Macarron User Manual

Abstract

Macarron is a workflow to systematically annotate and prioritize potentially bioactive (and often unannotated) small molecules in microbial community metabolomic datasets. Macarron prioritizes metabolic features as potentially bioactive in a phenotype/condition of interest using a combination of (a) covariance with annotated metabolites, (b) ecological properties such as abundance with respect to covarying annotated compounds, and (c) differential abundance in the phenotype/condition of interest.

If you have questions, please direct it to: Macarron Forum

Installation

Macarron requires R version 4.2.0 or higher. Install Bioconductor and then install Macarron:

if(!requireNamespace("BiocManager", quietly = TRUE))
    install.packages("BiocManager")
BiocManager::install("Macarron")

Running Macarron

Macarron can be run from the command line or as an R function. Both methods require the same arguments, have the same options, and use the same default settings. The package includes the wrapper Macarron() as well as functions which perform different steps in the Macarron framework.

Input CSV files

Macarron requires 4 comma-separated, appropriately formatted input files. The files and their formatting constraints are described below.

  1. Metabolic features abundances
    • Must contain features in rows and samples in columns.
    • First column must identify features.
  2. Metabolic features annotations
    • Must contain features in rows and annotations in columns.
    • First column must identify features.
    • Second column must contain either HMDB ID or PubChem Compound Identifier (CID).
    • Third column must contain the name of the metabolite.
    • Fourth column must contain a continuous chemical property such as m/z or RT or shift/ppm.
    • Other annotations such as RT, m/z or other identifiers can be listed column 4 onward.
  3. Sample metadata
    • Must contain samples in rows and metadata in columns.
    • First column must identify samples.
    • Second column must contain categorical metadata relevant to prioritization such as phenotypes, exposures or environments.
  4. Chemical taxonomy
    • First column must contain the HMDB ID or PubChem CID. IDs must be consistent between annotation and taxonomy files.
    • Second and third columns must contain chemical subclass and class of the respective metabolite.

If you do not have the chemical taxonomy file, you can generate this file using the annotation dataframe and Macarron utility decorate_ID (see Advanced Topics).

Output Files

By default, all files will be stored in a folder named Macarron_output inside the current working directory. The main prioritization results are stored in prioritized_metabolites_all.csv. Another file, prioritized_metabolites_characterizable.csv is a subset of prioritized_metabolites_all.csv and only contains metabolic features which covary with at least one annotated metabolite. The columns in these output files are:

  • Feature_index: Lists the identifier of the metabolic feature found in column 1 of abundance and annotation files.
  • HMDB_ID (or PubChem ID): Public database identifier from column 2 of annotation file (column 1 of annotation dataframe).
  • Metabolite name: From column 2 of annotation dataframe.
  • mz: The continuous numerical chemical property from column 3 of the annotation dataframe.
  • Priority_score: 1 indicates most prioritized. It is the percentile from the meta-rank of AVA, q-value and effect size.
  • Status: Direction of perturbation (differential abundance) in the phenotype (or environment) of interest compared to reference phenotype.
  • Module: ID of the covariance module a metabolic feature is a member of. Module = 0 indicates a singleton i.e., a metabolic feature that is not assigned to any module.
  • Anchor (of a module): Metabolic feature that has the highest abundance in any phenotype.
  • Related_classes: Chemical taxonomy of the annotated features that covary with a metabolic feature.
  • Covaries_with_standard: 1 (yes) and 0 (no). Column specifies if the metabolic feature covaries with at least one annotated (standard) metabolite.
  • AVA: Abundance versus anchor which is a ratio of the highest abundance (in any phenotype) of a metabolic feature and highest abundance of the covarying anchor. Naturally, the AVA of an anchor metabolite is 1.
  • qvalue: Estimated from multivariate linear model using Maaslin2.
  • effect_size
  • Remaining columns from the annotation dataframe are appended.

Run a demo in R

Using CSV files as inputs

Example (demo) input files can be found under inst/extdata folder of the Macarron source. These files were generated from the PRISM study of stool metabolomes of individuals with inflammatory bowel disease (IBD) and healthy “Control” individuals. Control and IBD are the two phenotypes in this example. Macarron will be applied to prioritize metabolic features with respect to their bioactivity in IBD. Therefore, in this example, the phenotype of interest is “IBD” and the reference phenotype is “Control”. The four input files are demo_abundances.csv, demo_annotations.csv, demo_metadata.csv, and demo_taxonomy.csv.

