Macarron User Manual

Abstract

Macarron is a workflow to systematically annotate and prioritize potentially bioactive (and often unannotated) small molecules in microbial community metabolomic datasets. Macarron prioritizes metabolic features as potentially bioactive in a phenotype/condition of interest using a combination of (a) covariance with annotated metabolites, (b) ecological properties such as abundance with respect to covarying annotated compounds, and (c) differential abundance in the phenotype/condition of interest.

If you have questions, please direct it to: Macarron Forum

Installation

Macarron requires R version 4.2.0 or higher. Install Bioconductor and then install Macarron:

if(!requireNamespace("BiocManager", quietly = TRUE))
    install.packages("BiocManager")
BiocManager::install("Macarron")

Running Macarron

Macarron can be run from the command line or as an R function. Both methods require the same arguments, have the same options, and use the same default settings. The package includes the wrapper Macarron() as well as functions which perform different steps in the Macarron framework.

Input CSV files

Macarron requires 4 comma-separated, appropriately formatted input files. The files and their formatting constraints are described below.

  1. Metabolic features abundances
    • Must contain features in rows and samples in columns.
    • First column must identify features.
  2. Metabolic features annotations
    • Must contain features in rows and annotations in columns.
    • First column must identify features.
    • Second column must contain either HMDB ID or PubChem Compound Identifier (CID).
    • Third column must contain the name of the metabolite.
    • Fourth column must contain a continuous chemical property such as m/z or RT or shift/ppm.
    • Other annotations such as RT, m/z or other identifiers can be listed column 4 onward.
  3. Sample metadata
    • Must contain samples in rows and metadata in columns.
    • First column must identify samples.
    • Second column must contain categorical metadata relevant to prioritization such as phenotypes, exposures or environments.
  4. Chemical taxonomy
    • First column must contain the HMDB ID or PubChem CID. IDs must be consistent between annotation and taxonomy files.
    • Second and third columns must contain chemical subclass and class of the respective metabolite.

If you do not have the chemical taxonomy file, you can generate this file using the annotation dataframe and Macarron utility decorate_ID (see Advanced Topics).

Output Files

By default, all files will be stored in a folder named Macarron_output inside the current working directory. The main prioritization results are stored in prioritized_metabolites_all.csv. Another file, prioritized_metabolites_characterizable.csv is a subset of prioritized_metabolites_all.csv and only contains metabolic features which covary with at least one annotated metabolite. The columns in these output files are:

  • Feature_index: Lists the identifier of the metabolic feature found in column 1 of abundance and annotation files.
  • HMDB_ID (or PubChem ID): Public database identifier from column 2 of annotation file (column 1 of annotation dataframe).
  • Metabolite name: From column 2 of annotation dataframe.
  • mz: The continuous numerical chemical property from column 3 of the annotation dataframe.
  • Priority_score: 1 indicates most prioritized. It is the percentile from the meta-rank of AVA, q-value and effect size.
  • Status: Direction of perturbation (differential abundance) in the phenotype (or environment) of interest compared to reference phenotype.
  • Module: ID of the covariance module a metabolic feature is a member of. Module = 0 indicates a singleton i.e., a metabolic feature that is not assigned to any module.
  • Anchor (of a module): Metabolic feature that has the highest abundance in any phenotype.
  • Related_classes: Chemical taxonomy of the annotated features that covary with a metabolic feature.
  • Covaries_with_standard: 1 (yes) and 0 (no). Column specifies if the metabolic feature covaries with at least one annotated (standard) metabolite.
  • AVA: Abundance versus anchor which is a ratio of the highest abundance (in any phenotype) of a metabolic feature and highest abundance of the covarying anchor. Naturally, the AVA of an anchor metabolite is 1.
  • qvalue: Estimated from multivariate linear model using Maaslin2.
  • effect_size
  • Remaining columns from the annotation dataframe are appended.

Run a demo in R

Using CSV files as inputs

Example (demo) input files can be found under inst/extdata folder of the Macarron source. These files were generated from the PRISM study of stool metabolomes of individuals with inflammatory bowel disease (IBD) and healthy “Control” individuals. Control and IBD are the two phenotypes in this example. Macarron will be applied to prioritize metabolic features with respect to their bioactivity in IBD. Therefore, in this example, the phenotype of interest is “IBD” and the reference phenotype is “Control”. The four input files are demo_abundances.csv, demo_annotations.csv, demo_metadata.csv, and demo_taxonomy.csv.

