# -------------------------------------------- # CITATION file created with {cffr} R package # See also: https://docs.ropensci.org/cffr/ # -------------------------------------------- cff-version: 1.2.0 message: 'To cite package "STdeconvolve" in publications use:' type: software license: GPL-3.0-only title: 'STdeconvolve: Reference-free Cell-Type Deconvolution of Multi-Cellular Spatially Resolved Transcriptomics Data' version: 1.9.0 abstract: STdeconvolve as an unsupervised, reference-free approach to infer latent cell-type proportions and transcriptional profiles within multi-cellular spatially-resolved pixels from spatial transcriptomics (ST) datasets. STdeconvolve builds on latent Dirichlet allocation (LDA), a generative statistical model commonly used in natural language processing for discovering latent topics in collections of documents. In the context of natural language processing, given a count matrix of words in documents, LDA infers the distribution of words for each topic and the distribution of topics in each document. In the context of ST data, given a count matrix of gene expression in multi-cellular ST pixels, STdeconvolve applies LDA to infer the putative transcriptional profile for each cell-type and the proportional representation of each cell-type in each multi-cellular ST pixel. authors: - family-names: Miller given-names: Brendan email: bmill3r@gmail.com orcid: https://orcid.org/0000-0002-9559-4045 - family-names: Fan given-names: Jean email: jeanfan@jhu.edu orcid: https://orcid.org/0000-0002-0212-5451 repository: https://bioc.r-universe.dev repository-code: https://github.com/JEFworks-Lab/STdeconvolve url: https://jef.works/STdeconvolve/ contact: - family-names: Miller given-names: Brendan email: bmill3r@gmail.com orcid: https://orcid.org/0000-0002-9559-4045