Package: RNAsense Type: Package Title: Analysis of Time-Resolved RNA-Seq Data Version: 1.27.0 Authors@R: c(person("Marcus", "Rosenblatt", email = "marcus.rosenblatt@gmail.com", role = "cre"), person("Gao", "Meijang", role = "aut"), person("Helge", "Hass", role = "aut"), person("Daria", "Onichtchouk", role = "aut")) Description: RNA-sense tool compares RNA-seq time curves in two experimental conditions, i.e. wild-type and mutant, and works in three steps. At Step 1, it builds expression profile for each transcript in one condition (i.e. wild-type) and tests if the transcript abundance grows or decays significantly. Dynamic transcripts are then sorted to non-overlapping groups (time profiles) by the time point of switch up or down. At Step 2, RNA-sense outputs the groups of differentially expressed transcripts, which are up- or downregulated in the mutant compared to the wild-type at each time point. At Step 3, Correlations (Fisher's exact test) between the outputs of Step 1 (switch up- and switch down- time profile groups) and the outputs of Step2 (differentially expressed transcript groups) are calculated. The results of the correlation analysis are printed as two-dimensional color plot, with time profiles and differential expression groups at y- and x-axis, respectively, and facilitates the biological interpretation of the data. License: GPL-3 Encoding: UTF-8 LazyData: false Depends: R (>= 3.6) RoxygenNote: 6.1.1 BugReports: https://github.com/marcusrosenblatt/RNAsense biocViews: RNASeq, GeneExpression, DifferentialExpression Imports: ggplot2, parallel, NBPSeq, qvalue, SummarizedExperiment, stats, utils, methods Suggests: knitr, rmarkdown VignetteBuilder: knitr Config/pak/sysreqs: libicu-dev zlib1g-dev Repository: https://bioc.r-universe.dev Date/Publication: 2026-04-28 12:51:23 UTC RemoteUrl: https://github.com/bioc/RNAsense RemoteRef: HEAD RemoteSha: 329cc51125c26c3d432d04dc7f71ce033167eb7e NeedsCompilation: no Packaged: 2026-06-18 11:26:10 UTC; root Author: Marcus Rosenblatt [cre], Gao Meijang [aut], Helge Hass [aut], Daria Onichtchouk [aut] Maintainer: Marcus Rosenblatt