library(Macarron)
## Loading required package: SummarizedExperiment
## Loading required package: MatrixGenerics
## Loading required package: matrixStats
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## Attaching package: 'MatrixGenerics'
## The following objects are masked from 'package:matrixStats':
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## Loading required package: GenomicRanges
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## Attaching package: 'S4Vectors'
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prism_abundances <- system.file(
    'extdata','demo_abundances.csv', package="Macarron")
prism_annotations <-system.file(
    'extdata','demo_annotations.csv', package="Macarron")
prism_metadata <-system.file(
    'extdata','demo_metadata.csv', package="Macarron")
mets_taxonomy <-system.file(
    'extdata','demo_taxonomy.csv', package="Macarron")
prism_prioritized <- Macarron::Macarron(input_abundances = prism_abundances,
                                        input_annotations = prism_annotations,
                                        input_metadata = prism_metadata,
                                        input_taxonomy = mets_taxonomy)
## 2025-03-29 06:51:16.983404 INFO::Creating output folder.
## 2025-03-29 06:51:16.990893 INFO::Writing function arguments to log file
## Samples with both abundances and metadata: 102
## 2025-03-29 06:51:17.397866 INFO::Summarized Experiment created.
## 2025-03-29 06:51:17.398857 INFO::Metadata chosen for prevalence filtering: diagnosis
## 869 features pass chosen minimum prevalence threshold of 0.7.
## Calculating pairwise correlations in phenotype: IBD
## 
## Calculating pairwise correlations in phenotype: Control
## Distance matrix with 869 features created.
## 2025-03-29 06:51:20.43359 INFO::Distance matrix with 869 metabolic features created.
## Initiating module detection
## 2025-03-29 06:51:20.434532 INFO::Minimum module size used for this dataset: 10
## Tree constructed
## Evaluating measures of success
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
## 2025-03-29 06:51:21.416885 INFO::Total number of modules detected: 30
## Initiating AVA calculations
## Finding anchors
## Calculating AVA
## Initiating q-value calculations
## [1] "Creating output folder"
## [1] "Creating output feature tables folder"
## [1] "Creating output fits folder"
## [1] "Creating output figures folder"
## 2025-03-29 06:51:22.743647 INFO::Writing function arguments to log file
## 2025-03-29 06:51:22.747532 INFO::Verifying options selected are valid
## 2025-03-29 06:51:22.773779 INFO::Determining format of input files
## 2025-03-29 06:51:22.774405 INFO::Input format is data samples as columns and metadata samples as rows
## 2025-03-29 06:51:22.787312 INFO::Formula for fixed effects: expr ~  diagnosis + age + antibiotics
## 2025-03-29 06:51:22.788289 INFO::Filter data based on min abundance and min prevalence
## 2025-03-29 06:51:22.788752 INFO::Total samples in data: 102
## 2025-03-29 06:51:22.789208 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000
## 2025-03-29 06:51:22.798015 INFO::Total filtered features: 0
## 2025-03-29 06:51:22.798565 INFO::Filtered feature names from abundance and prevalence filtering:
## 2025-03-29 06:51:22.821347 INFO::Total filtered features with variance filtering: 0
## 2025-03-29 06:51:22.821966 INFO::Filtered feature names from variance filtering:
## 2025-03-29 06:51:22.822399 INFO::Running selected normalization method: NONE
## 2025-03-29 06:51:22.822857 INFO::Applying z-score to standardize continuous metadata
## 2025-03-29 06:51:22.836697 INFO::Running selected transform method: NONE
## 2025-03-29 06:51:22.837557 INFO::Running selected analysis method: LM
## 2025-03-29 06:51:22.841025 INFO::Fitting model to feature number 1, F1
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## 2025-03-29 06:51:23.216907 INFO::Fitting model to feature number 159, F165
## 2025-03-29 06:51:23.219187 INFO::Fitting model to feature number 160, F166
## 2025-03-29 06:51:23.2214 INFO::Fitting model to feature number 161, F167
## 2025-03-29 06:51:23.223601 INFO::Fitting model to feature number 162, F168
## 2025-03-29 06:51:23.225774 INFO::Fitting model to feature number 163, F169
## 2025-03-29 06:51:23.227978 INFO::Fitting model to feature number 164, F170
## 2025-03-29 06:51:23.230148 INFO::Fitting model to feature number 165, F171
## 2025-03-29 06:51:23.232326 INFO::Fitting model to feature number 166, F172
## 2025-03-29 06:51:23.234521 INFO::Fitting model to feature number 167, F173
## 2025-03-29 06:51:23.236701 INFO::Fitting model to feature number 168, F174
## 2025-03-29 06:51:23.238919 INFO::Fitting model to feature number 169, F175
## 2025-03-29 06:51:23.241112 INFO::Fitting model to feature number 170, F176
## 2025-03-29 06:51:23.243322 INFO::Fitting model to feature number 171, F177
## 2025-03-29 06:51:23.245532 INFO::Fitting model to feature number 172, F178
## 2025-03-29 06:51:23.247741 INFO::Fitting model to feature number 173, F179
## 2025-03-29 06:51:23.249965 INFO::Fitting model to feature number 174, F180
## 2025-03-29 06:51:23.252197 INFO::Fitting model to feature number 175, F181
## 2025-03-29 06:51:23.254424 INFO::Fitting model to feature number 176, F182
## 2025-03-29 06:51:23.256613 INFO::Fitting model to feature number 177, F183
## 2025-03-29 06:51:23.258813 INFO::Fitting model to feature number 178, F184
## 2025-03-29 06:51:23.261014 INFO::Fitting model to feature number 179, F185
## 2025-03-29 06:51:23.263198 INFO::Fitting model to feature number 180, F186
## 2025-03-29 06:51:23.265403 INFO::Fitting model to feature number 181, F187
## 2025-03-29 06:51:23.267582 INFO::Fitting model to feature number 182, F188
## 2025-03-29 06:51:23.269815 INFO::Fitting model to feature number 183, F189
## 2025-03-29 06:51:23.272027 INFO::Fitting model to feature number 184, F190
## 2025-03-29 06:51:23.274238 INFO::Fitting model to feature number 185, F191
## 2025-03-29 06:51:23.276438 INFO::Fitting model to feature number 186, F192
## 2025-03-29 06:51:23.278633 INFO::Fitting model to feature number 187, F193
## 2025-03-29 06:51:23.280808 INFO::Fitting model to feature number 188, F194
## 2025-03-29 06:51:23.283039 INFO::Fitting model to feature number 189, F195
## 2025-03-29 06:51:23.285275 INFO::Fitting model to feature number 190, F196
## 2025-03-29 06:51:23.287476 INFO::Fitting model to feature number 191, F197
## 2025-03-29 06:51:23.289689 INFO::Fitting model to feature number 192, F198
## 2025-03-29 06:51:23.291899 INFO::Fitting model to feature number 193, F199
## 2025-03-29 06:51:23.294115 INFO::Fitting model to feature number 194, F200
## 2025-03-29 06:51:23.296323 INFO::Fitting model to feature number 195, F201
## 2025-03-29 06:51:23.298551 INFO::Fitting model to feature number 196, F202
## 2025-03-29 06:51:23.300781 INFO::Fitting model to feature number 197, F203
## 2025-03-29 06:51:23.303031 INFO::Fitting model to feature number 198, F204
## 2025-03-29 06:51:23.305244 INFO::Fitting model to feature number 199, F206
## 2025-03-29 06:51:23.307421 INFO::Fitting model to feature number 200, F207
## 2025-03-29 06:51:23.3096 INFO::Fitting model to feature number 201, F208
## 2025-03-29 06:51:23.311786 INFO::Fitting model to feature number 202, F209
## 2025-03-29 06:51:23.314008 INFO::Fitting model to feature number 203, F210
## 2025-03-29 06:51:23.316209 INFO::Fitting model to feature number 204, F211
## 2025-03-29 06:51:23.318458 INFO::Fitting model to feature number 205, F212
## 2025-03-29 06:51:23.320641 