Changes in version 2.22.1 (2018-02-01)                 

    o   Fixed some bugs.

                 Changes in version 2.14.1 (2016-02-11)                 

    o   NOISeqBIO has been modified when few replicates are available and the computation time has been drastically removed.  

    o   Gene clustering in NOISeqBIO when few replicates are available: It will be done when total number of samples is 9 or less (instead of 10 or less).

    o   Fixed a bug in "biotype detection" plot. It failed when none of the genes in the sample had values = 0.

    o   Corrected an error in the calculation of standard deviation of D statistic in NOISeqBIO.

                 Changes in version 2.14.0 (2015-08-05)                 

    o   Fixed a bug in "MD" plot

    o   Fixed a bug in NOISeq-sim (i.e. noiseq function for no replicates)

                 Changes in version 2.12.0 (2015-06-09)                 

    o   New "biotype detection" plot for comparing two samples or conditions. Also a proportion test is performed to compare the abundance of a given biotype between two samples/condtions.

    o   New functions to generate Principal Component Analysis plots from either NOISeq object or expression matrix.

    o   New ARSyNseq function to correct batch effect or reduce noise from unknown sources when batch information is not available.

    o   Quality Control PDF report now includes the new "biotype detection" plot and PCA.

    o   The User's Guide has been improved and extended to include the new functionalities.

    o   Bugs were fixed.

                 Changes in version 2.6.0 (2014-02-24)                  

    o   Fixed bug in dat() function. Now data with two samples are allowed.

    o   dat() function was also modified so parameter "norm" is accepted for "countsbio", "lengthbias" and "GCbias" plots.

                 Changes in version 2.4.0 (2013-11-20)                  

    o   A bug in "RNA composition" plot was fixed.

    o   The "CountsBio" barplot has been modified.

    o   User's guide and Reference manual have been improved.

    o   A bug in "Saturation" plot has been fixed.

    o   Normalization function has been modified so the user may choose the possibility of not applying a length correction although the length is provided.

    o   NOISeqBIO results now include the log fold change (log2FC).

    o   MD plot is now available also for NOISeqBIO results and D is plotted in log-scale.

    o   A bug in "explo.plot" function has been fixed.

                 Changes in version 2.2.0 (2013-10-14)                  

    o   New function to generate a Quality Control Report in PDF format including all the exploratory plots.

    o   Plot to evaluate RNA composition bias has been changed.

    o   Some bugs have been fixed.

                 Changes in version 2.0.0 (2013-07-25)                  

    o   Included the new version of NOISeq for biological replicates: NOISeqBIO

    o   Improved the exploratory plots for the quality control of the data that now include diagnostic plots for bias detection

    o   Included a function to filter out low count features

    o   Fixed the readData function so it can read the chromosome information if the chromosomes are not in numeric format.

    o   The NOISeq output includes now the biotype information, if provided to the readData function.

    o   A new exploratory plot for differential expression results has been added to the DE.plot function, in which the distribution of differentially expressed features across chromosomes or biotypes is shown.