library(Macarron)
## Loading required package: SummarizedExperiment
## Loading required package: MatrixGenerics
## Loading required package: matrixStats
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## Attaching package: 'MatrixGenerics'
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## Loading required package: GenomicRanges
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prism_abundances <- system.file(
    'extdata','demo_abundances.csv', package="Macarron")
prism_annotations <-system.file(
    'extdata','demo_annotations.csv', package="Macarron")
prism_metadata <-system.file(
    'extdata','demo_metadata.csv', package="Macarron")
mets_taxonomy <-system.file(
    'extdata','demo_taxonomy.csv', package="Macarron")
prism_prioritized <- Macarron::Macarron(input_abundances = prism_abundances,
                                        input_annotations = prism_annotations,
                                        input_metadata = prism_metadata,
                                        input_taxonomy = mets_taxonomy)
## 2024-12-29 07:41:22.738968 INFO::Creating output folder.
## 2024-12-29 07:41:22.748068 INFO::Writing function arguments to log file
## Samples with both abundances and metadata: 102
## 2024-12-29 07:41:23.164257 INFO::Summarized Experiment created.
## 2024-12-29 07:41:23.16531 INFO::Metadata chosen for prevalence filtering: diagnosis
## 869 features pass chosen minimum prevalence threshold of 0.7.
## Calculating pairwise correlations in phenotype: IBD
## 
## Calculating pairwise correlations in phenotype: Control
## Distance matrix with 869 features created.
## 2024-12-29 07:41:26.121905 INFO::Distance matrix with 869 metabolic features created.
## Initiating module detection
## 2024-12-29 07:41:26.122811 INFO::Minimum module size used for this dataset: 10
## Tree constructed
## Evaluating measures of success
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
## 2024-12-29 07:41:27.516362 INFO::Total number of modules detected: 30
## Initiating AVA calculations
## Finding anchors
## Calculating AVA
## Initiating q-value calculations
## [1] "Creating output folder"
## [1] "Creating output feature tables folder"
## [1] "Creating output fits folder"
## [1] "Creating output figures folder"
## 2024-12-29 07:41:28.830895 INFO::Writing function arguments to log file
## 2024-12-29 07:41:28.834633 INFO::Verifying options selected are valid
## 2024-12-29 07:41:28.85818 INFO::Determining format of input files
## 2024-12-29 07:41:28.858747 INFO::Input format is data samples as columns and metadata samples as rows
## 2024-12-29 07:41:28.868775 INFO::Formula for fixed effects: expr ~  diagnosis + age + antibiotics
## 2024-12-29 07:41:28.869686 INFO::Filter data based on min abundance and min prevalence
## 2024-12-29 07:41:28.870136 INFO::Total samples in data: 102
## 2024-12-29 07:41:28.870558 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000
## 2024-12-29 07:41:28.878358 INFO::Total filtered features: 0
## 2024-12-29 07:41:28.878872 INFO::Filtered feature names from abundance and prevalence filtering:
## 2024-12-29 07:41:28.890815 INFO::Total filtered features with variance filtering: 0
## 2024-12-29 07:41:28.891327 INFO::Filtered feature names from variance filtering:
## 2024-12-29 07:41:28.891749 INFO::Running selected normalization method: NONE
## 2024-12-29 07:41:28.892216 INFO::Applying z-score to standardize continuous metadata
## 2024-12-29 07:41:28.904887 INFO::Running selected transform method: NONE
## 2024-12-29 07:41:28.905398 INFO::Running selected analysis method: LM
## 2024-12-29 07:41:28.90858 INFO::Fitting model to feature number 1, F1
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## 2024-12-29 07:41:29.273463 INFO::Fitting model to feature number 159, F165
## 2024-12-29 07:41:29.275799 INFO::Fitting model to feature number 160, F166
## 2024-12-29 07:41:29.278148 INFO::Fitting model to feature number 161, F167
## 2024-12-29 07:41:29.280527 INFO::Fitting model to feature number 162, F168
## 2024-12-29 07:41:29.282835 INFO::Fitting model to feature number 163, F169
## 2024-12-29 07:41:29.285159 INFO::Fitting model to feature number 164, F170
## 2024-12-29 07:41:29.287491 INFO::Fitting model to feature number 165, F171
## 2024-12-29 07:41:29.289865 INFO::Fitting model to feature number 166, F172
## 2024-12-29 07:41:29.292227 INFO::Fitting model to feature number 167, F173
## 2024-12-29 07:41:29.294538 INFO::Fitting model to feature number 168, F174
## 2024-12-29 07:41:29.296913 INFO::Fitting model to feature number 169, F175
## 2024-12-29 07:41:29.299227 INFO::Fitting model to feature number 170, F176
## 2024-12-29 07:41:29.30156 INFO::Fitting model to feature number 171, F177
## 2024-12-29 07:41:29.303872 INFO::Fitting model to feature number 172, F178
## 2024-12-29 07:41:29.306237 INFO::Fitting model to feature number 173, F179
## 2024-12-29 07:41:29.308601 INFO::Fitting model to feature number 174, F180
## 2024-12-29 07:41:29.310914 INFO::Fitting model to feature number 175, F181
## 2024-12-29 07:41:29.313282 INFO::Fitting model to feature number 176, F182
## 2024-12-29 07:41:29.315587 INFO::Fitting model to feature number 177, F183
## 2024-12-29 07:41:29.31793 INFO::Fitting model to feature number 178, F184
## 2024-12-29 07:41:29.320303 INFO::Fitting model to feature number 179, F185
## 2024-12-29 07:41:29.322621 INFO::Fitting model to feature number 180, F186
## 2024-12-29 07:41:29.324966 INFO::Fitting model to feature number 181, F187
## 2024-12-29 07:41:29.327322 INFO::Fitting model to feature number 182, F188
## 2024-12-29 07:41:29.329689 INFO::Fitting model to feature number 183, F189
## 2024-12-29 07:41:29.331995 INFO::Fitting model to feature number 184, F190
## 2024-12-29 07:41:29.334422 INFO::Fitting model to feature number 185, F191
## 2024-12-29 07:41:29.336777 INFO::Fitting model to feature number 186, F192
## 2024-12-29 07:41:29.339137 INFO::Fitting model to feature number 187, F193
## 2024-12-29 07:41:29.341485 INFO::Fitting model to feature number 188, F194
## 2024-12-29 07:41:29.343824 INFO::Fitting model to feature number 189, F195
## 2024-12-29 07:41:29.34621 INFO::Fitting model to feature number 190, F196
## 2024-12-29 07:41:29.348571 INFO::Fitting model to feature number 191, F197
## 2024-12-29 07:41:29.350878 INFO::Fitting model to feature number 192, F198
## 2024-12-29 07:41:29.353252 INFO::Fitting model to feature number 193, F199
## 2024-12-29 07:41:29.369851 INFO::Fitting model to feature number 194, F200
## 2024-12-29 07:41:29.37204 INFO::Fitting model to feature number 195, F201
## 2024-12-29 07:41:29.374277 INFO::Fitting model to feature number 196, F202
## 2024-12-29 07:41:29.376466 INFO::Fitting model to feature number 197, F203
## 2024-12-29 07:41:29.378629 INFO::Fitting model to feature number 198, F204
## 2024-12-29 07:41:29.380841 INFO::Fitting model to feature number 199, F206
## 2024-12-29 07:41:29.383016 INFO::Fitting model to feature number 200, F207
## 2024-12-29 07:41:29.385222 INFO::Fitting model to feature number 201, F208
## 2024-12-29 07:41:29.387375 INFO::Fitting model to feature number 202, F209
## 2024-12-29 07:41:29.389567 INFO::Fitting model to feature number 203, F210
## 2024-12-29 07:41:29.39172 INFO::Fitting model to feature number 204, F211
## 2024-12-29 07:41:29.393891 INFO::Fitting model to feature number 205, F212
## 2024-12-29 07:41:29.39604 INFO::Fitting model to feature number 206, F213
## 2024-12-29 07:41:29.398227 INFO::Fitting model to feature number 207, F214
## 2024-12-29 07:41:29.400392 INFO::Fitting model to feature number 208, F215
## 2024-12-29 07:41:29.402543 INFO::Fitting model to feature number 209, F216
## 2024-12-29 07:41:29.404722 INFO::Fitting model to feature number 210, F217
## 2024-12-29 07:41:29.406864 INFO::Fitting model to feature number 211, F218
## 2024-12-29 07:41:29.40906 INFO::Fitting model to feature number 212, F219
## 2024-12-29 07:41:29.411206 INFO::Fitting model to feature number 213, F220
## 2024-12-29 07:41:29.413405 INFO::Fitting model to feature number 214, F221
## 2024-12-29 07:41:29.415559 INFO::Fitting model to feature number 215, F222
## 2024-12-29 07:41:29.417778 INFO::Fitting model to feature number 216, F223
## 2024-12-29 07:41:29.419921 INFO::Fitting model to feature number 217, F224
## 2024-12-29 07:41:29.422117 INFO::Fitting model to feature number 218, F225
## 2024-12-29 07:41:29.424301 INFO::Fitting model to feature number 219, F226
## 2024-12-29 07:41:29.426464 INFO::Fitting model to feature number 220, F227
## 2024-12-29 07:41:29.428666 INFO::Fitting model to feature number 221, F228
## 2024-12-29 07:41:29.430825 INFO::Fitting model to feature number 222, F229
## 2024-12-29 07:41:29.433033 INFO::Fitting model to feature number 223, F230
## 2024-12-29 07:41:29.435205 INFO::Fitting model to feature number 224, F231
## 2024-12-29 07:41:29.437421 INFO::Fitting model to feature number 225, F232
## 2024-12-29 07:41:29.439587 INFO::Fitting model to feature number 226, F233
## 2024-12-29 07:41:29.441767 INFO::Fitting model to feature number 227, F234
## 2024-12-29 07:41:29.443937 INFO::Fitting model to feature number 228, F235
## 2024-12-29 07:41:29.446145 INFO::Fitting model to feature number 229, F236
## 2024-12-29 07:41:29.448363 INFO::Fitting model to feature number 230, F237
## 2024-12-29 07:41:29.450526 INFO::Fitting model to feature number 231, F238
## 2024-12-29 07:41:29.452747 INFO::Fitting model to feature number 232, F239
## 2024-12-29 07:41:29.45493 INFO::Fitting model to feature number 233, F240
## 2024-12-29 07:41:29.457135 INFO::Fitting model to feature number 234, F241
## 2024-12-29 07:41:29.459306 INFO::Fitting model to feature number 235, F242
## 2024-12-29 07:41:29.461532 INFO::Fitting model to feature number 236, F243
## 2024-12-29 07:41:29.46372 INFO::Fitting model to feature number 237, F244
## 2024-12-29 07:41:29.465914 INFO::Fitting model to feature number 238, F245
## 2024-12-29 07:41:29.468082 INFO::Fitting model to feature number 239, F246
## 2024-12-29 07:41:29.4703 INFO::Fitting model to feature number 240, F247
## 2024-12-29 07:41:29.472486 INFO::Fitting model to feature number 241, F248
## 2024-12-29 07:41:29.474646 INFO::Fitting model to feature number 242, F249
## 2024-12-29 07:41:29.476847 INFO::Fitting model to feature number 243, F250
## 2024-12-29 07:41:29.479004 INFO::Fitting model to feature number 244, F252
## 2024-12-29 07:41:29.481209 INFO::Fitting model to feature number 245, F253
## 2024-12-29 07:41:29.483366 INFO::Fitting model to feature number 246, F254
## 2024-12-29 07:41:29.485589 INFO::Fitting model to feature number 247, F255
## 2024-12-29 07:41:29.487759 INFO::Fitting model to feature number 248, F256
## 2024-12-29 07:41:29.489959 INFO::Fitting model to feature number 249, F257
## 2024-12-29 07:41:29.492121 INFO::Fitting model to feature number 250, F259
## 2024-12-29 07:41:29.49433 INFO::Fitting model to feature number 251, F260
## 2024-12-29 07:41:29.496557 INFO::Fitting model to feature number 252, F261
## 2024-12-29 07:41:29.498718 INFO::Fitting model to feature number 253, F262
## 2024-12-29 07:41:29.500931 INFO::Fitting model to feature number 254, F263
## 2024-12-29 07:41:29.5031 INFO::Fitting model to feature number 255, F264
## 2024-12-29 07:41:29.5053 INFO::Fitting model to feature number 256, F265
## 2024-12-29 07:41:29.507469 INFO::Fitting model to feature number 257, F266
## 2024-12-29 07:41:29.509677 INFO::Fitting model to feature number 258, F267
## 2024-12-29 07:41:29.511877 INFO::Fitting model to feature number 259, F269
## 2024-12-29 07:41:29.514065 INFO::Fitting model to feature number 260, F270
## 2024-12-29 07:41:29.516253 INFO::Fitting model to feature number 261, F271
## 2024-12-29 07:41:29.51849 INFO::Fitting model to feature number 262, F272
## 2024-12-29 07:41:29.520682 INFO::Fitting model to feature number 263, F273
## 2024-12-29 07:41:29.522857 INFO::Fitting model to feature number 264, F274
## 2024-12-29 07:41:29.525057 INFO::Fitting model to feature number 265, F276
## 2024-12-29 07:41:29.527231 INFO::Fitting model to feature number 266, F277
## 2024-12-29 07:41:29.529414 INFO::Fitting model to feature number 267, F278
## 2024-12-29 07:41:29.531579 INFO::Fitting model to feature number 268, F279
## 2024-12-29 07:41:29.533785 INFO::Fitting model to feature number 269, F280
## 2024-12-29 07:41:29.535947 INFO::Fitting model to feature number 270, F281
## 2024-12-29 07:41:29.538135 INFO::Fitting model to feature number 271, F282
## 2024-12-29 07:41:29.540331 INFO::Fitting model to feature number 272, F283
## 2024-12-29 07:41:29.542515 INFO::Fitting model to feature number 273, F284
## 2024-12-29 07:41:29.544696 INFO::Fitting model to feature number 274, F285
## 2024-12-29 07:41:29.546848 INFO::Fitting model to feature number 275, F286
## 2024-12-29 07:41:29.549033 INFO::Fitting model to feature number 276, F287
## 2024-12-29 07:41:29.55118 INFO::Fitting model to feature number 277, F288
## 2024-12-29 07:41:29.553359 INFO::Fitting model to feature number 278, F289
## 2024-12-29 07:41:29.555567 INFO::Fitting model to feature number 279, F290
## 2024-12-29 07:41:29.557799 INFO::Fitting model to feature number 280, F292
## 2024-12-29 07:41:29.55995 INFO::Fitting model to feature number 281, F293
## 2024-12-29 07:41:29.562135 INFO::Fitting model to feature number 282, F294
## 2024-12-29 07:41:29.564323 INFO::Fitting model to feature number 283, F295
## 2024-12-29 07:41:29.566502 INFO::Fitting model to feature number 284, F296
## 2024-12-29 07:41:29.56871 INFO::Fitting model to feature number 285, F297
## 2024-12-29 07:41:29.570907 INFO::Fitting model to feature number 286, F298
## 2024-12-29 07:41:29.573148 INFO::Fitting model to feature number 287, F299
## 2024-12-29 07:41:29.57533 INFO::Fitting model to feature number 288, F300
## 2024-12-29 07:41:29.577553 INFO::Fitting model to feature number 289, F301
## 2024-12-29 07:41:29.579833 INFO::Fitting model to feature number 290, F302
## 2024-12-29 07:41:29.582069 INFO::Fitting model to feature number 291, F303
## 2024-12-29 07:41:29.58427 INFO::Fitting model to feature number 292, F304
## 2024-12-29 07:41:29.586441 INFO::Fitting model to feature number 293, F305
## 2024-12-29 07:41:29.588667 INFO::Fitting model to feature number 294, F306
## 2024-12-29 07:41:29.590884 INFO::Fitting model to feature number 295, F307
## 2024-12-29 07:41:29.593106 INFO::Fitting model to feature number 296, F308
## 2024-12-29 07:41:29.595262 INFO::Fitting model to feature number 297, F309
## 2024-12-29 07:41:29.597521 INFO::Fitting model to feature number 298, F310
## 2024-12-29 07:41:29.599727 INFO::Fitting model to feature number 299, F311
## 2024-12-29 07:41:29.601969 INFO::Fitting model to feature number 300, F312
## 2024-12-29 07:41:29.604255 INFO::Fitting model to feature number 301, F313
## 2024-12-29 07:41:29.606468 INFO::Fitting model to feature number 302, F315
## 2024-12-29 07:41:29.60871 INFO::Fitting model to feature number 303, F316
## 2024-12-29 07:41:29.610908 INFO::Fitting model to feature number 304, F317
## 2024-12-29 07:41:29.613152 INFO::Fitting model to feature number 305, F318
## 2024-12-29 07:41:29.615356 INFO::Fitting model to feature number 306, F319
## 2024-12-29 07:41:29.617569 INFO::Fitting model to feature number 307, F320
## 2024-12-29 07:41:29.619777 INFO::Fitting model to feature number 308, F321
## 2024-12-29 07:41:29.622011 INFO::Fitting model to feature number 309, F322
## 2024-12-29 07:41:29.62422 INFO::Fitting model to feature number 310, F323
## 2024-12-29 07:41:29.626438 INFO::Fitting model to feature number 311, F324
## 2024-12-29 07:41:29.62875 INFO::Fitting model to feature number 312, F325
## 2024-12-29 07:41:29.630982 INFO::Fitting model to feature number 313, F326
## 2024-12-29 07:41:29.63319 INFO::Fitting model to feature number 314, F327
## 2024-12-29 07:41:29.63537 INFO::Fitting model to feature number 315, F328
## 2024-12-29 07:41:29.637587 INFO::Fitting model to feature number 316, F329
## 2024-12-29 07:41:29.639772 INFO::Fitting model to feature number 317, F330
## 2024-12-29 07:41:29.642062 INFO::Fitting model to feature number 318, F331
## 2024-12-29 07:41:29.644295 INFO::Fitting model to feature number 319, F332
## 2024-12-29 07:41:29.646482 INFO::Fitting model to feature number 320, F333
## 2024-12-29 07:41:29.648704 INFO::Fitting model to feature number 321, F334
## 2024-12-29 07:41:29.650948 INFO::Fitting model to feature number 322, F335
## 2024-12-29 07:41:29.653185 INFO::Fitting model to feature number 323, F336
## 2024-12-29 07:41:29.65541 INFO::Fitting model to feature number 324, F337
## 2024-12-29 07:41:29.657641 INFO::Fitting model to feature number 325, F338
## 2024-12-29 07:41:29.659826 INFO::Fitting model to feature number 326, F339
## 2024-12-29 07:41:29.662043 INFO::Fitting model to feature number 327, F340
## 2024-12-29 07:41:29.664248 INFO::Fitting model to feature number 328, F342
## 2024-12-29 07:41:29.666436 INFO::Fitting model to feature number 329, F343
## 2024-12-29 07:41:29.668651 INFO::Fitting model to feature number 330, F344
## 2024-12-29 07:41:29.670858 INFO::Fitting model to feature number 331, F345
## 2024-12-29 07:41:29.673086 INFO::Fitting model to feature number 332, F346
## 2024-12-29 07:41:29.675259 INFO::Fitting model to feature number 333, F347
## 2024-12-29 07:41:29.677494 INFO::Fitting model to feature number 334, F348
## 2024-12-29 07:41:29.679659 INFO::Fitting model to feature number 335, F350
## 2024-12-29 07:41:29.681877 INFO::Fitting model to feature number 336, F351
## 2024-12-29 07:41:29.684093 INFO::Fitting model to feature number 337, F352
## 2024-12-29 07:41:29.686324 INFO::Fitting model to feature number 338, F353
## 2024-12-29 07:41:29.688535 INFO::Fitting model to feature number 339, F355
## 2024-12-29 07:41:29.690718 INFO::Fitting model to feature number 340, F356
## 2024-12-29 07:41:29.692949 INFO::Fitting model to feature number 341, F357
## 2024-12-29 07:41:29.695129 INFO::Fitting model to feature number 342, F358
## 2024-12-29 07:41:29.697344 INFO::Fitting model to feature number 343, F359
## 2024-12-29 07:41:29.699543 INFO::Fitting model to feature number 344, F360
## 2024-12-29 07:41:29.701781 INFO::Fitting model to feature number 345, F361
## 2024-12-29 07:41:29.703979 INFO::Fitting model to feature number 346, F362
## 2024-12-29 07:41:29.706207 INFO::Fitting model to feature number 347, F363
## 2024-12-29 07:41:29.708448 INFO::Fitting model to feature number 348, F364
## 2024-12-29 07:41:29.710638 INFO::Fitting model to feature number 349, F365
## 2024-12-29 07:41:29.712853 INFO::Fitting model to feature number 350, F366
## 2024-12-29 07:41:29.715056 INFO::Fitting model to feature number 351, F367
## 2024-12-29 07:41:29.717293 INFO::Fitting model to feature number 352, F368
## 2024-12-29 07:41:29.719467 INFO::Fitting model to feature number 353, F369
## 2024-12-29 07:41:29.721686 INFO::Fitting model to feature number 354, F370
## 2024-12-29 07:41:29.723862 INFO::Fitting model to feature number 355, F371
## 2024-12-29 07:41:29.726115 INFO::Fitting model to feature number 356, F372
## 2024-12-29 07:41:29.728349 INFO::Fitting model to feature number 357, F373
## 2024-12-29 07:41:29.730578 INFO::Fitting model to feature number 358, F374
## 2024-12-29 07:41:29.732814 INFO::Fitting model to feature number 359, F375
## 2024-12-29 07:41:29.735003 INFO::Fitting model to feature number 360, F376
## 2024-12-29 07:41:29.737237 INFO::Fitting model to feature number 361, F377
## 2024-12-29 07:41:29.739432 INFO::Fitting model to feature number 362, F378
## 2024-12-29 07:41:29.741661 INFO::Fitting model to feature number 363, F379
## 2024-12-29 07:41:29.743848 INFO::Fitting model to feature number 364, F380
## 2024-12-29 07:41:29.746081 INFO::Fitting model to feature number 365, F381
## 2024-12-29 07:41:29.748315 INFO::Fitting model to feature number 366, F382
## 2024-12-29 07:41:29.75051 INFO::Fitting model to feature number 367, F383
## 2024-12-29 07:41:29.752738 INFO::Fitting model to feature number 368, F384
## 2024-12-29 07:41:29.754917 INFO::Fitting model to feature number 369, F386
## 2024-12-29 07:41:29.757147 INFO::Fitting model to feature number 370, F387
## 2024-12-29 07:41:29.75933 INFO::Fitting model to feature number 371, F388
## 2024-12-29 07:41:29.761543 INFO::Fitting model to feature number 372, F389
## 2024-12-29 07:41:29.763716 INFO::Fitting model to feature number 373, F390
## 2024-12-29 07:41:29.76593 INFO::Fitting model to feature number 374, F391
## 2024-12-29 07:41:29.768128 INFO::Fitting model to feature number 375, F392
## 2024-12-29 07:41:29.77035 INFO::Fitting model to feature number 376, F393
## 2024-12-29 07:41:29.772571 INFO::Fitting model to feature number 377, F394
## 2024-12-29 07:41:29.774758 INFO::Fitting model to feature number 378, F395
## 2024-12-29 07:41:29.777095 INFO::Fitting model to feature number 379, F396
## 2024-12-29 07:41:29.779299 INFO::Fitting model to feature number 380, F397
## 2024-12-29 07:41:29.781529 INFO::Fitting model to feature number 381, F398
## 2024-12-29 07:41:29.783727 INFO::Fitting model to feature number 382, F399
## 2024-12-29 07:41:29.785948 INFO::Fitting model to feature number 383, F400
## 2024-12-29 07:41:29.788165 INFO::Fitting model to feature number 384, F401
## 2024-12-29 07:41:29.790373 INFO::Fitting model to feature number 385, F402
## 2024-12-29 07:41:29.792601 INFO::Fitting model to feature number 386, F403
## 2024-12-29 07:41:29.794783 INFO::Fitting model to feature number 387, F404
## 2024-12-29 07:41:29.797046 INFO::Fitting model to feature number 388, F406
## 2024-12-29 07:41:29.799237 INFO::Fitting model to feature number 389, F407
## 2024-12-29 07:41:29.801458 INFO::Fitting model to feature number 390, F408
## 2024-12-29 07:41:29.803654 INFO::Fitting model to feature number 391, F409
## 2024-12-29 07:41:29.80589 INFO::Fitting model to feature number 392, F410
## 2024-12-29 07:41:29.808097 INFO::Fitting model to feature number 393, F411
## 2024-12-29 07:41:29.810304 INFO::Fitting model to feature number 394, F412
## 2024-12-29 07:41:29.812526 INFO::Fitting model to feature number 395, F413
## 2024-12-29 07:41:29.814717 INFO::Fitting model to feature number 396, F414
## 2024-12-29 07:41:29.816934 INFO::Fitting model to feature number 397, F415
## 2024-12-29 07:41:29.819124 INFO::Fitting model to feature number 398, F416
## 2024-12-29 07:41:29.821365 INFO::Fitting model to feature number 399, F417
## 2024-12-29 07:41:29.823571 INFO::Fitting model to feature number 400, F418
## 2024-12-29 07:41:29.825845 INFO::Fitting model to feature number 401, F419
## 2024-12-29 07:41:29.828031 INFO::Fitting model to feature number 402, F420
## 2024-12-29 07:41:29.830257 INFO::Fitting model to feature number 403, F421
## 2024-12-29 07:41:29.832449 INFO::Fitting model to feature number 404, F422
## 2024-12-29 07:41:29.834613 INFO::Fitting model to feature number 405, F423
## 2024-12-29 07:41:29.836898 INFO::Fitting model to feature number 406, F425
## 2024-12-29 07:41:29.839115 INFO::Fitting model to feature number 407, F426
## 2024-12-29 07:41:29.841343 INFO::Fitting model to feature number 408, F428
## 2024-12-29 07:41:29.843662 INFO::Fitting model to feature number 409, F429
## 2024-12-29 07:41:29.845882 INFO::Fitting model to feature number 410, F430
## 2024-12-29 07:41:29.848072 INFO::Fitting model to feature number 411, F431
## 2024-12-29 07:41:29.850293 INFO::Fitting model to feature number 412, F432
## 2024-12-29 07:41:29.852519 INFO::Fitting model to feature number 413, F433
## 2024-12-29 07:41:29.854803 INFO::Fitting model to feature number 414, F434
## 2024-12-29 07:41:29.857018 INFO::Fitting model to feature number 415, F435
## 2024-12-29 07:41:29.859212 INFO::Fitting model to feature number 416, F436
## 2024-12-29 07:41:29.861451 INFO::Fitting model to feature number 417, F437
## 2024-12-29 07:41:29.863629 INFO::Fitting model to feature number 418, F438
## 2024-12-29 07:41:29.865835 INFO::Fitting model to feature number 419, F439
## 2024-12-29 07:41:29.868013 INFO::Fitting model to feature number 420, F440
## 2024-12-29 07:41:29.870245 INFO::Fitting model to feature number 421, F441
## 2024-12-29 07:41:29.872436 INFO::Fitting model to feature number 422, F442
## 2024-12-29 07:41:29.874594 INFO::Fitting model to feature number 423, F443
## 2024-12-29 07:41:29.887883 INFO::Fitting model to feature number 424, F444
## 2024-12-29 07:41:29.89011 INFO::Fitting model to feature number 425, F445
## 2024-12-29 07:41:29.892307 INFO::Fitting model to feature number 426, F446
## 2024-12-29 07:41:29.894478 INFO::Fitting model to feature number 427, F447
## 2024-12-29 07:41:29.896698 INFO::Fitting model to feature number 428, F448
## 2024-12-29 07:41:29.898964 INFO::Fitting model to feature number 429, F449
## 2024-12-29 07:41:29.901173 INFO::Fitting model to feature number 430, F450
## 2024-12-29 07:41:29.903349 INFO::Fitting model to feature number 431, F451
## 2024-12-29 07:41:29.905597 INFO::Fitting model to feature number 432, F452
## 2024-12-29 07:41:29.907768 INFO::Fitting model to feature number 433, F454
## 2024-12-29 07:41:29.909956 INFO::Fitting model to feature number 434, F455
## 2024-12-29 07:41:29.912105 INFO::Fitting model to feature number 435, F456
## 2024-12-29 07:41:29.914299 INFO::Fitting model to feature number 436, F457
## 2024-12-29 07:41:29.916494 INFO::Fitting model to feature number 437, F458
## 2024-12-29 07:41:29.918654 INFO::Fitting model to feature number 438, F459
## 2024-12-29 07:41:29.920837 INFO::Fitting model to feature number 439, F461
## 2024-12-29 07:41:29.922977 INFO::Fitting model to feature number 440, F462
## 2024-12-29 07:41:29.925168 INFO::Fitting model to feature number 441, F463
## 2024-12-29 07:41:29.927322 INFO::Fitting model to feature number 442, F464
## 2024-12-29 07:41:29.929528 INFO::Fitting model to feature number 443, F465
## 2024-12-29 07:41:29.931687 INFO::Fitting model to feature number 444, F466
## 2024-12-29 07:41:29.933873 INFO::Fitting model to feature number 445, F467
## 2024-12-29 07:41:29.93603 INFO::Fitting model to feature number 446, F468
## 2024-12-29 07:41:29.938236 INFO::Fitting model to feature number 447, F469
## 2024-12-29 07:41:29.940429 INFO::Fitting model to feature number 448, F470
## 2024-12-29 07:41:29.942592 INFO::Fitting model to feature number 449, F471
## 2024-12-29 07:41:29.944777 INFO::Fitting model to feature number 450, F474
## 2024-12-29 07:41:29.946935 INFO::Fitting model to feature number 451, F475
## 2024-12-29 07:41:29.949143 INFO::Fitting model to feature number 452, F476
## 2024-12-29 07:41:29.951308 INFO::Fitting model to feature number 453, F477
## 2024-12-29 07:41:29.953499 INFO::Fitting model to feature number 454, F478
## 2024-12-29 07:41:29.955662 INFO::Fitting model to feature number 455, F479
## 2024-12-29 07:41:29.957905 INFO::Fitting model to feature number 456, F480
## 2024-12-29 07:41:29.960086 INFO::Fitting model to feature number 457, F481
## 2024-12-29 07:41:29.962296 INFO::Fitting model to feature number 458, F482
## 2024-12-29 07:41:29.964502 INFO::Fitting model to feature number 459, F483
## 2024-12-29 07:41:29.966687 INFO::Fitting model to feature number 460, F484
## 2024-12-29 07:41:29.968891 INFO::Fitting model to feature number 461, F485
## 2024-12-29 07:41:29.971072 INFO::Fitting model to feature number 462, F486
## 2024-12-29 07:41:29.973294 INFO::Fitting model to feature number 463, F487
## 2024-12-29 07:41:29.975478 INFO::Fitting model to feature number 464, F488
## 2024-12-29 07:41:29.977702 INFO::Fitting model to feature number 465, F489
## 2024-12-29 07:41:29.979896 INFO::Fitting model to feature number 466, F490
## 2024-12-29 07:41:29.982098 INFO::Fitting model to feature number 467, F491
## 2024-12-29 07:41:29.984287 INFO::Fitting model to feature number 468, F492
## 2024-12-29 07:41:29.986474 INFO::Fitting model to feature number 469, F493
## 2024-12-29 07:41:29.988686 INFO::Fitting model to feature number 470, F494
## 2024-12-29 07:41:29.990835 INFO::Fitting model to feature number 471, F495
## 2024-12-29 07:41:29.992997 INFO::Fitting model to feature number 472, F496
## 2024-12-29 07:41:29.995164 INFO::Fitting model to feature number 473, F497
## 2024-12-29 07:41:29.99735 INFO::Fitting model to feature number 474, F498
## 2024-12-29 07:41:29.999508 INFO::Fitting model to feature number 475, F499
## 2024-12-29 07:41:30.001693 INFO::Fitting model to feature number 476, F500
## 2024-12-29 07:41:30.003863 INFO::Fitting model to feature number 477, F501
## 2024-12-29 07:41:30.006055 INFO::Fitting model to feature number 478, F502
## 2024-12-29 07:41:30.008273 INFO::Fitting model to feature number 479, F503
## 2024-12-29 07:41:30.010473 INFO::Fitting model to feature number 480, F504
## 2024-12-29 07:41:30.012662 INFO::Fitting model to feature number 481, F505
## 2024-12-29 07:41:30.014812 INFO::Fitting model to feature number 482, F506
## 2024-12-29 07:41:30.017009 INFO::Fitting model to feature number 483, F507
## 2024-12-29 07:41:30.019264 INFO::Fitting model to feature number 484, F508
## 2024-12-29 07:41:30.021457 INFO::Fitting model to feature