INFO::Fitting model to feature number 206, F213
## 2025-03-29 06:51:23.322826 INFO::Fitting model to feature number 207, F214
## 2025-03-29 06:51:23.325027 INFO::Fitting model to feature number 208, F215
## 2025-03-29 06:51:23.327205 INFO::Fitting model to feature number 209, F216
## 2025-03-29 06:51:23.329387 INFO::Fitting model to feature number 210, F217
## 2025-03-29 06:51:23.331571 INFO::Fitting model to feature number 211, F218
## 2025-03-29 06:51:23.333747 INFO::Fitting model to feature number 212, F219
## 2025-03-29 06:51:23.335945 INFO::Fitting model to feature number 213, F220
## 2025-03-29 06:51:23.338144 INFO::Fitting model to feature number 214, F221
## 2025-03-29 06:51:23.340317 INFO::Fitting model to feature number 215, F222
## 2025-03-29 06:51:23.342505 INFO::Fitting model to feature number 216, F223
## 2025-03-29 06:51:23.344701 INFO::Fitting model to feature number 217, F224
## 2025-03-29 06:51:23.346912 INFO::Fitting model to feature number 218, F225
## 2025-03-29 06:51:23.349098 INFO::Fitting model to feature number 219, F226
## 2025-03-29 06:51:23.351331 INFO::Fitting model to feature number 220, F227
## 2025-03-29 06:51:23.353567 INFO::Fitting model to feature number 221, F228
## 2025-03-29 06:51:23.355744 INFO::Fitting model to feature number 222, F229
## 2025-03-29 06:51:23.357974 INFO::Fitting model to feature number 223, F230
## 2025-03-29 06:51:23.360178 INFO::Fitting model to feature number 224, F231
## 2025-03-29 06:51:23.362376 INFO::Fitting model to feature number 225, F232
## 2025-03-29 06:51:23.364575 INFO::Fitting model to feature number 226, F233
## 2025-03-29 06:51:23.366758 INFO::Fitting model to feature number 227, F234
## 2025-03-29 06:51:23.368989 INFO::Fitting model to feature number 228, F235
## 2025-03-29 06:51:23.37118 INFO::Fitting model to feature number 229, F236
## 2025-03-29 06:51:23.373364 INFO::Fitting model to feature number 230, F237
## 2025-03-29 06:51:23.375572 INFO::Fitting model to feature number 231, F238
## 2025-03-29 06:51:23.377768 INFO::Fitting model to feature number 232, F239
## 2025-03-29 06:51:23.379981 INFO::Fitting model to feature number 233, F240
## 2025-03-29 06:51:23.382166 INFO::Fitting model to feature number 234, F241
## 2025-03-29 06:51:23.384376 INFO::Fitting model to feature number 235, F242
## 2025-03-29 06:51:23.386572 INFO::Fitting model to feature number 236, F243
## 2025-03-29 06:51:23.388749 INFO::Fitting model to feature number 237, F244
## 2025-03-29 06:51:23.390943 INFO::Fitting model to feature number 238, F245
## 2025-03-29 06:51:23.393128 INFO::Fitting model to feature number 239, F246
## 2025-03-29 06:51:23.395305 INFO::Fitting model to feature number 240, F247
## 2025-03-29 06:51:23.397527 INFO::Fitting model to feature number 241, F248
## 2025-03-29 06:51:23.399712 INFO::Fitting model to feature number 242, F249
## 2025-03-29 06:51:23.401917 INFO::Fitting model to feature number 243, F250
## 2025-03-29 06:51:23.404115 INFO::Fitting model to feature number 244, F252
## 2025-03-29 06:51:23.406315 INFO::Fitting model to feature number 245, F253
## 2025-03-29 06:51:23.40852 INFO::Fitting model to feature number 246, F254
## 2025-03-29 06:51:23.410704 INFO::Fitting model to feature number 247, F255
## 2025-03-29 06:51:23.4129 INFO::Fitting model to feature number 248, F256
## 2025-03-29 06:51:23.415094 INFO::Fitting model to feature number 249, F257
## 2025-03-29 06:51:23.417326 INFO::Fitting model to feature number 250, F259
## 2025-03-29 06:51:23.41951 INFO::Fitting model to feature number 251, F260
## 2025-03-29 06:51:23.4217 INFO::Fitting model to feature number 252, F261
## 2025-03-29 06:51:23.423915 INFO::Fitting model to feature number 253, F262
## 2025-03-29 06:51:23.426139 INFO::Fitting model to feature number 254, F263
## 2025-03-29 06:51:23.428345 INFO::Fitting model to feature number 255, F264
## 2025-03-29 06:51:23.43052 INFO::Fitting model to feature number 256, F265
## 2025-03-29 06:51:23.432717 INFO::Fitting model to feature number 257, F266
## 2025-03-29 06:51:23.434922 INFO::Fitting model to feature number 258, F267
## 2025-03-29 06:51:23.437093 INFO::Fitting model to feature number 259, F269
## 2025-03-29 06:51:23.439275 INFO::Fitting model to feature number 260, F270
## 2025-03-29 06:51:23.441454 INFO::Fitting model to feature number 261, F271
## 2025-03-29 06:51:23.443625 INFO::Fitting model to feature number 262, F272
## 2025-03-29 06:51:23.44582 INFO::Fitting model to feature number 263, F273
## 2025-03-29 06:51:23.448033 INFO::Fitting model to feature number 264, F274
## 2025-03-29 06:51:23.450264 INFO::Fitting model to feature number 265, F276
## 2025-03-29 06:51:23.452486 INFO::Fitting model to feature number 266, F277
## 2025-03-29 06:51:23.454758 INFO::Fitting model to feature number 267, F278
## 2025-03-29 06:51:23.456988 INFO::Fitting model to feature number 268, F279
## 2025-03-29 06:51:23.459251 INFO::Fitting model to feature number 269, F280
## 2025-03-29 06:51:23.46147 INFO::Fitting model to feature number 270, F281
## 2025-03-29 06:51:23.463673 INFO::Fitting model to feature number 271, F282
## 2025-03-29 06:51:23.465898 INFO::Fitting model to feature number 272, F283
## 2025-03-29 06:51:23.468096 INFO::Fitting model to feature number 273, F284
## 2025-03-29 06:51:23.470315 INFO::Fitting model to feature number 274, F285
## 2025-03-29 06:51:23.472533 INFO::Fitting model to feature number 275, F286
## 2025-03-29 06:51:23.474778 INFO::Fitting model to feature number 276, F287
## 2025-03-29 06:51:23.477004 INFO::Fitting model to feature number 277, F288
## 2025-03-29 06:51:23.479217 INFO::Fitting model to feature number 278, F289
## 2025-03-29 06:51:23.481433 INFO::Fitting model to feature number 279, F290
## 2025-03-29 06:51:23.483714 INFO::Fitting model to feature number 280, F292
## 2025-03-29 06:51:23.486015 INFO::Fitting model to feature number 281, F293
## 2025-03-29 06:51:23.48827 INFO::Fitting model to feature number 282, F294
## 2025-03-29 06:51:23.490512 INFO::Fitting model to feature number 283, F295
## 2025-03-29 06:51:23.492719 INFO::Fitting model to feature number 284, F296
## 2025-03-29 06:51:23.494939 INFO::Fitting model to feature number 285, F297
## 2025-03-29 06:51:23.497169 INFO::Fitting model to feature number 286, F298
## 2025-03-29 06:51:23.499372 INFO::Fitting model to feature number 287, F299
## 2025-03-29 06:51:23.501601 INFO::Fitting model to feature number 288, F300
## 2025-03-29 06:51:23.503913 INFO::Fitting model to feature number 289, F301
## 2025-03-29 06:51:23.506149 INFO::Fitting model to feature number 290, F302
## 2025-03-29 06:51:23.508361 INFO::Fitting model to feature number 291, F303
## 2025-03-29 06:51:23.510567 INFO::Fitting model to feature number 292, F304
## 2025-03-29 06:51:23.512806 INFO::Fitting model to feature number 293, F305
## 2025-03-29 06:51:23.515083 INFO::Fitting model to feature number 294, F306
## 2025-03-29 06:51:23.51736 INFO::Fitting model to feature number 295, F307
## 2025-03-29 06:51:23.519637 INFO::Fitting model to feature number 296, F308
## 2025-03-29 06:51:23.521842 INFO::Fitting model to feature number 297, F309
## 2025-03-29 06:51:23.524073 INFO::Fitting model to feature number 298, F310
## 2025-03-29 06:51:23.526274 INFO::Fitting model to feature number 299, F311
## 2025-03-29 06:51:23.528473 INFO::Fitting model to feature number 300, F312
## 2025-03-29 06:51:23.530674 INFO::Fitting model to feature number 301, F313
## 2025-03-29 06:51:23.53294 INFO::Fitting model to feature number 302, F315
## 2025-03-29 