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  "Title": "OUTRIDER - OUTlier in RNA-Seq fInDER",
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  "Date": "2026-02-10",
  "URL": "https://github.com/gagneurlab/OUTRIDER",
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  "Authors@R": "c(\nperson(\"Felix\", \"Brechtmann\", role=c(\"aut\"),\nemail=\"brechtma@in.tum.de\", comment=c(ORCID=\"0000-0002-0110-152X\")),\nperson(\"Christian\", \"Mertes\", role=c(\"aut\", \"cre\"),\nemail=\"mertes@in.tum.de\", comment=c(ORCID=\"0000-0002-1091-205X\")),\nperson(\"Agne\", \"Matuseviciute\", role=c(\"aut\")),\nperson(c(\"Michaela\", \"Fee\"), \"Müller\", role=c(\"ctb\")),\nperson(\"Andrea\", \"Raithel\", role=c(\"ctb\")),\nperson(\"Vicente\", \"Yepez\", role=c(\"aut\"), email=\"yepez@in.tum.de\",\ncomment=c(ORCID=\"0000-0001-7916-3643\")),\nperson(\"Julien\", \"Gagneur\", role=c(\"aut\"), email=\"gagneur@in.tum.de\",\ncomment=c(ORCID=\"0000-0002-8924-8365\")))",
  "Description": "Identification of aberrant gene expression in RNA-seq\ndata. Read count expectations are modeled by an autoencoder to\ncontrol for confounders in the data. Given these expectations,\nthe RNA-seq read counts are assumed to follow a negative\nbinomial distribution with a gene-specific dispersion. Outliers\nare then identified as read counts that significantly deviate\nfrom this distribution. Furthermore, OUTRIDER provides useful\nplotting functions to analyze and visualize the results.",
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  "Collate": "package-OUTRIDER.R class-OutriderDataSet.R AllGenerics.R\ninputCheckerFunctions.R helperFunctions.R getNSetterFuns.R\ngetNSetterFunsInternal.R autoencoder.R fitNB.R ZscoreMatrix.R\nmethod-evaluation.R method-counts.R method-estimateBestQ.R\nmethod-plot.R method-results.R pValMatrix.R filterExpression.R\nOUTRIDER.R sizeFactor.R RcppExports.R updateE.R updateD.R\nupdateTheta.R PCAcorrections.R thetaMethodOfMoments.R\ncontrolForConfounders.R lossNGradientRVersion.R",
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  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 12:48:19 UTC",
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  "Packaged": {
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  "Author": "Felix Brechtmann [aut] (ORCID: <https://orcid.org/0000-0002-0110-152X>),\nChristian Mertes [aut, cre] (ORCID:\n<https://orcid.org/0000-0002-1091-205X>),\nAgne Matuseviciute [aut],\nMichaela Fee Müller [ctb],\nAndrea Raithel [ctb],\nVicente Yepez [aut] (ORCID: <https://orcid.org/0000-0001-7916-3643>),\nJulien Gagneur [aut] (ORCID: <https://orcid.org/0000-0002-8924-8365>)",
  "Maintainer": "Christian Mertes <mertes@in.tum.de>",
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  "_created": "2026-06-23T19:21:39.000Z",
  "_published": "2026-07-04T21:33:32.221Z",
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    "OUTRIDER",
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    "plotCountGeneSampleHeatmap",
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    "plotExpressedGenes",
    "plotExpressionRank",
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    "plotQQ",
    "plotSizeFactors",
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    "pValue",
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    "sampleExclusionMask<-",
    "sizeFactors",
    "sizeFactors<-",
    "theta",
    "zScore"
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    {
      "page": "aberrant",
      "title": "Number of aberrant events",
      "topics": [
        "aberrant",
        "aberrant,OutriderDataSet-method"
      ]
    },
    {
      "page": "computeGeneLength",
      "title": "Extracting the gene length from annotations",
      "topics": [
        "computeGeneLength"
      ]
    },
    {
      "page": "computeLatentSpace",
      "title": "Extracting the latent space",
      "topics": [
        "computeLatentSpace"
      ]
    },
    {
      "page": "computePvalues",
      "title": "Calculate P-values",
      "topics": [
        "computePvalues",
        "computePvalues,OutriderDataSet-method"
      ]
    },
    {
      "page": "computeZscores",
      "title": "Z score computation",
      "topics": [
        "computeZscores",
        "computeZscores,OutriderDataSet-method"
      ]
    },
    {
      "page": "controlForConfounders",
      "title": "Autoencoder function to correct for confounders.",
      "topics": [
        "controlForConfounders"