number 485, F509
## 2024-12-29 07:41:30.023634 INFO::Fitting model to feature number 486, F510
## 2024-12-29 07:41:30.025831 INFO::Fitting model to feature number 487, F511
## 2024-12-29 07:41:30.027987 INFO::Fitting model to feature number 488, F512
## 2024-12-29 07:41:30.03018 INFO::Fitting model to feature number 489, F513
## 2024-12-29 07:41:30.032372 INFO::Fitting model to feature number 490, F514
## 2024-12-29 07:41:30.034523 INFO::Fitting model to feature number 491, F515
## 2024-12-29 07:41:30.036741 INFO::Fitting model to feature number 492, F516
## 2024-12-29 07:41:30.038911 INFO::Fitting model to feature number 493, F517
## 2024-12-29 07:41:30.04111 INFO::Fitting model to feature number 494, F518
## 2024-12-29 07:41:30.04328 INFO::Fitting model to feature number 495, F519
## 2024-12-29 07:41:30.045462 INFO::Fitting model to feature number 496, F520
## 2024-12-29 07:41:30.047622 INFO::Fitting model to feature number 497, F521
## 2024-12-29 07:41:30.049812 INFO::Fitting model to feature number 498, F522
## 2024-12-29 07:41:30.051956 INFO::Fitting model to feature number 499, F523
## 2024-12-29 07:41:30.054135 INFO::Fitting model to feature number 500, F524
## 2024-12-29 07:41:30.05634 INFO::Fitting model to feature number 501, F525
## 2024-12-29 07:41:30.058546 INFO::Fitting model to feature number 502, F526
## 2024-12-29 07:41:30.060729 INFO::Fitting model to feature number 503, F527
## 2024-12-29 07:41:30.062885 INFO::Fitting model to feature number 504, F528
## 2024-12-29 07:41:30.065065 INFO::Fitting model to feature number 505, F529
## 2024-12-29 07:41:30.067231 INFO::Fitting model to feature number 506, F530
## 2024-12-29 07:41:30.069413 INFO::Fitting model to feature number 507, F531
## 2024-12-29 07:41:30.071636 INFO::Fitting model to feature number 508, F532
## 2024-12-29 07:41:30.073893 INFO::Fitting model to feature number 509, F533
## 2024-12-29 07:41:30.076059 INFO::Fitting model to feature number 510, F534
## 2024-12-29 07:41:30.078245 INFO::Fitting model to feature number 511, F535
## 2024-12-29 07:41:30.080455 INFO::Fitting model to feature number 512, F536
## 2024-12-29 07:41:30.082608 INFO::Fitting model to feature number 513, F537
## 2024-12-29 07:41:30.084835 INFO::Fitting model to feature number 514, F539
## 2024-12-29 07:41:30.087029 INFO::Fitting model to feature number 515, F540
## 2024-12-29 07:41:30.089256 INFO::Fitting model to feature number 516, F541
## 2024-12-29 07:41:30.091449 INFO::Fitting model to feature number 517, F543
## 2024-12-29 07:41:30.093651 INFO::Fitting model to feature number 518, F544
## 2024-12-29 07:41:30.095826 INFO::Fitting model to feature number 519, F545
## 2024-12-29 07:41:30.098088 INFO::Fitting model to feature number 520, F546
## 2024-12-29 07:41:30.100305 INFO::Fitting model to feature number 521, F547
## 2024-12-29 07:41:30.102471 INFO::Fitting model to feature number 522, F548
## 2024-12-29 07:41:30.104711 INFO::Fitting model to feature number 523, F549
## 2024-12-29 07:41:30.106893 INFO::Fitting model to feature number 524, F550
## 2024-12-29 07:41:30.109096 INFO::Fitting model to feature number 525, F551
## 2024-12-29 07:41:30.111292 INFO::Fitting model to feature number 526, F552
## 2024-12-29 07:41:30.113486 INFO::Fitting model to feature number 527, F553
## 2024-12-29 07:41:30.115701 INFO::Fitting model to feature number 528, F554
## 2024-12-29 07:41:30.117915 INFO::Fitting model to feature number 529, F555
## 2024-12-29 07:41:30.120165 INFO::Fitting model to feature number 530, F556
## 2024-12-29 07:41:30.122387 INFO::Fitting model to feature number 531, F557
## 2024-12-29 07:41:30.124632 INFO::Fitting model to feature number 532, F558
## 2024-12-29 07:41:30.126841 INFO::Fitting model to feature number 533, F559
## 2024-12-29 07:41:30.129052 INFO::Fitting model to feature number 534, F560
## 2024-12-29 07:41:30.131231 INFO::Fitting model to feature number 535, F561
## 2024-12-29 07:41:30.133451 INFO::Fitting model to feature number 536, F562
## 2024-12-29 07:41:30.135652 INFO::Fitting model to feature number 537, F563
## 2024-12-29 07:41:30.137858 INFO::Fitting model to feature number 538, F564
## 2024-12-29 07:41:30.140038 INFO::Fitting model to feature number 539, F566
## 2024-12-29 07:41:30.142262 INFO::Fitting model to feature number 540, F567
## 2024-12-29 07:41:30.144601 INFO::Fitting model to feature number 541, F568
## 2024-12-29 07:41:30.146891 INFO::Fitting model to feature number 542, F569
## 2024-12-29 07:41:30.149153 INFO::Fitting model to feature number 543, F570
## 2024-12-29 07:41:30.151348 INFO::Fitting model to feature number 544, F571
## 2024-12-29 07:41:30.153556 INFO::Fitting model to feature number 545, F572
## 2024-12-29 07:41:30.15579 INFO::Fitting model to feature number 546, F573
## 2024-12-29 07:41:30.158029 INFO::Fitting model to feature number 547, F574
## 2024-12-29 07:41:30.16024 INFO::Fitting model to feature number 548, F575
## 2024-12-29 07:41:30.162446 INFO::Fitting model to feature number 549, F576
## 2024-12-29 07:41:30.164668 INFO::Fitting model to feature number 550, F577
## 2024-12-29 07:41:30.166871 INFO::Fitting model to feature number 551, F578
## 2024-12-29 07:41:30.169069 INFO::Fitting model to feature number 552, F579
## 2024-12-29 07:41:30.171253 INFO::Fitting model to feature number 553, F580
## 2024-12-29 07:41:30.17344 INFO::Fitting model to feature number 554, F581
## 2024-12-29 07:41:30.175604 INFO::Fitting model to feature number 555, F582
## 2024-12-29 07:41:30.177799 INFO::Fitting model to feature number 556, F583
## 2024-12-29 07:41:30.179984 INFO::Fitting model to feature number 557, F584
## 2024-12-29 07:41:30.182198 INFO::Fitting model to feature number 558, F585
## 2024-12-29 07:41:30.184407 INFO::Fitting model to feature number 559, F586
## 2024-12-29 07:41:30.186593 INFO::Fitting model to feature number 560, F587
## 2024-12-29 07:41:30.188883 INFO::Fitting model to feature number 561, F588
## 2024-12-29 07:41:30.191057 INFO::Fitting model to feature number 562, F589
## 2024-12-29 07:41:30.193275 INFO::Fitting model to feature number 563, F590
## 2024-12-29 07:41:30.195453 INFO::Fitting model to feature number 564, F591
## 2024-12-29 07:41:30.197655 INFO::Fitting model to feature number 565, F592
## 2024-12-29 07:41:30.199859 INFO::Fitting model to feature number 566, F593
## 2024-12-29 07:41:30.202076 INFO::Fitting model to feature number 567, F594
## 2024-12-29 07:41:30.204295 INFO::Fitting model to feature number 568, F595
## 2024-12-29 07:41:30.206481 INFO::Fitting model to feature number 569, F596
## 2024-12-29 07:41:30.2087 INFO::Fitting model to feature number 570, F597
## 2024-12-29 07:41:30.210892 INFO::Fitting model to feature number 571, F598
## 2024-12-29 07:41:30.213146 INFO::Fitting model to feature number 572, F599
## 2024-12-29 07:41:30.215355 INFO::Fitting model to feature number 573, F600
## 2024-12-29 07:41:30.217577 INFO::Fitting model to feature number 574, F601
## 2024-12-29 07:41:30.219763 INFO::Fitting model to feature number 575, F602
## 2024-12-29 07:41:30.221999 INFO::Fitting model to feature number 576, F603
## 2024-12-29 07:41:30.224206 INFO::Fitting model to feature number 577, F605
## 2024-12-29 07:41:30.226381 INFO::Fitting model to feature number 578, F606
## 2024-12-29 07:41:30.228617 INFO::Fitting model to feature number 579, F607
## 2024-12-29 07:41:30.230825 INFO::Fitting model to feature number 580, F608
## 2024-12-29 07:41:30.233042 INFO::Fitting model to feature number 581, F609
## 2024-12-29 07:41:30.235228 INFO::Fitting model to feature number 582, F610
## 2024-12-29 07:41:30.237453 INFO::Fitting model to feature number 583, F611
## 2024-12-29 07:41:30.239655 INFO::Fitting model to feature number 584, F612
## 2024-12-29 07:41:30.241862 INFO::Fitting model to feature number 585, F613
## 2024-12-29 07:41:30.244046 INFO::Fitting model to feature number 586, F614
## 2024-12-29 07:41:30.246314 INFO::Fitting model to feature number 587, F615
## 2024-12-29 07:41:30.248544 INFO::Fitting model to feature number 588, F616
## 2024-12-29 07:41:30.250729 INFO::Fitting model to feature number 589, F617
## 2024-12-29 07:41:30.252949 INFO::Fitting model to feature number 590, F618
## 2024-12-29 07:41:30.255137 INFO::Fitting model to feature number 591, F619
## 2024-12-29 07:41:30.257352 INFO::Fitting model to feature number 592, F620
## 2024-12-29 07:41:30.259555 INFO::Fitting model to feature number 593, F621
## 2024-12-29 07:41:30.261789 INFO::Fitting model to feature number 594, F622
## 2024-12-29 07:41:30.263989 INFO::Fitting model to feature number 595, F623
## 2024-12-29 07:41:30.26622 INFO::Fitting model to feature number 596, F624
## 2024-12-29 07:41:30.268456 INFO::Fitting model to feature number 597, F625
## 2024-12-29 07:41:30.270652 INFO::Fitting model to feature number 598, F626
## 2024-12-29 07:41:30.272869 INFO::Fitting model to feature number 599, F627
## 2024-12-29 07:41:30.275056 INFO::Fitting model to feature number 600, F628
## 2024-12-29 07:41:30.277321 INFO::Fitting model to feature number 601, F629
## 2024-12-29 07:41:30.27951 INFO::Fitting model to feature number 602, F630
## 2024-12-29 07:41:30.28173 INFO::Fitting model to feature number 603, F631
## 2024-12-29 07:41:30.283922 INFO::Fitting model to feature number 604, F632
## 2024-12-29 07:41:30.286145 INFO::Fitting model to feature number 605, F633
## 2024-12-29 07:41:30.288359 INFO::Fitting model to feature number 606, F634
## 2024-12-29 07:41:30.290557 INFO::Fitting model to feature number 607, F635
## 2024-12-29 07:41:30.292818 INFO::Fitting model to feature number 608, F636
## 2024-12-29 07:41:30.295033 INFO::Fitting model to feature number 609, F637
## 2024-12-29 07:41:30.297261 INFO::Fitting model to feature number 610, F638
## 2024-12-29 07:41:30.299452 INFO::Fitting model to feature number 611, F639
## 2024-12-29 07:41:30.301659 INFO::Fitting model to feature number 612, F640
## 2024-12-29 07:41:30.303848 INFO::Fitting model to feature number 613, F641
## 2024-12-29 07:41:30.306053 INFO::Fitting model to feature number 614, F642
## 2024-12-29 07:41:30.308298 INFO::Fitting model to feature number 615, F643
## 2024-12-29 07:41:30.310483 INFO::Fitting model to feature number 616, F644
## 2024-12-29 07:41:30.312702 INFO::Fitting model to feature number 617, F645
## 2024-12-29 07:41:30.314887 INFO::Fitting model to feature number 618, F646
## 2024-12-29 07:41:30.317166 INFO::Fitting model to feature number 619, F647
## 2024-12-29 07:41:30.319363 INFO::Fitting model to feature number 620, F648
## 2024-12-29 07:41:30.321576 INFO::Fitting model to feature number 621, F649
## 2024-12-29 07:41:30.323777 INFO::Fitting model to feature number 622, F650
## 2024-12-29 07:41:30.326045 INFO::Fitting model to feature number 623, F651
## 2024-12-29 07:41:30.328272 INFO::Fitting model to feature number 624, F652
## 2024-12-29 07:41:30.330465 INFO::Fitting model to feature number 625, F653
## 2024-12-29 07:41:30.332667 INFO::Fitting model to feature number 626, F654
## 2024-12-29 07:41:30.334865 INFO::Fitting model to feature number 627, F655
## 2024-12-29 07:41:30.337081 INFO::Fitting model to feature number 628, F656
## 2024-12-29 07:41:30.339277 INFO::Fitting model to feature number 629, F657
## 2024-12-29 07:41:30.341513 INFO::Fitting model to feature number 630, F658
## 2024-12-29 07:41:30.343716 INFO::Fitting model to feature number 631, F659
## 2024-12-29 07:41:30.345934 INFO::Fitting model to feature number 632, F660
## 2024-12-29 07:41:30.348127 INFO::Fitting model to feature number 633, F661
## 2024-12-29 07:41:30.350342 INFO::Fitting model to feature number 634, F662
## 2024-12-29 07:41:30.352538 INFO::Fitting model to feature number 635, F663
## 2024-12-29 07:41:30.354733 INFO::Fitting model to feature number 636, F664
## 2024-12-29 07:41:30.356968 INFO::Fitting model to feature number 637, F665
## 2024-12-29 07:41:30.359169 INFO::Fitting model to feature number 638, F666
## 2024-12-29 07:41:30.36138 INFO::Fitting model to feature number 639, F667
## 2024-12-29 07:41:30.36356 INFO::Fitting model to feature number 640, F668
## 2024-12-29 07:41:30.365775 INFO::Fitting model to feature number 641, F669
## 2024-12-29 07:41:30.367975 INFO::Fitting model to feature number 642, F670
## 2024-12-29 07:41:30.370198 INFO::Fitting model to feature number 643, F671
## 2024-12-29 07:41:30.372413 INFO::Fitting model to feature number 644, F672
## 2024-12-29 07:41:30.374593 INFO::Fitting model to feature number 645, F673
## 2024-12-29 07:41:30.376812 INFO::Fitting model to feature number 646, F674
## 2024-12-29 07:41:30.37899 INFO::Fitting model to feature number 647, F675
## 2024-12-29 07:41:30.381196 INFO::Fitting model to feature number 648, F676
## 2024-12-29 07:41:30.383361 INFO::Fitting model to feature number 649, F677
## 2024-12-29 07:41:30.385575 INFO::Fitting model to feature number 650, F678
## 2024-12-29 07:41:30.387752 INFO::Fitting model to feature number 651, F679
## 2024-12-29 07:41:30.389948 INFO::Fitting model to feature number 652, F680
## 2024-12-29 07:41:30.403308 INFO::Fitting model to feature number 653, F681
## 2024-12-29 07:41:30.405582 INFO::Fitting model to feature number 654, F682
## 2024-12-29 07:41:30.407753 INFO::Fitting model to feature number 655, F683
## 2024-12-29 07:41:30.409954 INFO::Fitting model to feature number 656, F684
## 2024-12-29 07:41:30.412114 INFO::Fitting model to feature number 657, F685
## 2024-12-29 07:41:30.41433 INFO::Fitting model to feature number 658, F686
## 2024-12-29 07:41:30.41655 INFO::Fitting model to feature number 659, F687
## 2024-12-29 07:41:30.418727 INFO::Fitting model to feature number 660, F688
## 2024-12-29 07:41:30.420912 INFO::Fitting model to feature number 661, F689
## 2024-12-29 07:41:30.423081 INFO::Fitting model to feature number 662, F690
## 2024-12-29 07:41:30.425295 INFO::Fitting model to feature number 663, F691
## 2024-12-29 07:41:30.427473 INFO::Fitting model to feature number 664, F692
## 2024-12-29 07:41:30.429661 INFO::Fitting model to feature number 665, F693
## 2024-12-29 07:41:30.431813 INFO::Fitting model to feature number 666, F694
## 2024-12-29 07:41:30.434003 INFO::Fitting model to feature number 667, F695
## 2024-12-29 07:41:30.436157 INFO::Fitting model to feature number 668, F696
## 2024-12-29 07:41:30.438319 INFO::Fitting model to feature number 669, F697
## 2024-12-29 07:41:30.440513 INFO::Fitting model to feature number 670, F698
## 2024-12-29 07:41:30.442677 INFO::Fitting model to feature number 671, F699
## 2024-12-29 07:41:30.444883 INFO::Fitting model to feature number 672, F700
## 2024-12-29 07:41:30.447051 INFO::Fitting model to feature number 673, F701
## 2024-12-29 07:41:30.449231 INFO::Fitting model to feature number 674, F702
## 2024-12-29 07:41:30.451377 INFO::Fitting model to feature number 675, F704
## 2024-12-29 07:41:30.453566 INFO::Fitting model to feature number 676, F705
## 2024-12-29 07:41:30.455718 INFO::Fitting model to feature number 677, F706
## 2024-12-29 07:41:30.457903 INFO::Fitting model to feature number 678, F707
## 2024-12-29 07:41:30.46006 INFO::Fitting model to feature number 679, F708
## 2024-12-29 07:41:30.462268 INFO::Fitting model to feature number 680, F709
## 2024-12-29 07:41:30.464465 INFO::Fitting model to feature number 681, F710
## 2024-12-29 07:41:30.466674 INFO::Fitting model to feature number 682, F711
## 2024-12-29 07:41:30.468872 INFO::Fitting model to feature number 683, F712
## 2024-12-29 07:41:30.471032 INFO::Fitting model to feature number 684, F713
## 2024-12-29 07:41:30.473265 INFO::Fitting model to feature number 685, F714
## 2024-12-29 07:41:30.47543 INFO::Fitting model to feature number 686, F715
## 2024-12-29 07:41:30.477618 INFO::Fitting model to feature number 687, F716
## 2024-12-29 07:41:30.479798 INFO::Fitting model to feature number 688, F717
## 2024-12-29 07:41:30.482001 INFO::Fitting model to feature number 689, F718
## 2024-12-29 07:41:30.484207 INFO::Fitting model to feature number 690, F719
## 2024-12-29 07:41:30.486379 INFO::Fitting model to feature number 691, F720
## 2024-12-29 07:41:30.488594 INFO::Fitting model to feature number 692, F721
## 2024-12-29 07:41:30.490786 INFO::Fitting model to feature number 693, F722
## 2024-12-29 07:41:30.492986 INFO::Fitting model to feature number 694, F723
## 2024-12-29 07:41:30.495165 INFO::Fitting model to feature number 695, F724
## 2024-12-29 07:41:30.497361 INFO::Fitting model to feature number 696, F725
## 2024-12-29 07:41:30.499562 INFO::Fitting model to feature number 697, F726
## 2024-12-29 07:41:30.501747 INFO::Fitting model to feature number 698, F727
## 2024-12-29 07:41:30.503939 INFO::Fitting model to feature number 699, F728
## 2024-12-29 07:41:30.506122 INFO::Fitting model to feature number 700, F729
## 2024-12-29 07:41:30.508312 INFO::Fitting model to feature number 701, F730
## 2024-12-29 07:41:30.510504 INFO::Fitting model to feature number 702, F731
## 2024-12-29 07:41:30.512715 INFO::Fitting model to feature number 703, F732
## 2024-12-29 07:41:30.514881 INFO::Fitting model to feature number 704, F733
## 2024-12-29 07:41:30.51716 INFO::Fitting model to feature number 705, F734
## 2024-12-29 07:41:30.519332 INFO::Fitting model to feature number 706, F735
## 2024-12-29 07:41:30.521513 INFO::Fitting model to feature number 707, F736
## 2024-12-29 07:41:30.523686 INFO::Fitting model to feature number 708, F737
## 2024-12-29 07:41:30.525883 INFO::Fitting model to feature number 709, F739
## 2024-12-29 07:41:30.528053 INFO::Fitting model to feature number 710, F740
## 2024-12-29 07:41:30.530244 INFO::Fitting model to feature number 711, F741
## 2024-12-29 07:41:30.532435 INFO::Fitting model to feature number 712, F742
## 2024-12-29 07:41:30.534594 INFO::Fitting model to feature number 713, F743
## 2024-12-29 07:41:30.536796 INFO::Fitting model to feature number 714, F744
## 2024-12-29 07:41:30.538981 INFO::Fitting model to feature number 715, F745
## 2024-12-29 07:41:30.541192 INFO::Fitting model to feature number 716, F746
## 2024-12-29 07:41:30.543381 INFO::Fitting model to feature number 717, F747
## 2024-12-29 07:41:30.54557 INFO::Fitting model to feature number 718, F748
## 2024-12-29 07:41:30.547742 INFO::Fitting model to feature number 719, F749
## 2024-12-29 07:41:30.549938 INFO::Fitting model to feature number 720, F750
## 2024-12-29 07:41:30.552106 INFO::Fitting model to feature number 721, F751
## 2024-12-29 07:41:30.554329 INFO::Fitting model to feature number 722, F752
## 2024-12-29 07:41:30.556522 INFO::Fitting model to feature number 723, F753
## 2024-12-29 07:41:30.558702 INFO::Fitting model to feature number 724, F754
## 2024-12-29 07:41:30.560932 INFO::Fitting model to feature number 725, F755
## 2024-12-29 07:41:30.56313 INFO::Fitting model to feature number 726, F756
## 2024-12-29 07:41:30.565329 INFO::Fitting model to feature number 727, F757
## 2024-12-29 07:41:30.567502 INFO::Fitting model to feature number 728, F758
## 2024-12-29 07:41:30.569675 INFO::Fitting model to feature number 729, F759
## 2024-12-29 07:41:30.571858 INFO::Fitting model to feature number 730, F760
## 2024-12-29 07:41:30.574063 INFO::Fitting model to feature number 731, F761
## 2024-12-29 07:41:30.576253 INFO::Fitting model to feature number 732, F762
## 2024-12-29 07:41:30.57841 INFO::Fitting model to feature number 733, F763
## 2024-12-29 07:41:30.580592 INFO::Fitting model to feature number 734, F764
## 2024-12-29 07:41:30.582748 INFO::Fitting model to feature number 735, F765
## 2024-12-29 07:41:30.584932 INFO::Fitting model to feature number 736, F766
## 2024-12-29 07:41:30.58711 INFO::Fitting model to feature number 737, F767
## 2024-12-29 07:41:30.589342 INFO::Fitting model to feature number 738, F768
## 2024-12-29 07:41:30.59154 INFO::Fitting model to feature number 739, F769
## 2024-12-29 07:41:30.593734 INFO::Fitting model to feature number 740, F770
## 2024-12-29 07:41:30.595888 INFO::Fitting model to feature number 741, F771
## 2024-12-29 07:41:30.598083 INFO::Fitting model to feature number 742, F772
## 2024-12-29 07:41:30.600281 INFO::Fitting model to feature number 743, F773
## 2024-12-29 07:41:30.602471 INFO::Fitting model to feature number 744, F774
## 2024-12-29 07:41:30.604672 INFO::Fitting model to feature number 745, F775
## 2024-12-29 07:41:30.606869 INFO::Fitting model to feature number 746, F776
## 2024-12-29 07:41:30.609067 INFO::Fitting model to feature number 747, F777
## 2024-12-29 07:41:30.611242 INFO::Fitting model to feature number 748, F778
## 2024-12-29 07:41:30.613477 INFO::Fitting model to feature number 749, F779
## 2024-12-29 07:41:30.61568 INFO::Fitting model to feature number 750, F780
## 2024-12-29 07:41:30.617892 INFO::Fitting model to feature number 751, F781
## 2024-12-29 07:41:30.620078 INFO::Fitting model to feature number 752, F782
## 2024-12-29 07:41:30.622296 INFO::Fitting model to feature number 753, F783
## 2024-12-29 07:41:30.624512 INFO::Fitting model to feature number 754, F784
## 2024-12-29 07:41:30.626678 INFO::Fitting model to feature number 755, F785
## 2024-12-29 07:41:30.628916 INFO::Fitting model to feature number 756, F786
## 2024-12-29 07:41:30.631128 INFO::Fitting model to feature number 757, F787
## 2024-12-29 07:41:30.633353 INFO::Fitting model to feature number 758, F788
## 2024-12-29 07:41:30.635581 INFO::Fitting model to feature number 759, F789
## 2024-12-29 07:41:30.637828 INFO::Fitting model to feature number 760, F790
## 2024-12-29 07:41:30.640046 INFO::Fitting model to feature number 761, F791
## 2024-12-29 07:41:30.642386 INFO::Fitting model to feature number 762, F792
## 2024-12-29 07:41:30.644608 INFO::Fitting model to feature number 763, F793
## 2024-12-29 07:41:30.646801 INFO::Fitting model to feature number 764, F794
## 2024-12-29 07:41:30.649019 INFO::Fitting model to feature number 765, F795
## 2024-12-29 07:41:30.651215 INFO::Fitting model to feature number 766, F796
## 2024-12-29 07:41:30.653415 INFO::Fitting model to feature number 767, F797
## 2024-12-29 07:41:30.655643 INFO::Fitting model to feature number 768, F798
## 2024-12-29 07:41:30.657871 INFO::Fitting model to feature number 769, F799
## 2024-12-29 07:41:30.660106 INFO::Fitting model to feature number 770, F800
## 2024-12-29 07:41:30.66242 INFO::Fitting model to feature number 771, F801
## 2024-12-29 07:41:30.664756 INFO::Fitting model to feature number 772, F802
## 2024-12-29 07:41:30.666998 INFO::Fitting model to feature number 773, F803
## 2024-12-29 07:41:30.669237 INFO::Fitting model to feature number 774, F804
## 2024-12-29 07:41:30.671516 INFO::Fitting model to feature number 775, F805
## 2024-12-29 07:41:30.673733 INFO::Fitting model to feature number 776, F806
## 2024-12-29 07:41:30.675917 INFO::Fitting model to feature number 777, F808
## 2024-12-29 07:41:30.678154 INFO::Fitting model to feature number 778, F809
## 2024-12-29 07:41:30.68038 INFO::Fitting model to feature number 779, F810
## 2024-12-29 07:41:30.682578 INFO::Fitting model to feature number 780, F811
## 2024-12-29 07:41:30.684802 INFO::Fitting model to feature number 781, F812
## 2024-12-29 07:41:30.687002 INFO::Fitting model to feature number 782, F813
## 2024-12-29 07:41:30.689224 INFO::Fitting model to feature number 783, F814
## 2024-12-29 07:41:30.691388 INFO::Fitting model to feature number 784, F815
## 2024-12-29 07:41:30.693587 INFO::Fitting model to feature number 785, F816
## 2024-12-29 07:41:30.695753 INFO::Fitting model to feature number 786, F817
## 2024-12-29 07:41:30.697984 INFO::Fitting model to feature number 787, F818
## 2024-12-29 07:41:30.700158 INFO::Fitting model to feature number 788, F819
## 2024-12-29 07:41:30.702331 INFO::Fitting model to feature number 789, F820
## 2024-12-29 07:41:30.704531 INFO::Fitting model to feature number 790, F821
## 2024-12-29 07:41:30.706723 INFO::Fitting model to feature number 791, F822
## 2024-12-29 07:41:30.708937 INFO::Fitting model to feature number 792, F823
## 2024-12-29 07:41:30.71115 INFO::Fitting model to feature number 793, F824
## 2024-12-29 07:41:30.713381 INFO::Fitting model to feature number 794, F825
## 2024-12-29 07:41:30.715539 INFO::Fitting model to feature number 795, F826
## 2024-12-29 07:41:30.717757 INFO::Fitting model to feature number 796, F827
## 2024-12-29 07:41:30.719931 INFO::Fitting model to feature number 797, F828
## 2024-12-29 07:41:30.722135 INFO::Fitting model to feature number 798, F829
## 2024-12-29 07:41:30.72434 INFO::Fitting model to feature number 799, F830
## 2024-12-29 07:41:30.726524 INFO::Fitting model to feature number 800, F831
## 2024-12-29 07:41:30.728739 INFO::Fitting model to feature number 801, F832
## 2024-12-29 07:41:30.730912 INFO::Fitting model to feature number 802, F833
## 2024-12-29 07:41:30.733127 INFO::Fitting model to feature number 803, F834
## 2024-12-29 07:41:30.735305 INFO::Fitting model to feature number 804, F835
## 2024-12-29 07:41:30.737519 INFO::Fitting model to feature number 805, F836
## 2024-12-29 07:41:30.739697 INFO::Fitting model to feature number 806, F837
## 2024-12-29 07:41:30.741913 INFO::Fitting model to feature number 807, F838
## 2024-12-29 07:41:30.744094 INFO::Fitting model to feature number 808, F839
## 2024-12-29 07:41:30.746313 INFO::Fitting model to feature number 809, F840
## 2024-12-29 07:41:30.748529 INFO::Fitting model to feature number 810, F841
## 2024-12-29 07:41:30.750704 INFO::Fitting model to feature number 811, F842
## 2024-12-29 07:41:30.752916 INFO::Fitting model to feature number 812, F843
## 2024-12-29 07:41:30.755098 INFO::Fitting model to feature number 813, F844
## 2024-12-29 07:41:30.75731 INFO::Fitting model to feature number 814, F845
## 2024-12-29 07:41:30.75949 INFO::Fitting model to feature number 815, F846
## 2024-12-29 07:41:30.761708 INFO::Fitting model to feature number 816, F847
## 2024-12-29 07:41:30.763881 INFO::Fitting model to feature number 817, F848
## 2024-12-29 07:41:30.766095 INFO::Fitting model to feature number 818, F849
## 2024-12-29 07:41:30.7683 INFO::Fitting model to feature number 819, F850
## 2024-12-29 07:41:30.77048 INFO::Fitting model to feature number 820, F851
## 2024-12-29 07:41:30.772679 INFO::Fitting model to feature number 821, F852
## 2024-12-29 07:41:30.774853 INFO::Fitting model to feature number 822, F853
## 2024-12-29 07:41:30.777075 INFO::Fitting model to feature number 823, F854
## 2024-12-29 07:41:30.779251 INFO::Fitting model to feature number 824, F855
## 2024-12-29 07:41:30.781466 INFO::Fitting model to feature number 825, F856
## 2024-12-29 07:41:30.783658 INFO::Fitting model to feature number 826, F857
## 2024-12-29 07:41:30.785875 INFO::Fitting model to feature number 827, F858
## 2024-12-29 07:41:30.788069 INFO::Fitting model to feature number 828, F859
## 2024-12-29 07:41:30.790301 INFO::Fitting model to feature number 829, F860
## 2024-12-29 07:41:30.792512 INFO::Fitting model to feature number 830, F861
## 2024-12-29 07:41:30.794698 INFO::Fitting model to feature number 831, F862
## 2024-12-29 07:41:30.796929 INFO::Fitting model to feature number 832, F863
## 2024-12-29 07:41:30.799098 INFO::Fitting model to feature number 833, F864
## 2024-12-29 07:41:30.801315 INFO::Fitting model to feature number 834, F865
## 2024-12-29 07:41:30.803499 INFO::Fitting model to feature number 835, F866
## 2024-12-29 07:41:30.805719 INFO::Fitting model to feature number 836, F867
## 2024-12-29 07:41:30.807991 INFO::Fitting model to feature number 837, F868
## 2024-12-29 07:41:30.810204 INFO::Fitting model to feature number 838, F869
## 2024-12-29 07:41:30.81241 INFO::Fitting model to feature number 839, F870
## 2024-12-29 07:41:30.814588 INFO::Fitting model to feature number 840, F871
## 2024-12-29 07:41:30.816823 INFO::Fitting model to feature number 841, F872
## 2024-12-29 07:41:30.819011 INFO::Fitting model to feature number 842, F873
## 2024-12-29 07:41:30.821226 INFO::Fitting model to feature number 843, F874
## 2024-12-29 07:41:30.82342 INFO::Fitting model to feature number 844, F875
## 2024-12-29 07:41:30.825656 INFO::Fitting model to feature number 845, F876
## 2024-12-29 07:41:30.827853 INFO::Fitting model to feature number 846, F877
## 2024-12-29 07:41:30.83008 INFO::Fitting model to feature number 847, F878
## 2024-12-29 07:41:30.832319 INFO::Fitting model to feature number 848, F879
## 2024-12-29 07:41:30.834515 INFO::Fitting model to feature number 849, F880
## 2024-12-29 07:41:30.836733 INFO::Fitting model to feature number 850, F881
## 2024-12-29 07:41:30.838938 INFO::Fitting model to feature number 851, F882
## 2024-12-29 07:41:30.84118 INFO::Fitting model to feature number 852, F883
## 2024-12-29 07:41:30.843386 INFO::Fitting model to feature number 853, F884
## 2024-12-29 07:41:30.845609 INFO::Fitting model to feature number 854, F885
## 2024-12-29 07:41:30.847805 INFO::Fitting model to feature number 855, F886
## 2024-12-29 07:41:30.850036 INFO::Fitting model to feature number 856, F887
## 2024-12-29 07:41:30.852257 INFO::Fitting model to feature number 857, F888
## 2024-12-29 07:41:30.854495 INFO::Fitting model to feature number 858, F889
## 2024-12-29 07:41:30.856708 INFO::Fitting model to feature number 859, F890