06:51:23.535156 INFO::Fitting model to feature number 303, F316
## 2025-03-29 06:51:23.537372 INFO::Fitting model to feature number 304, F317
## 2025-03-29 06:51:23.539588 INFO::Fitting model to feature number 305, F318
## 2025-03-29 06:51:23.541807 INFO::Fitting model to feature number 306, F319
## 2025-03-29 06:51:23.544034 INFO::Fitting model to feature number 307, F320
## 2025-03-29 06:51:23.54623 INFO::Fitting model to feature number 308, F321
## 2025-03-29 06:51:23.548447 INFO::Fitting model to feature number 309, F322
## 2025-03-29 06:51:23.550662 INFO::Fitting model to feature number 310, F323
## 2025-03-29 06:51:23.552899 INFO::Fitting model to feature number 311, F324
## 2025-03-29 06:51:23.555101 INFO::Fitting model to feature number 312, F325
## 2025-03-29 06:51:23.557321 INFO::Fitting model to feature number 313, F326
## 2025-03-29 06:51:23.559534 INFO::Fitting model to feature number 314, F327
## 2025-03-29 06:51:23.561734 INFO::Fitting model to feature number 315, F328
## 2025-03-29 06:51:23.563976 INFO::Fitting model to feature number 316, F329
## 2025-03-29 06:51:23.566164 INFO::Fitting model to feature number 317, F330
## 2025-03-29 06:51:23.568373 INFO::Fitting model to feature number 318, F331
## 2025-03-29 06:51:23.570562 INFO::Fitting model to feature number 319, F332
## 2025-03-29 06:51:23.572754 INFO::Fitting model to feature number 320, F333
## 2025-03-29 06:51:23.574997 INFO::Fitting model to feature number 321, F334
## 2025-03-29 06:51:23.577193 INFO::Fitting model to feature number 322, F335
## 2025-03-29 06:51:23.579404 INFO::Fitting model to feature number 323, F336
## 2025-03-29 06:51:23.581597 INFO::Fitting model to feature number 324, F337
## 2025-03-29 06:51:23.583816 INFO::Fitting model to feature number 325, F338
## 2025-03-29 06:51:23.586062 INFO::Fitting model to feature number 326, F339
## 2025-03-29 06:51:23.588283 INFO::Fitting model to feature number 327, F340
## 2025-03-29 06:51:23.590491 INFO::Fitting model to feature number 328, F342
## 2025-03-29 06:51:23.592748 INFO::Fitting model to feature number 329, F343
## 2025-03-29 06:51:23.594978 INFO::Fitting model to feature number 330, F344
## 2025-03-29 06:51:23.597175 INFO::Fitting model to feature number 331, F345
## 2025-03-29 06:51:23.599382 INFO::Fitting model to feature number 332, F346
## 2025-03-29 06:51:23.601584 INFO::Fitting model to feature number 333, F347
## 2025-03-29 06:51:23.603809 INFO::Fitting model to feature number 334, F348
## 2025-03-29 06:51:23.606038 INFO::Fitting model to feature number 335, F350
## 2025-03-29 06:51:23.608237 INFO::Fitting model to feature number 336, F351
## 2025-03-29 06:51:23.610454 INFO::Fitting model to feature number 337, F352
## 2025-03-29 06:51:23.612652 INFO::Fitting model to feature number 338, F353
## 2025-03-29 06:51:23.614933 INFO::Fitting model to feature number 339, F355
## 2025-03-29 06:51:23.617137 INFO::Fitting model to feature number 340, F356
## 2025-03-29 06:51:23.619337 INFO::Fitting model to feature number 341, F357
## 2025-03-29 06:51:23.621531 INFO::Fitting model to feature number 342, F358
## 2025-03-29 06:51:23.623771 INFO::Fitting model to feature number 343, F359
## 2025-03-29 06:51:23.626016 INFO::Fitting model to feature number 344, F360
## 2025-03-29 06:51:23.628224 INFO::Fitting model to feature number 345, F361
## 2025-03-29 06:51:23.63045 INFO::Fitting model to feature number 346, F362
## 2025-03-29 06:51:23.632655 INFO::Fitting model to feature number 347, F363
## 2025-03-29 06:51:23.634843 INFO::Fitting model to feature number 348, F364
## 2025-03-29 06:51:23.637064 INFO::Fitting model to feature number 349, F365
## 2025-03-29 06:51:23.639277 INFO::Fitting model to feature number 350, F366
## 2025-03-29 06:51:23.641496 INFO::Fitting model to feature number 351, F367
## 2025-03-29 06:51:23.643698 INFO::Fitting model to feature number 352, F368
## 2025-03-29 06:51:23.645922 INFO::Fitting model to feature number 353, F369
## 2025-03-29 06:51:23.648148 INFO::Fitting model to feature number 354, F370
## 2025-03-29 06:51:23.650352 INFO::Fitting model to feature number 355, F371
## 2025-03-29 06:51:23.652568 INFO::Fitting model to feature number 356, F372
## 2025-03-29 06:51:23.654819 INFO::Fitting model to feature number 357, F373
## 2025-03-29 06:51:23.657048 INFO::Fitting model to feature number 358, F374
## 2025-03-29 06:51:23.659235 INFO::Fitting model to feature number 359, F375
## 2025-03-29 06:51:23.66144 INFO::Fitting model to feature number 360, F376
## 2025-03-29 06:51:23.663645 INFO::Fitting model to feature number 361, F377
## 2025-03-29 06:51:23.665849 INFO::Fitting model to feature number 362, F378
## 2025-03-29 06:51:23.668076 INFO::Fitting model to feature number 363, F379
## 2025-03-29 06:51:23.670272 INFO::Fitting model to feature number 364, F380
## 2025-03-29 06:51:23.672481 INFO::Fitting model to feature number 365, F381
## 2025-03-29 06:51:23.674684 INFO::Fitting model to feature number 366, F382
## 2025-03-29 06:51:23.67689 INFO::Fitting model to feature number 367, F383
## 2025-03-29 06:51:23.679104 INFO::Fitting model to feature number 368, F384
## 2025-03-29 06:51:23.681308 INFO::Fitting model to feature number 369, F386
## 2025-03-29 06:51:23.683516 INFO::Fitting model to feature number 370, F387
## 2025-03-29 06:51:23.685719 INFO::Fitting model to feature number 371, F388
## 2025-03-29 06:51:23.687977 INFO::Fitting model to feature number 372, F389
## 2025-03-29 06:51:23.69018 INFO::Fitting model to feature number 373, F390
## 2025-03-29 06:51:23.704025 INFO::Fitting model to feature number 374, F391
## 2025-03-29 06:51:23.706579 INFO::Fitting model to feature number 375, F392
## 2025-03-29 06:51:23.708786 INFO::Fitting model to feature number 376, F393
## 2025-03-29 06:51:23.71101 INFO::Fitting model to feature number 377, F394
## 2025-03-29 06:51:23.713208 INFO::Fitting model to feature number 378, F395
## 2025-03-29 06:51:23.715433 INFO::Fitting model to feature number 379, F396
## 2025-03-29 06:51:23.71766 INFO::Fitting model to feature number 380, F397
## 2025-03-29 06:51:23.719944 INFO::Fitting model to feature number 381, F398
## 2025-03-29 06:51:23.722142 INFO::Fitting model to feature number 382, F399
## 2025-03-29 06:51:23.724334 INFO::Fitting model to feature number 383, F400
## 2025-03-29 06:51:23.726512 INFO::Fitting model to feature number 384, F401
## 2025-03-29 06:51:23.72869 INFO::Fitting model to feature number 385, F402
## 2025-03-29 06:51:23.730883 INFO::Fitting model to feature number 386, F403
## 2025-03-29 06:51:23.733074 INFO::Fitting model to feature number 387, F404
## 2025-03-29 06:51:23.735289 INFO::Fitting model to feature number 388, F406
## 2025-03-29 06:51:23.737471 INFO::Fitting model to feature number 389, F407
## 2025-03-29 06:51:23.739653 INFO::Fitting model to feature number 390, F408
## 2025-03-29 06:51:23.741851 INFO::Fitting model to feature number 391, F409
## 2025-03-29 06:51:23.744062 INFO::Fitting model to feature number 392, F410
## 2025-03-29 06:51:23.746241 INFO::Fitting model to feature number 393, F411
## 2025-03-29 06:51:23.748422 INFO::Fitting model to feature number 394, F412
## 2025-03-29 06:51:23.750622 INFO::Fitting model to feature number 395, F413
## 2025-03-29 06:51:23.752813 INFO::Fitting model to feature number 396, F414
## 2025-03-29 06:51:23.755015 INFO::Fitting model to feature number 397, F415
## 2025-03-29 06:51:23.757208 INFO::Fitting model to feature number 398, F416
## 2025-03-29 06:51:23.759377 INFO::Fitting model to feature number 