{
  "_id": "6a34f18e3efcd9bda43d0735",
  "Package": "MultiMed",
  "Title": "Testing multiple biological mediators simultaneously",
  "Version": "2.35.0",
  "Date": "2013-07-07",
  "Author": "Simina M. Boca, Ruth Heller, Joshua N. Sampson",
  "Maintainer": "Simina M. Boca <smb310@georgetown.edu>",
  "Description": "Implements methods for testing multiple mediators",
  "License": "GPL (>= 2) + file LICENSE",
  "biocViews": "MultipleComparison, StatisticalMethod, Software",
  "Repository": "https://bioc.r-universe.dev",
  "Date/Publication": "2026-04-28 12:39:26 UTC",
  "RemoteUrl": "https://github.com/bioc/MultiMed",
  "RemoteRef": "HEAD",
  "RemoteSha": "70f5c457fc2119d393294be48f78cdd7124c808d",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-06-19 07:33:55 UTC",
    "User": "root"
  },
  "MD5sum": "61830126308f97849802b61a80aadd8d",
  "_user": "bioc",
  "_type": "src",
  "_file": "MultiMed_2.35.0.tar.gz",
  "_fileid": "b7bcba9523bdea0b5af23c1367e4dc509887603203364f47200c5c90270867c7",
  "_filesize": 536685,
  "_sha256": "b7bcba9523bdea0b5af23c1367e4dc509887603203364f47200c5c90270867c7",
  "_created": "2026-06-19T07:33:55.000Z",
  "_published": "2026-06-19T07:36:46.858Z",
  "_jobs": [
    {
      "job": 82304899295,
      "time": 124,
      "config": "bioc-checks",
      "r": "4.6.0",
      "check": "ERROR",
      "artifact": "7744185763"
    },
    {
      "job": 82304899359,
      "time": 118,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "7744184149"
    },
    {
      "job": 82304899362,
      "time": 139,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7744190306"
    },
    {
      "job": 82304899329,
      "time": 88,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "7744175915"
    },
    {
      "job": 82304899318,
      "time": 112,
      "config": "macos-release-arm64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7744182474"
    },
    {
      "job": 82304569239,
      "time": 141,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7744150833"
    },
    {
      "job": 82304899309,
      "time": 88,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7744175877"
    },
    {
      "job": 82304899345,
      "time": 69,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "7744170427"
    },
    {
      "job": 82304899371,
      "time": 55,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "7744167080"
    },
    {
      "job": 82304899351,
      "time": 64,
      "config": "windows-release",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7744169249"
    }
  ],
  "_bioccheck": {
    "error": 1,
    "warning": 2,
    "note": 9
  },
  "_buildurl": "https://github.com/r-universe/bioc/actions/runs/27812075066",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/bioc/MultiMed",
  "_commit": {
    "id": "70f5c457fc2119d393294be48f78cdd7124c808d",
    "author": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "committer": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "message": "bump x.y.z version to odd y following creation of RELEASE_3_23 branch\n",
    "time": 1777379966
  },
  "_maintainer": {
    "name": "Simina M. Boca",
    "email": "smb310@georgetown.edu"
  },
  "_distro": "noble",
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 3.1.0",
      "role": "Depends"
    },
    {
      "package": "RUnit",
      "role": "Suggests"
    },
    {
      "package": "BiocGenerics",
      "role": "Suggests"
    }
  ],
  "_owner": "bioc",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [
    {
      "week": "2025-44",
      "n": 2
    },
    {
      "week": "2026-18",
      "n": 2
    }
  ],
  "_tags": [],
  "_bioc": [
    {
      "branch": "devel",
      "version": "2.35.0",
      "bioc": "3.24"
    },
    {
      "branch": "release",
      "version": "2.34.0",
      "bioc": "3.23"
    }
  ],
  "_topics": [
    "multiplecomparison",
    "statisticalmethod",
    "software"
  ],
  "_userbio": {
    "uuid": 2286807,
    "type": "organization",
    "name": "Bioconductor",
    "followers": 440,
    "description": "Software for the analysis and comprehension of high-throughput genomic data"
  },
  "_mentions": 2,
  "_searchresults": 14,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/MultiMed.html",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md",
    "LICENSE",
    "manual.pdf"
  ],
  "_realowner": "bioc",
  "_cranurl": false,
