{"Hugo_Symbol":"TP53","Entrez_Gene_Id":7157,"Center":"hgsc.bcm.edu","NCBI_Build":36,"Chromosome":"17","Start_position":7519131,"End_position":7519131,"Strand":"+","Variant_Classification":"Missense_Mutation","Variant_Type":"SNP","Reference_Allele":"C","Tumor_Seq_Allele1":"C","Tumor_Seq_Allele2":"T","dbSNP_RS":"rs28934578","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-2670-01A-02W-0831-10","Matched_Norm_Sample_Barcode":"TCGA-A6-2670-10A-01W-0831-10","Match_Norm_Seq_Allele1":"C","Match_Norm_Seq_Allele2":"C","Tumor_Validation_Allele1":"C","Tumor_Validation_Allele2":"T","Match_Norm_Validation_Allele1":"C","Match_Norm_Validation_Allele2":"C","Verification_Status":"Unknown","Validation_Status":"Valid","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":"454_PCR_WGA","Sequencer":"SOLID","TranscriptID":"NM_001126114","Exon":"exon5","ChromChange":"c.G524A","AAChange":"p.R175H","COSMIC_Codon":" TP53,lung,NS,Substitution - Missense,0 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,17,7519131,C,T&fts=all","MA":1,"MA.variant":"hg18,17,7519131,C,T","MA.protein.change":"R175H","MA.Gene":"TP53","MA.link.MSA":"http://getma.org/v1/?cm=msa&ty=f&p=P53_HUMAN&rb=95&re=289&var=R175H","MA.link.PDB":"http://getma.org/v1/pdb.php?prot=P53_HUMAN&from=95&to=289&var=R175H","MA.FImpact":"high","MA.FI.score":3.63,"MA.Cytoband":"17p13.1","MA.Uniprot":"P53_HUMAN","MA.Refseq":"NP_000537","MA.MSA_height":152,"MA.TumorSuppressor":1,"MA.Oncogene":1}
{"Hugo_Symbol":"FBXW7","Entrez_Gene_Id":55294,"Center":"hgsc.bcm.edu","NCBI_Build":36,"Chromosome":"4","Start_position":153466817,"End_position":153466817,"Strand":"+","Variant_Classification":"Nonsense_Mutation","Variant_Type":"SNP","Reference_Allele":"G","Tumor_Seq_Allele1":"G","Tumor_Seq_Allele2":"A","dbSNP_RS":"novel","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-2672-01A-01W-0833-10","Matched_Norm_Sample_Barcode":"TCGA-A6-2672-10A-01W-0833-10","Match_Norm_Seq_Allele1":"G","Match_Norm_Seq_Allele2":"G","Tumor_Validation_Allele1":"G","Tumor_Validation_Allele2":"A","Match_Norm_Validation_Allele1":"G","Match_Norm_Validation_Allele2":"G","Verification_Status":"Unknown","Validation_Status":"Valid","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":"Illumina","Sequencer":"SOLID","TranscriptID":"NM_018315","Exon":"exon9","ChromChange":"c.C1195T","AAChange":"p.R399X","COSMIC_Codon":" FBXW7,haematopoietic_and_lymphoid_tissue,NS,Substitution - Missense,+1 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,4,153466817,G,A&fts=all","MA":1,"MA.variant":"hg18,4,153466817,G,A","MA.protein.change":"R479","MA.Gene":"FBXW7","MA.link.MSA":"","MA.link.PDB":"","MA.FImpact":"","MA.Cytoband":"4q31.3","MA.Uniprot":"FBXW7_HUMAN","MA.Refseq":"NP_001013433","MA.TumorSuppressor":1}
