Changes in version 0.99.1 - Added an Installation section to the package vignette with Bioconductor installation instructions using BiocManager. - Replaced protected_rows <- 1:2 with protected_rows <- c(1, 2) in R/rpbc-engine.R; this does not change the statistical behavior of RPBC. Changes in version 0.99.0 - Initial Bioconductor submission. - Implemented Ordinary RPBC for preserving the patient-balanced population-average regional effect while harmonizing patient-associated nuisance variation. - Implemented Adaptive RPBC with group-size-dependent stabilization of patient-region scale adjustments. - Implemented Covariate-adjusted RPBC for protecting prespecified patient-level covariate-associated variation. - Added support for SingleCellExperiment and SpatialExperiment objects. - Added the haley_gbm_example dataset, package vignette, documentation, and test suite.