Package: QUBIC Type: Package Title: An R Package for Qualitative Biclustering in Support of Gene Co-Expression Analyses Description: The core function of this R package is to provide the implementation of the well-cited and well-reviewed QUBIC algorithm, aiming to deliver an effective and efficient biclustering capability. This package also includes the following related functions: (i) a qualitative representation of the input gene expression data, through a well-designed discretization way considering the underlying data property, which can be directly used in other biclustering programs; (ii) visualization of identified biclusters using heatmap in support of overall expression pattern analysis; (iii) bicluster-based co-expression network elucidation and visualization, where different correlation coefficient scores between a pair of genes are provided; and (iv) a generalize output format of biclusters and corresponding network can be freely downloaded so that a user can easily do following comprehensive functional enrichment analysis (e.g. DAVID) and advanced network visualization (e.g. Cytoscape). Authors@R: c(person("Yu", "Zhang", role = c("aut", "cre"), email = "zy26@jlu.edu.cn"), person("Qin", "Ma", role = "aut", email = "qin.ma@sdstate.edu")) VignetteBuilder: knitr biocViews: StatisticalMethod, Microarray, DifferentialExpression, MultipleComparison, Clustering, Visualization, GeneExpression, Network Version: 1.41.0 License: CC BY-NC-ND 4.0 + file LICENSE Encoding: UTF-8 Depends: R (>= 4.5.0) Imports: Rcpp (>= 0.11.0), methods, Matrix LinkingTo: Rcpp, RcppArmadillo Suggests: QUBICdata, qgraph, fields, knitr, rmarkdown SystemRequirements: C++11, Rtools (>= 3.1) Enhances: RColorBrewer URL: https://github.com/zy26/QUBIC BugReports: https://github.com/zy26/QUBIC/issues Repository: https://bioc.r-universe.dev Date/Publication: 2026-04-28 12:43:11 UTC RemoteUrl: https://github.com/bioc/QUBIC RemoteRef: HEAD RemoteSha: 98c3be30403637c9979e0af80f9e8e021dab74b6 NeedsCompilation: yes Packaged: 2026-07-03 22:53:10 UTC; root Author: Yu Zhang [aut, cre], Qin Ma [aut] Maintainer: Yu Zhang