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  "Package": "DSS",
  "Title": "Dispersion shrinkage for sequencing data",
  "Version": "2.61.0",
  "Date": "2026-4-9",
  "Author": "Hao Wu<hao.wu@emory.edu>, Hao Feng<hxf155@case.edu>",
  "Maintainer": "Hao Wu <hao.wu@emory.edu>, Hao Feng <hxf155@case.edu>",
  "Description": "DSS is an R library performing differntial analysis for\ncount-based sequencing data. It detectes differentially\nexpressed genes (DEGs) from RNA-seq, and differentially\nmethylated loci or regions (DML/DMRs) from bisulfite sequencing\n(BS-seq). The core of DSS is a new dispersion shrinkage method\nfor estimating the dispersion parameter from Gamma-Poisson or\nBeta-Binomial distributions.",
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  "VignetteBuilder": "knitr",
  "biocViews": "Sequencing, RNASeq, DNAMethylation,GeneExpression,\nDifferentialExpression,DifferentialMethylation",
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  "Date/Publication": "2026-04-28 12:36:36 UTC",
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    "description": "Distinguished Professor in Artificial Intelligence ",
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      "title": "Dispersion shrinkage for sequencing data",
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        "DSS"
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      "page": "callDML",
      "title": "Function to detect differntially methylated loci (DML) from bisulfite sequencing (BS-seq) data.",
      "topics": [
        "callDML"
      ]
    },
    {
      "page": "callDMR",
      "title": "Function to detect differntially methylated regions (DMR) from bisulfite sequencing (BS-seq) data.",
      "topics": [
        "callDMR"
      ]
    },
    {
      "page": "design",
      "title": "Experimental design for the example RRBS dataset",
      "topics": [
        "design"
      ]
    },
    {
      "page": "dispersion",
      "title": "Acessor functions for the 'dispersion' slot in a SeqCountData object.",
      "topics": [
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        "dispersion,SeqCountSet-method",
        "dispersion<-",
        "dispersion<-,SeqCountSet,numeric-method"
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      "topics": [
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    },
    {
      "page": "DMLtest",
      "title": "Function to perform statistical test of differntially methylated loci (DML) for two group comparisons of bisulfite sequencing (BS-seq) data.",
      "topics": [
        "DMLtest"
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    },
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    {
      "page": "DSS.DE",
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      "topics": [
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      ]
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        "estDispersion,SeqCountSet-method"
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      "topics": [
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        "estNormFactors,SeqCountSet-method"
      ]
    },
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      ]
    },
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        "normalizationFactor,SeqCountSet-method",
        "normalizationFactor<-",
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      "title": "An example dataset for multiple factor design",
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        "SeqCountSet-class"
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      "title": "A simulated 'SeqCountData' object.",
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      "title": "Visualze the count data for one DMR",
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