399, F417
## 2025-03-29 06:51:23.761552 INFO::Fitting model to feature number 400, F418
## 2025-03-29 06:51:23.763734 INFO::Fitting model to feature number 401, F419
## 2025-03-29 06:51:23.765968 INFO::Fitting model to feature number 402, F420
## 2025-03-29 06:51:23.768166 INFO::Fitting model to feature number 403, F421
## 2025-03-29 06:51:23.770353 INFO::Fitting model to feature number 404, F422
## 2025-03-29 06:51:23.772536 INFO::Fitting model to feature number 405, F423
## 2025-03-29 06:51:23.774759 INFO::Fitting model to feature number 406, F425
## 2025-03-29 06:51:23.776969 INFO::Fitting model to feature number 407, F426
## 2025-03-29 06:51:23.779159 INFO::Fitting model to feature number 408, F428
## 2025-03-29 06:51:23.781398 INFO::Fitting model to feature number 409, F429
## 2025-03-29 06:51:23.783599 INFO::Fitting model to feature number 410, F430
## 2025-03-29 06:51:23.785788 INFO::Fitting model to feature number 411, F431
## 2025-03-29 06:51:23.788015 INFO::Fitting model to feature number 412, F432
## 2025-03-29 06:51:23.790213 INFO::Fitting model to feature number 413, F433
## 2025-03-29 06:51:23.792407 INFO::Fitting model to feature number 414, F434
## 2025-03-29 06:51:23.794593 INFO::Fitting model to feature number 415, F435
## 2025-03-29 06:51:23.796794 INFO::Fitting model to feature number 416, F436
## 2025-03-29 06:51:23.799016 INFO::Fitting model to feature number 417, F437
## 2025-03-29 06:51:23.801209 INFO::Fitting model to feature number 418, F438
## 2025-03-29 06:51:23.803423 INFO::Fitting model to feature number 419, F439
## 2025-03-29 06:51:23.805617 INFO::Fitting model to feature number 420, F440
## 2025-03-29 06:51:23.807806 INFO::Fitting model to feature number 421, F441
## 2025-03-29 06:51:23.809999 INFO::Fitting model to feature number 422, F442
## 2025-03-29 06:51:23.812208 INFO::Fitting model to feature number 423, F443
## 2025-03-29 06:51:23.814444 INFO::Fitting model to feature number 424, F444
## 2025-03-29 06:51:23.816633 INFO::Fitting model to feature number 425, F445
## 2025-03-29 06:51:23.818935 INFO::Fitting model to feature number 426, F446
## 2025-03-29 06:51:23.821156 INFO::Fitting model to feature number 427, F447
## 2025-03-29 06:51:23.823346 INFO::Fitting model to feature number 428, F448
## 2025-03-29 06:51:23.825553 INFO::Fitting model to feature number 429, F449
## 2025-03-29 06:51:23.827784 INFO::Fitting model to feature number 430, F450
## 2025-03-29 06:51:23.830005 INFO::Fitting model to feature number 431, F451
## 2025-03-29 06:51:23.832207 INFO::Fitting model to feature number 432, F452
## 2025-03-29 06:51:23.834421 INFO::Fitting model to feature number 433, F454
## 2025-03-29 06:51:23.836632 INFO::Fitting model to feature number 434, F455
## 2025-03-29 06:51:23.83882 INFO::Fitting model to feature number 435, F456
## 2025-03-29 06:51:23.841039 INFO::Fitting model to feature number 436, F457
## 2025-03-29 06:51:23.84323 INFO::Fitting model to feature number 437, F458
## 2025-03-29 06:51:23.845447 INFO::Fitting model to feature number 438, F459
## 2025-03-29 06:51:23.847639 INFO::Fitting model to feature number 439, F461
## 2025-03-29 06:51:23.849831 INFO::Fitting model to feature number 440, F462
## 2025-03-29 06:51:23.852066 INFO::Fitting model to feature number 441, F463
## 2025-03-29 06:51:23.854264 INFO::Fitting model to feature number 442, F464
## 2025-03-29 06:51:23.856449 INFO::Fitting model to feature number 443, F465
## 2025-03-29 06:51:23.858627 INFO::Fitting model to feature number 444, F466
## 2025-03-29 06:51:23.860818 INFO::Fitting model to feature number 445, F467
## 2025-03-29 06:51:23.863013 INFO::Fitting model to feature number 446, F468
## 2025-03-29 06:51:23.865203 INFO::Fitting model to feature number 447, F469
## 2025-03-29 06:51:23.867391 INFO::Fitting model to feature number 448, F470
## 2025-03-29 06:51:23.869588 INFO::Fitting model to feature number 449, F471
## 2025-03-29 06:51:23.871786 INFO::Fitting model to feature number 450, F474
## 2025-03-29 06:51:23.873994 INFO::Fitting model to feature number 451, F475
## 2025-03-29 06:51:23.876216 INFO::Fitting model to feature number 452, F476
## 2025-03-29 06:51:23.878413 INFO::Fitting model to feature number 453, F477
## 2025-03-29 06:51:23.88061 INFO::Fitting model to feature number 454, F478
## 2025-03-29 06:51:23.882812 INFO::Fitting model to feature number 455, F479
## 2025-03-29 06:51:23.885041 INFO::Fitting model to feature number 456, F480
## 2025-03-29 06:51:23.887226 INFO::Fitting model to feature number 457, F481
## 2025-03-29 06:51:23.88944 INFO::Fitting model to feature number 458, F482
## 2025-03-29 06:51:23.891644 INFO::Fitting model to feature number 459, F483
## 2025-03-29 06:51:23.893866 INFO::Fitting model to feature number 460, F484
## 2025-03-29 06:51:23.89608 INFO::Fitting model to feature number 461, F485
## 2025-03-29 06:51:23.898273 INFO::Fitting model to feature number 462, F486
## 2025-03-29 06:51:23.900476 INFO::Fitting model to feature number 463, F487
## 2025-03-29 06:51:23.902651 INFO::Fitting model to feature number 464, F488
## 2025-03-29 06:51:23.904868 INFO::Fitting model to feature number 465, F489
## 2025-03-29 06:51:23.907098 INFO::Fitting model to feature number 466, F490
## 2025-03-29 06:51:23.909271 INFO::Fitting model to feature number 467, F491
## 2025-03-29 06:51:23.911453 INFO::Fitting model to feature number 468, F492
## 2025-03-29 06:51:23.913644 INFO::Fitting model to feature number 469, F493
## 2025-03-29 06:51:23.915832 INFO::Fitting model to feature number 470, F494
## 2025-03-29 06:51:23.918045 INFO::Fitting model to feature number 471, F495
## 2025-03-29 06:51:23.920238 INFO::Fitting model to feature number 472, F496
## 2025-03-29 06:51:23.922455 INFO::Fitting model to feature number 473, F497
## 2025-03-29 06:51:23.924645 INFO::Fitting model to feature number 474, F498
## 2025-03-29 06:51:23.926839 INFO::Fitting model to feature number 475, F499
## 2025-03-29 06:51:23.92907 INFO::Fitting model to feature number 476, F500
## 2025-03-29 06:51:23.931241 INFO::Fitting model to feature number 477, F501
## 2025-03-29 06:51:23.933429 INFO::Fitting model to feature number 478, F502
## 2025-03-29 06:51:23.935606 INFO::Fitting model to feature number 479, F503
## 2025-03-29 06:51:23.937808 INFO::Fitting model to feature number 480, F504
## 2025-03-29 06:51:23.940018 INFO::Fitting model to feature number 481, F505
## 2025-03-29 06:51:23.94222 INFO::Fitting model to feature number 482, F506
## 2025-03-29 06:51:23.94443 INFO::Fitting model to feature number 483, F507
## 2025-03-29 06:51:23.946673 INFO::Fitting model to feature number 484, F508
## 2025-03-29 06:51:23.948866 INFO::Fitting model to feature number 485, F509
## 2025-03-29 06:51:23.951103 INFO::Fitting model to feature number 486, F510
## 2025-03-29 06:51:23.953316 INFO::Fitting model to feature number 487, F511
## 2025-03-29 06:51:23.955517 INFO::Fitting model to feature number 488, F512
## 2025-03-29 06:51:23.957707 INFO::Fitting model to feature number 489, F513
## 2025-03-29 06:51:23.95991 INFO::Fitting model to feature number 490, F514
## 2025-03-29 06:51:23.962125 INFO::Fitting model to feature number 491, F515
## 2025-03-29 06:51:23.964343 INFO::Fitting model to feature number 492, F516
## 2025-03-29 06:51:23.966526 INFO::Fitting model to feature number 493, F517
## 2025-03-29 06:51:23.968729 INFO::Fitting model to feature number 494, F518
## 2025-03-29 06:51:23.970948 INFO::Fitting model to feature number 495, F519
## 2025-03-29 06:51:23.973123 INFO::Fitting model to