{ "_id": "6af46aa9f58eaab79920a00f", "Package": "HIREewas", "Type": "Package", "Title": "Detection of cell-type-specific risk-CpG sites in epigenome-wide\nassociation studies", "Version": "1.31.0", "Date": "2018-06-11", "Author": "Xiangyu Luo , Can Yang ,\nYingying Wei ", "Maintainer": "Xiangyu Luo ", "Description": "In epigenome-wide association studies, the measured\nsignals for each sample are a mixture of methylation profiles\nfrom different cell types. The current approaches to the\nassociation detection only claim whether a\ncytosine-phosphate-guanine (CpG) site is associated with the\nphenotype or not, but they cannot determine the cell type in\nwhich the risk-CpG site is affected by the phenotype. We\npropose a solid statistical method, HIgh REsolution (HIRE),\nwhich not only substantially improves the power of association\ndetection at the aggregated level as compared to the existing\nmethods but also enables the detection of risk-CpG sites for\nindividual cell types. The \"HIREewas\" R package is to implement\nHIRE model in R.", "VignetteBuilder": "knitr", "biocViews": "DNAMethylation, DifferentialMethylation, FeatureExtraction", "LazyLoad": "yes", "License": "GPL (>= 2)", "Repository": "https://bioc.r-universe.dev", "Date/Publication": "2026-04-28 12:48:54 UTC", "RemoteUrl": "https://github.com/bioc/HIREewas", "RemoteRef": "HEAD", "RemoteSha": "7edc56bd5c44cfd118989ad46daf8fe993f4aae8", "NeedsCompilation": "yes", "Packaged": { "Date": "2026-11-11 13:10:41 UTC", "User": "root" }, "_user": "bioc", "_type": "src", "_file": "HIREewas_1.31.0.tar.gz", "_fileid": "https://r2.ropensci.org/f95c092a4440a1736e02abe11ba34f05da1299a1c371df32b24190113436e602", "_filesize": 378697, "_sha256": "f95c092a4440a1736e02abe11ba34f05da1299a1c371df32b24190113436e602", "_expires": "2027-02-19T13:16:23.000Z", "_created": "2026-11-11T13:10:41.000Z", "_published": "2026-11-11T13:16:25.363Z", "_upstream": "https://github.com/bioc/HIREewas", "_status": "success", 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