## 2024-12-29 07:41:30.85891 INFO::Fitting model to feature number 860, F891
## 2024-12-29 07:41:30.861137 INFO::Fitting model to feature number 861, F892
## 2024-12-29 07:41:30.863324 INFO::Fitting model to feature number 862, F893
## 2024-12-29 07:41:30.865535 INFO::Fitting model to feature number 863, F894
## 2024-12-29 07:41:30.867722 INFO::Fitting model to feature number 864, F895
## 2024-12-29 07:41:30.869942 INFO::Fitting model to feature number 865, F896
## 2024-12-29 07:41:30.872113 INFO::Fitting model to feature number 866, F897
## 2024-12-29 07:41:30.874334 INFO::Fitting model to feature number 867, F898
## 2024-12-29 07:41:30.876541 INFO::Fitting model to feature number 868, F899
## 2024-12-29 07:41:30.878736 INFO::Fitting model to feature number 869, F900
## 2024-12-29 07:41:30.994375 INFO::Counting total values for each feature
## 2024-12-29 07:41:31.069509 INFO::Writing filtered data to file Macarron_output/maaslin2_results/features/filtered_data.tsv
## 2024-12-29 07:41:31.126165 INFO::Writing filtered, normalized data to file Macarron_output/maaslin2_results/features/filtered_data_norm.tsv
## 2024-12-29 07:41:31.182524 INFO::Writing filtered, normalized, transformed data to file Macarron_output/maaslin2_results/features/filtered_data_norm_transformed.tsv
## 2024-12-29 07:41:31.238801 INFO::Writing residuals to file Macarron_output/maaslin2_results/fits/residuals.rds
## 2024-12-29 07:41:31.266757 INFO::Writing fitted values to file Macarron_output/maaslin2_results/fits/fitted.rds
## 2024-12-29 07:41:31.291903 INFO::Writing all results to file (ordered by increasing q-values): Macarron_output/maaslin2_results/all_results.tsv
## 2024-12-29 07:41:31.302699 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): Macarron_output/maaslin2_results/significant_results.tsv
## 2024-12-29 07:41:31.30707 INFO::Writing association plots (one for each significant association) to output folder: Macarron_output/maaslin2_results
## 2024-12-29 07:41:31.31751 INFO::Plotting associations from most to least significant, grouped by metadata
## 2024-12-29 07:41:31.318103 INFO::Plotting data for metadata number 1, diagnosis
## 2024-12-29 07:41:31.346993 INFO::Creating boxplot for categorical data, diagnosis vs F504
## 2024-12-29 07:41:31.531723 INFO::Creating boxplot for categorical data, diagnosis vs F859
## 2024-12-29 07:41:31.687784 INFO::Creating boxplot for categorical data, diagnosis vs F533
## 2024-12-29 07:41:31.807733 INFO::Creating boxplot for categorical data, diagnosis vs F587
## 2024-12-29 07:41:31.91911 INFO::Creating boxplot for categorical data, diagnosis vs F584
## 2024-12-29 07:41:32.0246 INFO::Creating boxplot for categorical data, diagnosis vs F197
## 2024-12-29 07:41:32.136115 INFO::Creating boxplot for categorical data, diagnosis vs F380
## 2024-12-29 07:41:32.241566 INFO::Creating boxplot for categorical data, diagnosis vs F829
## 2024-12-29 07:41:32.346838 INFO::Creating boxplot for categorical data, diagnosis vs F664
## 2024-12-29 07:41:32.49862 INFO::Creating boxplot for categorical data, diagnosis vs F93
## 2024-12-29 07:41:32.60474 INFO::Creating boxplot for categorical data, diagnosis vs F15
## 2024-12-29 07:41:32.71463 INFO::Creating boxplot for categorical data, diagnosis vs F881
## 2024-12-29 07:41:32.822275 INFO::Creating boxplot for categorical data, diagnosis vs F806
## 2024-12-29 07:41:32.952572 INFO::Creating boxplot for categorical data, diagnosis vs F78
## 2024-12-29 07:41:33.057487 INFO::Creating boxplot for categorical data, diagnosis vs F189
## 2024-12-29 07:41:33.163184 INFO::Creating boxplot for categorical data, diagnosis vs F369
## 2024-12-29 07:41:33.268982 INFO::Creating boxplot for categorical data, diagnosis vs F623
## 2024-12-29 07:41:33.382446 INFO::Creating boxplot for categorical data, diagnosis vs F710
## 2024-12-29 07:41:33.487004 INFO::Creating boxplot for categorical data, diagnosis vs F851
## 2024-12-29 07:41:33.594821 INFO::Creating boxplot for categorical data, diagnosis vs F257
## 2024-12-29 07:41:33.702007 INFO::Creating boxplot for categorical data, diagnosis vs F330
## 2024-12-29 07:41:33.816927 INFO::Creating boxplot for categorical data, diagnosis vs F344
## 2024-12-29 07:41:33.921799 INFO::Creating boxplot for categorical data, diagnosis vs F696
## 2024-12-29 07:41:34.027195 INFO::Creating boxplot for categorical data, diagnosis vs F741
## 2024-12-29 07:41:34.140723 INFO::Creating boxplot for categorical data, diagnosis vs F509
## 2024-12-29 07:41:34.24623 INFO::Creating boxplot for categorical data, diagnosis vs F479
## 2024-12-29 07:41:34.352291 INFO::Creating boxplot for categorical data, diagnosis vs F550
## 2024-12-29 07:41:34.459425 INFO::Creating boxplot for categorical data, diagnosis vs F640
## 2024-12-29 07:41:34.573417 INFO::Creating boxplot for categorical data, diagnosis vs F281
## 2024-12-29 07:41:34.677968 INFO::Creating boxplot for categorical data, diagnosis vs F80
## 2024-12-29 07:41:34.785323 INFO::Creating boxplot for categorical data, diagnosis vs F285
## 2024-12-29 07:41:34.907413 INFO::Creating boxplot for categorical data, diagnosis vs F531
## 2024-12-29 07:41:35.02142 INFO::Creating boxplot for categorical data, diagnosis vs F737
## 2024-12-29 07:41:35.126046 INFO::Creating boxplot for categorical data, diagnosis vs F875
## 2024-12-29 07:41:35.231266 INFO::Creating boxplot for categorical data, diagnosis vs F864
## 2024-12-29 07:41:35.344726 INFO::Creating boxplot for categorical data, diagnosis vs F379
## 2024-12-29 07:41:35.449303 INFO::Creating boxplot for categorical data, diagnosis vs F190
## 2024-12-29 07:41:35.554877 INFO::Creating boxplot for categorical data, diagnosis vs F4
## 2024-12-29 07:41:35.663306 INFO::Creating boxplot for categorical data, diagnosis vs F591
## 2024-12-29 07:41:35.778029 INFO::Creating boxplot for categorical data, diagnosis vs F773
## 2024-12-29 07:41:35.882386 INFO::Creating boxplot for categorical data, diagnosis vs F283
## 2024-12-29 07:41:35.988204 INFO::Creating boxplot for categorical data, diagnosis vs F233
## 2024-12-29 07:41:36.094897 INFO::Creating boxplot for categorical data, diagnosis vs F420
## 2024-12-29 07:41:36.208807 INFO::Creating boxplot for categorical data, diagnosis vs F5
## 2024-12-29 07:41:36.314115 INFO::Creating boxplot for categorical data, diagnosis vs F137
## 2024-12-29 07:41:36.419765 INFO::Creating boxplot for categorical data, diagnosis vs F215
## 2024-12-29 07:41:36.544048 INFO::Creating boxplot for categorical data, diagnosis vs F489
## 2024-12-29 07:41:36.650504 INFO::Creating boxplot for categorical data, diagnosis vs F220
## 2024-12-29 07:41:36.758505 INFO::Creating boxplot for categorical data, diagnosis vs F691
## 2024-12-29 07:41:36.865726 INFO::Creating boxplot for categorical data, diagnosis vs F381
## 2024-12-29 07:41:36.980832 INFO::Creating boxplot for categorical data, diagnosis vs F539
## 2024-12-29 07:41:37.085387 INFO::Creating boxplot for categorical data, diagnosis vs F490
## 2024-12-29 07:41:37.192871 INFO::Creating boxplot for categorical data, diagnosis vs F832
## 2024-12-29 07:41:37.299327 INFO::Creating boxplot for categorical data, diagnosis vs F396
## 2024-12-29 07:41:37.413369 INFO::Creating boxplot for categorical data, diagnosis vs F528
## 2024-12-29 07:41:37.518708 INFO::Creating boxplot for categorical data, diagnosis vs F234
## 2024-12-29 07:41:37.629257 INFO::Creating boxplot for categorical data, diagnosis vs F178
## 2024-12-29 07:41:37.744479 INFO::Creating boxplot for categorical data, diagnosis vs F761
## 2024-12-29 07:41:37.849896 INFO::Creating boxplot for categorical data, diagnosis vs F2
## 2024-12-29 07:41:37.955942 INFO::Creating boxplot for categorical data, diagnosis vs F260
## 2024-12-29 07:41:38.063854 INFO::Creating boxplot for categorical data, diagnosis vs F734
## 2024-12-29 07:41:38.179204 INFO::Creating boxplot for categorical data, diagnosis vs F429
## 2024-12-29 07:41:38.283726 INFO::Creating boxplot for categorical data, diagnosis vs F630
## 2024-12-29 07:41:38.390476 INFO::Creating boxplot for categorical data, diagnosis vs F817
## 2024-12-29 07:41:38.505089 INFO::Creating boxplot for categorical data, diagnosis vs F847
## 2024-12-29 07:41:38.611869 INFO::Creating boxplot for categorical data, diagnosis vs F896
## 2024-12-29 07:41:38.718255 INFO::Creating boxplot for categorical data, diagnosis vs F81
## 2024-12-29 07:41:38.826014 INFO::Creating boxplot for categorical data, diagnosis vs F110
## 2024-12-29 07:41:38.941054 INFO::Creating boxplot for categorical data, diagnosis vs F3
## 2024-12-29 07:41:39.04679 INFO::Creating boxplot for categorical data, diagnosis vs F33
## 2024-12-29 07:41:39.153987 INFO::Creating boxplot for categorical data, diagnosis vs F270
## 2024-12-29 07:41:39.268329 INFO::Creating boxplot for categorical data, diagnosis vs F278
## 2024-12-29 07:41:39.37227 INFO::Creating boxplot for categorical data, diagnosis vs F264
## 2024-12-29 07:41:39.477267 INFO::Creating boxplot for categorical data, diagnosis vs F90
## 2024-12-29 07:41:39.583219 INFO::Creating boxplot for categorical data, diagnosis vs F403
## 2024-12-29 07:41:39.699629 INFO::Creating boxplot for categorical data, diagnosis vs F727
## 2024-12-29 07:41:39.805397 INFO::Creating boxplot for categorical data, diagnosis vs F394
## 2024-12-29 07:41:39.912244 INFO::Creating boxplot for categorical data, diagnosis vs F800
## 2024-12-29 07:41:40.026787 INFO::Creating boxplot for categorical data, diagnosis vs F439
## 2024-12-29 07:41:40.132425 INFO::Creating boxplot for categorical data, diagnosis vs F554
## 2024-12-29 07:41:40.237261 INFO::Creating boxplot for categorical data, diagnosis vs F559
## 2024-12-29 07:41:40.3421 INFO::Creating boxplot for categorical data, diagnosis vs F548
## 2024-12-29 07:41:40.457082 INFO::Creating boxplot for categorical data, diagnosis vs F794
## 2024-12-29 07:41:40.574603 INFO::Creating boxplot for categorical data, diagnosis vs F45
## 2024-12-29 07:41:40.682779 INFO::Creating boxplot for categorical data, diagnosis vs F158
## 2024-12-29 07:41:40.818206 INFO::Creating boxplot for categorical data, diagnosis vs F477
## 2024-12-29 07:41:40.93062 INFO::Creating boxplot for categorical data, diagnosis vs F1
## 2024-12-29 07:41:41.036082 INFO::Creating boxplot for categorical data, diagnosis vs F862
## 2024-12-29 07:41:41.1423 INFO::Creating boxplot for categorical data, diagnosis vs F803
## 2024-12-29 07:41:41.262386 INFO::Creating boxplot for categorical data, diagnosis vs F751
## 2024-12-29 07:41:41.374507 INFO::Creating boxplot for categorical data, diagnosis vs F98
## 2024-12-29 07:41:41.478996 INFO::Creating boxplot for categorical data, diagnosis vs F22
## 2024-12-29 07:41:41.583514 INFO::Creating boxplot for categorical data, diagnosis vs F625
## 2024-12-29 07:41:41.708302 INFO::Creating boxplot for categorical data, diagnosis vs F206
## 2024-12-29 07:41:41.81526 INFO::Creating boxplot for categorical data, diagnosis vs F779
## 2024-12-29 07:41:41.920741 INFO::Creating boxplot for categorical data, diagnosis vs F532
## 2024-12-29 07:41:42.025928 INFO::Creating boxplot for categorical data, diagnosis vs F676
## 2024-12-29 07:41:42.152682 INFO::Creating boxplot for categorical data, diagnosis vs F644
## 2024-12-29 07:41:42.259726 INFO::Creating boxplot for categorical data, diagnosis vs F7
## 2024-12-29 07:41:42.364908 INFO::Creating boxplot for categorical data, diagnosis vs F596
## 2024-12-29 07:41:42.482779 INFO::Creating boxplot for categorical data, diagnosis vs F250
## 2024-12-29 07:41:42.593199 INFO::Creating boxplot for categorical data, diagnosis vs F462
## 2024-12-29 07:41:42.698885 INFO::Creating boxplot for categorical data, diagnosis vs F516
## 2024-12-29 07:41:42.805392 INFO::Creating boxplot for categorical data, diagnosis vs F659
## 2024-12-29 07:41:42.927437 INFO::Creating boxplot for categorical data, diagnosis vs F663
## 2024-12-29 07:41:43.034525 INFO::Creating boxplot for categorical data, diagnosis vs F837
## 2024-12-29 07:41:43.14102 INFO::Creating boxplot for categorical data, diagnosis vs F138
## 2024-12-29 07:41:43.247466 INFO::Creating boxplot for categorical data, diagnosis vs F445
## 2024-12-29 07:41:43.370803 INFO::Creating boxplot for categorical data, diagnosis vs F697
## 2024-12-29 07:41:43.477427 INFO::Creating boxplot for categorical data, diagnosis vs F225
## 2024-12-29 07:41:43.583083 INFO::Creating boxplot for categorical data, diagnosis vs F148
## 2024-12-29 07:41:43.690354 INFO::Creating boxplot for categorical data, diagnosis vs F448
## 2024-12-29 07:41:43.81108 INFO::Creating boxplot for categorical data, diagnosis vs F91
## 2024-12-29 07:41:43.91864 INFO::Creating boxplot for categorical data, diagnosis vs F123
## 2024-12-29 07:41:44.024304 INFO::Creating boxplot for categorical data, diagnosis vs F665
## 2024-12-29 07:41:44.144738 INFO::Creating boxplot for categorical data, diagnosis vs F845
## 2024-12-29 07:41:44.252472 INFO::Creating boxplot for categorical data, diagnosis vs F331
## 2024-12-29 07:41:44.358872 INFO::Creating boxplot for categorical data, diagnosis vs F361
## 2024-12-29 07:41:44.46569 INFO::Creating boxplot for categorical data, diagnosis vs F421
## 2024-12-29 07:41:44.587686 INFO::Creating boxplot for categorical data, diagnosis vs F277
## 2024-12-29 07:41:44.694339 INFO::Creating boxplot for categorical data, diagnosis vs F307
## 2024-12-29 07:41:44.812922 INFO::Creating boxplot for categorical data, diagnosis vs F503
## 2024-12-29 07:41:44.935591 INFO::Creating boxplot for categorical data, diagnosis vs F34
## 2024-12-29 07:41:45.047602 INFO::Creating boxplot for categorical data, diagnosis vs F649
## 2024-12-29 07:41:45.155559 INFO::Creating boxplot for categorical data, diagnosis vs F825
## 2024-12-29 07:41:45.260712 INFO::Creating boxplot for categorical data, diagnosis vs F298
## 2024-12-29 07:41:45.384233 INFO::Creating boxplot for categorical data, diagnosis vs F461
## 2024-12-29 07:41:45.49024 INFO::Creating boxplot for categorical data, diagnosis vs F242
## 2024-12-29 07:41:45.600599 INFO::Creating boxplot for categorical data, diagnosis vs F375
## 2024-12-29 07:41:45.708303 INFO::Creating boxplot for categorical data, diagnosis vs F648
## 2024-12-29 07:41:45.831107 INFO::Creating boxplot for categorical data, diagnosis vs F724
## 2024-12-29 07:41:45.938334 INFO::Creating boxplot for categorical data, diagnosis vs F678
## 2024-12-29 07:41:46.045339 INFO::Creating boxplot for categorical data, diagnosis vs F290
## 2024-12-29 07:41:46.167762 INFO::Creating boxplot for categorical data, diagnosis vs F743
## 2024-12-29 07:41:46.275511 INFO::Creating boxplot for categorical data, diagnosis vs F495
## 2024-12-29 07:41:46.382172 INFO::Creating boxplot for categorical data, diagnosis vs F261
## 2024-12-29 07:41:46.490014 INFO::Creating boxplot for categorical data, diagnosis vs F43
## 2024-12-29 07:41:46.61146 INFO::Creating boxplot for categorical data, diagnosis vs F714
## 2024-12-29 07:41:46.718414 INFO::Creating boxplot for categorical data, diagnosis vs F131
## 2024-12-29 07:41:46.823997 INFO::Creating boxplot for categorical data, diagnosis vs F150
## 2024-12-29 07:41:46.950564 INFO::Creating boxplot for categorical data, diagnosis vs F651
## 2024-12-29 07:41:47.060037 INFO::Creating boxplot for categorical data, diagnosis vs F798
## 2024-12-29 07:41:47.165806 INFO::Creating boxplot for categorical data, diagnosis vs F289
## 2024-12-29 07:41:47.272948 INFO::Creating boxplot for categorical data, diagnosis vs F661
## 2024-12-29 07:41:47.399793 INFO::Creating boxplot for categorical data, diagnosis vs F199
## 2024-12-29 07:41:47.504794 INFO::Creating boxplot for categorical data, diagnosis vs F406
## 2024-12-29 07:41:47.610472 INFO::Creating boxplot for categorical data, diagnosis vs F139
## 2024-12-29 07:41:47.733566 INFO::Creating boxplot for categorical data, diagnosis vs F506
## 2024-12-29 07:41:47.839635 INFO::Creating boxplot for categorical data, diagnosis vs F552
## 2024-12-29 07:41:47.947828 INFO::Creating boxplot for categorical data, diagnosis vs F94
## 2024-12-29 07:41:48.055823 INFO::Creating boxplot for categorical data, diagnosis vs F430
## 2024-12-29 07:41:48.178195 INFO::Creating boxplot for categorical data, diagnosis vs F639
## 2024-12-29 07:41:48.285194 INFO::Creating boxplot for categorical data, diagnosis vs F500
## 2024-12-29 07:41:48.391314 INFO::Creating boxplot for categorical data, diagnosis vs F609
## 2024-12-29 07:41:48.526018 INFO::Creating boxplot for categorical data, diagnosis vs F306
## 2024-12-29 07:41:48.633374 INFO::Creating boxplot for categorical data, diagnosis vs F507
## 2024-12-29 07:41:48.740107 INFO::Creating boxplot for categorical data, diagnosis vs F671
## 2024-12-29 07:41:48.847448 INFO::Creating boxplot for categorical data, diagnosis vs F894
## 2024-12-29 07:41:48.97329 INFO::Creating boxplot for categorical data, diagnosis vs F345
## 2024-12-29 07:41:49.079433 INFO::Creating boxplot for categorical data, diagnosis vs F801
## 2024-12-29 07:41:49.186698 INFO::Creating boxplot for categorical data, diagnosis vs F194
## 2024-12-29 07:41:49.845309 INFO::Creating boxplot for categorical data, diagnosis vs F195
## 2024-12-29 07:41:49.951942 INFO::Creating boxplot for categorical data, diagnosis vs F119
## 2024-12-29 07:41:50.055065 INFO::Creating boxplot for categorical data, diagnosis vs F120
## 2024-12-29 07:41:50.160784 INFO::Creating boxplot for categorical data, diagnosis vs F231
## 2024-12-29 07:41:50.273003 INFO::Creating boxplot for categorical data, diagnosis vs F311
## 2024-12-29 07:41:50.375248 INFO::Creating boxplot for categorical data, diagnosis vs F646
## 2024-12-29 07:41:50.478401 INFO::Creating boxplot for categorical data, diagnosis vs F814
## 2024-12-29 07:41:50.584522 INFO::Creating boxplot for categorical data, diagnosis vs F510
## 2024-12-29 07:41:50.697547 INFO::Creating boxplot for categorical data, diagnosis vs F398
## 2024-12-29 07:41:50.7997 INFO::Creating boxplot for categorical data, diagnosis vs F60
## 2024-12-29 07:41:50.907923 INFO::Creating boxplot for categorical data, diagnosis vs F153
## 2024-12-29 07:41:51.013982 INFO::Creating boxplot for categorical data, diagnosis vs F858
## 2024-12-29 07:41:51.124126 INFO::Creating boxplot for categorical data, diagnosis vs F775
## 2024-12-29 07:41:51.227239 INFO::Creating boxplot for categorical data, diagnosis vs F684
## 2024-12-29 07:41:51.330995 INFO::Creating boxplot for categorical data, diagnosis vs F384
## 2024-12-29 07:41:51.451694 INFO::Creating boxplot for categorical data, diagnosis vs F134
## 2024-12-29 07:41:51.554322 INFO::Creating boxplot for categorical data, diagnosis vs F670
## 2024-12-29 07:41:51.657214 INFO::Creating boxplot for categorical data, diagnosis vs F632
## 2024-12-29 07:41:51.765578 INFO::Creating boxplot for categorical data, diagnosis vs F721
## 2024-12-29 07:41:51.876726 INFO::Creating boxplot for categorical data, diagnosis vs F700
## 2024-12-29 07:41:51.984442 INFO::Creating boxplot for categorical data, diagnosis vs F376
## 2024-12-29 07:41:52.088 INFO::Creating boxplot for categorical data, diagnosis vs F301
## 2024-12-29 07:41:52.19334 INFO::Creating boxplot for categorical data, diagnosis vs F27
## 2024-12-29 07:41:52.302461 INFO::Creating boxplot for categorical data, diagnosis vs F280
## 2024-12-29 07:41:52.415996 INFO::Creating boxplot for categorical data, diagnosis vs F391
## 2024-12-29 07:41:52.519682 INFO::Creating boxplot for categorical data, diagnosis vs F725
## 2024-12-29 07:41:52.630739 INFO::Creating boxplot for categorical data, diagnosis vs F186
## 2024-12-29 07:41:52.736106 INFO::Creating boxplot for categorical data, diagnosis vs F481
## 2024-12-29 07:41:52.838764 INFO::Creating boxplot for categorical data, diagnosis vs F333
## 2024-12-29 07:41:52.943464 INFO::Creating boxplot for categorical data, diagnosis vs F720
## 2024-12-29 07:41:53.054636 INFO::Creating boxplot for categorical data, diagnosis vs F520
## 2024-12-29 07:41:53.159752 INFO::Creating boxplot for categorical data, diagnosis vs F129
## 2024-12-29 07:41:53.262707 INFO::Creating boxplot for categorical data, diagnosis vs F204
## 2024-12-29 07:41:53.373917 INFO::Creating boxplot for categorical data, diagnosis vs F259
## 2024-12-29 07:41:53.483938 INFO::Creating boxplot for categorical data, diagnosis vs F831
## 2024-12-29 07:41:53.587354 INFO::Creating boxplot for categorical data, diagnosis vs F891
## 2024-12-29 07:41:53.69071 INFO::Creating boxplot for categorical data, diagnosis vs F262
## 2024-12-29 07:41:53.802275 INFO::Creating boxplot for categorical data, diagnosis vs F592
## 2024-12-29 07:41:53.904871 INFO::Creating boxplot for categorical data, diagnosis vs F343
## 2024-12-29 07:41:54.01268 INFO::Creating boxplot for categorical data, diagnosis vs F505
## 2024-12-29 07:41:54.118322 INFO::Creating boxplot for categorical data, diagnosis vs F622
## 2024-12-29 07:41:54.229174 INFO::Creating boxplot for categorical data, diagnosis vs F348
## 2024-12-29 07:41:54.331916 INFO::Creating boxplot for categorical data, diagnosis vs F133
## 2024-12-29 07:41:54.435093 INFO::Creating boxplot for categorical data, diagnosis vs F371
## 2024-12-29 07:41:54.541878 INFO::Creating boxplot for categorical data, diagnosis vs F113
## 2024-12-29 07:41:54.651173 INFO::Creating boxplot for categorical data, diagnosis vs F336
## 2024-12-29 07:41:54.754709 INFO::Creating boxplot for categorical data, diagnosis vs F399
## 2024-12-29 07:41:54.859248 INFO::Creating boxplot for categorical data, diagnosis vs F416
## 2024-12-29 07:41:54.971467 INFO::Creating boxplot for categorical data, diagnosis vs F657
## 2024-12-29 07:41:55.075528 INFO::Creating boxplot for categorical data, diagnosis vs F241
## 2024-12-29 07:41:55.17995 INFO::Creating boxplot for categorical data, diagnosis vs F95
## 2024-12-29 07:41:55.284655 INFO::Creating boxplot for categorical data, diagnosis vs F128
## 2024-12-29 07:41:55.39642 INFO::Creating boxplot for categorical data, diagnosis vs F595
## 2024-12-29 07:41:55.500862 INFO::Creating boxplot for categorical data, diagnosis vs F428
## 2024-12-29 07:41:55.604842 INFO::Creating boxplot for categorical data, diagnosis vs F796
## 2024-12-29 07:41:55.719051 INFO::Creating boxplot for categorical data, diagnosis vs F709
## 2024-12-29 07:41:55.823972 INFO::Creating boxplot for categorical data, diagnosis vs F602
## 2024-12-29 07:41:55.929843 INFO::Creating boxplot for categorical data, diagnosis vs F293
## 2024-12-29 07:41:56.041401 INFO::Creating boxplot for categorical data, diagnosis vs F867
## 2024-12-29 07:41:56.153456 INFO::Creating boxplot for categorical data, diagnosis vs F108
## 2024-12-29 07:41:56.255792 INFO::Creating boxplot for categorical data, diagnosis vs F846
## 2024-12-29 07:41:56.360177 INFO::Creating boxplot for categorical data, diagnosis vs F633
## 2024-12-29 07:41:56.466465 INFO::Creating boxplot for categorical data, diagnosis vs F564
## 2024-12-29 07:41:56.578367 INFO::Creating boxplot for categorical data, diagnosis vs F183
## 2024-12-29 07:41:56.683224 INFO::Creating boxplot for categorical data, diagnosis vs F647
## 2024-12-29 07:41:56.790802 INFO::Creating boxplot for categorical data, diagnosis vs F288
## 2024-12-29 07:41:56.902516 INFO::Creating boxplot for categorical data, diagnosis vs F159
## 2024-12-29 07:41:57.010102 INFO::Creating boxplot for categorical data, diagnosis vs F638
## 2024-12-29 07:41:57.129717 INFO::Creating boxplot for categorical data, diagnosis vs F484
## 2024-12-29 07:41:57.23449 INFO::Creating boxplot for categorical data, diagnosis vs F20
## 2024-12-29 07:41:57.344648 INFO::Creating boxplot for categorical data, diagnosis vs F19
## 2024-12-29 07:41:57.447796 INFO::Creating boxplot for categorical data, diagnosis vs F897
## 2024-12-29 07:41:57.554394 INFO::Creating boxplot for categorical data, diagnosis vs F442
## 2024-12-29 07:41:57.668881 INFO::Creating boxplot for categorical data, diagnosis vs F372
## 2024-12-29 07:41:57.773177 INFO::Creating boxplot for categorical data, diagnosis vs F771
## 2024-12-29 07:41:57.875735 INFO::Creating boxplot for categorical data, diagnosis vs F370
## 2024-12-29 07:41:57.982667 INFO::Creating boxplot for categorical data, diagnosis vs F620
## 2024-12-29 07:41:58.120021 INFO::Creating boxplot for categorical data, diagnosis vs F753
## 2024-12-29 07:41:58.225546 INFO::Creating boxplot for categorical data, diagnosis vs F568
## 2024-12-29 07:41:58.329999 INFO::Creating boxplot for categorical data, diagnosis vs F312
## 2024-12-29 07:41:58.445807 INFO::Creating boxplot for categorical data, diagnosis vs F485
## 2024-12-29 07:41:58.556592 INFO::Creating boxplot for categorical data, diagnosis vs F627
## 2024-12-29 07:41:58.66028 INFO::Creating boxplot for categorical data, diagnosis vs F72
## 2024-12-29 07:41:58.766399 INFO::Creating boxplot for categorical data, diagnosis vs F575
## 2024-12-29 07:41:58.885229 INFO::Creating boxplot for categorical data, diagnosis vs F332
## 2024-12-29 07:41:58.995321 INFO::Creating boxplot for categorical data, diagnosis vs F674
## 2024-12-29 07:41:59.103589 INFO::Creating boxplot for categorical data, diagnosis vs F537
## 2024-12-29 07:41:59.209191 INFO::Creating boxplot for categorical data, diagnosis vs F839
## 2024-12-29 07:41:59.329983 INFO::Creating boxplot for categorical data, diagnosis vs F715
## 2024-12-29 07:41:59.435249 INFO::Creating boxplot for categorical data, diagnosis vs F768
## 2024-12-29 07:41:59.53958 INFO::Creating boxplot for categorical data, diagnosis vs F202
## 2024-12-29 07:41:59.647726 INFO::Creating boxplot for categorical data, diagnosis vs F756
## 2024-12-29 07:41:59.766553 INFO::Creating boxplot for categorical data, diagnosis vs F536
## 2024-12-29 07:41:59.872721 INFO::Creating boxplot for categorical data, diagnosis vs F677
## 2024-12-29 07:41:59.976972 INFO::Creating boxplot for categorical data, diagnosis vs F435
## 2024-12-29 07:42:00.09873 INFO::Creating boxplot for categorical data, diagnosis vs F574
## 2024-12-29 07:42:00.206046 INFO::Creating boxplot for categorical data, diagnosis vs F70
## 2024-12-29 07:42:00.310411 INFO::Creating boxplot for categorical data, diagnosis vs F146
## 2024-12-29 07:42:00.415948 INFO::Creating boxplot for categorical data, diagnosis vs F236
## 2024-12-29 07:42:00.536721 INFO::Creating boxplot for categorical data, diagnosis vs F527
## 2024-12-29 07:42:00.649643 INFO::Creating boxplot for categorical data, diagnosis vs F624
## 2024-12-29 07:42:00.754507 INFO::Creating boxplot for categorical data, diagnosis vs F426
## 2024-12-29 07:42:00.861341 INFO::Creating boxplot for categorical data, diagnosis vs F880
## 2024-12-29 07:42:00.982262 INFO::Creating boxplot for categorical data, diagnosis vs F549
## 2024-12-29 07:42:01.092402 INFO::Creating boxplot for categorical data, diagnosis vs F49
## 2024-12-29 07:42:01.196529 INFO::Creating boxplot for categorical data, diagnosis vs F67
## 2024-12-29 07:42:01.316239 INFO::Creating boxplot for categorical data, diagnosis vs F491
## 2024-12-29 07:42:01.426651 INFO::Creating boxplot for categorical data, diagnosis vs F174
## 2024-12-29 07:42:01.530536 INFO::Creating boxplot for categorical data, diagnosis vs F254
## 2024-12-29 07:42:01.634971 INFO::Creating boxplot for categorical data, diagnosis vs F112
## 2024-12-29 07:42:01.755016 INFO::Creating boxplot for categorical data, diagnosis vs F235
## 2024-12-29 07:42:01.85988 INFO::Creating boxplot for categorical data, diagnosis vs F833
## 2024-12-29 07:42:01.965226 INFO::Creating boxplot for categorical data, diagnosis vs F752
## 2024-12-29 07:42:02.076701 INFO::Creating boxplot for categorical data, diagnosis vs F792
## 2024-12-29 07:42:02.198523 INFO::Creating boxplot for categorical data, diagnosis vs F422
## 2024-12-29 07:42:02.304674 INFO::Creating boxplot for categorical data, diagnosis vs F6
## 2024-12-29 07:42:02.409495 INFO::Creating boxplot for categorical data, diagnosis vs F463
## 2024-12-29 07:42:02.529368 INFO::Creating boxplot for categorical data, diagnosis vs F706
## 2024-12-29 07:42:02.637062 INFO::Creating boxplot for categorical data, diagnosis vs F642
## 2024-12-29 07:42:02.742983 INFO::Creating boxplot for categorical data, diagnosis vs F65
## 2024-12-29 07:42:02.850097 INFO::Creating boxplot for categorical data, diagnosis vs F102
## 2024-12-29 07:42:02.969505 INFO::Creating boxplot for categorical data, diagnosis vs F783
## 2024-12-29 07:42:03.074421 INFO::Creating boxplot for categorical data, diagnosis vs F478
## 2024-12-29 07:42:03.178704 INFO::Creating boxplot for categorical data, diagnosis vs F889
## 2024-12-29 07:42:03.295942 INFO::Creating boxplot for categorical data, diagnosis vs F350
## 2024-12-29 07:42:03.407038 INFO::Creating boxplot for categorical data, diagnosis vs F681
## 2024-12-29 07:42:03.510509 INFO::Creating boxplot for categorical data, diagnosis vs F748
## 2024-12-29 07:42:03.616774 INFO::Creating boxplot for categorical data, diagnosis vs F762
## 2024-12-29 07:42:03.736019 INFO::Creating boxplot for categorical data, diagnosis vs F852
## 2024-12-29 07:42:03.842339 INFO::Creating boxplot for categorical data, diagnosis vs F180
## 