feature number 496, F520
## 2025-03-29 06:51:23.975306 INFO::Fitting model to feature number 497, F521
## 2025-03-29 06:51:23.977502 INFO::Fitting model to feature number 498, F522
## 2025-03-29 06:51:23.979687 INFO::Fitting model to feature number 499, F523
## 2025-03-29 06:51:23.981888 INFO::Fitting model to feature number 500, F524
## 2025-03-29 06:51:23.984179 INFO::Fitting model to feature number 501, F525
## 2025-03-29 06:51:23.986487 INFO::Fitting model to feature number 502, F526
## 2025-03-29 06:51:23.988787 INFO::Fitting model to feature number 503, F527
## 2025-03-29 06:51:23.991572 INFO::Fitting model to feature number 504, F528
## 2025-03-29 06:51:23.994012 INFO::Fitting model to feature number 505, F529
## 2025-03-29 06:51:23.996301 INFO::Fitting model to feature number 506, F530
## 2025-03-29 06:51:23.998561 INFO::Fitting model to feature number 507, F531
## 2025-03-29 06:51:24.000772 INFO::Fitting model to feature number 508, F532
## 2025-03-29 06:51:24.003039 INFO::Fitting model to feature number 509, F533
## 2025-03-29 06:51:24.005279 INFO::Fitting model to feature number 510, F534
## 2025-03-29 06:51:24.007504 INFO::Fitting model to feature number 511, F535
## 2025-03-29 06:51:24.009717 INFO::Fitting model to feature number 512, F536
## 2025-03-29 06:51:24.011952 INFO::Fitting model to feature number 513, F537
## 2025-03-29 06:51:24.014328 INFO::Fitting model to feature number 514, F539
## 2025-03-29 06:51:24.016605 INFO::Fitting model to feature number 515, F540
## 2025-03-29 06:51:24.018856 INFO::Fitting model to feature number 516, F541
## 2025-03-29 06:51:24.021101 INFO::Fitting model to feature number 517, F543
## 2025-03-29 06:51:24.023351 INFO::Fitting model to feature number 518, F544
## 2025-03-29 06:51:24.025599 INFO::Fitting model to feature number 519, F545
## 2025-03-29 06:51:24.027796 INFO::Fitting model to feature number 520, F546
## 2025-03-29 06:51:24.030033 INFO::Fitting model to feature number 521, F547
## 2025-03-29 06:51:24.032227 INFO::Fitting model to feature number 522, F548
## 2025-03-29 06:51:24.034456 INFO::Fitting model to feature number 523, F549
## 2025-03-29 06:51:24.036669 INFO::Fitting model to feature number 524, F550
## 2025-03-29 06:51:24.038897 INFO::Fitting model to feature number 525, F551
## 2025-03-29 06:51:24.041161 INFO::Fitting model to feature number 526, F552
## 2025-03-29 06:51:24.043391 INFO::Fitting model to feature number 527, F553
## 2025-03-29 06:51:24.045608 INFO::Fitting model to feature number 528, F554
## 2025-03-29 06:51:24.047833 INFO::Fitting model to feature number 529, F555
## 2025-03-29 06:51:24.050087 INFO::Fitting model to feature number 530, F556
## 2025-03-29 06:51:24.052341 INFO::Fitting model to feature number 531, F557
## 2025-03-29 06:51:24.054579 INFO::Fitting model to feature number 532, F558
## 2025-03-29 06:51:24.056884 INFO::Fitting model to feature number 533, F559
## 2025-03-29 06:51:24.059113 INFO::Fitting model to feature number 534, F560
## 2025-03-29 06:51:24.061345 INFO::Fitting model to feature number 535, F561
## 2025-03-29 06:51:24.063578 INFO::Fitting model to feature number 536, F562
## 2025-03-29 06:51:24.065807 INFO::Fitting model to feature number 537, F563
## 2025-03-29 06:51:24.068084 INFO::Fitting model to feature number 538, F564
## 2025-03-29 06:51:24.070311 INFO::Fitting model to feature number 539, F566
## 2025-03-29 06:51:24.072549 INFO::Fitting model to feature number 540, F567
## 2025-03-29 06:51:24.074773 INFO::Fitting model to feature number 541, F568
## 2025-03-29 06:51:24.077045 INFO::Fitting model to feature number 542, F569
## 2025-03-29 06:51:24.079291 INFO::Fitting model to feature number 543, F570
## 2025-03-29 06:51:24.081526 INFO::Fitting model to feature number 544, F571
## 2025-03-29 06:51:24.083758 INFO::Fitting model to feature number 545, F572
## 2025-03-29 06:51:24.086043 INFO::Fitting model to feature number 546, F573
## 2025-03-29 06:51:24.088259 INFO::Fitting model to feature number 547, F574
## 2025-03-29 06:51:24.090473 INFO::Fitting model to feature number 548, F575
## 2025-03-29 06:51:24.0927 INFO::Fitting model to feature number 549, F576
## 2025-03-29 06:51:24.094935 INFO::Fitting model to feature number 550, F577
## 2025-03-29 06:51:24.097143 INFO::Fitting model to feature number 551, F578
## 2025-03-29 06:51:24.099353 INFO::Fitting model to feature number 552, F579
## 2025-03-29 06:51:24.101563 INFO::Fitting model to feature number 553, F580
## 2025-03-29 06:51:24.103782 INFO::Fitting model to feature number 554, F581
## 2025-03-29 06:51:24.106005 INFO::Fitting model to feature number 555, F582
## 2025-03-29 06:51:24.108226 INFO::Fitting model to feature number 556, F583
## 2025-03-29 06:51:24.110431 INFO::Fitting model to feature number 557, F584
## 2025-03-29 06:51:24.112644 INFO::Fitting model to feature number 558, F585
## 2025-03-29 06:51:24.114863 INFO::Fitting model to feature number 559, F586
## 2025-03-29 06:51:24.117095 INFO::Fitting model to feature number 560, F587
## 2025-03-29 06:51:24.119293 INFO::Fitting model to feature number 561, F588
## 2025-03-29 06:51:24.121484 INFO::Fitting model to feature number 562, F589
## 2025-03-29 06:51:24.123731 INFO::Fitting model to feature number 563, F590
## 2025-03-29 06:51:24.125992 INFO::Fitting model to feature number 564, F591
## 2025-03-29 06:51:24.128199 INFO::Fitting model to feature number 565, F592
## 2025-03-29 06:51:24.130425 INFO::Fitting model to feature number 566, F593
## 2025-03-29 06:51:24.132656 INFO::Fitting model to feature number 567, F594
## 2025-03-29 06:51:24.134887 INFO::Fitting model to feature number 568, F595
## 2025-03-29 06:51:24.137094 INFO::Fitting model to feature number 569, F596
## 2025-03-29 06:51:24.139301 INFO::Fitting model to feature number 570, F597
## 2025-03-29 06:51:24.14154 INFO::Fitting model to feature number 571, F598
## 2025-03-29 06:51:24.143779 INFO::Fitting model to feature number 572, F599
## 2025-03-29 06:51:24.14603 INFO::Fitting model to feature number 573, F600
## 2025-03-29 06:51:24.148249 INFO::Fitting model to feature number 574, F601
## 2025-03-29 06:51:24.15046 INFO::Fitting model to feature number 575, F602
## 2025-03-29 06:51:24.152794 INFO::Fitting model to feature number 576, F603
## 2025-03-29 06:51:24.155078 INFO::Fitting model to feature number 577, F605
## 2025-03-29 06:51:24.157287 INFO::Fitting model to feature number 578, F606
## 2025-03-29 06:51:24.159504 INFO::Fitting model to feature number 579, F607
## 2025-03-29 06:51:24.161734 INFO::Fitting model to feature number 580, F608
## 2025-03-29 06:51:24.163984 INFO::Fitting model to feature number 581, F609
## 2025-03-29 06:51:24.166197 INFO::Fitting model to feature number 582, F610
## 2025-03-29 06:51:24.168422 INFO::Fitting model to feature number 583, F611
## 2025-03-29 06:51:24.17066 INFO::Fitting model to feature number 584, F612
## 2025-03-29 06:51:24.172886 INFO::Fitting model to feature number 585, F613
## 2025-03-29 06:51:24.175114 INFO::Fitting model to feature number 586, F614
## 2025-03-29 06:51:24.177313 INFO::Fitting model to feature number 587, F615
## 2025-03-29 06:51:24.179546 INFO::Fitting model to feature number 588, F616
## 2025-03-29 06:51:24.181787 INFO::Fitting model to feature number 589, F617
## 2025-03-29 06:51:24.18403 INFO::Fitting model to feature number 590, F618
## 2025-03-29 06:51:24.186262 INFO::Fitting model to feature number 591, F619
## 2025-03-29 06:51:24.18848 INFO::Fitting model to feature number 592, F620
## 2025-03-29 06:51:24.190782 