  "_exports": [
    "medTest",
    "medTest.SBMH"
  ],
  "_datasets": [
    {
      "name": "NavyAdenoma",
      "title": "Data from the Sinha et al. 1999 and Boca et al. 2014 studies concerning the Navy Colorectal Adenoma case-control study.",
      "object": "NavyAdenoma",
      "file": "NavyAdenoma.RData",
      "class": [
        "data.frame"
      ],
      "fields": [
        "Fish",
        "BMI",
        "Female",
        "Age",
        "Smoking",
        "glycine",
        "serine",
        "betaine",
        "alanine",
        "N-acetylalanine",
        "N-acetyl-beta-alanine",
        "aspartate",
        "asparagine",
        "glutamate",
        "glutamine",
        "pyroglutamine*",
        "histidine",
        "lysine",
        "pipecolate",
        "N6-acetyllysine",
        "glutaroyl carnitine",
        "phenylalanine",
        "p-cresol sulfate",
        "tyrosine",
        "3-(4-hydroxyphenyl)lactate",
        "phenol sulfate",
        "kynurenine",
        "tryptophan",
        "indolelactate",
        "C-glycosyltryptophan*",
        "3-indoxyl sulfate",
        "3-methyl-2-oxobutyrate",
        "3-methyl-2-oxovalerate",
        "levulinate (4-oxovalerate)",
        "isoleucine",
        "leucine",
        "valine",
        "2-hydroxyisobutyrate",
        "3-hydroxyisobutyrate",
        "4-methyl-2-oxopentanoate",
        "alpha-hydroxyisovalerate",
        "isobutyrylcarnitine",
        "isovalerylcarnitine",
        "S-methylcysteine",
        "methionine",
        "2-hydroxybutyrate (AHB)",
        "urea",
        "proline",
        "citrulline",
        "creatine",
        "creatinine",
        "2-aminobutyrate",
        "5-oxoproline",
        "glycylvaline",
        "aspartylphenylalanine",
        "phenylalanylphenylalanine",
        "gamma-glutamylvaline",
        "gamma-glutamylleucine",
        "gamma-glutamylphenylalanine",
        "gamma-glutamylalanine",
        "ADSGEGDFXAEGGGVR*",
        "DSGEGDFXAEGGGVR*",
        "fructose",
        "mannose",
        "glycerate",
        "glucose",
        "pyruvate",
        "lactate",
        "citrate",
        "fumarate",
        "malate",
        "acetylphosphate",
        "phosphate",
        "linoleate (18:2n6)",
        "linolenate [alpha or gamma; (18:3n3 or 6)]",
        "dihomo-linolenate (20:3n3 or n6)",
        "docosapentaenoate (n3 DPA; 22:5n3)",
        "docosahexaenoate (DHA; 22:6n3)",
        "caproate (6:0)",
        "heptanoate (7:0)",
        "caprylate (8:0)",
        "pelargonate (9:0)",
        "caprate (10:0)",
        "undecanoate (11:0)",
        "10-undecenoate (11:1n1)",
        "laurate (12:0)",
        "myristate (14:0)",
        "myristoleate (14:1n5)",
        "palmitate (16:0)",
        "palmitoleate (16:1n7)",
        "10-heptadecenoate (17:1n7)",
        "stearate (18:0)",
        "oleate (18:1n9)",
        "10-nonadecenoate (19:1n9)",
        "eicosenoate (20:1n9 or 11)",
        "dihomo-linoleate (20:2n6)",
        "arachidonate (20:4n6)",
        "adrenate (22:4n6)",
        "2-hydroxystearate",
        "2-hydroxypalmitate",
        "sebacate (decanedioate)",
        "methyl palmitate (15 or 2)",
        "propionylcarnitine",
        "butyrylcarnitine",
        "isovalerate",
        "carnitine",
        "3-dehydrocarnitine*",
        "acetylcarnitine",
        "octanoylcarnitine",
        "decanoylcarnitine",
        "glycerol",
        "choline",
        "glycerol 3-phosphate (G3P)",
        "myo-inositol",
        "3-hydroxybutyrate (BHBA)",
        "1,2-propanediol",
        "1-palmitoylglycerophosphoethanolamine",
        "1-stearoylglycerophosphoethanolamine",
        "1-oleoylglycerophosphoethanolamine",
        "1-linoleoylglycerophosphoethanolamine*",
        "1-arachidonoylglycerophosphoethanolamine*",
        "1-myristoylglycerophosphocholine",
        "1-palmitoylglycerophosphocholine",
        "1-palmitoleoylglycerophosphocholine*",
        "1-stearoylglycerophosphocholine",
        "1-oleoylglycerophosphocholine",
        "1-linoleoylglycerophosphocholine",
        "1-eicosatrienoylglycerophosphocholine*",
        "1-stearoylglycerophosphoinositol",
        "1-arachidonoylglycerophosphoinositol*",
        "1-palmitoylplasmenylethanolamine*",
        "1-palmitoylglycerol (1-monopalmitin)",
        "palmitoyl sphingomyelin",
        "stearoyl sphingomyelin",