{"Hugo_Symbol":"APC","Entrez_Gene_Id":324,"Center":"hgsc.bcm.edu","NCBI_Build":36,"Chromosome":"5","Start_position":112192485,"End_position":112192485,"Strand":"+","Variant_Classification":"Nonsense_Mutation","Variant_Type":"SNP","Reference_Allele":"C","Tumor_Seq_Allele1":"C","Tumor_Seq_Allele2":"T","dbSNP_RS":"novel","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-2674-01A-02W-0831-10","Matched_Norm_Sample_Barcode":"TCGA-A6-2674-10A-01W-0831-10","Match_Norm_Seq_Allele1":"C","Match_Norm_Seq_Allele2":"C","Tumor_Validation_Allele1":".","Tumor_Validation_Allele2":".","Match_Norm_Validation_Allele1":".","Match_Norm_Validation_Allele2":".","Verification_Status":"Unknown","Validation_Status":"Unknown","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":".","Sequencer":"SOLID","TranscriptID":"NM_001127511","Exon":"exon12","ChromChange":"c.C1606T","AAChange":"p.R536X","COSMIC_Codon":" APC,ovary,NS,Substitution - Nonsense,0 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,5,112192485,C,T&fts=all","MA":1,"MA.variant":"hg18,5,112192485,C,T","MA.protein.change":"R554","MA.Gene":"APC","MA.link.MSA":"","MA.link.PDB":"","MA.FImpact":"","MA.Cytoband":"5q21-q22","MA.Uniprot":"APC_HUMAN","MA.Refseq":"NP_000029","MA.TumorSuppressor":1}
{"Hugo_Symbol":"TP53","Entrez_Gene_Id":7157,"Center":"hgsc.bcm.edu","NCBI_Build":36,"Chromosome":"17","Start_position":7518937,"End_position":7518937,"Strand":"+","Variant_Classification":"Nonsense_Mutation","Variant_Type":"SNP","Reference_Allele":"G","Tumor_Seq_Allele1":"G","Tumor_Seq_Allele2":"A","dbSNP_RS":"novel","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-2674-01A-02W-0831-10","Matched_Norm_Sample_Barcode":"TCGA-A6-2674-10A-01W-0831-10","Match_Norm_Seq_Allele1":"G","Match_Norm_Seq_Allele2":"G","Tumor_Validation_Allele1":".","Tumor_Validation_Allele2":".","Match_Norm_Validation_Allele1":".","Match_Norm_Validation_Allele2":".","Verification_Status":"Unknown","Validation_Status":"Unknown","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":".","Sequencer":"SOLID","TranscriptID":"NM_001126114","Exon":"exon6","ChromChange":"c.C637T","AAChange":"p.R213X","COSMIC_Codon":" TP53,central_nervous_system,brain,Substitution - Missense,+1 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,17,7518937,G,A&fts=all","MA":1,"MA.variant":"hg18,17,7518937,G,A","MA.protein.change":"R213","MA.Gene":"TP53","MA.link.MSA":"","MA.link.PDB":"","MA.FImpact":"","MA.Cytoband":"17p13.1","MA.Uniprot":"P53_HUMAN","MA.Refseq":"NP_000537","MA.TumorSuppressor":1,"MA.Oncogene":1}
{"Hugo_Symbol":"FBXW7","Entrez_Gene_Id":55294,"Center":"hgsc.bcm.edu","NCBI_Build":36,"Chromosome":"4","Start_position":153468834,"End_position":153468834,"Strand":"+","Variant_Classification":"Missense_Mutation","Variant_Type":"SNP","Reference_Allele":"C","Tumor_Seq_Allele1":"C","Tumor_Seq_Allele2":"T","dbSNP_RS":"novel","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-2676-01A-01W-0833-10","Matched_Norm_Sample_Barcode":"TCGA-A6-2676-10A-01W-0833-10","Match_Norm_Seq_Allele1":"C","Match_Norm_Seq_Allele2":"C","Tumor_Validation_Allele1":"C","Tumor_Validation_Allele2":"T","Match_Norm_Validation_Allele1":"C","Match_Norm_Validation_Allele2":"C","Verification_Status":"Unknown","Validation_Status":"Valid","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":"Illumina","Sequencer":"SOLID","TranscriptID":"NM_018315","Exon":"exon8","ChromChange":"c.G1154A","AAChange":"p.R385H","COSMIC_Codon":" FBXW7,large_intestine,NS,Substitution - Missense,0 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,4,153468834,C,T&fts=all","MA":1,"MA.variant":"hg18,4,153468834,C,T","MA.protein.change":"R465H","MA.Gene":"FBXW7","MA.link.MSA":"http://getma.org/v1/?cm=msa&ty=f&p=FBXW7_HUMAN&rb=451&re=487&var=R465H","MA.link.PDB":"http://getma.org/v1/pdb.php?prot=FBXW7_HUMAN&from=451&to=487&var=R465H","MA.FImpact":"high","MA.FI.score":3.865,"MA.Cytoband":"4q31.3","MA.Uniprot":"FBXW7_HUMAN","MA.Refseq":"NP_001013433","MA.MSA_height":127,"MA.TumorSuppressor":1}
{"Hugo_Symbol":"TP53","Entrez_Gene_Id":7157,"Center":"hgsc.bcm.edu","NCBI_Build":36,"Chromosome":"17","Start_position":7517864,"End_position":7517864,"Strand":"+","Variant_Classification":"Missense_Mutation","Variant_Type":"SNP","Reference_Allele":"G","Tumor_Seq_Allele1":"G","Tumor_Seq_Allele2":"A","dbSNP_RS":"rs55832599","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-2676-01A-01W-0833-10","Matched_Norm_Sample_Barcode":"TCGA-A6-2676-10A-01W-0833-10","Match_Norm_Seq_Allele1":"G","Match_Norm_Seq_Allele2":"G","Tumor_Validation_Allele1":"G","Tumor_Validation_Allele2":"A","Match_Norm_Validation_Allele1":"G","Match_Norm_Validation_Allele2":"G","Verification_Status":"Unknown","Validation_Status":"Valid","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":"Illumina","Sequencer":"SOLID","TranscriptID":"NM_001126114","Exon":"exon8","ChromChange":"c.C799T","AAChange":"p.R267W","COSMIC_Codon":" TP53,vulva,NS,Substitution - Missense,-2 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,17,7517864,G,A&fts=all","MA":1,"MA.variant":"hg18,17,7517864,G,A","MA.protein.change":"R267W","MA.Gene":"TP53","MA.link.MSA":"http://getma.org/v1/?cm=msa&ty=f&p=P53_HUMAN&rb=95&re=289&var=R267W","MA.link.PDB":"http://getma.org/v1/pdb.php?prot=P53_HUMAN&from=95&to=289&var=R267W","MA.FImpact":"high","MA.FI.score":3.87,"MA.Cytoband":"17p13.1","MA.Uniprot":"P53_HUMAN","MA.Refseq":"NP_000537","MA.MSA_height":152,"MA.TumorSuppressor":1,"MA.Oncogene":1}
{"Hugo_Symbol":"APC","Entrez_Gene_Id":324,"Center":"hgsc.bcm.edu","NCBI_Build":36,"Chromosome":"5","Start_position":112190733,"End_position":112190733,"Strand":"+","Variant_Classification":"Nonsense_Mutation","Variant_Type":"SNP","Reference_Allele":"C","Tumor_Seq_Allele1":"C","Tumor_Seq_Allele2":"T","dbSNP_RS":"novel","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-2677-01A-01W-0831-10","Matched_Norm_Sample_Barcode":"TCGA-A6-2677-10A-01W-0831-10","Match_Norm_Seq_Allele1":"C","Match_Norm_Seq_Allele2":"C","Tumor_Validation_Allele1":"C","Tumor_Validation_Allele2":"T","Match_