INFO::Fitting model to feature number 593, F621
## 2025-03-29 06:51:24.193022 INFO::Fitting model to feature number 594, F622
## 2025-03-29 06:51:24.19525 INFO::Fitting model to feature number 595, F623
## 2025-03-29 06:51:24.197463 INFO::Fitting model to feature number 596, F624
## 2025-03-29 06:51:24.199673 INFO::Fitting model to feature number 597, F625
## 2025-03-29 06:51:24.201933 INFO::Fitting model to feature number 598, F626
## 2025-03-29 06:51:24.204152 INFO::Fitting model to feature number 599, F627
## 2025-03-29 06:51:24.206366 INFO::Fitting model to feature number 600, F628
## 2025-03-29 06:51:24.208581 INFO::Fitting model to feature number 601, F629
## 2025-03-29 06:51:24.210804 INFO::Fitting model to feature number 602, F630
## 2025-03-29 06:51:24.213046 INFO::Fitting model to feature number 603, F631
## 2025-03-29 06:51:24.215262 INFO::Fitting model to feature number 604, F632
## 2025-03-29 06:51:24.217469 INFO::Fitting model to feature number 605, F633
## 2025-03-29 06:51:24.219696 INFO::Fitting model to feature number 606, F634
## 2025-03-29 06:51:24.221897 INFO::Fitting model to feature number 607, F635
## 2025-03-29 06:51:24.224122 INFO::Fitting model to feature number 608, F636
## 2025-03-29 06:51:24.226322 INFO::Fitting model to feature number 609, F637
## 2025-03-29 06:51:24.228529 INFO::Fitting model to feature number 610, F638
## 2025-03-29 06:51:24.242416 INFO::Fitting model to feature number 611, F639
## 2025-03-29 06:51:24.244825 INFO::Fitting model to feature number 612, F640
## 2025-03-29 06:51:24.247046 INFO::Fitting model to feature number 613, F641
## 2025-03-29 06:51:24.249252 INFO::Fitting model to feature number 614, F642
## 2025-03-29 06:51:24.25147 INFO::Fitting model to feature number 615, F643
## 2025-03-29 06:51:24.253678 INFO::Fitting model to feature number 616, F644
## 2025-03-29 06:51:24.255922 INFO::Fitting model to feature number 617, F645
## 2025-03-29 06:51:24.258129 INFO::Fitting model to feature number 618, F646
## 2025-03-29 06:51:24.260313 INFO::Fitting model to feature number 619, F647
## 2025-03-29 06:51:24.262507 INFO::Fitting model to feature number 620, F648
## 2025-03-29 06:51:24.264707 INFO::Fitting model to feature number 621, F649
## 2025-03-29 06:51:24.266917 INFO::Fitting model to feature number 622, F650
## 2025-03-29 06:51:24.269122 INFO::Fitting model to feature number 623, F651
## 2025-03-29 06:51:24.27132 INFO::Fitting model to feature number 624, F652
## 2025-03-29 06:51:24.273549 INFO::Fitting model to feature number 625, F653
## 2025-03-29 06:51:24.275748 INFO::Fitting model to feature number 626, F654
## 2025-03-29 06:51:24.27799 INFO::Fitting model to feature number 627, F655
## 2025-03-29 06:51:24.280186 INFO::Fitting model to feature number 628, F656
## 2025-03-29 06:51:24.282363 INFO::Fitting model to feature number 629, F657
## 2025-03-29 06:51:24.284552 INFO::Fitting model to feature number 630, F658
## 2025-03-29 06:51:24.286754 INFO::Fitting model to feature number 631, F659
## 2025-03-29 06:51:24.288971 INFO::Fitting model to feature number 632, F660
## 2025-03-29 06:51:24.291172 INFO::Fitting model to feature number 633, F661
## 2025-03-29 06:51:24.293414 INFO::Fitting model to feature number 634, F662
## 2025-03-29 06:51:24.295599 INFO::Fitting model to feature number 635, F663
## 2025-03-29 06:51:24.297784 INFO::Fitting model to feature number 636, F664
## 2025-03-29 06:51:24.3 INFO::Fitting model to feature number 637, F665
## 2025-03-29 06:51:24.302575 INFO::Fitting model to feature number 638, F666
## 2025-03-29 06:51:24.305276 INFO::Fitting model to feature number 639, F667
## 2025-03-29 06:51:24.30755 INFO::Fitting model to feature number 640, F668
## 2025-03-29 06:51:24.309777 INFO::Fitting model to feature number 641, F669
## 2025-03-29 06:51:24.312036 INFO::Fitting model to feature number 642, F670
## 2025-03-29 06:51:24.314287 INFO::Fitting model to feature number 643, F671
## 2025-03-29 06:51:24.316502 INFO::Fitting model to feature number 644, F672
## 2025-03-29 06:51:24.318777 INFO::Fitting model to feature number 645, F673
## 2025-03-29 06:51:24.321011 INFO::Fitting model to feature number 646, F674
## 2025-03-29 06:51:24.323227 INFO::Fitting model to feature number 647, F675
## 2025-03-29 06:51:24.32544 INFO::Fitting model to feature number 648, F676
## 2025-03-29 06:51:24.327649 INFO::Fitting model to feature number 649, F677
## 2025-03-29 06:51:24.329867 INFO::Fitting model to feature number 650, F678
## 2025-03-29 06:51:24.332089 INFO::Fitting model to feature number 651, F679
## 2025-03-29 06:51:24.334301 INFO::Fitting model to feature number 652, F680
## 2025-03-29 06:51:24.336505 INFO::Fitting model to feature number 653, F681
## 2025-03-29 06:51:24.338735 INFO::Fitting model to feature number 654, F682
## 2025-03-29 06:51:24.340942 INFO::Fitting model to feature number 655, F683
## 2025-03-29 06:51:24.343165 INFO::Fitting model to feature number 656, F684
## 2025-03-29 06:51:24.345369 INFO::Fitting model to feature number 657, F685
## 2025-03-29 06:51:24.347585 INFO::Fitting model to feature number 658, F686
## 2025-03-29 06:51:24.349803 INFO::Fitting model to feature number 659, F687
## 2025-03-29 06:51:24.35205 INFO::Fitting model to feature number 660, F688
## 2025-03-29 06:51:24.354289 INFO::Fitting model to feature number 661, F689
## 2025-03-29 06:51:24.35654 INFO::Fitting model to feature number 662, F690
## 2025-03-29 06:51:24.358758 INFO::Fitting model to feature number 663, F691
## 2025-03-29 06:51:24.361008 INFO::Fitting model to feature number 664, F692
## 2025-03-29 06:51:24.363236 INFO::Fitting model to feature number 665, F693
## 2025-03-29 06:51:24.36547 INFO::Fitting model to feature number 666, F694
## 2025-03-29 06:51:24.367679 INFO::Fitting model to feature number 667, F695
## 2025-03-29 06:51:24.369931 INFO::Fitting model to feature number 668, F696
## 2025-03-29 06:51:24.372163 INFO::Fitting model to feature number 669, F697
## 2025-03-29 06:51:24.374382 INFO::Fitting model to feature number 670, F698
## 2025-03-29 06:51:24.37661 INFO::Fitting model to feature number 671, F699
## 2025-03-29 06:51:24.37882 INFO::Fitting model to feature number 672, F700
## 2025-03-29 06:51:24.381072 INFO::Fitting model to feature number 673, F701
## 2025-03-29 06:51:24.383279 INFO::Fitting model to feature number 674, F702
## 2025-03-29 06:51:24.385532 INFO::Fitting model to feature number 675, F704
## 2025-03-29 06:51:24.387748 INFO::Fitting model to feature number 676, F705
## 2025-03-29 06:51:24.389975 INFO::Fitting model to feature number 677, F706
## 2025-03-29 06:51:24.392182 INFO::Fitting model to feature number 678, F707
## 2025-03-29 06:51:24.39441 INFO::Fitting model to feature number 679, F708
## 2025-03-29 06:51:24.39661 INFO::Fitting model to feature number 680, F709
## 2025-03-29 06:51:24.398815 INFO::Fitting model to feature number 681, F710
## 2025-03-29 06:51:24.401086 INFO::Fitting model to feature number 682, F711
## 2025-03-29 06:51:24.403309 INFO::Fitting model to feature number 683, F712
## 2025-03-29 06:51:24.405537 INFO::Fitting model to feature number 684, F713
## 2025-03-29 06:51:24.407754 INFO::Fitting model to feature number 685, F714
## 2025-03-29 06:51:24.410012 INFO::Fitting model to feature number 686, F715
## 2025-03-29 06:51:24.412238 INFO::Fitting model to feature number 687, F716
## 2025-03-29 06:51:24.414449 INFO::Fitting model to feature number 688, F717
## 2025-03-29 06:51:24.416668 INFO::Fitting model to feature number 689, F718
## 2025-03-29 06:51:24.418894 