Version: 1.8.0 Category: NEW FEATURES Text: Add callGenotypes function for annotating a set of tallies with diploid genotype quality, likelihoods, etc in a way that is conformant with the gVCF spec. The methods are somewhat similar to those used by the GATK UnifiedGenotyper. Version: 1.6.0 Category: NEW FEATURES Text: Add pileupVariants function as an alternative to tallyVariants for computing nucleotide pileups using Rsamtools, instead of gmapR. In the future, this should allow VariantTools to become independent of gmapR, but the full variant statistics will only be available via tallyVariants. Version: 1.6.0 Category: USER-VISIBLE CHANGES Text: See the NEWS for gmapR to learn about changes to tallyVariants output. Version: 1.4.0 Category: NEW FEATURES Text: tallyVariants will now keep ref rows if variant_strand=0; this is useful for getting information when no alts are present (e.g., for making wildtype calls). Better have a big cluster to do this over the whole genome. Version: 1.4.0 Category: NEW FEATURES Text: add a keep_extra_stats param to TallyVariantsParam; setting this to FALSE will speed things up when the extra stats are not needed. Version: 1.4.0 Category: NEW FEATURES Text: idVerify now supports VCF input like that output by GATK. Version: 1.4.0 Category: NEW FEATURES Text: callableFraction() now supports GRangesList and TranscriptDb. Version: 1.4.0 Category: USER-VISIBLE CHANGES Text: The API is now based on VRanges, a formal GRanges-derived class for representing variants; use of so-called "tally" or "variant" GRanges is deprecated. Version: 1.4.0 Category: USER-VISIBLE CHANGES Text: Disable proximity filter by default; we recommend this now only for whole genome calling. Version: 1.4.0 Category: USER-VISIBLE CHANGES Text: QA filtering is no longer a formal part of the calling pipeline; we recommend to apply QA filters "softly" via qaVariants() and use the results for diagnostics only. Version: 1.4.0 Category: USER-VISIBLE CHANGES Text: Use BiocParallel (BPPARAM argument) for tallyVariants Version: 1.4.0 Category: USER-VISIBLE CHANGES Text: VariantTallyParam deprecated; use TallyVariantsParam Version: 1.4.0 Category: BUG FIXES Text: idVerify now correctly computes cliques instead of connected components Version: 1.4.0 Category: BUG FIXES Text: use the total count, rather than the ref count when calculating the alt frequency Version: 1.2.0 Category: NEW FEATURES Text: Tally, call and export indels (using same algorithm as for SNVs). Version: 1.2.0 Category: NEW FEATURES Text: Add post-filter that discards variants that are clumped together on the chromosome (likely mapping errors). Version: 1.2.0 Category: NEW FEATURES Text: Add filter for masking regions like simple / low complexity repeats. Version: 1.2.0 Category: NEW FEATURES Text: Add a filter that performs a t-test on the alt vs. ref read positions. Version: 1.2.0 Category: NEW FEATURES Text: Add callWidtype() function for determining whether a position is variant, wildtype or uncallable, assuming the built-in variant calling filters. This is based on a power calculation that considers the coverage. Version: 1.2.0 Category: NEW FEATURES Text: Some functions for estimating concordance between samples have been added; these were developed for sample ID verification and should be considered experimental. Version: 1.2.0 Category: NEW FEATURES Text: matchVariants() utility for matching variants by pos and alt. Version: 1.2.0 Category: USER-VISIBLE CHANGES Text: The VCF output is now always in expanded form (one alt per row). The AD (allele depth) geno tag contains the REF and ALT counts, while AP (allele present) indicates presence of the REF and/or ALT allele. Besides the DP tag, all other tags were removed. These changes bring VariantTools more in line with GATK. Version: 1.2.0 Category: USER-VISIBLE CHANGES Text: Control alt and total counts are returned from callSampleSpecificVariants. Version: 1.2.0 Category: BUG FIXES Text: The power cutoff in the sample-specific algorithm was not considering the minimum alt read count filter. Version: 1.0.0 Category: Initial release Text: (start date: 12 September, 2012)