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  "Title": "Analysis of Error-Corrected Sequencing Data for Mutation\nDetection",
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  "Date": "2025-12-09",
  "Authors@R": "c(\nperson(\"Annette E.\", \"Dodge\",\nemail = \"annette.dodge@hc-sc.gc.ca\",\nrole = \"aut\",\ncomment = c(ORCID = \"0000-0002-0446-9055\")),\nperson(\"Andrew\", \"Williams\", role = \"aut\",\ncomment = c(ORCID = \"0000-0002-7637-7686\")),\nperson(\"Danielle P.M.\", \"LeBlanc\", role = \"aut\",\ncomment = c(ORCID = \"0000-0002-3847-8371\")),\nperson(\"David M.\", \"Schuster\", role = \"aut\",\ncomment = c(ORCID = \"0009-0001-6316-4358\")),\nperson(\"Elena\", \"Esina\", role = \"aut\",\ncomment = c(ORCID = \"0009-0002-3443-378X\")),\nperson(\"Clint C.\", \"Valentine\", role = \"aut\",\ncomment = c(ORCID = \"0000-0001-5630-7368\")),\nperson(\"Jesse J.\", \"Salk\", role = \"aut\",\ncomment = c(ORCID = \"0000-0002-7804-0550\")),\nperson(\"Alexander Y.\", \"Maslov\", role = \"aut\"),\nperson(\"Christopher\", \"Bradley\", role = \"aut\"),\nperson(\"Carole L.\", \"Yauk\", role = \"aut\",\ncomment = c(ORCID = \"0000-0002-6725-3454\")),\nperson(\"Francesco\", \"Marchetti\", role = \"aut\",\ncomment = c(ORCID = \"0000-0002-9435-4867\")),\nperson(\"Matthew J.\", \"Meier\",\nemail = \"matthew.meier@hc-sc.gc.ca\",\nrole = c(\"aut\", \"cre\"),\ncomment = c(ORCID = \"0000-0001-8199-8754\")),\nperson(\"Geronimo\", \"Matteo\", role = \"ctb\",\ncomment = c(ORCID = \"0000-0003-0819-4471\")),\nperson(\"Health Canada's Genomics Research and Development Initiative\", role = \"fnd\"),\nperson(\"Canada Research Chairs Program\", role = \"fnd\", comment = \"CRC-2020-00060\"),\nperson(\"Burroughs Wellcome Fund\", role = \"fnd\")\n)",
  "Description": "Standard methods for analysis of mutation data following\nerror- corrected sequencing (ECS) for the purpose of\nmutagencity assessment. Functions include importing the\nmutation lists provided by a variant caller, and a set of\nanalytical tools for statistical testing and visualization of\nmutation data; comparison to COSMIC and/or germline signatures;\netc.",
  "License": "MIT + file LICENSE",
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  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 13:06:12 UTC",
  "RemoteUrl": "https://github.com/bioc/MutSeqR",
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    "User": "root"
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  "Author": "Annette E. Dodge [aut] (ORCID: <https://orcid.org/0000-0002-0446-9055>),\nAndrew Williams [aut] (ORCID: <https://orcid.org/0000-0002-7637-7686>),\nDanielle P.M. LeBlanc [aut] (ORCID:\n<https://orcid.org/0000-0002-3847-8371>),\nDavid M. Schuster [aut] (ORCID:\n<https://orcid.org/0009-0001-6316-4358>),\nElena Esina [aut] (ORCID: <https://orcid.org/0009-0002-3443-378X>),\nClint C. Valentine [aut] (ORCID:\n<https://orcid.org/0000-0001-5630-7368>),\nJesse J. Salk [aut] (ORCID: <https://orcid.org/0000-0002-7804-0550>),\nAlexander Y. Maslov [aut],\nChristopher Bradley [aut],\nCarole L. Yauk [aut] (ORCID: <https://orcid.org/0000-0002-6725-3454>),\nFrancesco Marchetti [aut] (ORCID:\n<https://orcid.org/0000-0002-9435-4867>),\nMatthew J. Meier [aut, cre] (ORCID:\n<https://orcid.org/0000-0001-8199-8754>),\nGeronimo Matteo [ctb] (ORCID: <https://orcid.org/0000-0003-0819-4471>),\nHealth Canada's Genomics Research and Development Initiative [fnd],\nCanada Research Chairs Program [fnd] (CRC-2020-00060),\nBurroughs Wellcome Fund [fnd]",
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    "op",
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    "plot_mf",
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    "subtype_dict",
    "subtype_list",
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    "write_reference_fasta",
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      "page": "annotate_cpg_sites",
      "title": "Annotate CpG sites",
      "topics": [
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      "title": "BMD modeling using PROAST",
      "topics": [
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      "title": "BS genome organism dictionary",
      "topics": [
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      "page": "calculate_mf",
      "title": "Calculate mutation frequency",
      "topics": [
        "calculate_mf"
      ]
    },
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      "title": "Characterize Variants",
      "topics": [
        "characterize_variants"
      ]
    },
    {
      "page": "check_required_columns",
      "title": "Check that all required columns are present before proceeding with the function",
      "topics": [
        "check_required_columns"
      ]
    },
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      "title": "classify_variation",
      "topics": [
        "classify_variation"
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      "title": "Cleveland Plot",
      "topics": [
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      "title": "Hierarchical Clustering",
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      "title": "A list of reference contexts at different resolutions",
      "topics": [
        "context_list"
      ]
    },
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      "title": "Values used for denominators in frequency calculations",
      "topics": [
        "denominator_dict"
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    },
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      "title": "dm_loglik_ridge_stable",
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        "dm_loglik_ridge_stable"
