Changes in version 1.23.1 o Sometimes prefit.beta was NaN, now properly handled in apeglm(). Resolves some "Error in optimHess" issue propagated to DESeq2. Changes in version 1.8.0 o Bringing in Josh Zitovsky's work on fast beta binomial GLM fitting in C++. Changes in version 1.5.4 o Added possibility for weights and standard errors to bbEstDisp(). The standard errors are for the log of dispersion (theta). Changes in version 1.3.2 o Fix simple bug when no sample has only intercept coefficient. Changes in version 1.2.0 o Faster fitting of Negative Binomial using RcppNumerical. Changes in version 1.0.0 o apeglm is released on Bioconductor! Methods can be accessed from within DESeq2 by calling 'lfcShrink' with type="apeglm".