{
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  "Package": "QDNAseq",
  "Version": "1.49.0",
  "Title": "Quantitative DNA Sequencing for Chromosomal Aberrations",
  "Description": "Quantitative DNA sequencing for chromosomal aberrations.\nThe genome is divided into non-overlapping fixed-sized bins,\nnumber of sequence reads in each counted, adjusted with a\nsimultaneous two-dimensional loess correction for sequence\nmappability and GC content, and filtered to remove spurious\nregions in the genome. Downstream steps of segmentation and\ncalling are also implemented via packages DNAcopy and CGHcall,\nrespectively.",
  "Authors@R": "c(\nperson(\"Ilari\", \"Scheinin\", role=\"aut\"),\nperson(\"Daoud\", \"Sie\", role=c(\"aut\", \"cre\"), email=\"d.sie@vumc.nl\"),\nperson(\"Henrik\", \"Bengtsson\", role=\"aut\"),\nperson(\"Erik\", \"van Dijk\", role=\"ctb\"))",
  "biocViews": "CopyNumberVariation, DNASeq, Genetics, GenomeAnnotation,\nPreprocessing, QualityControl, Sequencing",
  "License": "GPL",
  "URL": "https://github.com/ccagc/QDNAseq",
  "BugReports": "https://github.com/ccagc/QDNAseq/issues",
  "RoxygenNote": "7.3.2",
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  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 12:38:48 UTC",
  "RemoteUrl": "https://github.com/bioc/QDNAseq",
  "RemoteRef": "HEAD",
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  "NeedsCompilation": "no",
  "Packaged": {
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    "User": "root"
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  "Author": "Ilari Scheinin [aut],\nDaoud Sie [aut, cre],\nHenrik Bengtsson [aut],\nErik van Dijk [ctb]",
  "Maintainer": "Daoud Sie <d.sie@vumc.nl>",
  "MD5sum": "b8121a689e4aea554b910d21b7a17bb7",
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    "bpend",
    "bpstart",
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    "chromosomes",
    "compareToReference",
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    "createBins",
    "estimateCorrection",
    "exportBins",
    "frequencyPlot",
    "getBinAnnotations",
    "highlightFilters",
    "isobarPlot",
    "iterateResiduals",
    "makeCgh",
    "noisePlot",
    "normalizeBins",
    "normalizeSegmentedBins",
    "plot",
    "poolRuns",
    "segmentBins",
    "smoothOutlierBins"
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      "title": "LGG150 chromosomes 7-10",
      "object": "LGG150",
      "file": "LGG150.rda",
      "class": [
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      "table": false,
      "tojson": false
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      "title": "Package QDNAseq",
      "topics": [
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        "QDNAseq"
      ]
    },
    {
      "page": "addPhenodata",
      "title": "Adds phenotype data from a file to a QDNAseqReadCounts or a QDNAseqCopyNumbers object",
      "topics": [
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      ]
    },
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      "title": "Adjusts the filtering on which bins are used",
      "topics": [
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        "applyFilters,QDNAseqReadCounts-method"
      ]
    },
    {
      "page": "binReadCounts",
      "title": "Calculate binned read counts from a set of BAM files",
      "topics": [
        "binReadCounts"
      ]
    },
    {
      "page": "callBins",
      "title": "Call aberrations from segmented copy number data",
      "topics": [
        "callBins",
        "callBins,QDNAseqCopyNumbers-method"
      ]
    },
    {
      "page": "compareToReference",
      "title": "Divide binned read counts with those of reference samples",
      "topics": [
        "compareToReference",
        "compareToReference,QDNAseqCopyNumbers,numeric-method"
      ]
    },
    {
      "page": "correctBins",
      "title": "Correct binned read counts for GC content and mappability",
      "topics": [
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        "correctBins,QDNAseqReadCounts-method"
      ]
    },
    {
      "page": "createBins",
      "title": "Builds bin annotation data for a particular bin size",
      "topics": [
        "calculateBlacklist",
        "calculateBlacklistByRegions",
        "calculateMappability",
        "createBins",
        "iterateResiduals"
      ]
    },
    {
      "page": "estimateCorrection",
      "title": "Estimate correction to read counts for GC content and mappability",
      "topics": [
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        "estimateCorrection,QDNAseqReadCounts-method"
      ]
    },
    {
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      "title": "Exports to a file",
      "topics": [
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        "exportBins,QDNAseqSignals-method"
      ]
    },
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      "title": "Plot copy number aberration frequencies",
      "topics": [
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      ]
    },
    {
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      "topics": [
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      ]
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        "highlightFilters,QDNAseqSignals-method"
      ]
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    {
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      "topics": [
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      ]
    },
    {
      "page": "LGG150",
      "title": "LGG150 chromosomes 7-10",
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      ]
    },
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      "topics": [
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        "makeCgh,QDNAseqCopyNumbers-method"
      ]
    },
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    },
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      "title": "Plot copy number profile",
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        "plot,QDNAseqSignals,missing-method"
      ]
    },
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      ]
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    },
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      ]
    },
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