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  "Description": "DifferentialRegulation is a method for detecting\ndifferentially regulated genes between two groups of samples\n(e.g., healthy vs. disease, or treated vs. untreated samples),\nby targeting differences in the balance of spliced and\nunspliced mRNA abundances, obtained from single-cell\nRNA-sequencing (scRNA-seq) data. From a mathematical point of\nview, DifferentialRegulation accounts for the sample-to-sample\nvariability, and embeds multiple samples in a Bayesian\nhierarchical model. Furthermore, our method also deals with two\nmajor sources of mapping uncertainty: i) 'ambiguous' reads,\ncompatible with both spliced and unspliced versions of a gene,\nand ii) reads mapping to multiple genes. In particular,\nambiguous reads are treated separately from spliced and\nunsplced reads, while reads that are compatible with multiple\ngenes are allocated to the gene of origin. Parameters are\ninferred via Markov chain Monte Carlo (MCMC) techniques\n(Metropolis-within-Gibbs).",
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