NEWS

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RPBC 0.99.1

• Added an Installation section to the package vignette with Bioconductor installation instructions using BiocManager.
• Replaced protected_rows <- 1:2 with protected_rows <- c(1, 2) in R/rpbc-engine.R; this does not change the statistical behavior of RPBC.

RPBC 0.99.0

• Initial Bioconductor submission.
• Implemented Ordinary RPBC for preserving the patient-balanced population-average regional effect while harmonizing patient-associated nuisance variation.
• Implemented Adaptive RPBC with group-size-dependent stabilization of patient-region scale adjustments.
• Implemented Covariate-adjusted RPBC for protecting prespecified patient-level covariate-associated variation.
• Added support for SingleCellExperiment and SpatialExperiment objects.
• Added the haley_gbm_example dataset, package vignette, documentation, and test suite.