2024-12-29 07:42:03.947762 INFO::Creating boxplot for categorical data, diagnosis vs F248
## 2024-12-29 07:42:04.053953 INFO::Creating boxplot for categorical data, diagnosis vs F759
## 2024-12-29 07:42:04.174001 INFO::Creating boxplot for categorical data, diagnosis vs F824
## 2024-12-29 07:42:04.278268 INFO::Creating boxplot for categorical data, diagnosis vs F145
## 2024-12-29 07:42:04.383322 INFO::Creating boxplot for categorical data, diagnosis vs F16
## 2024-12-29 07:42:04.504578 INFO::Creating boxplot for categorical data, diagnosis vs F169
## 2024-12-29 07:42:04.611669 INFO::Creating boxplot for categorical data, diagnosis vs F392
## 2024-12-29 07:42:04.716411 INFO::Creating boxplot for categorical data, diagnosis vs F468
## 2024-12-29 07:42:04.824629 INFO::Creating boxplot for categorical data, diagnosis vs F476
## 2024-12-29 07:42:04.946768 INFO::Creating boxplot for categorical data, diagnosis vs F699
## 2024-12-29 07:42:05.050994 INFO::Creating boxplot for categorical data, diagnosis vs F735
## 2024-12-29 07:42:05.159588 INFO::Creating boxplot for categorical data, diagnosis vs F182
## 2024-12-29 07:42:05.280841 INFO::Creating boxplot for categorical data, diagnosis vs F64
## 2024-12-29 07:42:05.386798 INFO::Creating boxplot for categorical data, diagnosis vs F203
## 2024-12-29 07:42:05.490428 INFO::Creating boxplot for categorical data, diagnosis vs F877
## 2024-12-29 07:42:05.596294 INFO::Creating boxplot for categorical data, diagnosis vs F433
## 2024-12-29 07:42:05.717623 INFO::Creating boxplot for categorical data, diagnosis vs F739
## 2024-12-29 07:42:05.823651 INFO::Creating boxplot for categorical data, diagnosis vs F749
## 2024-12-29 07:42:05.928048 INFO::Creating boxplot for categorical data, diagnosis vs F382
## 2024-12-29 07:42:06.047313 INFO::Creating boxplot for categorical data, diagnosis vs F162
## 2024-12-29 07:42:06.156704 INFO::Creating boxplot for categorical data, diagnosis vs F438
## 2024-12-29 07:42:06.261319 INFO::Creating boxplot for categorical data, diagnosis vs F360
## 2024-12-29 07:42:06.369632 INFO::Creating boxplot for categorical data, diagnosis vs F56
## 2024-12-29 07:42:06.52 INFO::Creating boxplot for categorical data, diagnosis vs F529
## 2024-12-29 07:42:06.633316 INFO::Creating boxplot for categorical data, diagnosis vs F48
## 2024-12-29 07:42:06.740976 INFO::Creating boxplot for categorical data, diagnosis vs F826
## 2024-12-29 07:42:06.861027 INFO::Creating boxplot for categorical data, diagnosis vs F488
## 2024-12-29 07:42:06.971039 INFO::Creating boxplot for categorical data, diagnosis vs F309
## 2024-12-29 07:42:07.078111 INFO::Creating boxplot for categorical data, diagnosis vs F834
## 2024-12-29 07:42:07.186978 INFO::Creating boxplot for categorical data, diagnosis vs F449
## 2024-12-29 07:42:07.305875 INFO::Creating boxplot for categorical data, diagnosis vs F77
## 2024-12-29 07:42:07.413485 INFO::Creating boxplot for categorical data, diagnosis vs F365
## 2024-12-29 07:42:07.520923 INFO::Creating boxplot for categorical data, diagnosis vs F346
## 2024-12-29 07:42:07.627434 INFO::Creating boxplot for categorical data, diagnosis vs F654
## 2024-12-29 07:42:07.748943 INFO::Creating boxplot for categorical data, diagnosis vs F79
## 2024-12-29 07:42:07.858097 INFO::Creating boxplot for categorical data, diagnosis vs F785
## 2024-12-29 07:42:07.963768 INFO::Creating boxplot for categorical data, diagnosis vs F415
## 2024-12-29 07:42:08.069346 INFO::Creating boxplot for categorical data, diagnosis vs F466
## 2024-12-29 07:42:08.191642 INFO::Creating boxplot for categorical data, diagnosis vs F643
## 2024-12-29 07:42:08.29954 INFO::Creating boxplot for categorical data, diagnosis vs F160
## 2024-12-29 07:42:08.406117 INFO::Creating boxplot for categorical data, diagnosis vs F69
## 2024-12-29 07:42:08.523913 INFO::Creating boxplot for categorical data, diagnosis vs F498
## 2024-12-29 07:42:08.634462 INFO::Creating boxplot for categorical data, diagnosis vs F207
## 2024-12-29 07:42:08.750851 INFO::Creating boxplot for categorical data, diagnosis vs F679
## 2024-12-29 07:42:08.85679 INFO::Creating boxplot for categorical data, diagnosis vs F618
## 2024-12-29 07:42:08.976059 INFO::Creating boxplot for categorical data, diagnosis vs F255
## 2024-12-29 07:42:09.085107 INFO::Creating boxplot for categorical data, diagnosis vs F267
## 2024-12-29 07:42:09.193504 INFO::Creating boxplot for categorical data, diagnosis vs F143
## 2024-12-29 07:42:09.29979 INFO::Creating boxplot for categorical data, diagnosis vs F286
## 2024-12-29 07:42:09.419733 INFO::Creating boxplot for categorical data, diagnosis vs F562
## 2024-12-29 07:42:09.527868 INFO::Creating boxplot for categorical data, diagnosis vs F100
## 2024-12-29 07:42:09.638984 INFO::Creating boxplot for categorical data, diagnosis vs F374
## 2024-12-29 07:42:09.758961 INFO::Creating boxplot for categorical data, diagnosis vs F535
## 2024-12-29 07:42:09.869275 INFO::Creating boxplot for categorical data, diagnosis vs F658
## 2024-12-29 07:42:09.9753 INFO::Creating boxplot for categorical data, diagnosis vs F707
## 2024-12-29 07:42:10.080652 INFO::Creating boxplot for categorical data, diagnosis vs F325
## 2024-12-29 07:42:10.200831 INFO::Creating boxplot for categorical data, diagnosis vs F89
## 2024-12-29 07:42:10.309331 INFO::Creating boxplot for categorical data, diagnosis vs F214
## 2024-12-29 07:42:10.414864 INFO::Creating boxplot for categorical data, diagnosis vs F578
## 2024-12-29 07:42:10.520795 INFO::Creating boxplot for categorical data, diagnosis vs F790
## 2024-12-29 07:42:10.652304 INFO::Creating boxplot for categorical data, diagnosis vs F265
## 2024-12-29 07:42:10.76074 INFO::Creating boxplot for categorical data, diagnosis vs F253
## 2024-12-29 07:42:10.867719 INFO::Creating boxplot for categorical data, diagnosis vs F294
## 2024-12-29 07:42:10.985978 INFO::Creating boxplot for categorical data, diagnosis vs F410
## 2024-12-29 07:42:11.095875 INFO::Creating boxplot for categorical data, diagnosis vs F614
## 2024-12-29 07:42:11.202034 INFO::Creating boxplot for categorical data, diagnosis vs F764
## 2024-12-29 07:42:11.31044 INFO::Creating boxplot for categorical data, diagnosis vs F59
## 2024-12-29 07:42:11.43077 INFO::Creating boxplot for categorical data, diagnosis vs F675
## 2024-12-29 07:42:11.555277 INFO::Creating boxplot for categorical data, diagnosis vs F441
## 2024-12-29 07:42:11.663491 INFO::Creating boxplot for categorical data, diagnosis vs F193
## 2024-12-29 07:42:11.783214 INFO::Creating boxplot for categorical data, diagnosis vs F689
## 2024-12-29 07:42:11.893021 INFO::Creating boxplot for categorical data, diagnosis vs F249
## 2024-12-29 07:42:11.999756 INFO::Creating boxplot for categorical data, diagnosis vs F821
## 2024-12-29 07:42:12.108479 INFO::Creating boxplot for categorical data, diagnosis vs F351
## 2024-12-29 07:42:12.229053 INFO::Creating boxplot for categorical data, diagnosis vs F66
## 2024-12-29 07:42:12.361952 INFO::Creating boxplot for categorical data, diagnosis vs F413
## 2024-12-29 07:42:12.466316 INFO::Creating boxplot for categorical data, diagnosis vs F172
## 2024-12-29 07:42:12.584666 INFO::Creating boxplot for categorical data, diagnosis vs F317
## 2024-12-29 07:42:12.695846 INFO::Creating boxplot for categorical data, diagnosis vs F167
## 2024-12-29 07:42:12.804558 INFO::Creating boxplot for categorical data, diagnosis vs F229
## 2024-12-29 07:42:12.911486 INFO::Creating boxplot for categorical data, diagnosis vs F243
## 2024-12-29 07:42:13.032966 INFO::Creating boxplot for categorical data, diagnosis vs F732
## 2024-12-29 07:42:13.141295 INFO::Creating boxplot for categorical data, diagnosis vs F467
## 2024-12-29 07:42:13.248259 INFO::Creating boxplot for categorical data, diagnosis vs F474
## 2024-12-29 07:42:13.36669 INFO::Creating boxplot for categorical data, diagnosis vs F156
## 2024-12-29 07:42:13.489038 INFO::Creating boxplot for categorical data, diagnosis vs F786
## 2024-12-29 07:42:13.59519 INFO::Creating boxplot for categorical data, diagnosis vs F216
## 2024-12-29 07:42:13.701009 INFO::Creating boxplot for categorical data, diagnosis vs F85
## 2024-12-29 07:42:13.821679 INFO::Creating boxplot for categorical data, diagnosis vs F621
## 2024-12-29 07:42:13.930497 INFO::Creating boxplot for categorical data, diagnosis vs F558
## 2024-12-29 07:42:14.035376 INFO::Creating boxplot for categorical data, diagnosis vs F582
## 2024-12-29 07:42:14.142544 INFO::Creating boxplot for categorical data, diagnosis vs F898
## 2024-12-29 07:42:14.266761 INFO::Creating boxplot for categorical data, diagnosis vs F402
## 2024-12-29 07:42:14.375151 INFO::Creating boxplot for categorical data, diagnosis vs F71
## 2024-12-29 07:42:14.481244 INFO::Creating boxplot for categorical data, diagnosis vs F99
## 2024-12-29 07:42:14.602846 INFO::Creating boxplot for categorical data, diagnosis vs F366
## 2024-12-29 07:42:14.709829 INFO::Creating boxplot for categorical data, diagnosis vs F778
## 2024-12-29 07:42:14.815365 INFO::Creating boxplot for categorical data, diagnosis vs F188
## 2024-12-29 07:42:14.951826 INFO::Creating boxplot for categorical data, diagnosis vs F857
## 2024-12-29 07:42:15.070281 INFO::Creating boxplot for categorical data, diagnosis vs F440
## 2024-12-29 07:42:15.181509 INFO::Creating boxplot for categorical data, diagnosis vs F799
## 2024-12-29 07:42:15.291984 INFO::Creating boxplot for categorical data, diagnosis vs F482
## 2024-12-29 07:42:15.415371 INFO::Creating boxplot for categorical data, diagnosis vs F212
## 2024-12-29 07:42:15.523226 INFO::Creating boxplot for categorical data, diagnosis vs F882
## 2024-12-29 07:42:15.632889 INFO::Creating boxplot for categorical data, diagnosis vs F599
## 2024-12-29 07:42:15.742285 INFO::Creating boxplot for categorical data, diagnosis vs F302
## 2024-12-29 07:42:15.86755 INFO::Creating boxplot for categorical data, diagnosis vs F543
## 2024-12-29 07:42:15.977702 INFO::Creating boxplot for categorical data, diagnosis vs F269
## 2024-12-29 07:42:16.087536 INFO::Creating boxplot for categorical data, diagnosis vs F650
## 2024-12-29 07:42:16.196062 INFO::Creating boxplot for categorical data, diagnosis vs F456
## 2024-12-29 07:42:16.321829 INFO::Creating boxplot for categorical data, diagnosis vs F573
## 2024-12-29 07:42:16.432323 INFO::Creating boxplot for categorical data, diagnosis vs F8
## 2024-12-29 07:42:16.54249 INFO::Creating boxplot for categorical data, diagnosis vs F810
## 2024-12-29 07:42:16.663993 INFO::Creating boxplot for categorical data, diagnosis vs F401
## 2024-12-29 07:42:16.777686 INFO::Creating boxplot for categorical data, diagnosis vs F606
## 2024-12-29 07:42:16.887401 INFO::Creating boxplot for categorical data, diagnosis vs F662
## 2024-12-29 07:42:16.997662 INFO::Creating boxplot for categorical data, diagnosis vs F765
## 2024-12-29 07:42:17.122893 INFO::Creating boxplot for categorical data, diagnosis vs F887
## 2024-12-29 07:42:17.232772 INFO::Creating boxplot for categorical data, diagnosis vs F770
## 2024-12-29 07:42:17.340648 INFO::Creating boxplot for categorical data, diagnosis vs F469
## 2024-12-29 07:42:17.45026 INFO::Creating boxplot for categorical data, diagnosis vs F86
## 2024-12-29 07:42:17.577428 INFO::Creating boxplot for categorical data, diagnosis vs F400
## 2024-12-29 07:42:17.686431 INFO::Creating boxplot for categorical data, diagnosis vs F579
## 2024-12-29 07:42:17.79882 INFO::Creating boxplot for categorical data, diagnosis vs F871
## 2024-12-29 07:42:17.923161 INFO::Creating boxplot for categorical data, diagnosis vs F37
## 2024-12-29 07:42:18.035443 INFO::Creating boxplot for categorical data, diagnosis vs F446
## 2024-12-29 07:42:18.145716 INFO::Creating boxplot for categorical data, diagnosis vs F218
## 2024-12-29 07:42:18.254748 INFO::Creating boxplot for categorical data, diagnosis vs F321
## 2024-12-29 07:42:18.380063 INFO::Creating boxplot for categorical data, diagnosis vs F487
## 2024-12-29 07:42:18.497993 INFO::Creating boxplot for categorical data, diagnosis vs F740
## 2024-12-29 07:42:18.607075 INFO::Creating boxplot for categorical data, diagnosis vs F141
## 2024-12-29 07:42:18.713929 INFO::Creating boxplot for categorical data, diagnosis vs F327
## 2024-12-29 07:42:18.839765 INFO::Creating boxplot for categorical data, diagnosis vs F196
## 2024-12-29 07:42:18.950125 INFO::Creating boxplot for categorical data, diagnosis vs F883
## 2024-12-29 07:42:19.058886 INFO::Creating boxplot for categorical data, diagnosis vs F279
## 2024-12-29 07:42:19.185854 INFO::Creating boxplot for categorical data, diagnosis vs F838
## 2024-12-29 07:42:19.296516 INFO::Creating boxplot for categorical data, diagnosis vs F451
## 2024-12-29 07:42:19.406422 INFO::Creating boxplot for categorical data, diagnosis vs F854
## 2024-12-29 07:42:19.51336 INFO::Creating boxplot for categorical data, diagnosis vs F434
## 2024-12-29 07:42:19.640622 INFO::Creating boxplot for categorical data, diagnosis vs F519
## 2024-12-29 07:42:19.749482 INFO::Creating boxplot for categorical data, diagnosis vs F694
## 2024-12-29 07:42:19.859345 INFO::Creating boxplot for categorical data, diagnosis vs F561
## 2024-12-29 07:42:19.985625 INFO::Creating boxplot for categorical data, diagnosis vs F10
## 2024-12-29 07:42:20.103733 INFO::Creating boxplot for categorical data, diagnosis vs F303
## 2024-12-29 07:42:20.211543 INFO::Creating boxplot for categorical data, diagnosis vs F512
## 2024-12-29 07:42:20.322195 INFO::Creating boxplot for categorical data, diagnosis vs F645
## 2024-12-29 07:42:20.447953 INFO::Creating boxplot for categorical data, diagnosis vs F793
## 2024-12-29 07:42:20.558795 INFO::Creating boxplot for categorical data, diagnosis vs F404
## 2024-12-29 07:42:20.668022 INFO::Creating boxplot for categorical data, diagnosis vs F362
## 2024-12-29 07:42:20.777115 INFO::Creating boxplot for categorical data, diagnosis vs F525
## 2024-12-29 07:42:20.904988 INFO::Creating boxplot for categorical data, diagnosis vs F742
## 2024-12-29 07:42:21.015022 INFO::Creating boxplot for categorical data, diagnosis vs F276
## 2024-12-29 07:42:21.129175 INFO::Creating boxplot for categorical data, diagnosis vs F499
## 2024-12-29 07:42:21.256166 INFO::Creating boxplot for categorical data, diagnosis vs F328
## 2024-12-29 07:42:21.368606 INFO::Creating boxplot for categorical data, diagnosis vs F787
## 2024-12-29 07:42:21.477855 INFO::Creating boxplot for categorical data, diagnosis vs F30
## 2024-12-29 07:42:21.586807 INFO::Creating boxplot for categorical data, diagnosis vs F122
## 2024-12-29 07:42:21.714385 INFO::Creating boxplot for categorical data, diagnosis vs F619
## 2024-12-29 07:42:21.825098 INFO::Creating boxplot for categorical data, diagnosis vs F572
## 2024-12-29 07:42:21.934982 INFO::Creating boxplot for categorical data, diagnosis vs F47
## 2024-12-29 07:42:22.061129 INFO::Creating boxplot for categorical data, diagnosis vs F570
## 2024-12-29 07:42:22.169548 INFO::Creating boxplot for categorical data, diagnosis vs F26
## 2024-12-29 07:42:22.278015 INFO::Creating boxplot for categorical data, diagnosis vs F252
## 2024-12-29 07:42:22.387363 INFO::Creating boxplot for categorical data, diagnosis vs F117
## 2024-12-29 07:42:22.514612 INFO::Creating boxplot for categorical data, diagnosis vs F683
## 2024-12-29 07:42:22.623729 INFO::Creating boxplot for categorical data, diagnosis vs F395
## 2024-12-29 07:42:22.732752 INFO::Creating boxplot for categorical data, diagnosis vs F822
## 2024-12-29 07:42:22.872392 INFO::Creating boxplot for categorical data, diagnosis vs F46
## 2024-12-29 07:42:22.981328 INFO::Creating boxplot for categorical data, diagnosis vs F154
## 2024-12-29 07:42:23.090344 INFO::Creating boxplot for categorical data, diagnosis vs F540
## 2024-12-29 07:42:23.199736 INFO::Creating boxplot for categorical data, diagnosis vs F884
## 2024-12-29 07:42:23.327342 INFO::Creating boxplot for categorical data, diagnosis vs F368
## 2024-12-29 07:42:23.437262 INFO::Creating boxplot for categorical data, diagnosis vs F607
## 2024-12-29 07:42:23.545405 INFO::Creating boxplot for categorical data, diagnosis vs F111
## 2024-12-29 07:42:23.700865 INFO::Creating boxplot for categorical data, diagnosis vs F745
## 2024-12-29 07:42:23.822748 INFO::Creating boxplot for categorical data, diagnosis vs F673
## 2024-12-29 07:42:23.933655 INFO::Creating boxplot for categorical data, diagnosis vs F92
## 2024-12-29 07:42:24.046638 INFO::Creating boxplot for categorical data, diagnosis vs F493
## 2024-12-29 07:42:24.173761 INFO::Creating boxplot for categorical data, diagnosis vs F835
## 2024-12-29 07:42:24.28655 INFO::Creating boxplot for categorical data, diagnosis vs F872
## 2024-12-29 07:42:24.398836 INFO::Creating boxplot for categorical data, diagnosis vs F879
## 2024-12-29 07:42:24.517624 INFO::Creating boxplot for categorical data, diagnosis vs F432
## 2024-12-29 07:42:24.633021 INFO::Creating boxplot for categorical data, diagnosis vs F518
## 2024-12-29 07:42:24.741171 INFO::Creating boxplot for categorical data, diagnosis vs F44
## 2024-12-29 07:42:24.850484 INFO::Creating boxplot for categorical data, diagnosis vs F240
## 2024-12-29 07:42:24.974092 INFO::Creating boxplot for categorical data, diagnosis vs F819
## 2024-12-29 07:42:25.085042 INFO::Creating boxplot for categorical data, diagnosis vs F411
## 2024-12-29 07:42:25.195726 INFO::Creating boxplot for categorical data, diagnosis vs F353
## 2024-12-29 07:42:25.306033 INFO::Creating boxplot for categorical data, diagnosis vs F763
## 2024-12-29 07:42:25.431123 INFO::Creating boxplot for categorical data, diagnosis vs F97
## 2024-12-29 07:42:25.539497 INFO::Creating boxplot for categorical data, diagnosis vs F40
## 2024-12-29 07:42:25.649863 INFO::Creating boxplot for categorical data, diagnosis vs F652
## 2024-12-29 07:42:25.759024 INFO::Creating boxplot for categorical data, diagnosis vs F789
## 2024-12-29 07:42:25.885379 INFO::Creating boxplot for categorical data, diagnosis vs F25
## 2024-12-29 07:42:25.995188 INFO::Creating boxplot for categorical data, diagnosis vs F256
## 2024-12-29 07:42:26.106388 INFO::Creating boxplot for categorical data, diagnosis vs F423
## 2024-12-29 07:42:26.231074 INFO::Creating boxplot for categorical data, diagnosis vs F594
## 2024-12-29 07:42:26.342562 INFO::Creating boxplot for categorical data, diagnosis vs F201
## 2024-12-29 07:42:26.466718 INFO::Creating boxplot for categorical data, diagnosis vs F813
## 2024-12-29 07:42:26.577727 INFO::Creating boxplot for categorical data, diagnosis vs F653
## 2024-12-29 07:42:26.70281 INFO::Creating boxplot for categorical data, diagnosis vs F524
## 2024-12-29 07:42:26.811451 INFO::Creating boxplot for categorical data, diagnosis vs F777
## 2024-12-29 07:42:26.923172 INFO::Creating boxplot for categorical data, diagnosis vs F226
## 2024-12-29 07:42:27.045024 INFO::Creating boxplot for categorical data, diagnosis vs F227
## 2024-12-29 07:42:27.160032 INFO::Creating boxplot for categorical data, diagnosis vs F521
## 2024-12-29 07:42:27.276196 INFO::Creating boxplot for categorical data, diagnosis vs F14
## 2024-12-29 07:42:27.387942 INFO::Creating boxplot for categorical data, diagnosis vs F310
## 2024-12-29 07:42:27.513227 INFO::Creating boxplot for categorical data, diagnosis vs F452
## 2024-12-29 07:42:27.623321 INFO::Creating boxplot for categorical data, diagnosis vs F52
## 2024-12-29 07:42:27.73382 INFO::Creating boxplot for categorical data, diagnosis vs F53
## 2024-12-29 07:42:27.844119 INFO::Creating boxplot for categorical data, diagnosis vs F844
## 2024-12-29 07:42:27.970241 INFO::Creating boxplot for categorical data, diagnosis vs F31
## 2024-12-29 07:42:28.080454 INFO::Creating boxplot for categorical data, diagnosis vs F795
## 2024-12-29 07:42:28.191003 INFO::Creating boxplot for categorical data, diagnosis vs F766
## 2024-12-29 07:42:28.315964 INFO::Creating boxplot for categorical data, diagnosis vs F342
## 2024-12-29 07:42:28.426781 INFO::Creating boxplot for categorical data, diagnosis vs F408
## 2024-12-29 07:42:28.537373 INFO::Creating boxplot for categorical data, diagnosis vs F282
## 2024-12-29 07:42:28.646604 INFO::Creating boxplot for categorical data, diagnosis vs F508
## 2024-12-29 07:42:28.773176 INFO::Creating boxplot for categorical data, diagnosis vs F805
## 2024-12-29 07:42:28.884031 INFO::Creating boxplot for categorical data, diagnosis vs F337
## 2024-12-29 07:42:28.996762 INFO::Creating boxplot for categorical data, diagnosis vs F820
## 2024-12-29 07:42:29.122452 INFO::Creating boxplot for categorical data, diagnosis vs F593
## 2024-12-29 07:42:29.233944 INFO::Creating boxplot for categorical data, diagnosis vs F701
## 2024-12-29 07:42:29.345284 INFO::Creating boxplot for categorical data, diagnosis vs F459
## 2024-12-29 07:42:29.456736 INFO::Creating boxplot for categorical data, diagnosis vs F305
## 2024-12-29 07:42:29.582089 INFO::Creating boxplot for categorical data, diagnosis vs F142
## 2024-12-29 07:42:29.69155 INFO::Creating boxplot for categorical data, diagnosis vs F534
## 2024-12-29 07:42:29.801884 INFO::Creating boxplot for categorical data, diagnosis vs F135
## 2024-12-29 07:42:29.925364 INFO::Creating boxplot for categorical data, diagnosis vs F702
## 2024-12-29 07:42:30.038601 INFO::Creating boxplot for categorical data, diagnosis vs F776
## 2024-12-29 07:42:30.149637 INFO::Creating boxplot for categorical data, diagnosis vs F295
## 2024-12-29 07:42:30.261754 INFO::Creating boxplot for categorical data, diagnosis vs F355
## 2024-12-29 07:42:30.387216 INFO::Creating boxplot for categorical data, diagnosis vs F797
## 2024-12-29 07:42:30.497697 INFO::Creating boxplot for categorical data, diagnosis vs F13
## 2024-12-29 07:42:30.608491 INFO::Creating boxplot for categorical data, diagnosis vs F356
## 2024-12-29 07:42:30.733469 INFO::Creating boxplot for categorical data, diagnosis vs F359
## 2024-12-29 07:42:30.844096 INFO::Creating boxplot for categorical data, diagnosis vs F121
## 2024-12-29 07:42:30.955521 INFO::Creating boxplot for categorical data, diagnosis vs F850
## 2024-12-29 07:42:31.066053 INFO::Creating boxplot for categorical data, diagnosis vs F899
## 2024-12-29 07:42:31.192809 INFO::Creating boxplot for categorical data, diagnosis vs F628
## 2024-12-29 07:42:31.301808 INFO::Creating boxplot for categorical data, diagnosis vs F843
## 2024-12-29 07:42:31.42464 INFO::Creating boxplot for categorical data, diagnosis vs F107
## 2024-12-29 07:42:31.547934 INFO::Creating boxplot for categorical data, diagnosis vs F287
## 2024-12-29 07:42:31.660456 INFO::Creating boxplot for categorical data, diagnosis vs F165
## 2024-12-29 07:42:31.77695 INFO::Creating boxplot for categorical data, diagnosis vs F557
## 2024-12-29 07:42:31.887481 INFO::Creating boxplot for categorical data, diagnosis vs F127
## 2024-12-29 07:42:32.013432 INFO::Creating boxplot for categorical data, diagnosis vs F299
## 2024-12-29 07:42:32.123926 INFO::Creating boxplot for categorical data, diagnosis vs F497
## 2024-12-29 07:42:32.235846 INFO::Creating boxplot for categorical data, diagnosis vs F711
## 2024-12-29 07:42:32.389105 INFO::Creating boxplot for categorical data, diagnosis vs F319
## 2024-12-29 07:42:32.501438 INFO::Creating boxplot for categorical data, diagnosis vs F271
## 2024-12-29 07:42:32.610412 INFO::Creating boxplot for categorical data, diagnosis vs F157
## 2024-12-29 07:42:32.721639 INFO::Creating boxplot for categorical data, diagnosis vs F560
## 2024-12-29 07:42:32.854215 INFO::Creating boxplot for categorical data, diagnosis vs F680
## 2024-12-29 07:42:32.965801 INFO::Creating boxplot for categorical data, diagnosis vs F580
## 2024-12-29 07:42:33.077224 INFO::Creating boxplot for categorical data, diagnosis vs F152
## 2024-12-29 07:42:33.189116 INFO::Creating boxplot for categorical data, diagnosis vs F12
## 2024-12-29 07:42:33.321244 INFO::Creating boxplot for categorical data, diagnosis vs F324
## 2024-12-29 07:42:33.433178 INFO::Creating boxplot for categorical data, diagnosis vs F893
## 2024-12-29 07:42:33.546689 INFO::Creating boxplot for categorical data, diagnosis vs F318
## 2024-12-29 07:42:33.674487 INFO::Creating boxplot for categorical data, diagnosis vs F784
## 2024-12-29 07:42:33.792743 INFO::Creating boxplot for categorical data, diagnosis vs F567
## 2024-12-29 07:42:33.903647 INFO::Creating boxplot for categorical data, diagnosis vs F457
## 2024-12-29 07:42:34.016195 INFO::Creating boxplot for categorical data, diagnosis vs F708
## 2024-12-29 07:42:34.149832 INFO::Creating boxplot for categorical data, diagnosis vs F669
## 2024-12-29 07:42:34.259973 INFO::Creating boxplot for categorical data, diagnosis vs F87
## 2024-12-29 07:42:35.804353 INFO::Plotting data for metadata number 2, antibiotics
## 2024-12-29 07:42:35.805677 INFO::Creating boxplot for categorical data, antibiotics vs F663
## 2024-12-29 07:42:35.923367 INFO::Creating boxplot for categorical data, antibiotics vs F838
## 2024-12-29 07:42:36.040982 INFO::Creating boxplot for categorical data, antibiotics vs F764
## 2024-12-29 07:42:36.160499 INFO::Creating boxplot for categorical data, antibiotics vs F880
## 2024-12-29 07:42:36.300603 INFO::Creating boxplot for categorical data, antibiotics vs F751
## 2024-12-29 07:42:36.418488 INFO::Creating boxplot for categorical data, antibiotics vs F288
## 2024-12-29 07:42:36.538246 INFO::Creating boxplot for categorical data, antibiotics vs F65
## 2024-12-29 07:42:36.679878 INFO::Creating boxplot for categorical data, antibiotics vs F742
## 2024-12-29 07:42:36.79766 INFO::Creating boxplot for categorical data, antibiotics vs F528
## 2024-12-29 07:42:36.915668 INFO::Creating boxplot for categorical data, antibiotics vs F790
## 2024-12-29 07:42:37.053227 INFO::Creating boxplot for categorical data, antibiotics vs F777
## 2024-12-29 07:42:37.17582 INFO::Creating boxplot for categorical data, antibiotics vs F178
## 2024-12-29 07:42:37.293543 INFO::Creating boxplot for categorical data, antibiotics vs F139
## 2024-12-29 07:42:37.41269 INFO::Creating boxplot for categorical data, antibiotics vs F202
## 2024-12-29 07:42:37.553339 INFO::Creating boxplot for categorical data, antibiotics vs F220
## 2024-12-29 07:42:37.670673 INFO::Creating boxplot for categorical data, antibiotics vs F397
## 2024-12-29 07:42:37.789596 INFO::Creating boxplot for categorical data, antibiotics vs F882
## 2024-12-29 07:42:37.929765 INFO::Creating boxplot for categorical data, antibiotics vs F446
## 2024-12-29 07:42:38.051128 INFO::Creating boxplot for categorical data, antibiotics vs F418
## 2024-12-29 07:42:38.169441 INFO::Creating boxplot for categorical data, antibiotics vs F133
## 2024-12-29 07:42:38.304833 INFO::Creating boxplot for categorical data, antibiotics vs F696
## 2024-12-29 07:42:38.428208 INFO::Creating boxplot for categorical data, antibiotics vs F548
## 2024-12-29 07:42:38.546912 INFO::Creating boxplot for categorical data, antibiotics vs F536
## 2024-12-29 07:42:38.667435 INFO::Creating boxplot for categorical data, antibiotics vs F194
## 2024-12-29 07:42:38.808425 INFO::Creating boxplot for categorical data, antibiotics vs F34
## 2024-12-29 07:42:38.925822 INFO::Creating boxplot for categorical data, antibiotics vs F153
## 2024-12-29 07:42:39.045429 INFO::Creating boxplot for categorical data, antibiotics vs F400
## 2024-12-29 07:42:39.188866 INFO::Creating boxplot for categorical data, antibiotics vs F794
## 2024-12-29 07:42:39.306721 INFO::Creating boxplot for categorical data, antibiotics vs F396
## 2024-12-29 07:42:39.425512 INFO::Creating boxplot for categorical data, antibiotics vs F182
## 2024-12-29 07:42:39.574599 INFO::Creating boxplot for categorical data, antibiotics vs F719
## 2024-12-29 07:42:39.694499 INFO::Creating boxplot for categorical data, antibiotics vs F109
## 2024-12-29 07:42:39.812227 INFO::Creating boxplot for categorical data, antibiotics vs F180
## 2024-12-29 07:42:39.940994 INFO::Creating boxplot for categorical data, antibiotics vs F552
## 2024-12-29 07:42:40.07058 INFO::Creating boxplot for categorical data, antibiotics vs F789
## 2024-12-29 07:42:40.189728 INFO::Creating boxplot for categorical data, antibiotics vs F893
## 2024-12-29 07:42:40.310837 INFO::Creating boxplot for categorical data, antibiotics vs F834
## 2024-12-29 07:42:40.452416 INFO::Creating boxplot for categorical data, antibiotics vs F889
## 2024-12-29 07:42:40.571417 INFO::Creating boxplot for categorical data, antibiotics vs F143
## 2024-12-29 07:42:40.689364 INFO::Creating boxplot for categorical data, antibiotics vs F224
## 2024-12-29 07:42:40.829979 INFO::Creating boxplot for categorical data, antibiotics vs F5
## 2024-12-29 07:42:40.947334 INFO::Creating boxplot for categorical data, antibiotics vs F873
## 2024-12-29 07:42:41.08007 INFO::Creating boxplot for categorical data, antibiotics vs F452
## 2024-12-29 07:42:41.220644 INFO::Creating boxplot for categorical data, antibiotics vs F681
## 2024-12-29 07:42:41.337596 INFO::Creating boxplot for categorical data, antibiotics vs F468
## 2024-12-29 07:42:41.457774 INFO::Creating boxplot for categorical data, antibiotics vs F731
## 2024-12-29 07:42:42.107861 