Norm_Validation_Allele1":"C","Match_Norm_Validation_Allele2":"C","Verification_Status":"Unknown","Validation_Status":"Valid","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":"454_PCR_WGA","Sequencer":"SOLID","TranscriptID":"NM_001127511","Exon":"exon10","ChromChange":"c.C1384T","AAChange":"p.Q462X","COSMIC_Codon":".","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,5,112190733,C,T&fts=all","MA":1,"MA.variant":"hg18,5,112190733,C,T","MA.protein.change":"Q480","MA.Gene":"APC","MA.link.MSA":"","MA.link.PDB":"","MA.FImpact":"","MA.Cytoband":"5q21-q22","MA.Uniprot":"APC_HUMAN","MA.Refseq":"NP_000029","MA.TumorSuppressor":1}
{"Hugo_Symbol":"FBXW7","Entrez_Gene_Id":55294,"Center":"hgsc.bcm.edu","NCBI_Build":36,"Chromosome":"4","Start_position":153466739,"End_position":153466739,"Strand":"+","Variant_Classification":"Missense_Mutation","Variant_Type":"SNP","Reference_Allele":"G","Tumor_Seq_Allele1":"G","Tumor_Seq_Allele2":"C","dbSNP_RS":"novel","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-2677-01A-01W-0831-10","Matched_Norm_Sample_Barcode":"TCGA-A6-2677-10A-01W-0831-10","Match_Norm_Seq_Allele1":"G","Match_Norm_Seq_Allele2":"G","Tumor_Validation_Allele1":".","Tumor_Validation_Allele2":".","Match_Norm_Validation_Allele1":".","Match_Norm_Validation_Allele2":".","Verification_Status":"Unknown","Validation_Status":"Unknown","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":".","Sequencer":"SOLID","TranscriptID":"NM_018315","Exon":"exon9","ChromChange":"c.C1273G","AAChange":"p.R425G","COSMIC_Codon":" FBXW7,haematopoietic_and_lymphoid_tissue,NS,Substitution - Missense,0 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,4,153466739,G,C&fts=all","MA":1,"MA.variant":"hg18,4,153466739,G,C","MA.protein.change":"R505G","MA.Gene":"FBXW7","MA.link.MSA":"http://getma.org/v1/?cm=msa&ty=f&p=FBXW7_HUMAN&rb=491&re=527&var=R505G","MA.link.PDB":"http://getma.org/v1/pdb.php?prot=FBXW7_HUMAN&from=491&to=527&var=R505G","MA.FImpact":"high","MA.FI.score":3.545,"MA.Cytoband":"4q31.3","MA.Uniprot":"FBXW7_HUMAN","MA.Refseq":"NP_001013433","MA.MSA_height":136,"MA.TumorSuppressor":1}
{"Hugo_Symbol":"CTNNB1","Entrez_Gene_Id":1499,"Center":"hgsc.bcm.edu","NCBI_Build":36,"Chromosome":"3","Start_position":41241105,"End_position":41241105,"Strand":"+","Variant_Classification":"Missense_Mutation","Variant_Type":"SNP","Reference_Allele":"C","Tumor_Seq_Allele1":"C","Tumor_Seq_Allele2":"G","dbSNP_RS":"novel","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-2678-01A-01W-0831-10","Matched_Norm_Sample_Barcode":"TCGA-A6-2678-10A-01W-0831-10","Match_Norm_Seq_Allele1":"C","Match_Norm_Seq_Allele2":"C","Tumor_Validation_Allele1":"C","Tumor_Validation_Allele2":"G","Match_Norm_Validation_Allele1":"C","Match_Norm_Validation_Allele2":"C","Verification_Status":"Unknown","Validation_Status":"Valid","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":"454_PCR_WGA","Sequencer":"SOLID","TranscriptID":"NM_001098210","Exon":"exon3","ChromChange":"c.C98G","AAChange":"p.S33C","COSMIC_Codon":" CTNNB1,biliary_tract,gallbladder,Substitution - Missense,+1 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,3,41241105,C,G&fts=all","MA":1,"MA.variant":"hg18,3,41241105,C,G","MA.protein.change":"S33C","MA.Gene":"CTNNB1","MA.link.MSA":"http://getma.org/v1/?cm=msa&ty=f&p=CTNB1_HUMAN&rb=1&re=200&var=S33C","MA.link.PDB":"http://getma.org/v1/pdb.php?prot=CTNB1_HUMAN&from=1&to=200&var=S33C","MA.FImpact":"medium","MA.FI.score":3.285,"MA.Cytoband":"","MA.Uniprot":"CTNB1_HUMAN","MA.Refseq":"NP_001091680","MA.MSA_height":61}
{"Hugo_Symbol":"NRAS","Entrez_Gene_Id":4893,"Center":"hgsc.bcm.edu","NCBI_Build":36,"Chromosome":"1","Start_position":115058052,"End_position":115058052,"Strand":"+","Variant_Classification":"Missense_Mutation","Variant_Type":"SNP","Reference_Allele":"T","Tumor_Seq_Allele1":"T","Tumor_Seq_Allele2":"A","dbSNP_RS":"novel","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-2678-01A-01W-0831-10","Matched_Norm_Sample_Barcode":"TCGA-A6-2678-10A-01W-0831-10","Match_Norm_Seq_Allele1":"T","Match_Norm_Seq_Allele2":"T","Tumor_Validation_Allele1":"T","Tumor_Validation_Allele2":"A","Match_Norm_Validation_Allele1":"T","Match_Norm_Validation_Allele2":"T","Verification_Status":"Unknown","Validation_Status":"Valid","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":"454_PCR_WGA","Sequencer":"SOLID","TranscriptID":"NM_002524","Exon":"exon3","ChromChange":"c.A182T","AAChange":"p.Q61L","COSMIC_Codon":" NRAS,haematopoietic_and_lymphoid_tissue,NS,Substitution - Missense,-1 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,1,115058052,T,A&fts=all","MA":1,"MA.variant":"hg18,1,115058052,T,A","MA.protein.change":"Q61L","MA.Gene":"NRAS","MA.link.MSA":"http://getma.org/v1/?cm=msa&ty=f&p=RASN_HUMAN&rb=5&re=165&var=Q61L","MA.link.PDB":"http://getma.org/v1/pdb.php?prot=RASN_HUMAN&from=5&to=165&var=Q61L","MA.FImpact":"high","MA.FI.score":4.415,"MA.Cytoband":"1p13.2","MA.Uniprot":"RASN_HUMAN","MA.Refseq":"NP_002515","MA.MSA_height":225,"MA.Oncogene":1}
{"Hugo_Symbol":"TP53","Entrez_Gene_Id":7157,"Center":"hgsc.bcm.edu","NCBI_Build":36,"Chromosome":"17","Start_position":7518988,"End_position":7518988,"Strand":"+","Variant_Classification":"Nonsense_Mutation","Variant_Type":"SNP","Reference_Allele":"G","Tumor_Seq_Allele1":"G","Tumor_Seq_Allele2":"A","dbSNP_RS":"novel","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-2678-01A-01W-0831-10","Matched_Norm_Sample_Barcode":"TCGA-A6-2678-10A-01W-0831-10","Match_Norm_Seq_Allele1":"G","Match_Norm_Seq_Allele2":"G","Tumor_Validation_Allele1":"G","Tumor_Validation_Allele2":"A","Match_Norm_Validation_Allele1":"G","Match_Norm_Validation_Allele2":"G","Verification_Status":"Unknown","Validation_Status":"Valid","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":"454_PCR_WGA","Sequencer":"SOLID","TranscriptID":"NM_001126114","Exon":"exon6","ChromChange":"c.C586T","AAChange":"p.R196X","COSMIC_Codon":" TP53,central_nervous_system,brain,Substitution - Missense,-2 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,17,7518988,G,A&fts=all","MA":1,"MA.variant":"hg18,17,7518988,G,A","MA.protein.change":"R196","MA.Gene":"TP53","MA.link.MSA":"","MA.link.PDB":"","MA.FImpact":"","MA.Cytoband":"17p13.1","MA.Uniprot":"P53_HUMAN","MA.Refseq":"NP_000537","MA.TumorSuppressor":1,"MA.Oncogene":1}
{"Hugo_Symbol":"KRAS","Entrez_Gene_Id":3845,"Center":"hgsc.bcm.edu","NCBI_Build":36,"Chromosome":"12","Start_position":25289551,"End_position":25289551,"Strand":"+","Variant_Classification":"Missense_Mutation","Variant_Type":"SNP","Reference_Allele":"C","Tumor_Seq_Allele1":"C","Tumor_Seq_Allele2":"A","dbSNP_RS":"novel","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-2683-01A-01W-0831-10","Matched_Norm_Sample_Barcode":"TCGA-A6-2683-10A-01W-0831-10","Match_Norm_Seq_Allele1":"C","Match_Norm_Seq_Allele2":"C","Tumor_Validation_Allele1":"C","Tumor_Validation_Allele2":"A","Match_Norm_Validation_Allele1":"C","Match_Norm_Validation_Allele2":"C","Verification_Status":"Unknown","Validation_Status":"Valid","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":"454_PCR_WGA","Sequencer":"SOLID","TranscriptID":"NM_004985","Exon":"exon2","ChromChange":"c.G35T","AAChange":"p.G12V","COSMIC_Codon":" KRAS,haematopoietic_and_lymphoid_tissue,NS,Substitution - Missense,0 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,12,25289551,C,A&fts=all","MA":1,"MA.variant":"hg18,12,25289551,C,A","MA.protein.change":"G12V","MA.Gene":"KRAS","MA.link.MSA":"http://getma.org/v1/?cm=msa&ty=f&p=RASK_HUMAN&rb=5&re=165&var=G12V","MA.link.PDB":"http://getma.org/v1/pdb.php?prot=RASK_HUMAN&from=5&to=165&var=G12V","MA.FImpact":"high","MA.FI.score":3.895,"MA.Cytoband":"12p12.1","MA.Uniprot":"RASK_HUMAN","MA.Refseq":"NP_004976","MA.MSA_height":219,"MA.TumorSuppressor":1,"MA.Oncogene":1}
{"Hugo_Symbol":"TP53","Entrez_Gene_Id":7157,"Center":"hgsc.bcm.edu","NCBI_Build":36,"Chromosome":"17","Start_position":7519131,"End_position":7519131,"Strand":"+","Variant_Classification":"Missense_Mutation","Variant_Type":"SNP","Reference_Allele":"C","Tumor_Seq_Allele1":"C","Tumor_Seq_Allele2":"T","dbSNP_RS":"rs28934578","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-2683-01A-01W-0831-10","Matched_Norm_Sample_Barcode":"TCGA-A6-2683-10A-01W-0831-10","Match_Norm_Seq_Allele1":"C","Match_Norm_Seq_Allele2":"C","Tumor_Validation_Allele1":"C","Tumor_Validation_Allele2":"T","Match_Norm_Validation_Allele1":"C","Match_Norm_Validation_Allele2":"C","Verification_Status":"Unknown","Validation_Status":"Valid","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":"454_PCR_WGA","Sequencer":"SOLID","TranscriptID":"NM_001126114","Exon":"exon5","ChromChange":"c.G524A","AAChange":"p.R175H","COSMIC_Codon":" TP53,lung,NS,Substitution - Missense,0 