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  "Date": "2025-06-25",
  "Title": "Coordinate Covariation Analysis",
  "Description": "COCOA is a method for understanding epigenetic variation\namong samples. COCOA can be used with epigenetic data that\nincludes genomic coordinates and an epigenetic signal, such as\nDNA methylation and chromatin accessibility data. To describe\nthe method on a high level, COCOA quantifies inter-sample\nvariation with either a supervised or unsupervised technique\nthen uses a database of \"region sets\" to annotate the variation\namong samples. A region set is a set of genomic regions that\nshare a biological annotation, for instance transcription\nfactor (TF) binding regions, histone modification regions, or\nopen chromatin regions. COCOA can identify region sets that are\nassociated with epigenetic variation between samples and\nincrease understanding of variation in your data.",
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  "Date/Publication": "2026-04-28 12:49:01 UTC",
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      "object": "brcaPCScores",
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      "file": "brcaPCScores657.RData",
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      "page": "aggregateSignal",
      "title": "Score a region set using feature contribution scores",
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    {
      "page": "aggregateSignalGRList",
      "title": "Score many region sets",
      "topics": [
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      "page": "atf3_chr1",
      "title": "Atf3 binding regions.",
      "topics": [
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    },
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      "page": "brcaATACCoord1",
      "title": "A GRanges object with coordinates for select BRCA ATAC-seq peak regions from chr1.",
      "topics": [
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      ]
    },
    {
      "page": "brcaATACData1",
      "title": "A matrix with ATAC-seq counts in select peak regions from chromosome 1 for 37 patients.",
      "topics": [
        "brcaATACData1"
      ]
    },
    {
      "page": "brcaMCoord1",
      "title": "A GRanges object with genomic coordinates for cytosines from chr1 for the package's built-in DNA methylation data",
      "topics": [
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    },
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      "page": "brcaMetadata",
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      "topics": [
        "brcaMetadata"
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      "page": "brcaMethylData1",
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      "topics": [
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    },
    {
      "page": "brcaPCScores",
      "title": "A matrix with principal component scores for PCs 1-4 for four breast cancer patients.",
      "topics": [
        "brcaPCScores"
      ]
    },
    {
      "page": "brcaPCScores657",
      "title": "A data.frame with principal component scores for PCs 1-4 for 657 breast cancer patients as well as a column with estrogen receptor status.",
      "topics": [
        "brcaPCScores657"
      ]
    },
    {
      "page": "COCOA",
      "title": "Coordinate Covariation Analysis (COCOA)",
      "topics": [
        "COCOA"
      ]
    },
    {
      "page": "convertToFromNullDist",
      "title": "Converts COCOA permutation results to null distributions and vice versa",
      "topics": [
        "convertToFromNullDist"
      ]
    },
    {
      "page": "esr1_chr1",
      "title": "Estrogen receptor alpha binding regions.",
      "topics": [
        "esr1_chr1"
      ]
    },
    {
      "page": "gata3_chr1",
      "title": "Gata3 binding regions.",
      "topics": [
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      ]
    },
    {
      "page": "getGammaPVal",
      "title": "Get a p-value for region set scores based on a gamma distribution.",
      "topics": [
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      ]
    },
    {
      "page": "getMetaRegionProfile",
      "title": "Create a \"meta-region\" profile",
      "topics": [
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      ]
    },
    {
      "page": "getPermStat",
      "title": "Get p-value or z-score based on permutation results",
      "topics": [
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      ]
    },
    {
      "page": "getTopRegions",
      "title": "Get regions that are most associated with target variable",
      "topics": [
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    {
      "page": "nrf1_chr1",
      "title": "Nrf1 binding regions.",
      "topics": [
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    {
      "page": "plotAnnoScoreDist",
      "title": "Plot ranked region set scores, annotating groups of interest",
      "topics": [
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      ]
    },
    {
      "page": "regionQuantileByTargetVar",
      "title": "Visualize how individual regions are associated with target variable",
      "topics": [
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      ]
    },
    {
      "page": "rsRankingIndex",
      "title": "Get indices for top scored region sets",
      "topics": [
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      ]
    },
    {
      "page": "rsScoreHeatmap",
      "title": "Heatmap of region set scores",
      "topics": [
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    },
    {
      "page": "rsScores",
      "title": "Example COCOA Results (made up)",
      "topics": [
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    {
      "page": "runCOCOA",
      "title": "Run COCOA: quantify inter-sample variation, score region sets",
      "topics": [
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    },
    {
      "page": "runCOCOAPerm",
      "title": "Run COCOA permutations to get p-values",
      "topics": [
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    },
    {
      "page": "signalAlongAxis",
      "title": "Visualize how genomic signal in a region set changes along a given axis",
      "topics": [
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  "_vignettes": [
    {
      "source": "IntroToCOCOA.Rmd",
      "filename": "IntroToCOCOA.html",
      "title": "Introduction to Coordinate Covariation Analysis",
      "author": "John Lawson",
      "engine": "knitr::rmarkdown",
      "headings": [
        "The COCOA Bioconductor package",
        "Basic workflow",
        "Quantify inter-sample epigenetic variation",
        "Annotate variation with region sets",
        "Permutation test",
        "COCOA for DNA methylation data",
        "Our data",
        "Supervised COCOA",
        "Quantify relationship between chosen sample phenotype and epigenetic data",
        "Score region sets",
        "Estimating statistical significance",
        "Permutations",
        "Fit gamma distribution to null distributions and get p-values",
        "Unsupervised COCOA",
        "Quantify relationship between latent factors and epigenetic data",
        "Further understanding the results (visualization)",
        "Specificity of variation to the regions of interest",
        "The raw data",
        "Feature contribution scores of individual regions",
        "COCOA for chromatin accessibility data (ATAC-seq)",
        "Supervised COCOA",
        "Unsupervised COCOA",
        "Additional details",
        "Method details",
        "Region set database",
        "Aggregating info from individual features",
        "Making a \"meta-region\" profile",
        "Q and A",
        "Related references"
      ],
      "created": "2018-10-25 20:09:33",
      "modified": "2020-10-10 23:46:03",
      "commits": 28
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