INFO::Creating boxplot for categorical data, antibiotics vs F479
## 2024-12-29 07:42:42.219554 INFO::Creating boxplot for categorical data, antibiotics vs F520
## 2024-12-29 07:42:42.331531 INFO::Creating boxplot for categorical data, antibiotics vs F649
## 2024-12-29 07:42:42.445871 INFO::Creating boxplot for categorical data, antibiotics vs F259
## 2024-12-29 07:42:42.566373 INFO::Creating boxplot for categorical data, antibiotics vs F186
## 2024-12-29 07:42:42.677743 INFO::Creating boxplot for categorical data, antibiotics vs F312
## 2024-12-29 07:42:42.787678 INFO::Creating boxplot for categorical data, antibiotics vs F477
## 2024-12-29 07:42:42.927201 INFO::Creating boxplot for categorical data, antibiotics vs F4
## 2024-12-29 07:42:43.041574 INFO::Creating boxplot for categorical data, antibiotics vs F632
## 2024-12-29 07:42:43.154202 INFO::Creating boxplot for categorical data, antibiotics vs F31
## 2024-12-29 07:42:43.266564 INFO::Creating boxplot for categorical data, antibiotics vs F184
## 2024-12-29 07:42:43.384337 INFO::Creating boxplot for categorical data, antibiotics vs F7
## 2024-12-29 07:42:43.495435 INFO::Creating boxplot for categorical data, antibiotics vs F213
## 2024-12-29 07:42:43.624317 INFO::Creating boxplot for categorical data, antibiotics vs F691
## 2024-12-29 07:42:43.742818 INFO::Creating boxplot for categorical data, antibiotics vs F828
## 2024-12-29 07:42:43.853821 INFO::Creating boxplot for categorical data, antibiotics vs F831
## 2024-12-29 07:42:43.963909 INFO::Creating boxplot for categorical data, antibiotics vs F315
## 2024-12-29 07:42:44.076606 INFO::Creating boxplot for categorical data, antibiotics vs F159
## 2024-12-29 07:42:44.193931 INFO::Creating boxplot for categorical data, antibiotics vs F331
## 2024-12-29 07:42:44.305996 INFO::Creating boxplot for categorical data, antibiotics vs F757
## 2024-12-29 07:42:44.418013 INFO::Creating boxplot for categorical data, antibiotics vs F167
## 2024-12-29 07:42:44.538584 INFO::Creating boxplot for categorical data, antibiotics vs F85
## 2024-12-29 07:42:44.649664 INFO::Creating boxplot for categorical data, antibiotics vs F80
## 2024-12-29 07:42:44.760812 INFO::Creating boxplot for categorical data, antibiotics vs F105
## 2024-12-29 07:42:44.872995 INFO::Creating boxplot for categorical data, antibiotics vs F674
## 2024-12-29 07:42:44.99048 INFO::Creating boxplot for categorical data, antibiotics vs F50
## 2024-12-29 07:42:45.101947 INFO::Creating boxplot for categorical data, antibiotics vs F164
## 2024-12-29 07:42:45.213936 INFO::Creating boxplot for categorical data, antibiotics vs F840
## 2024-12-29 07:42:45.332891 INFO::Creating boxplot for categorical data, antibiotics vs F232
## 2024-12-29 07:42:45.44424 INFO::Creating boxplot for categorical data, antibiotics vs F872
## 2024-12-29 07:42:45.557789 INFO::Creating boxplot for categorical data, antibiotics vs F54
## 2024-12-29 07:42:45.678477 INFO::Creating boxplot for categorical data, antibiotics vs F365
## 2024-12-29 07:42:45.789586 INFO::Creating boxplot for categorical data, antibiotics vs F499
## 2024-12-29 07:42:45.900385 INFO::Creating boxplot for categorical data, antibiotics vs F510
## 2024-12-29 07:42:46.014001 INFO::Creating boxplot for categorical data, antibiotics vs F716
## 2024-12-29 07:42:46.133107 INFO::Creating boxplot for categorical data, antibiotics vs F454
## 2024-12-29 07:42:46.245434 INFO::Creating boxplot for categorical data, antibiotics vs F52
## 2024-12-29 07:42:46.357979 INFO::Creating boxplot for categorical data, antibiotics vs F273
## 2024-12-29 07:42:46.477653 INFO::Creating boxplot for categorical data, antibiotics vs F474
## 2024-12-29 07:42:46.589429 INFO::Creating boxplot for categorical data, antibiotics vs F267
## 2024-12-29 07:42:46.702107 INFO::Creating boxplot for categorical data, antibiotics vs F253
## 2024-12-29 07:42:46.821534 INFO::Creating boxplot for categorical data, antibiotics vs F247
## 2024-12-29 07:42:46.935496 INFO::Creating boxplot for categorical data, antibiotics vs F708
## 2024-12-29 07:42:47.04656 INFO::Creating boxplot for categorical data, antibiotics vs F438
## 2024-12-29 07:42:47.16021 INFO::Creating boxplot for categorical data, antibiotics vs F450
## 2024-12-29 07:42:47.279082 INFO::Creating boxplot for categorical data, antibiotics vs F666
## 2024-12-29 07:42:47.39043 INFO::Creating boxplot for categorical data, antibiotics vs F720
## 2024-12-29 07:42:47.500994 INFO::Creating boxplot for categorical data, antibiotics vs F48
## 2024-12-29 07:42:47.622601 INFO::Creating boxplot for categorical data, antibiotics vs F371
## 2024-12-29 07:42:47.734225 INFO::Creating boxplot for categorical data, antibiotics vs F423
## 2024-12-29 07:42:47.847429 INFO::Creating boxplot for categorical data, antibiotics vs F190
## 2024-12-29 07:42:47.966551 INFO::Creating boxplot for categorical data, antibiotics vs F351
## 2024-12-29 07:42:48.078161 INFO::Creating boxplot for categorical data, antibiotics vs F394
## 2024-12-29 07:42:48.189055 INFO::Creating boxplot for categorical data, antibiotics vs F581
## 2024-12-29 07:42:48.302377 INFO::Creating boxplot for categorical data, antibiotics vs F276
## 2024-12-29 07:42:48.445412 INFO::Creating boxplot for categorical data, antibiotics vs F608
## 2024-12-29 07:42:48.557187 INFO::Creating boxplot for categorical data, antibiotics vs F28
## 2024-12-29 07:42:48.671877 INFO::Creating boxplot for categorical data, antibiotics vs F805
## 2024-12-29 07:42:48.790813 INFO::Creating boxplot for categorical data, antibiotics vs F249
## 2024-12-29 07:42:48.901052 INFO::Creating boxplot for categorical data, antibiotics vs F776
## 2024-12-29 07:42:49.011697 INFO::Creating boxplot for categorical data, antibiotics vs F755
## 2024-12-29 07:42:49.132801 INFO::Creating boxplot for categorical data, antibiotics vs F68
## 2024-12-29 07:42:49.245323 INFO::Creating boxplot for categorical data, antibiotics vs F78
## 2024-12-29 07:42:49.355628 INFO::Creating boxplot for categorical data, antibiotics vs F381
## 2024-12-29 07:42:49.46916 INFO::Creating boxplot for categorical data, antibiotics vs F644
## 2024-12-29 07:42:49.58955 INFO::Creating boxplot for categorical data, antibiotics vs F358
## 2024-12-29 07:42:49.701865 INFO::Creating boxplot for categorical data, antibiotics vs F344
## 2024-12-29 07:42:49.814347 INFO::Creating boxplot for categorical data, antibiotics vs F209
## 2024-12-29 07:42:49.933113 INFO::Creating boxplot for categorical data, antibiotics vs F898
## 2024-12-29 07:42:50.048101 INFO::Creating boxplot for categorical data, antibiotics vs F51
## 2024-12-29 07:42:50.162373 INFO::Creating boxplot for categorical data, antibiotics vs F149
## 2024-12-29 07:42:50.309591 INFO::Creating boxplot for categorical data, antibiotics vs F108
## 2024-12-29 07:42:50.423999 INFO::Creating boxplot for categorical data, antibiotics vs F255
## 2024-12-29 07:42:50.535623 INFO::Creating boxplot for categorical data, antibiotics vs F823
## 2024-12-29 07:42:50.651728 INFO::Creating boxplot for categorical data, antibiotics vs F864
## 2024-12-29 07:42:50.780227 INFO::Creating boxplot for categorical data, antibiotics vs F214
## 2024-12-29 07:42:50.896902 INFO::Creating boxplot for categorical data, antibiotics vs F76
## 2024-12-29 07:42:51.010234 INFO::Creating boxplot for categorical data, antibiotics vs F575
## 2024-12-29 07:42:51.138801 INFO::Creating boxplot for categorical data, antibiotics vs F13
## 2024-12-29 07:42:51.252763 INFO::Creating boxplot for categorical data, antibiotics vs F389
## 2024-12-29 07:42:51.365641 INFO::Creating boxplot for categorical data, antibiotics vs F556
## 2024-12-29 07:42:51.488996 INFO::Creating boxplot for categorical data, antibiotics vs F49
## 2024-12-29 07:42:51.610772 INFO::Creating boxplot for categorical data, antibiotics vs F436
## 2024-12-29 07:42:51.728928 INFO::Creating boxplot for categorical data, antibiotics vs F378
## 2024-12-29 07:42:51.844844 INFO::Creating boxplot for categorical data, antibiotics vs F682
## 2024-12-29 07:42:51.974224 INFO::Creating boxplot for categorical data, antibiotics vs F47
## 2024-12-29 07:42:52.087948 INFO::Creating boxplot for categorical data, antibiotics vs F429
## 2024-12-29 07:42:52.201501 INFO::Creating boxplot for categorical data, antibiotics vs F588
## 2024-12-29 07:42:52.331966 INFO::Creating boxplot for categorical data, antibiotics vs F616
## 2024-12-29 07:42:52.448435 INFO::Creating boxplot for categorical data, antibiotics vs F323
## 2024-12-29 07:42:52.560607 INFO::Creating boxplot for categorical data, antibiotics vs F409
## 2024-12-29 07:42:52.678705 INFO::Creating boxplot for categorical data, antibiotics vs F326
## 2024-12-29 07:42:52.809098 INFO::Creating boxplot for categorical data, antibiotics vs F698
## 2024-12-29 07:42:52.922276 INFO::Creating boxplot for categorical data, antibiotics vs F567
## 2024-12-29 07:42:53.034549 INFO::Creating boxplot for categorical data, antibiotics vs F179
## 2024-12-29 07:42:53.164532 INFO::Creating boxplot for categorical data, antibiotics vs F787
## 2024-12-29 07:42:53.278708 INFO::Creating boxplot for categorical data, antibiotics vs F79
## 2024-12-29 07:42:53.390561 INFO::Creating boxplot for categorical data, antibiotics vs F335
## 2024-12-29 07:42:53.505797 INFO::Creating boxplot for categorical data, antibiotics vs F576
## 2024-12-29 07:42:53.63604 INFO::Creating boxplot for categorical data, antibiotics vs F667
## 2024-12-29 07:42:53.749468 INFO::Creating boxplot for categorical data, antibiotics vs F694
## 2024-12-29 07:42:53.871349 INFO::Creating boxplot for categorical data, antibiotics vs F297
## 2024-12-29 07:42:54.00021 INFO::Creating boxplot for categorical data, antibiotics vs F569
## 2024-12-29 07:42:54.114843 INFO::Creating boxplot for categorical data, antibiotics vs F138
## 2024-12-29 07:42:54.226751 INFO::Creating boxplot for categorical data, antibiotics vs F611
## 2024-12-29 07:42:54.35576 INFO::Creating boxplot for categorical data, antibiotics vs F810
## 2024-12-29 07:42:54.471455 INFO::Creating boxplot for categorical data, antibiotics vs F746
## 2024-12-29 07:42:54.58333 INFO::Creating boxplot for categorical data, antibiotics vs F23
## 2024-12-29 07:42:54.703622 INFO::Creating boxplot for categorical data, antibiotics vs F135
## 2024-12-29 07:42:54.833295 INFO::Creating boxplot for categorical data, antibiotics vs F411
## 2024-12-29 07:42:54.946184 INFO::Creating boxplot for categorical data, antibiotics vs F489
## 2024-12-29 07:42:55.058459 INFO::Creating boxplot for categorical data, antibiotics vs F492
## 2024-12-29 07:42:55.188072 INFO::Creating boxplot for categorical data, antibiotics vs F844
## 2024-12-29 07:42:55.301687 INFO::Creating boxplot for categorical data, antibiotics vs F586
## 2024-12-29 07:42:55.413254 INFO::Creating boxplot for categorical data, antibiotics vs F11
## 2024-12-29 07:42:55.541978 INFO::Creating boxplot for categorical data, antibiotics vs F900
## 2024-12-29 07:42:55.658673 INFO::Creating boxplot for categorical data, antibiotics vs F21
## 2024-12-29 07:42:55.77201 INFO::Creating boxplot for categorical data, antibiotics vs F736
## 2024-12-29 07:42:55.885834 INFO::Creating boxplot for categorical data, antibiotics vs F408
## 2024-12-29 07:42:56.014221 INFO::Creating boxplot for categorical data, antibiotics vs F788
## 2024-12-29 07:42:56.126326 INFO::Creating boxplot for categorical data, antibiotics vs F66
## 2024-12-29 07:42:56.25035 INFO::Creating boxplot for categorical data, antibiotics vs F493
## 2024-12-29 07:42:56.382547 INFO::Creating boxplot for categorical data, antibiotics vs F343
## 2024-12-29 07:42:56.496778 INFO::Creating boxplot for categorical data, antibiotics vs F352
## 2024-12-29 07:42:56.611957 INFO::Creating boxplot for categorical data, antibiotics vs F677
## 2024-12-29 07:42:56.745311 INFO::Creating boxplot for categorical data, antibiotics vs F816
## 2024-12-29 07:42:56.86043 INFO::Creating boxplot for categorical data, antibiotics vs F457
## 2024-12-29 07:42:56.973224 INFO::Creating boxplot for categorical data, antibiotics vs F330
## 2024-12-29 07:42:57.089375 INFO::Creating boxplot for categorical data, antibiotics vs F293
## 2024-12-29 07:42:57.218706 INFO::Creating boxplot for categorical data, antibiotics vs F725
## 2024-12-29 07:42:57.332106 INFO::Creating boxplot for categorical data, antibiotics vs F813
## 2024-12-29 07:42:57.461183 INFO::Creating boxplot for categorical data, antibiotics vs F295
## 2024-12-29 07:42:57.591852 INFO::Creating boxplot for categorical data, antibiotics vs F656
## 2024-12-29 07:42:57.706739 INFO::Creating boxplot for categorical data, antibiotics vs F669
## 2024-12-29 07:42:57.81998 INFO::Creating boxplot for categorical data, antibiotics vs F15
## 2024-12-29 07:42:57.948647 INFO::Creating boxplot for categorical data, antibiotics vs F419
## 2024-12-29 07:42:58.061944 INFO::Creating boxplot for categorical data, antibiotics vs F701
## 2024-12-29 07:42:58.174901 INFO::Creating boxplot for categorical data, antibiotics vs F176
## 2024-12-29 07:42:58.305455 INFO::Creating boxplot for categorical data, antibiotics vs F203
## 2024-12-29 07:42:58.419337 INFO::Creating boxplot for categorical data, antibiotics vs F501
## 2024-12-29 07:42:58.530823 INFO::Creating boxplot for categorical data, antibiotics vs F772
## 2024-12-29 07:42:58.646048 INFO::Creating boxplot for categorical data, antibiotics vs F488
## 2024-12-29 07:42:58.804585 INFO::Creating boxplot for categorical data, antibiotics vs F600
## 2024-12-29 07:42:58.920983 INFO::Creating boxplot for categorical data, antibiotics vs F768
## 2024-12-29 07:42:59.03525 INFO::Creating boxplot for categorical data, antibiotics vs F432
## 2024-12-29 07:42:59.165068 INFO::Creating boxplot for categorical data, antibiotics vs F26
## 2024-12-29 07:42:59.282943 INFO::Creating boxplot for categorical data, antibiotics vs F189
## 2024-12-29 07:42:59.396752 INFO::Creating boxplot for categorical data, antibiotics vs F200
## 2024-12-29 07:42:59.510578 INFO::Creating boxplot for categorical data, antibiotics vs F121
## 2024-12-29 07:42:59.640288 INFO::Creating boxplot for categorical data, antibiotics vs F624
## 2024-12-29 07:42:59.757824 INFO::Creating boxplot for categorical data, antibiotics vs F855
## 2024-12-29 07:42:59.872922 INFO::Creating boxplot for categorical data, antibiotics vs F380
## 2024-12-29 07:43:00.000623 INFO::Creating boxplot for categorical data, antibiotics vs F734
## 2024-12-29 07:43:00.11842 INFO::Creating boxplot for categorical data, antibiotics vs F16
## 2024-12-29 07:43:00.232647 INFO::Creating boxplot for categorical data, antibiotics vs F602
## 2024-12-29 07:43:00.359128 INFO::Creating boxplot for categorical data, antibiotics vs F210
## 2024-12-29 07:43:00.475313 INFO::Creating boxplot for categorical data, antibiotics vs F217
## 2024-12-29 07:43:00.591358 INFO::Creating boxplot for categorical data, antibiotics vs F640
## 2024-12-29 07:43:00.708237 INFO::Creating boxplot for categorical data, antibiotics vs F631
## 2024-12-29 07:43:00.83842 INFO::Creating boxplot for categorical data, antibiotics vs F32
## 2024-12-29 07:43:00.954602 INFO::Creating boxplot for categorical data, antibiotics vs F322
## 2024-12-29 07:43:01.083702 INFO::Creating boxplot for categorical data, antibiotics vs F476
## 2024-12-29 07:43:01.212663 INFO::Creating boxplot for categorical data, antibiotics vs F265
## 2024-12-29 07:43:01.330686 INFO::Creating boxplot for categorical data, antibiotics vs F283
## 2024-12-29 07:43:01.445985 INFO::Creating boxplot for categorical data, antibiotics vs F316
## 2024-12-29 07:43:01.566393 INFO::Creating boxplot for categorical data, antibiotics vs F465
## 2024-12-29 07:43:01.695439 INFO::Creating boxplot for categorical data, antibiotics vs F24
## 2024-12-29 07:43:01.814485 INFO::Creating boxplot for categorical data, antibiotics vs F38
## 2024-12-29 07:43:01.929594 INFO::Creating boxplot for categorical data, antibiotics vs F82
## 2024-12-29 07:43:02.054928 INFO::Creating boxplot for categorical data, antibiotics vs F86
## 2024-12-29 07:43:02.171894 INFO::Creating boxplot for categorical data, antibiotics vs F270
## 2024-12-29 07:43:02.286289 INFO::Creating boxplot for categorical data, antibiotics vs F485
## 2024-12-29 07:43:02.412132 INFO::Creating boxplot for categorical data, antibiotics vs F486
## 2024-12-29 07:43:02.531923 INFO::Creating boxplot for categorical data, antibiotics vs F399
## 2024-12-29 07:43:02.646867 INFO::Creating boxplot for categorical data, antibiotics vs F573
## 2024-12-29 07:43:02.762415 INFO::Creating boxplot for categorical data, antibiotics vs F877
## 2024-12-29 07:43:02.89125 INFO::Creating boxplot for categorical data, antibiotics vs F709
## 2024-12-29 07:43:03.00787 INFO::Creating boxplot for categorical data, antibiotics vs F227
## 2024-12-29 07:43:03.122368 INFO::Creating boxplot for categorical data, antibiotics vs F553
## 2024-12-29 07:43:03.250753 INFO::Creating boxplot for categorical data, antibiotics vs F123
## 2024-12-29 07:43:03.366463 INFO::Creating boxplot for categorical data, antibiotics vs F118
## 2024-12-29 07:43:03.481222 INFO::Creating boxplot for categorical data, antibiotics vs F605
## 2024-12-29 07:43:03.59636 INFO::Creating boxplot for categorical data, antibiotics vs F619
## 2024-12-29 07:43:03.727258 INFO::Creating boxplot for categorical data, antibiotics vs F830
## 2024-12-29 07:43:03.843681 INFO::Creating boxplot for categorical data, antibiotics vs F837
## 2024-12-29 07:43:03.958263 INFO::Creating boxplot for categorical data, antibiotics vs F12
## 2024-12-29 07:43:04.086973 INFO::Creating boxplot for categorical data, antibiotics vs F623
## 2024-12-29 07:43:04.203031 INFO::Creating boxplot for categorical data, antibiotics vs F806
## 2024-12-29 07:43:04.316074 INFO::Creating boxplot for categorical data, antibiotics vs F353
## 2024-12-29 07:43:04.444002 INFO::Creating boxplot for categorical data, antibiotics vs F829
## 2024-12-29 07:43:04.559882 INFO::Creating boxplot for categorical data, antibiotics vs F289
## 2024-12-29 07:43:04.673603 INFO::Creating boxplot for categorical data, antibiotics vs F93
## 2024-12-29 07:43:04.79044 INFO::Creating boxplot for categorical data, antibiotics vs F379
## 2024-12-29 07:43:04.919822 INFO::Creating boxplot for categorical data, antibiotics vs F370
## 2024-12-29 07:43:05.035946 INFO::Creating boxplot for categorical data, antibiotics vs F360
## 2024-12-29 07:43:05.151418 INFO::Creating boxplot for categorical data, antibiotics vs F710
## 2024-12-29 07:43:05.28071 INFO::Creating boxplot for categorical data, antibiotics vs F388
## 2024-12-29 07:43:05.397474 INFO::Creating boxplot for categorical data, antibiotics vs F796
## 2024-12-29 07:43:05.51092 INFO::Creating boxplot for categorical data, antibiotics vs F174
## 2024-12-29 07:43:05.640079 INFO::Creating boxplot for categorical data, antibiotics vs F601
## 2024-12-29 07:43:05.760072 INFO::Creating boxplot for categorical data, antibiotics vs F775
## 2024-12-29 07:43:05.874357 INFO::Creating boxplot for categorical data, antibiotics vs F836
## 2024-12-29 07:43:06.002506 INFO::Creating boxplot for categorical data, antibiotics vs F192
## 2024-12-29 07:43:06.119171 INFO::Creating boxplot for categorical data, antibiotics vs F463
## 2024-12-29 07:43:06.233481 INFO::Creating boxplot for categorical data, antibiotics vs F57
## 2024-12-29 07:43:06.35005 INFO::Creating boxplot for categorical data, antibiotics vs F658
## 2024-12-29 07:43:06.490964 INFO::Creating boxplot for categorical data, antibiotics vs F596
## 2024-12-29 07:43:06.605851 INFO::Creating boxplot for categorical data, antibiotics vs F218
## 2024-12-29 07:43:06.720338 INFO::Creating boxplot for categorical data, antibiotics vs F104
## 2024-12-29 07:43:06.852709 INFO::Creating boxplot for categorical data, antibiotics vs F466
## 2024-12-29 07:43:06.969796 INFO::Creating boxplot for categorical data, antibiotics vs F737
## 2024-12-29 07:43:07.083109 INFO::Creating boxplot for categorical data, antibiotics vs F487
## 2024-12-29 07:43:07.239293 INFO::Creating boxplot for categorical data, antibiotics vs F369
## 2024-12-29 07:43:07.35702 INFO::Creating boxplot for categorical data, antibiotics vs F584
## 2024-12-29 07:43:07.472008 INFO::Creating boxplot for categorical data, antibiotics vs F166
## 2024-12-29 07:43:07.591005 INFO::Creating boxplot for categorical data, antibiotics vs F822
## 2024-12-29 07:43:07.727978 INFO::Creating boxplot for categorical data, antibiotics vs F416
## 2024-12-29 07:43:07.846493 INFO::Creating boxplot for categorical data, antibiotics vs F70
## 2024-12-29 07:43:07.965973 INFO::Creating boxplot for categorical data, antibiotics vs F243
## 2024-12-29 07:43:08.103423 INFO::Creating boxplot for categorical data, antibiotics vs F498
## 2024-12-29 07:43:08.222254 INFO::Creating boxplot for categorical data, antibiotics vs F272
## 2024-12-29 07:43:08.340166 INFO::Creating boxplot for categorical data, antibiotics vs F846
## 2024-12-29 07:43:08.455489 INFO::Creating boxplot for categorical data, antibiotics vs F881
## 2024-12-29 07:43:08.592474 INFO::Creating boxplot for categorical data, antibiotics vs F280
## 2024-12-29 07:43:08.710907 INFO::Creating boxplot for categorical data, antibiotics vs F761
## 2024-12-29 07:43:08.831886 INFO::Creating boxplot for categorical data, antibiotics vs F781
## 2024-12-29 07:43:08.964723 INFO::Creating boxplot for categorical data, antibiotics vs F697
## 2024-12-29 07:43:09.081501 INFO::Creating boxplot for categorical data, antibiotics vs F890
## 2024-12-29 07:43:09.197756 INFO::Creating boxplot for categorical data, antibiotics vs F197
## 2024-12-29 07:43:09.323789 INFO::Creating boxplot for categorical data, antibiotics vs F826
## 2024-12-29 07:43:09.449657 INFO::Creating boxplot for categorical data, antibiotics vs F641
## 2024-12-29 07:43:09.581198 INFO::Creating boxplot for categorical data, antibiotics vs F700
## 2024-12-29 07:43:09.696429 INFO::Creating boxplot for categorical data, antibiotics vs F531
## 2024-12-29 07:43:09.830955 INFO::Creating boxplot for categorical data, antibiotics vs F660
## 2024-12-29 07:43:09.9479 INFO::Creating boxplot for categorical data, antibiotics vs F257
## 2024-12-29 07:43:10.063626 INFO::Creating boxplot for categorical data, antibiotics vs F136
## 2024-12-29 07:43:10.198425 INFO::Creating boxplot for categorical data, antibiotics vs F875
## 2024-12-29 07:43:10.316273 INFO::Creating boxplot for categorical data, antibiotics vs F160
## 2024-12-29 07:43:10.433534 INFO::Creating boxplot for categorical data, antibiotics vs F782
## 2024-12-29 07:43:10.550001 INFO::Creating boxplot for categorical data, antibiotics vs F642
## 2024-12-29 07:43:10.68593 INFO::Creating boxplot for categorical data, antibiotics vs F730
## 2024-12-29 07:43:10.801891 INFO::Creating boxplot for categorical data, antibiotics vs F679
## 2024-12-29 07:43:10.919202 INFO::Creating boxplot for categorical data, antibiotics vs F713
## 2024-12-29 07:43:11.056094 INFO::Creating boxplot for categorical data, antibiotics vs F821
## 2024-12-29 07:43:11.175988 INFO::Creating boxplot for categorical data, antibiotics vs F443
## 2024-12-29 07:43:11.294087 INFO::Creating boxplot for categorical data, antibiotics vs F729
## 2024-12-29 07:43:11.425432 INFO::Creating boxplot for categorical data, antibiotics vs F25
## 2024-12-29 07:43:11.549075 INFO::Creating boxplot for categorical data, antibiotics vs F338
## 2024-12-29 07:43:11.666993 INFO::Creating boxplot for categorical data, antibiotics vs F647
## 2024-12-29 07:43:11.783976 INFO::Creating boxplot for categorical data, antibiotics vs F817
## 2024-12-29 07:43:11.919956 INFO::Creating boxplot for categorical data, antibiotics vs F535
## 2024-12-29 07:43:12.037623 INFO::Creating boxplot for categorical data, antibiotics vs F634
## 2024-12-29 07:43:12.159757 INFO::Creating boxplot for categorical data, antibiotics vs F533
## 2024-12-29 07:43:12.294257 INFO::Creating boxplot for categorical data, antibiotics vs F808
## 2024-12-29 07:43:12.41218 INFO::Creating boxplot for categorical data, antibiotics vs F571
## 2024-12-29 07:43:12.528766 INFO::Creating boxplot for categorical data, antibiotics vs F529
## 2024-12-29 07:43:12.661261 INFO::Creating boxplot for categorical data, antibiotics vs F827
## 2024-12-29 07:43:12.780689 INFO::Creating boxplot for categorical data, antibiotics vs F107
## 2024-12-29 07:43:12.898609 INFO::Creating boxplot for categorical data, antibiotics vs F515
## 2024-12-29 07:43:13.014493 INFO::Creating boxplot for categorical data, antibiotics vs F305
## 2024-12-29 07:43:13.151236 INFO::Creating boxplot for categorical data, antibiotics vs F662
## 2024-12-29 07:43:13.267749 INFO::Creating boxplot for categorical data, antibiotics vs F310
## 2024-12-29 07:43:13.38558 INFO::Creating boxplot for categorical data, antibiotics vs F430
## 2024-12-29 07:43:13.519575 INFO::Creating boxplot for categorical data, antibiotics vs F173
## 2024-12-29 07:43:13.636085 INFO::Creating boxplot for categorical data, antibiotics vs F820
## 2024-12-29 07:43:13.751942 INFO::Creating boxplot for categorical data, antibiotics vs F743
## 2024-12-29 07:43:13.887122 INFO::Creating boxplot for categorical data, antibiotics vs F63
## 2024-12-29 07:43:14.005172 INFO::Creating boxplot for categorical data, antibiotics vs F215
## 2024-12-29 07:43:14.120099 INFO::Creating boxplot for categorical data, antibiotics vs F216
## 2024-12-29 07:43:14.236897 INFO::Creating boxplot for categorical data, antibiotics vs F245
## 2024-12-29 07:43:14.375321 INFO::Creating boxplot for categorical data, antibiotics vs F862
## 2024-12-29 07:43:14.490326 INFO::Creating boxplot for categorical data, antibiotics vs F541
## 2024-12-29 07:43:14.606168 INFO::Creating boxplot for categorical data, antibiotics vs F558
## 2024-12-29 07:43:14.74117 INFO::Creating boxplot for categorical data, antibiotics vs F633
## 2024-12-29 07:43:14.85897 INFO::Creating boxplot for categorical data, antibiotics vs F94
## 2024-12-29 07:43:14.97581 INFO::Creating boxplot for categorical data, antibiotics vs F574
## 2024-12-29 07:43:15.110701 INFO::Creating boxplot for categorical data, antibiotics vs F238
## 2024-12-29 07:43:15.227826 INFO::Creating boxplot for categorical data, antibiotics vs F815
## 2024-12-29 07:43:15.344278 INFO::Creating boxplot for categorical data, antibiotics vs F587
## 2024-12-29 07:43:15.47774 INFO::Creating boxplot for categorical data, antibiotics vs F464
## 2024-12-29 07:43:15.595513 INFO::Creating boxplot for categorical data, antibiotics vs F590
## 2024-12-29 07:43:15.712322 INFO::Creating boxplot for categorical data, antibiotics vs F124
## 2024-12-29 07:43:15.870497 INFO::Creating boxplot for categorical data, antibiotics vs F664
## 2024-12-29 07:43:15.995501 INFO::Creating boxplot for categorical data, antibiotics vs F100
## 2024-12-29 07:43:16.114415 INFO::Creating boxplot for categorical data, antibiotics vs F744
## 2024-12-29 07:43:16.233742 INFO::Creating boxplot for categorical data, antibiotics vs F444
## 2024-12-29 07:43:16.371236 INFO::Creating boxplot for categorical data, antibiotics vs F597
## 2024-12-29 07:43:16.488799 INFO::Creating boxplot for categorical data, antibiotics vs F650
## 2024-12-29 07:43:16.606253 INFO::Creating boxplot for categorical data, antibiotics vs F147
## 2024-12-29 07:43:16.734273 INFO::Creating boxplot for categorical data, antibiotics vs F363
## 2024-12-29 07:43:16.854855 INFO::Creating boxplot for categorical data, antibiotics vs F521
## 2024-12-29 07:43:16.972772 INFO::Creating boxplot for categorical data, antibiotics vs F412
## 2024-12-29 07:43:17.091012 INFO::Creating boxplot for categorical data, antibiotics vs F279
## 2024-12-29 07:43:17.233284 INFO::Creating boxplot for categorical data, antibiotics vs F225
## 2024-12-29 07:43:17.349843 INFO::Creating boxplot for categorical data, antibiotics vs F10
## 2024-12-29 07:43:17.469513 INFO::Creating boxplot for categorical data, antibiotics vs F481
## 2024-12-29 07:43:17.602501 INFO::Creating boxplot for categorical data, antibiotics vs F861
## 2024-12-29 07:43:17.719412 INFO::Creating boxplot for categorical data, antibiotics vs F888
## 2024-12-29 07:43:17.836273 INFO::Creating boxplot for categorical data, antibiotics vs F156
## 2024-12-29 07:43:17.974115 INFO::Creating boxplot for categorical data, antibiotics vs F857
## 2024-12-29 07:43:18.107716 INFO::Creating boxplot for categorical data, antibiotics vs F509
## 2024-12-29 07:43:18.223668 INFO::Creating boxplot for categorical data, antibiotics vs F244
## 2024-12-29 07:43:18.341262 INFO::Creating boxplot for categorical data, antibiotics vs F514
## 2024-12-29 07:43:18.475369 INFO::Creating boxplot for categorical data, antibiotics vs F196
## 2024-12-29 07:43:18.593948 INFO::Creating boxplot for categorical data, antibiotics vs F304
## 2024-12-29 07:43:18.711315 INFO::Creating boxplot for categorical data, antibiotics vs F833
## 2024-12-29 07:43:18.831443 INFO::Creating boxplot for categorical data, antibiotics vs F294
## 2024-12-29 07:43:18.966544 INFO::Creating boxplot for categorical data, antibiotics