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,17,7519131,C,T&fts=all","MA":1,"MA.variant":"hg18,17,7519131,C,T","MA.protein.change":"R175H","MA.Gene":"TP53","MA.link.MSA":"http://getma.org/v1/?cm=msa&ty=f&p=P53_HUMAN&rb=95&re=289&var=R175H","MA.link.PDB":"http://getma.org/v1/pdb.php?prot=P53_HUMAN&from=95&to=289&var=R175H","MA.FImpact":"high","MA.FI.score":3.63,"MA.Cytoband":"17p13.1","MA.Uniprot":"P53_HUMAN","MA.Refseq":"NP_000537","MA.MSA_height":152,"MA.TumorSuppressor":1,"MA.Oncogene":1}
{"Hugo_Symbol":"APC","Entrez_Gene_Id":324,"Center":"broad.mit.edu","NCBI_Build":36,"Chromosome":"5","Start_position":112144491,"End_position":112144491,"Strand":"+","Variant_Classification":"Nonsense_Mutation","Variant_Type":"SNP","Reference_Allele":"C","Tumor_Seq_Allele1":"T","Tumor_Seq_Allele2":"T","dbSNP_RS":"novel","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-3807-01A-01W-0995-10","Matched_Norm_Sample_Barcode":"TCGA-A6-3807-11A-01W-0995-10","Match_Norm_Seq_Allele1":"C","Match_Norm_Seq_Allele2":"C","Tumor_Validation_Allele1":"","Tumor_Validation_Allele2":"","Match_Norm_Validation_Allele1":"","Match_Norm_Validation_Allele2":"","Verification_Status":"Unknown","Validation_Status":"Unknown","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":"","Sequencer":"Illumina HiSeq","TranscriptID":"NM_001127511","Exon":"exon5","ChromChange":"c.C667T","AAChange":"p.R223X","COSMIC_Codon":" APC,large_intestine,rectum,Substitution - Nonsense,0 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,5,112144491,C,T&fts=all","MA":1,"MA.variant":"hg18,5,112144491,C,T","MA.protein.change":"R213","MA.Gene":"APC","MA.link.MSA":"","MA.link.PDB":"","MA.FImpact":"","MA.Cytoband":"5q21-q22","MA.Uniprot":"APC_HUMAN","MA.Refseq":"NP_000029","MA.TumorSuppressor":1}
{"Hugo_Symbol":"FBXW7","Entrez_Gene_Id":55294,"Center":"broad.mit.edu","NCBI_Build":36,"Chromosome":"4","Start_position":153466739,"End_position":153466739,"Strand":"+","Variant_Classification":"Missense_Mutation","Variant_Type":"SNP","Reference_Allele":"G","Tumor_Seq_Allele1":"A","Tumor_Seq_Allele2":"A","dbSNP_RS":"novel","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-3807-01A-01W-0995-10","Matched_Norm_Sample_Barcode":"TCGA-A6-3807-11A-01W-0995-10","Match_Norm_Seq_Allele1":"G","Match_Norm_Seq_Allele2":"G","Tumor_Validation_Allele1":"","Tumor_Validation_Allele2":"","Match_Norm_Validation_Allele1":"","Match_Norm_Validation_Allele2":"","Verification_Status":"Unknown","Validation_Status":"Unknown","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":"","Sequencer":"Illumina HiSeq","TranscriptID":"NM_018315","Exon":"exon9","ChromChange":"c.C1273T","AAChange":"p.R425C","COSMIC_Codon":" FBXW7,haematopoietic_and_lymphoid_tissue,NS,Substitution - Missense,0 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,4,153466739,G,A&fts=all","MA":1,"MA.variant":"hg18,4,153466739,G,A","MA.protein.change":"R505C","MA.Gene":"FBXW7","MA.link.MSA":"http://getma.org/v1/?cm=msa&ty=f&p=FBXW7_HUMAN&rb=491&re=527&var=R505C","MA.link.PDB":"http://getma.org/v1/pdb.php?prot=FBXW7_HUMAN&from=491&to=527&var=R505C","MA.FImpact":"high","MA.FI.score":3.545,"MA.Cytoband":"4q31.3","MA.Uniprot":"FBXW7_HUMAN","MA.Refseq":"NP_001013433","MA.MSA_height":136,"MA.TumorSuppressor":1}