      ]
    },
    {
      "page": "counts",
      "title": "Accessors for the 'counts' slot of an OutriderDataSet object.",
      "topics": [
        "counts",
        "counts,OutriderDataSet-method",
        "counts<-,OutriderDataSet,matrix-method"
      ]
    },
    {
      "page": "estimateBestQ",
      "title": "Find the optimal encoding dimension",
      "topics": [
        "estimateBestQ",
        "estimateBestQ,",
        "findInjectZscore"
      ]
    },
    {
      "page": "filterExpression",
      "title": "Filter expression",
      "topics": [
        "filterExpression",
        "filterExpression,OutriderDataSet-method"
      ]
    },
    {
      "page": "fit",
      "title": "Fit the negative binomial distribution",
      "topics": [
        "fit",
        "fit.OutriderDataSet"
      ]
    },
    {
      "page": "fpkm",
      "title": "Calculate FPM and FPKM values",
      "topics": [
        "fpkm",
        "fpm"
      ]
    },
    {
      "page": "getter_setter_functions",
      "title": "Getter/Setter functions",
      "topics": [
        "dispersion,",
        "dispersions",
        "dispersions,OutriderDataSet-method",
        "getBestQ",
        "getter_setter_functions",
        "padj",
        "padj,",
        "pValue",
        "pValue,",
        "theta",
        "theta,",
        "zScore",
        "zScore,"
      ]
    },
    {
      "page": "makeExampleOutriderDataSet",
      "title": "Create example data sets for OUTRIDER",
      "topics": [
        "makeExampleOutriderDataSet"
      ]
    },
    {
      "page": "normalizationFactors",
      "title": "Accessor functions for the normalization factors in an OutriderDataSet object.",
      "topics": [
        "normalizationFactors",
        "normalizationFactors,OutriderDataSet-method",
        "normalizationFactors<-,OutriderDataSet,data.frame-method",
        "normalizationFactors<-,OutriderDataSet,DataFrame-method",
        "normalizationFactors<-,OutriderDataSet,matrix-method",
        "normalizationFactors<-,OutriderDataSet,NULL-method"
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    {
      "page": "OUTRIDER",
      "title": "OUTRIDER - Finding expression outlier events",
      "topics": [
        "OUTRIDER"
      ]
    },
    {
      "page": "OutriderDataSet-class",
      "title": "OutriderDataSet class and constructors",
      "topics": [
        "OutriderDataSet",
        "OutriderDataSet-class"
      ]
    },
    {
      "page": "plotFunctions",
      "title": "Visualization functions for OUTRIDER",
      "topics": [
        "plotAberrantPerSample",
        "plotAberrantPerSample,OutriderDataSet-method",
        "plotCountCorHeatmap",
        "plotCountCorHeatmap,OutriderDataSet-method",
        "plotCountGeneSampleHeatmap",
        "plotDispEsts",
        "plotDispEsts,OutriderDataSet-method",
        "plotEncDimSearch",
        "plotEncDimSearch,OutriderDataSet-method",
        "plotExpectedVsObservedCounts",
        "plotExpressedGenes",
        "plotExpressionRank",
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        "plotFunction",
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        "plotManhattan,OutriderDataSet-method",
        "plotPowerAnalysis",
        "plotQQ",
        "plotQQ,OutriderDataSet-method",
        "plotSizeFactors",
        "plotVolcano",
        "plotVolcano,OutriderDataSet-method"
      ]
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      "page": "results",
      "title": "Accessor function for the 'results' object in an OutriderDataSet object.",
      "topics": [
        "results",
        "results,OutriderDataSet-method"
      ]
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      "page": "sampleExclusionMask",
      "title": "Sample exclusion",
      "topics": [
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        "sampleExclusionMask,",
        "sampleExclusionMask<-",
        "`sampleExclusionMask<-`"
      ]
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    {
      "page": "sizeFactors",
      "title": "SizeFactors accessor and estimation function",
      "topics": [
        "estimateSizeFactors",
        "estimateSizeFactors,OutriderDataSet-method",
        "sizeFactors",
        "sizeFactors,OutriderDataSet-method",
        "sizeFactors<-",
        "sizeFactors<-,OutriderDataSet,NULL-method",
        "sizeFactors<-,OutriderDataSet,numeric-method"
      ]
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