vs F550
## 2024-12-29 07:43:19.084766 INFO::Creating boxplot for categorical data, antibiotics vs F869
## 2024-12-29 07:43:19.202571 INFO::Creating boxplot for categorical data, antibiotics vs F364
## 2024-12-29 07:43:19.337254 INFO::Creating boxplot for categorical data, antibiotics vs F583
## 2024-12-29 07:43:19.454713 INFO::Creating boxplot for categorical data, antibiotics vs F441
## 2024-12-29 07:43:19.57532 INFO::Creating boxplot for categorical data, antibiotics vs F595
## 2024-12-29 07:43:19.711643 INFO::Creating boxplot for categorical data, antibiotics vs F35
## 2024-12-29 07:43:19.830554 INFO::Creating boxplot for categorical data, antibiotics vs F630
## 2024-12-29 07:43:19.950456 INFO::Creating boxplot for categorical data, antibiotics vs F401
## 2024-12-29 07:43:20.071353 INFO::Creating boxplot for categorical data, antibiotics vs F287
## 2024-12-29 07:43:20.206684 INFO::Creating boxplot for categorical data, antibiotics vs F250
## 2024-12-29 07:43:20.32351 INFO::Creating boxplot for categorical data, antibiotics vs F239
## 2024-12-29 07:43:20.441784 INFO::Creating boxplot for categorical data, antibiotics vs F88
## 2024-12-29 07:43:20.577828 INFO::Creating boxplot for categorical data, antibiotics vs F752
## 2024-12-29 07:43:20.697033 INFO::Creating boxplot for categorical data, antibiotics vs F539
## 2024-12-29 07:43:20.82489 INFO::Creating boxplot for categorical data, antibiotics vs F69
## 2024-12-29 07:43:20.958885 INFO::Creating boxplot for categorical data, antibiotics vs F126
## 2024-12-29 07:43:21.076804 INFO::Creating boxplot for categorical data, antibiotics vs F362
## 2024-12-29 07:43:21.195433 INFO::Creating boxplot for categorical data, antibiotics vs F753
## 2024-12-29 07:43:21.313663 INFO::Creating boxplot for categorical data, antibiotics vs F469
## 2024-12-29 07:43:21.451597 INFO::Creating boxplot for categorical data, antibiotics vs F14
## 2024-12-29 07:43:21.568806 INFO::Creating boxplot for categorical data, antibiotics vs F803
## 2024-12-29 07:43:21.686804 INFO::Creating boxplot for categorical data, antibiotics vs F814
## 2024-12-29 07:43:21.823176 INFO::Creating boxplot for categorical data, antibiotics vs F449
## 2024-12-29 07:43:21.942703 INFO::Creating boxplot for categorical data, antibiotics vs F494
## 2024-12-29 07:43:22.061955 INFO::Creating boxplot for categorical data, antibiotics vs F439
## 2024-12-29 07:43:22.198196 INFO::Creating boxplot for categorical data, antibiotics vs F686
## 2024-12-29 07:43:22.316737 INFO::Creating boxplot for categorical data, antibiotics vs F591
## 2024-12-29 07:43:22.435256 INFO::Creating boxplot for categorical data, antibiotics vs F735
## 2024-12-29 07:43:22.560607 INFO::Creating boxplot for categorical data, antibiotics vs F111
## 2024-12-29 07:43:22.687052 INFO::Creating boxplot for categorical data, antibiotics vs F346
## 2024-12-29 07:43:22.80429 INFO::Creating boxplot for categorical data, antibiotics vs F29
## 2024-12-29 07:43:22.924494 INFO::Creating boxplot for categorical data, antibiotics vs F376
## 2024-12-29 07:43:23.060735 INFO::Creating boxplot for categorical data, antibiotics vs F414
## 2024-12-29 07:43:23.178347 INFO::Creating boxplot for categorical data, antibiotics vs F555
## 2024-12-29 07:43:23.297147 INFO::Creating boxplot for categorical data, antibiotics vs F517
## 2024-12-29 07:43:23.433418 INFO::Creating boxplot for categorical data, antibiotics vs F544
## 2024-12-29 07:43:23.552328 INFO::Creating boxplot for categorical data, antibiotics vs F339
## 2024-12-29 07:43:23.671001 INFO::Creating boxplot for categorical data, antibiotics vs F689
## 2024-12-29 07:43:23.805928 INFO::Creating boxplot for categorical data, antibiotics vs F391
## 2024-12-29 07:43:23.922664 INFO::Creating boxplot for categorical data, antibiotics vs F502
## 2024-12-29 07:43:24.042427 INFO::Creating boxplot for categorical data, antibiotics vs F298
## 2024-12-29 07:43:24.172108 INFO::Creating boxplot for categorical data, antibiotics vs F337
## 2024-12-29 07:43:24.296651 INFO::Creating boxplot for categorical data, antibiotics vs F773
## 2024-12-29 07:43:24.413976 INFO::Creating boxplot for categorical data, antibiotics vs F592
## 2024-12-29 07:43:24.531005 INFO::Creating boxplot for categorical data, antibiotics vs F307
## 2024-12-29 07:43:24.695673 INFO::Creating boxplot for categorical data, antibiotics vs F115
## 2024-12-29 07:43:24.813289 INFO::Creating boxplot for categorical data, antibiotics vs F739
## 2024-12-29 07:43:24.932881 INFO::Creating boxplot for categorical data, antibiotics vs F433
## 2024-12-29 07:43:25.077825 INFO::Creating boxplot for categorical data, antibiotics vs F384
## 2024-12-29 07:43:25.197449 INFO::Creating boxplot for categorical data, antibiotics vs F750
## 2024-12-29 07:43:25.315835 INFO::Creating boxplot for categorical data, antibiotics vs F762
## 2024-12-29 07:43:25.435511 INFO::Creating boxplot for categorical data, antibiotics vs F277
## 2024-12-29 07:43:25.578239 INFO::Creating boxplot for categorical data, antibiotics vs F871
## 2024-12-29 07:43:25.695095 INFO::Creating boxplot for categorical data, antibiotics vs F839
## 2024-12-29 07:43:25.815636 INFO::Creating boxplot for categorical data, antibiotics vs F127
## 2024-12-29 07:43:25.964251 INFO::Creating boxplot for categorical data, antibiotics vs F554
## 2024-12-29 07:43:26.082134 INFO::Creating boxplot for categorical data, antibiotics vs F676
## 2024-12-29 07:43:26.198646 INFO::Creating boxplot for categorical data, antibiotics vs F568
## 2024-12-29 07:43:26.327849 INFO::Creating boxplot for categorical data, antibiotics vs F137
## 2024-12-29 07:43:26.458994 INFO::Creating boxplot for categorical data, antibiotics vs F131
## 2024-12-29 07:43:26.576405 INFO::Creating boxplot for categorical data, antibiotics vs F60
## 2024-12-29 07:43:26.695638 INFO::Creating boxplot for categorical data, antibiotics vs F98
## 2024-12-29 07:43:26.838072 INFO::Creating boxplot for categorical data, antibiotics vs F672
## 2024-12-29 07:43:26.956784 INFO::Creating boxplot for categorical data, antibiotics vs F530
## 2024-12-29 07:43:27.076509 INFO::Creating boxplot for categorical data, antibiotics vs F809
## 2024-12-29 07:43:27.215415 INFO::Creating boxplot for categorical data, antibiotics vs F894
## 2024-12-29 07:43:27.341266 INFO::Creating boxplot for categorical data, antibiotics vs F22
## 2024-12-29 07:43:27.459165 INFO::Creating boxplot for categorical data, antibiotics vs F818
## 2024-12-29 07:43:27.578234 INFO::Creating boxplot for categorical data, antibiotics vs F559
## 2024-12-29 07:43:27.719594 INFO::Creating boxplot for categorical data, antibiotics vs F741
## 2024-12-29 07:43:27.836956 INFO::Creating boxplot for categorical data, antibiotics vs F398
## 2024-12-29 07:43:27.955396 INFO::Creating boxplot for categorical data, antibiotics vs F357
## 2024-12-29 07:43:28.100579 INFO::Creating boxplot for categorical data, antibiotics vs F119
## 2024-12-29 07:43:28.218386 INFO::Creating boxplot for categorical data, antibiotics vs F426
## 2024-12-29 07:43:28.336219 INFO::Creating boxplot for categorical data, antibiotics vs F204
## 2024-12-29 07:43:28.467206 INFO::Creating boxplot for categorical data, antibiotics vs F851
## 2024-12-29 07:43:28.59883 INFO::Creating boxplot for categorical data, antibiotics vs F657
## 2024-12-29 07:43:28.715306 INFO::Creating boxplot for categorical data, antibiotics vs F801
## 2024-12-29 07:43:28.833985 INFO::Creating boxplot for categorical data, antibiotics vs F754
## 2024-12-29 07:43:28.976564 INFO::Creating boxplot for categorical data, antibiotics vs F859
## 2024-12-29 07:43:29.094885 INFO::Creating boxplot for categorical data, antibiotics vs F480
## 2024-12-29 07:43:29.215007 INFO::Creating boxplot for categorical data, antibiotics vs F507
## 2024-12-29 07:43:29.356292 INFO::Creating boxplot for categorical data, antibiotics vs F207
## 2024-12-29 07:43:30.981543 INFO::Plotting data for metadata number 3, age
## 2024-12-29 07:43:30.982743 INFO::Creating scatter plot for continuous data, age vs F340
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:31.144579 INFO::Creating scatter plot for continuous data, age vs F603
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:31.318717 INFO::Creating scatter plot for continuous data, age vs F356
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:31.472492 INFO::Creating scatter plot for continuous data, age vs F181
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:31.591408 INFO::Creating scatter plot for continuous data, age vs F177
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:31.737984 INFO::Creating scatter plot for continuous data, age vs F390
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:31.872843 INFO::Creating scatter plot for continuous data, age vs F743
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:31.988278 INFO::Creating scatter plot for continuous data, age vs F491
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:32.138608 INFO::Creating scatter plot for continuous data, age vs F436
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:32.254479 INFO::Creating scatter plot for continuous data, age vs F219
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:32.369876 INFO::Creating scatter plot for continuous data, age vs F483
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:32.524158 INFO::Creating scatter plot for continuous data, age vs F878
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:32.648381 INFO::Creating scatter plot for continuous data, age vs F876
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:32.773351 INFO::Creating scatter plot for continuous data, age vs F211
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:32.921534 INFO::Creating scatter plot for continuous data, age vs F732
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:33.050006 INFO::Creating scatter plot for continuous data, age vs F222
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:33.175837 INFO::Creating scatter plot for continuous data, age vs F688
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:33.323444 INFO::Creating scatter plot for continuous data, age vs F170
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:33.46045 INFO::Creating scatter plot for continuous data, age vs F431
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:34.128892 INFO::Creating scatter plot for continuous data, age vs F174
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:34.238578 INFO::Creating scatter plot for continuous data, age vs F17
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:34.346813 INFO::Creating scatter plot for continuous data, age vs F334
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:34.467524 INFO::Creating scatter plot for continuous data, age vs F835
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:34.584532 INFO::Creating scatter plot for continuous data, age vs F223
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:34.701993 INFO::Creating scatter plot for continuous data, age vs F383
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:34.809931 INFO::Creating scatter plot for continuous data, age vs F623
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:34.934224 INFO::Creating scatter plot for continuous data, age vs F329
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:35.052794 INFO::Creating scatter plot for continuous data, age vs F395
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:35.171679 INFO::Creating scatter plot for continuous data, age vs F528
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:35.286217 INFO::Creating scatter plot for continuous data, age vs F13
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:35.393929 INFO::Creating scatter plot for continuous data, age vs F36
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:35.502445 INFO::Creating scatter plot for continuous data, age vs F285
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:35.626917 INFO::Creating scatter plot for continuous data, age vs F404
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:35.734733 INFO::Creating scatter plot for continuous data, age vs F894
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:35.8524 INFO::Creating scatter plot for continuous data, age vs F300
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:35.976829 INFO::Creating scatter plot for continuous data, age vs F32
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:36.093612 INFO::Creating scatter plot for continuous data, age vs F24
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:36.211083 INFO::Creating scatter plot for continuous data, age vs F97
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:36.326379 INFO::Creating scatter plot for continuous data, age vs F849
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:36.436016 INFO::Creating scatter plot for continuous data, age vs F185
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:36.552834 INFO::Creating scatter plot for continuous data, age vs F513
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:36.690286 INFO::Creating scatter plot for continuous data, age vs F296
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:36.806244 INFO::Creating scatter plot for continuous data, age vs F471
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:36.923183 INFO::Creating scatter plot for continuous data, age vs F793
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:37.047025 INFO::Creating scatter plot for continuous data, age vs F402
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:37.165725 INFO::Creating scatter plot for continuous data, age vs F541
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:37.28292 INFO::Creating scatter plot for continuous data, age vs F496
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:37.401261 INFO::Creating scatter plot for continuous data, age vs F386
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:37.509919 INFO::Creating scatter plot for continuous data, age vs F594
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:37.63066 INFO::Creating scatter plot for continuous data, age vs F704
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:37.747889 INFO::Creating scatter plot for continuous data, age vs F330
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:37.86406 INFO::Creating scatter plot for continuous data, age vs F197
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:37.981179 INFO::Creating scatter plot for continuous data, age vs F735
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:38.105626 INFO::Creating scatter plot for continuous data, age vs F481
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:38.214226 INFO::Creating scatter plot for continuous data, age vs F635
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:38.331824 INFO::Creating scatter plot for continuous data, age vs F687
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:38.47378 INFO::Creating scatter plot for continuous data, age vs F652
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:38.591751 INFO::Creating scatter plot for continuous data, age vs F651
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:38.712208 INFO::Creating scatter plot for continuous data, age vs F82
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:38.828103 INFO::Creating scatter plot for continuous data, age vs F7
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:38.936534 INFO::Creating scatter plot for continuous data, age vs F866
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:39.054578 INFO::Creating scatter plot for continuous data, age vs F593
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:39.172696 INFO::Creating scatter plot for continuous data, age vs F733
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:39.28096 INFO::Creating scatter plot for continuous data, age vs F684
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:39.399769 INFO::Creating scatter plot for continuous data, age vs F410
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:39.517033 INFO::Creating scatter plot for continuous data, age vs F224
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:39.635801 INFO::Creating scatter plot for continuous data, age vs F722
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:39.755648 INFO::Creating scatter plot for continuous data, age vs F856
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:39.871798 INFO::Creating scatter plot for continuous data, age vs F680
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:39.980361 INFO::Creating scatter plot for continuous data, age vs F19
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:40.099006 INFO::Creating scatter plot for continuous data, age vs F860
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:40.216359 INFO::Creating scatter plot for continuous data, age vs F859
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:40.33287 INFO::Creating scatter plot for continuous data, age vs F522
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:40.451935 INFO::Creating scatter plot for continuous data, age vs F372
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:40.577907 INFO::Creating scatter plot for continuous data, age vs F899
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:40.70028 INFO::Creating scatter plot for continuous data, age vs F782
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:40.825141 INFO::Creating scatter plot for continuous data, age vs F839
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:40.941595 INFO::Creating scatter plot for continuous data, age vs F827
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:41.058123 INFO::Creating scatter plot for continuous data, age vs F817
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:41.185363 INFO::Creating scatter plot for continuous data, age vs F345
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:41.294206 INFO::Creating scatter plot for continuous data, age vs F127
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:41.412424 INFO::Creating scatter plot for continuous data, age vs F749
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:41.566746 INFO::Creating scatter plot for continuous data, age vs F877
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:41.686279 INFO::Creating scatter plot for continuous data, age vs F150
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:41.804785 INFO::Creating scatter plot for continuous data, age vs F752
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:41.93025 INFO::Creating scatter plot for continuous data, age vs F848
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:42.048657 INFO::Creating scatter plot for continuous data, age vs F809
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:42.167042 INFO::Creating scatter plot for continuous data, age vs F751
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:42.292495 INFO::Creating scatter plot for continuous data, age vs F15
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:42.404825 INFO::Creating scatter plot for continuous data, age vs F521
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:42.513908 INFO::Creating scatter plot for continuous data, age vs F842
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:42.643547 INFO::Creating scatter plot for continuous data, age vs F319
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:42.768998 INFO::Creating scatter plot for continuous data, age vs F96
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:42.8852 INFO::Creating scatter plot for continuous data, age vs F171
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:43.015612 INFO::Creating scatter plot for continuous data, age vs F241
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:43.132066 INFO::Creating scatter plot for continuous data, age vs F582
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:43.242641 INFO::Creating scatter plot for continuous data, age vs F822
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:43.352855 INFO::Creating scatter plot for continuous data, age vs F748
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:43.478927 INFO::Creating scatter plot for continuous data, age vs F147
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:43.597343 INFO::Creating scatter plot for continuous data, age vs F16
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:43.709642 INFO::Creating scatter plot for continuous data, age vs F212
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:43.857023 INFO::Creating scatter plot for continuous data, age vs F718
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:43.975615 INFO::Creating scatter plot for continuous data, age vs F663
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:44.086131 INFO::Creating scatter plot for continuous data, age vs F690
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:44.222516 INFO::Creating scatter plot for continuous data, age vs F865
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:44.33232 INFO::Creating scatter plot for continuous data, age vs F421
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:44.442401 INFO::Creating scatter plot for continuous data, age vs F110
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:44.576753 INFO::Creating scatter plot for continuous data, age vs F857
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:44.695205 INFO::Creating scatter plot for continuous data, age vs F84
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:44.813413 INFO::Creating scatter plot for continuous data, age vs F123
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:44.939514 INFO::Creating scatter plot for continuous data, age vs F566
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:45.049332 INFO::Creating scatter plot for continuous data, age vs F370
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:45.159113 INFO::Creating scatter plot for continuous data, age vs F65
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:45.28634 INFO::Creating scatter plot for continuous data, age vs F119
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:45.396962 INFO::Creating scatter plot for continuous data, age vs F263
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:45.505667 INFO::Creating scatter plot for continuous data, age vs F630
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:45.641182 INFO::Creating scatter plot for continuous data, age vs F628
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:45.750845 INFO::Creating scatter plot for continuous data, age vs F711
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:45.868864 INFO::Creating scatter plot for continuous data, age vs F152
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:46.004287 INFO::Creating scatter plot for continuous data, age vs F324
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:46.122166 INFO::Creating scatter plot for continuous data, age vs F575
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:46.234909 INFO::Creating scatter plot for continuous data, age vs F699
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:46.369663 INFO::Creating scatter plot for continuous data, age vs F846
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:46.495103 INFO::Creating scatter plot for continuous data, age vs F380
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:46.614583 INFO::Creating scatter plot for continuous data, age vs F172
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:46.74922 INFO::Creating scatter plot for continuous data, age vs F504
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:46.858731 INFO::Creating scatter plot for continuous data, age vs F34
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:46.969872 INFO::Creating scatter plot for continuous data, age vs F199
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:47.107111 INFO::Creating scatter plot for continuous data, age vs F198
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:47.224535 INFO::Creating scatter plot for continuous data, age vs F479
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:47.345159 INFO::Creating scatter plot for continuous data, age vs F673
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:47.472566 INFO::Creating scatter plot for continuous data, age vs F508
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:47.590982 INFO::Creating scatter plot for continuous data, age vs F337
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:47.726177 INFO::Creating scatter plot for continuous data, age vs F737
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:47.845781 INFO::Creating scatter plot for continuous data, age vs F609
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:47.963324 INFO::Creating scatter plot for continuous data, age vs F40
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:48.089799 INFO::Creating scatter plot for continuous data, age vs F821
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:48.211032 INFO::Creating scatter plot for continuous data, age vs F643
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:48.320424 INFO::Creating scatter plot for continuous data, age vs F759
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:48.447131 INFO::Creating scatter plot for continuous data, age vs F417
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:48.567572 INFO::Creating scatter plot for continuous data, age vs F58
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:48.686198 INFO::Creating scatter plot for continuous data, age vs F267
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:48.821527 INFO::Creating scatter plot for continuous data, age vs F101
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:48.933795 INFO::Creating scatter plot for continuous data, age vs F890
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:49.052995 INFO::Creating scatter plot for continuous data, age vs F655
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:49.22733 INFO::Creating scatter plot for continuous data, age vs F95
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:49.340982 INFO::Creating scatter plot for continuous data, age vs F775
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:49.452917 INFO::Creating scatter plot for continuous data, age vs F93
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:49.590749 INFO::Creating scatter plot for continuous data, age vs F353
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:49.705092 INFO::Creating scatter plot for continuous data, age vs F480
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:49.826737 INFO::Creating scatter plot for continuous data, age vs F567
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:49.961256 INFO::Creating scatter plot for continuous data, age vs F871
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:50.082155 INFO::Creating scatter plot for continuous data, age vs F295
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:50.194499 INFO::Creating scatter plot for continuous data, age vs F459
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:50.329305 INFO::Creating scatter plot for continuous data, age vs F812
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:50.450557 INFO::Creating scatter plot for continuous data, age vs F146
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:50.561482 INFO::Creating scatter plot for continuous data, age vs F239
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:50.698164 INFO::Creating scatter plot for continuous data, age vs F754
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:50.819225 INFO::Creating scatter plot for continuous data, age vs F443
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:50.931657 INFO::Creating scatter plot for continuous data, age vs F5
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:51.066533 INFO::Creating scatter plot for continuous data, age vs F864
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-29 07:43:51.179686 INFO::Creating scatter plot for continuous data, age vs F477
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:51.303754 INFO::Creating scatter plot for continuous data, age vs F571
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-29 07:43:51.43805 INFO::Creating scatter plot for continuous data, age vs F715
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Initiating effect size calculations
## 
## Calculating mean abundance in: IBD
## 
## Calculating mean abundance in: Control
## 
## Calculating effect size in: IBD
## 
## Initiating prioritization
## 
## Calculating meta-rank and prioritizing metabolic features
## 2024-12-29 07:43:53.041914 INFO::Writing all prioritized metabolites to file: Macarron_output/prioritized_metabolites_all.csv
## 2024-12-29 07:43:53.047316 INFO::Writing characterizable prioritized metabolites to file: Macarron_output/prioritized_metabolites_characterizable.csv
## 2024-12-29 07:43:53.061301 INFO::Writing highly prioritized metabolites in IBD to file: Macarron_output/highly_prioritized_per_module_in_IBD.csv

