SUITOR: selecting the number of mutational signatures through cross-validation

Introduction

For the de novo mutational signature analysis, estimating the correct number of signatures is the crucial starting point, since it influences all the downstream steps, including extraction of signature profiles, estimation of signature activities and classification of tumors based on the andestimated activities. Here we present an R package SUITOR, an unsupervised cross-validation tool to select the optimal number of signatures. The two main functions are suitor() and suitorExtractWH().

For more information please refer to the package user maunual and vignette.

Installation

To install from Bioconductor:

  if (!requireNamespace("BiocManager", quietly = TRUE)) install.packages("BiocManager") 
  BiocManager::install("SUITOR")