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  "Title": "Genome-wide Detection of Differential ORF Usage",
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  "Description": "Differential open reading frame (ORF) translation analysis\nframework for ribosome profiling (Ribo-seq) with matched\nRNA-seq. Implements (i) Differential ORF Usage (DOU), a\nbeta-binomial generalized linear model that models the expected\nproportion of Ribo-seq versus RNA-seq reads mapping to each ORF\nwithin a gene, and (ii) ORF-level Differential Translation\nEfficiency (DTE), a negative binomial GLM that capture changes\nin translation efficiency of individual ORFs across\nexperimental conditions. Supports ORF-level read summarization\nfor bulk and single-cell Ribo-seq.",
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  "Date/Publication": "2026-04-28 13:06:05 UTC",
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