversity",
      "topics": [
        "FAD"
      ]
    },
    {
      "page": "fn.ab",
      "title": "Vector of abundances with different methods",
      "topics": [
        "fn.ab"
      ]
    },
    {
      "page": "FreqMat",
      "title": "Matrix of nucleotide or amino acid frequencies in alignment by position",
      "topics": [
        "FreqMat"
      ]
    },
    {
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      "title": "Generate variants of a given haplotype",
      "topics": [
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      ]
    },
    {
      "page": "GenotypeStandards_A-H.fas",
      "title": "Genotype standards of hepatitis B virus",
      "topics": [
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      "title": "Geometric series",
      "topics": [
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      ]
    },
    {
      "page": "GetInfProfile",
      "title": "Information content profile of an alignment",
      "topics": [
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      ]
    },
    {
      "page": "GetQSData",
      "title": "Read the aligned sequences, filter at minimum abundance, and sort the sequences",
      "topics": [
        "GetQSData"
      ]
    },
    {
      "page": "GetRandomSeq",
      "title": "Generate a random sequence",
      "topics": [
        "GetRandomSeq"
      ]
    },
    {
      "page": "GiniSimpson",
      "title": "Functions to calculate the GiniSimpson index",
      "topics": [
        "GiniSimpson",
        "GiniSimpsonMVUE",
        "GiniSimpsonVar"
      ]
    },
    {
      "page": "HCq",
      "title": "Set of functions to compute the Havrda-Charvat estimator",
      "topics": [
        "HCq",
        "HCqProfile",
        "HCqVar"
      ]
    },
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      "title": "Hill numbers",
      "topics": [
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        "HillProfile"
      ]
    },
    {
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      "title": "Forward and reverse strand haplotype intersections",
      "topics": [
        "IntersectStrandHpls"
      ]
    },
    {
      "page": "MutationFreq",
      "title": "Mutation frequency with respect to the dominant haplotype",
      "topics": [
        "MutationFreq",
        "MutationFreqVar"
      ]
    },
    {
      "page": "MutsTbl",
      "title": "Table of mutation frequencies by position",
      "topics": [
        "MutsTbl"
      ]
    },
    {
      "page": "NucleotideDiversity",
      "title": "Nucleotide diversity",
      "topics": [
        "NucleotideDiversity"
      ]
    },
    {
      "page": "PolyDist",
      "title": "Fraction of substitutions by polymorphic site",
      "topics": [
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      ]
    },
    {
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      "title": "Functions to compute Rao’s entropy",
      "topics": [
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        "RaoPow",
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        "RaoVar"
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      "title": "Read a fasta file with haplotypes and frequencies",
      "topics": [
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      "title": "Rényi profiles",
      "topics": [
        "Renyi",
        "RenyiProfile"
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      "title": "Report variants",
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      ]
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      "title": "Compute the number of segregating sites",
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      "title": "Sort haplotypes by mutations and abundance",
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      "title": "Distribution of nucleotides or amino acids in polymorphic sites",
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