{"Hugo_Symbol":"TP53","Entrez_Gene_Id":7157,"Center":"broad.mit.edu","NCBI_Build":36,"Chromosome":"17","Start_position":7518298,"End_position":7518298,"Strand":"+","Variant_Classification":"Nonsense_Mutation","Variant_Type":"SNP","Reference_Allele":"G","Tumor_Seq_Allele1":"C","Tumor_Seq_Allele2":"C","dbSNP_RS":"novel","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-A6-3807-01A-01W-0995-10","Matched_Norm_Sample_Barcode":"TCGA-A6-3807-11A-01W-0995-10","Match_Norm_Seq_Allele1":"G","Match_Norm_Seq_Allele2":"G","Tumor_Validation_Allele1":"G","Tumor_Validation_Allele2":"C","Match_Norm_Validation_Allele1":"G","Match_Norm_Validation_Allele2":"G","Verification_Status":"Unknown","Validation_Status":"Valid","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":"454_PCR_WGA","Sequencer":"Illumina HiSeq","TranscriptID":"NM_001126114","Exon":"exon7","ChromChange":"c.C708G","AAChange":"p.Y236X","COSMIC_Codon":" TP53,haematopoietic_and_lymphoid_tissue,NS,Substitution - Missense,-1 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,17,7518298,G,C&fts=all","MA":1,"MA.variant":"hg18,17,7518298,G,C","MA.protein.change":"Y236","MA.Gene":"TP53","MA.link.MSA":"","MA.link.PDB":"","MA.FImpact":"","MA.Cytoband":"17p13.1","MA.Uniprot":"P53_HUMAN","MA.Refseq":"NP_000537","MA.TumorSuppressor":1,"MA.Oncogene":1}
{"Hugo_Symbol":"FBXW7","Entrez_Gene_Id":55294,"Center":"hgsc.bcm.edu","NCBI_Build":36,"Chromosome":"4","Start_position":153552369,"End_position":153552369,"Strand":"+","Variant_Classification":"Nonsense_Mutation","Variant_Type":"SNP","Reference_Allele":"G","Tumor_Seq_Allele1":"G","Tumor_Seq_Allele2":"A","dbSNP_RS":"novel","dbSNP_Val_Status":"unknown","Tumor_Sample_Barcode":"TCGA-AA-3516-01A-02W-0833-10","Matched_Norm_Sample_Barcode":"TCGA-AA-3516-10A-01W-0833-10","Match_Norm_Seq_Allele1":"G","Match_Norm_Seq_Allele2":"G","Tumor_Validation_Allele1":"G","Tumor_Validation_Allele2":"A","Match_Norm_Validation_Allele1":"G","Match_Norm_Validation_Allele2":"G","Verification_Status":"Unknown","Validation_Status":"Valid","Mutation_Status":"Somatic","Sequencing_Phase":"Phase_I","Sequence_Source":"Capture","Validation_Method":"Illumina","Sequencer":"SOLID","TranscriptID":"NM_033632","Exon":"exon2","ChromChange":"c.C37T","AAChange":"p.R13X","COSMIC_Codon":" FBXW7,kidney,NS,Substitution - Nonsense,0 ","COSMIC_Gene":".","Drug_Target":".","MA.link.var":"http://getma.org/v1/?cm=var&var=hg18,4,153552369,G,A&fts=all","MA":1,"MA.variant":"hg18,4,153552369,G,A","MA.protein.change":"R13","MA.Gene":"FBXW7","MA.link.MSA":"","MA.link.PDB":"","MA.FImpact":"","MA.Cytoband":"4q31.3","MA.Uniprot":"FBXW7_HUMAN","MA.Refseq":"NP_361014","MA.TumorSuppressor":1}