        "cholesterol",
        "cortisol",
        "7-alpha-hydroxy-3-oxo-4-cholestenoate (7-Hoca)",
        "xanthine",
        "N1-methyladenosine",
        "urate",
        "uridine",
        "pseudouridine",
        "threonate",
        "bilirubin (E,E)*",
        "pantothenate",
        "alpha-tocopherol",
        "pyridoxate",
        "hippurate",
        "catechol sulfate",
        "benzoate",
        "glycolate (hydroxyacetate)",
        "2-ethylhexanoate",
        "stachydrine",
        "erythritol",
        "Adenoma"
      ],
      "rows": 258,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "medTest",
      "title": "Permutation test for multiple mediators which uses a joint correction",
      "topics": [
        "medTest"
      ]
    },
    {
      "page": "medTest.SBMH",
      "title": "Test for multiple mediators which uses the Bogomolov and Heller approach",
      "topics": [
        "medTest.SBMH"
      ]
    },
    {
      "page": "NavyAdenoma",
      "title": "Data from the Sinha et al. 1999 and Boca et al. 2014 studies concerning the Navy Colorectal Adenoma case-control study.",
      "topics": [
        "NavyAdenoma"
      ]
    }
  ],
  "_readme": "https://github.com/bioc/MultiMed/raw/HEAD/README.md",
  "_rundeps": [],
  "_vignettes": [
    {
      "source": "MultiMed.Rnw",
      "filename": "MultiMed.pdf",
      "title": "MultiMedTutorial",
      "engine": "utils::Sweave",
      "headings": [
        "1 Overview",
        "2 Performing the test of mediation"
      ],
      "created": "2014-07-17 23:30:16",
      "modified": "2014-07-17 23:30:16",
      "commits": 1
    }
  ],
  "_score": 4.447158031342219,
  "_indexed": true,
  "_nocasepkg": "multimed",
  "_universes": [
    "bioc"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "2.35.0",
      "date": "2026-06-19T07:35:55.000Z",
      "distro": "noble",
      "commit": "70f5c457fc2119d393294be48f78cdd7124c808d",
      "fileid": "5328ff789decdec0b99bafffb9024b071cc24454d680e482f232bb24d00604fe",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/27812075066"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "2.35.0",
      "date": "2026-06-19T07:36:17.000Z",
      "distro": "noble",
      "commit": "70f5c457fc2119d393294be48f78cdd7124c808d",
      "fileid": "e54fc0d8f903ee88d8fd9ef1bcb827207c7d2e76ca4e0deef8058669d2270cdd",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/27812075066"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "2.35.0",
      "date": "2026-06-19T07:35:26.000Z",
      "commit": "70f5c457fc2119d393294be48f78cdd7124c808d",
      "fileid": "2a392c600e5bbfeb850a749b99757efc5d2bac79d72312302ca7d3dbfba95f78",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/27812075066"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "2.35.0",
      "date": "2026-06-19T07:35:46.000Z",
      "commit": "70f5c457fc2119d393294be48f78cdd7124c808d",
      "fileid": "e773bad5aeb65fbe86293086a8a945f3fa5240d78515549fac7400eb09f4c722",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/27812075066"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "2.35.0",
      "date": "2026-06-19T07:35:35.000Z",
      "commit": "70f5c457fc2119d393294be48f78cdd7124c808d",
      "fileid": "879eb0389a7b1bb6158ebbf6747d441046760e10cb895c1089e22a3b7f95bd0a",
      "status": "success",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/27812075066"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "2.35.0",
      "date": "2026-06-19T07:35:00.000Z",
      "commit": "70f5c457fc2119d393294be48f78cdd7124c808d",
      "fileid": "2d6c4c89773b71e8c87dd80512b506eaca9a5803f477229ca7d292aae1e8ec7d",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/27812075066"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "2.35.0",
      "date": "2026-06-19T07:34:51.000Z",
      "commit": "70f5c457fc2119d393294be48f78cdd7124c808d",
      "fileid": "1a7bb45b85eb4ef106820b8bb697029cb09cdb34b4dd5f9108b462f79c57f677",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/27812075066"
    },
    {
      "r": "4.6.0",
      "os": "win",
      "version": "2.35.0",
      "date": "2026-06-19T07:34:57.000Z",
      "commit": "70f5c457fc2119d393294be48f78cdd7124c808d",
      "fileid": "82b3d6b5683d817616fc55aca321aca0940e96061e1b20809d02aa8d9ddc587b",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc/actions/runs/27812075066"
    }
  ]
}