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  "Version": "1.49.0",
  "Title": "Quantitative DNA Sequencing for Chromosomal Aberrations",
  "Description": "Quantitative DNA sequencing for chromosomal aberrations.\nThe genome is divided into non-overlapping fixed-sized bins,\nnumber of sequence reads in each counted, adjusted with a\nsimultaneous two-dimensional loess correction for sequence\nmappability and GC content, and filtered to remove spurious\nregions in the genome. Downstream steps of segmentation and\ncalling are also implemented via packages DNAcopy and CGHcall,\nrespectively.",
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  "biocViews": "CopyNumberVariation, DNASeq, Genetics, GenomeAnnotation,\nPreprocessing, QualityControl, Sequencing",
  "License": "GPL",
  "URL": "https://github.com/ccagc/QDNAseq",
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  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 12:38:48 UTC",
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  "Author": "Ilari Scheinin [aut],\nDaoud Sie [aut, cre],\nHenrik Bengtsson [aut],\nErik van Dijk [ctb]",
  "Maintainer": "Daoud Sie <d.sie@vumc.nl>",
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    "committer": "A Wokaty <andres.wokaty@sph.cuny.edu>",
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    "bpend",
    "bpstart",
    "calculateBlacklist",
    "calculateBlacklistByRegions",
    "calculateMappability",
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    "chromosomes",
    "compareToReference",
    "correctBins",
    "createBins",
    "estimateCorrection",
    "exportBins",
    "frequencyPlot",
    "getBinAnnotations",
    "highlightFilters",
    "isobarPlot",
    "iterateResiduals",
    "makeCgh",
    "noisePlot",
    "normalizeBins",
    "normalizeSegmentedBins",
    "plot",
    "poolRuns",
    "segmentBins",
    "smoothOutlierBins"
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      "name": "LGG150",
      "title": "LGG150 chromosomes 7-10",
      "object": "LGG150",
      "file": "LGG150.rda",
      "class": [
        "QDNAseqReadCounts"
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      "fields": [],
      "table": false,
      "tojson": false
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      "page": "QDNAseq-package",
      "title": "Package QDNAseq",
      "topics": [
        "QDNAseq-package",
        "QDNAseq"
      ]
    },
    {
      "page": "addPhenodata",
      "title": "Adds phenotype data from a file to a QDNAseqReadCounts or a QDNAseqCopyNumbers object",
      "topics": [
        "addPhenodata"
      ]
    },
    {
      "page": "applyFilters",
      "title": "Adjusts the filtering on which bins are used",
      "topics": [
        "applyFilters",
        "applyFilters,QDNAseqReadCounts-method"
      ]
    },
    {
      "page": "binReadCounts",
      "title": "Calculate binned read counts from a set of BAM files",
      "topics": [
        "binReadCounts"
      ]
    },
    {
      "page": "callBins",
      "title": "Call aberrations from segmented copy number data",
      "topics": [
        "callBins",
        "callBins,QDNAseqCopyNumbers-method"
      ]
    },
    {
      "page": "compareToReference",
      "title": "Divide binned read counts with those of reference samples",
      "topics": [
        "compareToReference",
        "compareToReference,QDNAseqCopyNumbers,numeric-method"
      ]
    },
    {
      "page": "correctBins",
      "title": "Correct binned read counts for GC content and mappability",
      "topics": [
        "correctBins",
        "correctBins,QDNAseqReadCounts-method"
      ]
    },
    {
      "page": "createBins",
      "title": "Builds bin annotation data for a particular bin size",
      "topics": [
        "calculateBlacklist",
        "calculateBlacklistByRegions",
        "calculateMappability",
        "createBins",
        "iterateResiduals"
      ]
    },
    {
      "page": "estimateCorrection",
      "title": "Estimate correction to read counts for GC content and mappability",
      "topics": [
        "estimateCorrection",
        "estimateCorrection,QDNAseqReadCounts-method"
      ]
    },
    {
      "page": "exportBins",
      "title": "Exports to a file",
      "topics": [
        "exportBins",
        "exportBins,QDNAseqSignals-method"
      ]
    },
    {
      "page": "frequencyPlot",
      "title": "Plot copy number aberration frequencies",
      "topics": [
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        "frequencyPlot,QDNAseqCopyNumbers,missing-method"
      ]
    },
    {
      "page": "getBinAnnotations",
      "title": "Gets bin annotation data for a particular bin size",
      "topics": [
        "getBinAnnotations"
      ]
    },
    {
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      "title": "Highlights data points in a plotted profile to evaluate filtering",
      "topics": [
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        "highlightFilters,QDNAseqSignals-method"
      ]
    },
    {
      "page": "isobarPlot",
      "title": "Plot median read counts as a function of GC content and mappability",
      "topics": [
        "isobarPlot",
        "isobarPlot,QDNAseqReadCounts,missing-method"
      ]
    },
    {
      "page": "LGG150",
      "title": "LGG150 chromosomes 7-10",
      "topics": [
        "LGG150"
      ]
    },
    {
      "page": "makeCgh",
      "title": "Constructs a 'cghRaw', 'cghSeg', or 'cghCall' object",
      "topics": [
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        "makeCgh,QDNAseqCopyNumbers-method"
      ]
    },
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      "title": "Plot noise as a function of sequence depth",
      "topics": [
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        "noisePlot,QDNAseqReadCounts,missing-method"
      ]
    },
    {
      "page": "normalizeBins",
      "title": "Normalizes binned read counts",
      "topics": [
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        "normalizeBins,QDNAseqCopyNumbers-method"
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      "topics": [
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        "normalizeSegmentedBins,QDNAseqCopyNumbers-method"
      ]
    },
    {
      "page": "plot",
      "title": "Plot copy number profile",
      "topics": [
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        "plot,QDNAseqSignals,missing-method"
      ]
    },
    {
      "page": "poolRuns",
      "title": "Pools binned read counts across samples",
      "topics": [
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        "poolRuns,QDNAseqSignals,character-method"
      ]
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    {
      "page": "QDNAseq-defunct",
      "title": "Defunct functions in package 'QDNAseq'",
      "topics": [
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    },
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      "page": "QDNAseqCopyNumbers",
      "title": "Container for QDNAseq read count data",
      "topics": [
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        "QDNAseqCopyNumbers-class"
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      "topics": [
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        "QDNAseqReadCounts-class"
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      "title": "A parent class for containers of QDNAseq data",
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        "bpstart,QDNAseqSignals-method",
        "chromosomes,QDNAseqSignals-method",
        "QDNAseqSignals",
        "QDNAseqSignals-class"
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    },
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      "title": "Segments normalized copy number data",
      "topics": [
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        "segmentBins,QDNAseqCopyNumbers-method"
      ]
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      "page": "smoothOutlierBins",
      "title": "Smooth outlier bins after normalization",
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