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      ]
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      "title": "Plot the PROAST results",
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        "f.plot.result"
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      "title": "Run dose-response modeling using PROAST.",
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      "title": "Filter your mutation data",
      "topics": [
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      "topics": [
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    },
    {
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      "title": "Get the coordinates of the CpG sites within your genomic regions",
      "topics": [
        "get_cpg_regions"
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      "title": "A utility function that will return the reference context of a mutation",
      "topics": [
        "get_ref_of_mut"
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      "title": "Get sequence of genomic target regions",
      "topics": [
        "get_seq"
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    },
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      "title": "Derive end coordinates from a VCF object",
      "topics": [
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      "title": "Import tabular mutation data",
      "topics": [
        "import_mut_data"
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      "title": "Join Regions Metadata",
      "topics": [
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      "title": "Import Sample Metadata",
      "topics": [
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      "title": "Import a VCF file",
      "topics": [
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      "title": "Imports the regions file",
      "topics": [
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      "title": "Perform linear modelling on mutation frequency for given fixed and random effects",
      "topics": [
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      "page": "op",
      "title": "Dictionary of column name synonyms for required mutation data columns",
      "topics": [
        "op"
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    },
    {
      "page": "plot_bubbles",
      "title": "Generate Bubble Plots",
      "topics": [
        "plot_bubbles"
      ]
    },
    {
      "page": "plot_ci",
      "title": "plot_ci",
      "topics": [
        "plot_ci"
      ]
    },
    {
      "page": "plot_lollipop",
      "title": "Plot recurrent mutations in a lollipop plot using ggplot2",
      "topics": [
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    },
    {
      "page": "plot_mean_mf",
      "title": "Plot the Mean Mutatation Frequency",
      "topics": [
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      ]
    },
    {
      "page": "plot_mf",
      "title": "Plot the Mutation Frequency",
      "topics": [
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    },
    {
      "page": "plot_model_mf",
      "title": "Plot your mf model",
      "topics": [
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    },
    {
      "page": "plot_radar",
      "title": "Create a radar plot",
      "topics": [
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    },
    {
      "page": "plot_spectra",
      "title": "Plot spectra",
      "topics": [
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    },
    {
      "page": "plot_trinucleotide",
      "title": "Plot the trinucleotide spectrum",
      "topics": [
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    },
    {
      "page": "plot_trinucleotide_heatmap",
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    },
    {
      "page": "populate_sequence_context",
      "title": "Populate Sequence context",
      "topics": [
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    {
      "page": "print_ascii_art",
      "title": "This function prints ASCII art when the package is loaded",
      "topics": [
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      "page": "rdm_fast",
      "title": "rdm_fast",
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      "page": "render_report",
      "title": "Read configuration file and render R Markdown document",
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    {
      "page": "reverseComplement",
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      "topics": [
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      "page": "run_penalized_comparison",
      "title": "run_penalized_comparison",
      "topics": [
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      "page": "select_optimal_lambda",
      "title": "select_optimal_lambda",
      "topics": [
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      "title": "Set up Python environment for MutSeqR",
      "topics": [
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    {
      "page": "sidak",
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      "topics": [
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      "page": "signature_fitting",
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      "topics": [
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    {
      "page": "spectra_comparison",
      "title": "Compare the overall mutation spectra between groups",
      "topics": [
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      "page": "subtype_list",
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      "page": "write_excel",
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