{ "_id": "6a1acc371d7bb097a09de604", "Package": "HiCcompare", "Title": "HiCcompare: Joint normalization and comparative analysis of\nmultiple Hi-C datasets", "Version": "1.35.0", "Authors@R": "c(\nperson(given = \"Mikhail\",\nfamily = \"Dozmorov\",\nrole = c(\"aut\", \"cre\"),\nemail = \"mikhail.dozmorov@gmail.com\",\ncomment = c(ORCID = \"0000-0002-0086-8358\")),\nperson(given = \"Kellen\",\nfamily = \"Cresswell\",\nrole = c(\"aut\"),\nemail = \"cresswellkg@vcu.edu\"),\nperson(given = \"John\",\nfamily = \"Stansfield\",\nrole = c(\"aut\"),\nemail = \"stansfieldjc@vcu.edu\"))", "Description": "HiCcompare provides functions for joint normalization and\ndifference detection in multiple Hi-C datasets. HiCcompare\noperates on processed Hi-C data in the form of\nchromosome-specific chromatin interaction matrices. It accepts\nthree-column tab-separated text files storing chromatin\ninteraction matrices in a sparse matrix format which are\navailable from several sources. HiCcompare is designed to give\nthe user the ability to perform a comparative analysis on the\n3-Dimensional structure of the genomes of cells in different\nbiological states.`HiCcompare` differs from other packages that\nattempt to compare Hi-C data in that it works on processed data\nin chromatin interaction matrix format instead of pre-processed\nsequencing data. In addition, `HiCcompare` provides a\nnon-parametric method for the joint normalization and removal\nof biases between two Hi-C datasets for the purpose of\ncomparative analysis. `HiCcompare` also provides a simple yet\nrobust method for detecting differences between Hi-C datasets.", "biocViews": "Software, HiC, Sequencing, Normalization", "License": "MIT + file LICENSE", "Encoding": "UTF-8", "LazyData": "true", "LazyDataCompression": "xz", "RoxygenNote": "7.2.3", "VignetteBuilder": "knitr", "BugReports": "https://github.com/dozmorovlab/HiCcompare/issues", "URL": "https://github.com/dozmorovlab/HiCcompare", "Config/pak/sysreqs": "libssl-dev zlib1g-dev", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-04-28 12:46:03 UTC", "RemoteUrl": "https://github.com/bioc/HiCcompare", "RemoteRef": "HEAD", "RemoteSha": "52adf7edf3e32027a3b066fc46748365b48f7d86", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-30 08:02:56 UTC", "User": "root" }, "Author": "Mikhail 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