{ "_id": "6a1ac9891d7bb097a09dcd23", "Package": "INTACT", "Type": "Package", "Title": "Integrate TWAS and Colocalization Analysis for Gene Set\nEnrichment Analysis", "Version": "1.13.0", "Authors@R": "c(person(\"Jeffrey Okamoto\", role = c(\"aut\", \"cre\"),\nemail = \"jokamoto@umich.edu\",\ncomment=c(ORCID = \"0000-0001-9988-1618\")),\nperson(\"Xiaoquan Wen\", role = c(\"aut\"),\nemail = \"xwen@umich.edu\",\ncomment=c(ORCID = \"0000-0001-8990-2737\")))", "Description": "This package integrates colocalization probabilities from\ncolocalization analysis with transcriptome-wide association\nstudy (TWAS) scan summary statistics to implicate genes that\nmay be biologically relevant to a complex trait. The\nprobabilistic framework implemented in this package constrains\nthe TWAS scan z-score-based likelihood using a gene-level\ncolocalization probability. 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