Using dataframes as inputs

abundances_df = read.csv(file = prism_abundances, row.names = 1) # setting features as rownames
annotations_df = read.csv(file = prism_annotations, row.names = 1) # setting features as rownames
metadata_df = read.csv(file = prism_metadata, row.names = 1) # setting samples as rownames 
taxonomy_df = read.csv(file = mets_taxonomy)

# Running Macarron
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
                                        input_annotations = annotations_df,
                                        input_metadata = metadata_df,
                                        input_taxonomy = taxonomy_df)

Running Macarron as individual functions

The Macarron::Macarron() function is a wrapper for the Macarron framework. Users can also apply individual functions on the input dataframes to achieve same results as the wrapper with the added benefit of storing output from each function for other analyses. There are seven steps:

# Step 1: Storing input data in a summarized experiment object
prism_mbx <- prepInput(input_abundances = abundances_df,
                       input_annotations = annotations_df,
                       input_metadata = metadata_df)

# Step 2: Creating a distance matrix from pairwise correlations in abundances of metabolic features
prism_w <- makeDisMat(se = prism_mbx)

# Step 3: Finding covariance modules
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df)
# The output is a list containing two dataframes- module assignments and measures of success
# if evaluateMOS=TRUE. To write modules to a separate dataframe, do:
prism_module_assignments <- prism_modules[[1]]
prism_modules_mos <- prism_modules[[2]]

# Step 4: Calculating AVA
prism_ava <- calAVA(se = prism_mbx,
                    mod.assn = prism_modules)

# Step 5: Calculating q-value
prism_qval <- calQval(se = prism_mbx,
                      mod.assn = prism_modules)

# Step 6: Calculating effect size
prism_es <- calES(se = prism_mbx,
                   mac.qval = prism_qval)

# Step 7: Prioritizing metabolic features
prism_prioritized <- prioritize(se = prism_mbx,
                                mod.assn = prism_modules,
                                mac.ava = prism_ava,
                                mac.qval = prism_qval,
                                mac.es = prism_es)
# The output is a list containing two dataframes- all prioritized metabolic features and
# only characterizable metabolic features.
all_prioritized <- prism_prioritized[[1]]
char_prioritized <- prism_prioritized[[2]]

# Step 8 (optional): View only the highly prioritized metabolic features in each module
prism_highly_prioritized <- showBest(prism_prioritized)

Session info from running the demo in R can be displayed with the following command.

sessionInfo()
## R version 4.4.2 (2024-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=C              
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] Macarron_1.11.0             SummarizedExperiment_1.37.0
##  [3] Biobase_2.67.0              GenomicRanges_1.59.1       
##  [5] GenomeInfoDb_1.43.2         IRanges_2.41.2             
##  [7] S4Vectors_0.45.2            BiocGenerics_0.53.3        
##  [9] generics_0.1.3              MatrixGenerics_1.19.0      
## [11] matrixStats_1.4.1           BiocStyle_2.35.0           
## 
## loaded via a namespace (and not attached):
##   [1] mnormt_2.1.1            DBI_1.2.3               pbapply_1.7-2          
##   [4] gridExtra_2.3           rlang_1.1.4             magrittr_2.0.3         
##   [7] compiler_4.4.2          RSQLite_2.3.9           mgcv_1.9-1             
##  [10] png_0.1-8               vctrs_0.6.5             stringr_1.5.1          
##  [13] pkgconfig_2.0.3         crayon_1.5.3            fastmap_1.2.0          
##  [16] backports_1.5.0         XVector_0.47.1          labeling_0.4.3         
##  [19] rmarkdown_2.29          preprocessCore_1.69.0   UCSC.utils_1.3.0       
##  [22] bit_4.5.0.1             xfun_0.49               cachem_1.1.0           
##  [25] jsonlite_1.8.9          blob_1.2.4              DelayedArray_0.33.3    
##  [28] BiocParallel_1.41.0     psych_2.4.12            Maaslin2_1.21.0        
##  [31] parallel_4.4.2          cluster_2.1.8           biglm_0.9-3            
##  [34] R6_2.5.1                RColorBrewer_1.1-3      bslib_0.8.0            
##  [37] stringi_1.8.4           rpart_4.1.23            jquerylib_0.1.4        
##  [40] Rcpp_1.0.13-1           iterators_1.0.14        knitr_1.49             
##  [43] WGCNA_1.73              base64enc_0.1-3         Matrix_1.7-1           
##  [46] splines_4.4.2           nnet_7.3-19             tidyselect_1.2.1       
##  [49] rstudioapi_0.17.1       abind_1.4-8             yaml_2.3.10            
##  [52] doParallel_1.0.17       codetools_0.2-20        plyr_1.8.9             
##  [55] lattice_0.22-6          tibble_3.2.1            withr_3.0.2            
##  [58] KEGGREST_1.47.0         evaluate_1.0.1          foreign_0.8-87         
##  [61] survival_3.8-3          getopt_1.20.4           Biostrings_2.75.3      
##  [64] pillar_1.10.0           BiocManager_1.30.25     checkmate_2.3.2        
##  [67] foreach_1.5.2           pcaPP_2.0-5             ggplot2_3.5.1          
##  [70] munsell_0.5.1           scales_1.3.0            glue_1.8.0             
##  [73] Hmisc_5.2-1             maketools_1.3.1         tools_4.4.2            
##  [76] robustbase_0.99-4-1     sys_3.4.3               data.table_1.16.4      
##  [79] mvtnorm_1.3-2           buildtools_1.0.0        fastcluster_1.2.6      
##  [82] grid_4.4.2              optparse_1.7.5          impute_1.81.0          
##  [85] AnnotationDbi_1.69.0    colorspace_2.1-1        nlme_3.1-166           
##  [88] GenomeInfoDbData_1.2.13 htmlTable_2.4.3         Formula_1.2-5          
##  [91] cli_3.6.3               S4Arrays_1.7.1          dplyr_1.1.4            
##  [94] DEoptimR_1.1-3-1        gtable_0.3.6            hash_2.2.6.3           
##  [97] logging_0.10-108        dynamicTreeCut_1.63-1   sass_0.4.9             
## [100] digest_0.6.37           SparseArray_1.7.2       farver_2.1.2           
## [103] htmlwidgets_1.6.4       memoise_2.0.1           htmltools_0.5.8.1      
## [106] lifecycle_1.0.4         httr_1.4.7              GO.db_3.20.0           
## [109] bit64_4.5.2

Advanced Topics

Generating the input chemical taxonomy file

The input taxonomy dataframe can be generated using the input metabolic features annotation dataframe using Macarron::decorateID(). This function annotates an HMDB ID or a PubChem CID with the chemical class and subclass of the metabolite.

taxonomy_df <- decorateID(input_annotations = annotations_df)
write.csv(taxonomy_df, file="demo_taxonomy.csv", row.names = FALSE)

Accessory output files

Macarron.log

A record of all chosen parameters and steps that were followed during execution.

modules_measures_of_success.csv

This file provides information about the properties of covariance modules used in the analysis. By default, modules are generated using a minimum module size (MMS) (argument: min_module_size) equal to cube root of the total number of prevalent metabolic features. Macarron evaluates 9 measures of success (MOS) that collectively capture the “correctness” and chemical homogeneity of the modules. The MOS are as follows:

  • Total modules: Number of modules.
  • Singletons: Number of metabolic features that were not assigned to any module at MMS.
  • % Annotated modules: Percentage of modules that contained at least one annotated metabolic feature.
  • % Consistent assignments: Percentage of times the same metabolic feature was assigned to the same module e.g. if three metabolic features represent glucose, they should all be in the same module. This percentage must be high.
  • Max classes per module: The highest number of chemical classes observed in any module. This is evaluated using the chemical taxonomy of covarying annotated features.
  • 90p classes per module: 90th percentile of classes per module; captures the chemical homogeneity of the modules.
  • Max subclasses per module: The highest number of chemical subclasses observed in any module.
  • 90p subclasses per module: 90th percentile of subclasses per module; captures the chemical homogeneity of the modules.
  • % Features in HAM: Macarron first finds homogeneously annoted modules (HAMs): These are modules in which >75% annotated features have the same chemical class indicating that they are chemically homogeneous. It then calculates how many features the HAMs account for.

Maaslin2 results

This folder contains the Maaslin2 log file (maaslin2.log), significant associations found by Maaslin2 (significant_results.tsv) and the linear model residuals file (residuals.rds). For more information, see Maaslin2.

Changing defaults

Filtering metabolic features based on prevalence

Ideally, at least 50% metabolic features must be retained after prevalence filtering. By default, Macarron uses the union of metabolic features observed (non-zero abundance) in at least 70% samples of any phenotype for further analysis. This prevalence threshold may be high for some metabolomics datasets and can be changed using the min_prevalence argument.

prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
                                        input_annotations = annotations_df,
                                        input_metadata = metadata_df,
                                        input_taxonomy = taxonomy_df,
                                        min_prevalence = 0.5)
# or
prism_w <- makeDisMat(se = prism_mbx,
                      min_prevalence = 0.5)

Minimum module size

By default, cube root of the total number of prevalent features is used as the minimum module size (MMS) (argument: min_module_size) for module detection and generation. We expect this to work for most real world datasets. To determine if the modules are optimal for further analysis, Macarron evaluates several measures of success (MOS) as described above. In addition to evaluating MOS for modules generated using the default MMS, Macarron also evaluates MOS for MMS values that are larger (MMS+5, MMS+10) and smaller (MMS-5, MMS-10) than the default MMS. If you find that the MOS improve with larger or smaller MMS, you may change the default accordingly. For more details about module detection, please see WGCNA and dynamicTreeCut.

# See MOS of modules generated using default
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df)
prism_modules_mos <- prism_modules[[2]]
View(prism_modules_mos)

# Change MMS
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df,
                            min_module_size = 10)

Specifying fixed effects, random effects and reference

Macarron uses Maaslin2 for determining the q-value of differential abundance in a phenotype of interest. For default execution, the phenotype of interest must be a category in column 1 of the metadata dataframe e.g. IBD in diagnosis in the demo. This is also the column that is picked by the metadata_variable argument for identifying the main phenotypes/conditions in any dataset (see Macarron.log file). Further, in the default execution, all columns in the metadata table are considered as fixed effects and the alphabetically first categorical variable in each covariate with two categories is considered as the reference. Maaslin2 requires reference categories to be explicitly defined for all categorical metadata with more than two categories. Defaults can be changed with the arguments fixed_effects, random_effects and reference. In the demo example, fixed effects and reference can be defined as follows:

prism_qval <- calQval(se = prism_mbx,
                      mod.assn = prism_modules,
                      metadata_variable = "diagnosis",
                      fixed_effects = c("diagnosis","age","antibiotics"),
                      reference = c("diagnosis,Control";"antibiotics,No"))

Command line invocation

The package source contains a script MacarronCMD.R in inst/scripts to invoke Macarron in the command line using Rscript. The inst/scripts folder also contains a README file that comprehensively documents the usage of the script.