Package: ORFik Type: Package Title: Open Reading Frames in Genomics Version: 1.33.0 Encoding: UTF-8 Authors@R: c( person(given = "Haakon", family = "Tjeldnes", email = "hauken_heyken@hotmail.com", role = c("aut", "cre", "dtc"), comment = c(ORCID = "0000-0002-2077-747X")), person(given = "Kornel", family = "Labun", email = "kornellabun@gmail.com", role = c("aut", "cph")), person(given = "Michal", family = "Swirski", email = "michal.swirski@uw.edu.pl", role = c("ctb")), person(given = "Katarzyna", family = "Chyzynska", email = "katchyz@gmail.com", role = c("ctb", "dtc")), person(given = "Yamila", family = "Torres Cleuren", email = "yamilatorrescleuren@gmail.com", role = c("ctb", "ths")), person(given = "Eivind", family = "Valen", email = "eivind.valen@gmail.com", role = c("ths", "fnd"))) Description: R package for analysis of transcript and translation features through manipulation of sequence data and NGS data like Ribo-Seq, RNA-Seq, TCP-Seq and CAGE. It is generalized in the sense that any transcript region can be analysed, as the name hints to it was made with investigation of ribosomal patterns over Open Reading Frames (ORFs) as it's primary use case. ORFik is extremely fast through use of C++, data.table and GenomicRanges. Package allows to reassign starts of the transcripts with the use of CAGE-Seq data, automatic shifting of RiboSeq reads, finding of Open Reading Frames for whole genomes and much more. biocViews: ImmunoOncology, Software, Sequencing, RiboSeq, RNASeq, FunctionalGenomics, Coverage, Alignment, DataImport License: MIT + file LICENSE BugReports: https://github.com/Roleren/ORFik/issues URL: https://github.com/Roleren/ORFik Depends: R (>= 4.1.0), IRanges (>= 2.17.1), GenomicRanges (>= 1.35.1), GenomicAlignments (>= 1.19.0) Imports: AnnotationDbi (>= 1.45.0), Biostrings (>= 2.51.1), biomaRt, biomartr (>= 1.0.7), BiocFileCache, BiocGenerics (>= 0.29.1), BiocParallel (>= 1.19.0), BSgenome, cowplot (>= 1.0.0), data.table (>= 1.11.8), DESeq2 (>= 1.24.0), fst (>= 0.9.2), GenomeInfoDb (>= 1.15.5), GenomicFeatures (>= 1.31.10), ggplot2 (>= 2.2.1), gridExtra (>= 2.3), httr (>= 1.3.0), jsonlite, methods (>= 3.6.0), qs2, R.utils, Rcpp (>= 1.0.0), Rsamtools (>= 1.35.0), rtracklayer (>= 1.43.0), stats, SummarizedExperiment (>= 1.14.0), S4Vectors (>= 0.21.3), tools, txdbmaker, utils, XML, xml2 (>= 1.2.0), withr RoxygenNote: 7.3.3 Suggests: testthat, rmarkdown, knitr, BiocStyle, BSgenome.Hsapiens.UCSC.hg19, GenomeInfoDbData LinkingTo: Rcpp VignetteBuilder: knitr Config/pak/sysreqs: cmake make libbz2-dev libicu-dev liblzma-dev libpng-dev libuv1-dev libxml2-dev libssl-dev libx11-dev xz-utils zlib1g-dev Repository: https://bioc.r-universe.dev Date/Publication: 2026-04-28 12:47:59 UTC RemoteUrl: https://github.com/bioc/ORFik RemoteRef: HEAD RemoteSha: bcf19ce8103042e4b1babe8e2399223f3dd45dc6 NeedsCompilation: yes Packaged: 2026-06-23 16:03:44 UTC; root Author: Haakon Tjeldnes [aut, cre, dtc] (ORCID: ), Kornel Labun [aut, cph], Michal Swirski [ctb], Katarzyna Chyzynska [ctb, dtc], Yamila Torres Cleuren [ctb, ths], Eivind Valen [ths, fnd] Maintainer: Haakon Tjeldnes