INFO::Fitting model to feature number 690, F719
## 2025-03-29 06:51:24.421161 INFO::Fitting model to feature number 691, F720
## 2025-03-29 06:51:24.423385 INFO::Fitting model to feature number 692, F721
## 2025-03-29 06:51:24.425601 INFO::Fitting model to feature number 693, F722
## 2025-03-29 06:51:24.427836 INFO::Fitting model to feature number 694, F723
## 2025-03-29 06:51:24.430081 INFO::Fitting model to feature number 695, F724
## 2025-03-29 06:51:24.432309 INFO::Fitting model to feature number 696, F725
## 2025-03-29 06:51:24.434548 INFO::Fitting model to feature number 697, F726
## 2025-03-29 06:51:24.436858 INFO::Fitting model to feature number 698, F727
## 2025-03-29 06:51:24.439084 INFO::Fitting model to feature number 699, F728
## 2025-03-29 06:51:24.441298 INFO::Fitting model to feature number 700, F729
## 2025-03-29 06:51:24.44352 INFO::Fitting model to feature number 701, F730
## 2025-03-29 06:51:24.445753 INFO::Fitting model to feature number 702, F731
## 2025-03-29 06:51:24.447991 INFO::Fitting model to feature number 703, F732
## 2025-03-29 06:51:24.450196 INFO::Fitting model to feature number 704, F733
## 2025-03-29 06:51:24.452376 INFO::Fitting model to feature number 705, F734
## 2025-03-29 06:51:24.454584 INFO::Fitting model to feature number 706, F735
## 2025-03-29 06:51:24.45678 INFO::Fitting model to feature number 707, F736
## 2025-03-29 06:51:24.459013 INFO::Fitting model to feature number 708, F737
## 2025-03-29 06:51:24.461203 INFO::Fitting model to feature number 709, F739
## 2025-03-29 06:51:24.463421 INFO::Fitting model to feature number 710, F740
## 2025-03-29 06:51:24.465642 INFO::Fitting model to feature number 711, F741
## 2025-03-29 06:51:24.467844 INFO::Fitting model to feature number 712, F742
## 2025-03-29 06:51:24.470064 INFO::Fitting model to feature number 713, F743
## 2025-03-29 06:51:24.47227 INFO::Fitting model to feature number 714, F744
## 2025-03-29 06:51:24.47449 INFO::Fitting model to feature number 715, F745
## 2025-03-29 06:51:24.476694 INFO::Fitting model to feature number 716, F746
## 2025-03-29 06:51:24.478905 INFO::Fitting model to feature number 717, F747
## 2025-03-29 06:51:24.481133 INFO::Fitting model to feature number 718, F748
## 2025-03-29 06:51:24.483331 INFO::Fitting model to feature number 719, F749
## 2025-03-29 06:51:24.485602 INFO::Fitting model to feature number 720, F750
## 2025-03-29 06:51:24.487823 INFO::Fitting model to feature number 721, F751
## 2025-03-29 06:51:24.490062 INFO::Fitting model to feature number 722, F752
## 2025-03-29 06:51:24.492324 INFO::Fitting model to feature number 723, F753
## 2025-03-29 06:51:24.494552 INFO::Fitting model to feature number 724, F754
## 2025-03-29 06:51:24.496763 INFO::Fitting model to feature number 725, F755
## 2025-03-29 06:51:24.498987 INFO::Fitting model to feature number 726, F756
## 2025-03-29 06:51:24.501243 INFO::Fitting model to feature number 727, F757
## 2025-03-29 06:51:24.503474 INFO::Fitting model to feature number 728, F758
## 2025-03-29 06:51:24.505723 INFO::Fitting model to feature number 729, F759
## 2025-03-29 06:51:24.507954 INFO::Fitting model to feature number 730, F760
## 2025-03-29 06:51:24.51017 INFO::Fitting model to feature number 731, F761
## 2025-03-29 06:51:24.512378 INFO::Fitting model to feature number 732, F762
## 2025-03-29 06:51:24.514586 INFO::Fitting model to feature number 733, F763
## 2025-03-29 06:51:24.516792 INFO::Fitting model to feature number 734, F764
## 2025-03-29 06:51:24.519005 INFO::Fitting model to feature number 735, F765
## 2025-03-29 06:51:24.521214 INFO::Fitting model to feature number 736, F766
## 2025-03-29 06:51:24.523463 INFO::Fitting model to feature number 737, F767
## 2025-03-29 06:51:24.525693 INFO::Fitting model to feature number 738, F768
## 2025-03-29 06:51:24.52793 INFO::Fitting model to feature number 739, F769
## 2025-03-29 06:51:24.530165 INFO::Fitting model to feature number 740, F770
## 2025-03-29 06:51:24.53241 INFO::Fitting model to feature number 741, F771
## 2025-03-29 06:51:24.534647 INFO::Fitting model to feature number 742, F772
## 2025-03-29 06:51:24.536959 INFO::Fitting model to feature number 743, F773
## 2025-03-29 06:51:24.539201 INFO::Fitting model to feature number 744, F774
## 2025-03-29 06:51:24.541428 INFO::Fitting model to feature number 745, F775
## 2025-03-29 06:51:24.54365 INFO::Fitting model to feature number 746, F776
## 2025-03-29 06:51:24.545906 INFO::Fitting model to feature number 747, F777
## 2025-03-29 06:51:24.548187 INFO::Fitting model to feature number 748, F778
## 2025-03-29 06:51:24.550421 INFO::Fitting model to feature number 749, F779
## 2025-03-29 06:51:24.552674 INFO::Fitting model to feature number 750, F780
## 2025-03-29 06:51:24.554941 INFO::Fitting model to feature number 751, F781
## 2025-03-29 06:51:24.557166 INFO::Fitting model to feature number 752, F782
## 2025-03-29 06:51:24.559409 INFO::Fitting model to feature number 753, F783
## 2025-03-29 06:51:24.561663 INFO::Fitting model to feature number 754, F784
## 2025-03-29 06:51:24.563975 INFO::Fitting model to feature number 755, F785
## 2025-03-29 06:51:24.566239 INFO::Fitting model to feature number 756, F786
## 2025-03-29 06:51:24.568518 INFO::Fitting model to feature number 757, F787
## 2025-03-29 06:51:24.570752 INFO::Fitting model to feature number 758, F788
## 2025-03-29 06:51:24.573004 INFO::Fitting model to feature number 759, F789
## 2025-03-29 06:51:24.575281 INFO::Fitting model to feature number 760, F790
## 2025-03-29 06:51:24.577513 INFO::Fitting model to feature number 761, F791
## 2025-03-29 06:51:24.579767 INFO::Fitting model to feature number 762, F792
## 2025-03-29 06:51:24.582073 INFO::Fitting model to feature number 763, F793
## 2025-03-29 06:51:24.584342 INFO::Fitting model to feature number 764, F794
## 2025-03-29 06:51:24.586596 INFO::Fitting model to feature number 765, F795
## 2025-03-29 06:51:24.588831 INFO::Fitting model to feature number 766, F796
## 2025-03-29 06:51:24.591163 INFO::Fitting model to feature number 767, F797
## 2025-03-29 06:51:24.593426 INFO::Fitting model to feature number 768, F798
## 2025-03-29 06:51:24.595688 INFO::Fitting model to feature number 769, F799
## 2025-03-29 06:51:24.598009 INFO::Fitting model to feature number 770, F800
## 2025-03-29 06:51:24.600264 INFO::Fitting model to feature number 771, F801
## 2025-03-29 06:51:24.602516 INFO::Fitting model to feature number 772, F802
## 2025-03-29 06:51:24.604776 INFO::Fitting model to feature number 773, F803
## 2025-03-29 06:51:24.607031 INFO::Fitting model to feature number 774, F804
## 2025-03-29 06:51:24.609278 INFO::Fitting model to feature number 775, F805
## 2025-03-29 06:51:24.61152 INFO::Fitting model to feature number 776, F806
## 2025-03-29 06:51:24.613765 INFO::Fitting model to feature number 777, F808
## 2025-03-29 06:51:24.616022 INFO::Fitting model to feature number 778, F809
## 2025-03-29 06:51:24.618255 INFO::Fitting model to feature number 779, F810
## 2025-03-29 06:51:24.620488 INFO::Fitting model to feature number 780, F811
## 2025-03-29 06:51:24.622709 INFO::Fitting model to feature number 781, F812
## 2025-03-29 06:51:24.62497 INFO::Fitting model to feature number 782, F813
## 2025-03-29 06:51:24.6272 INFO::Fitting model to feature number 783, F814
## 2025-03-29 06:51:24.629417 INFO::Fitting model to feature number 784, F815
## 2025-03-29 06:51:24.631662 INFO::Fitting model to feature number 785, F816
## 2025-03-29 06:51:24.633916 INFO::Fitting model to feature number 786, F817
## 2025-03-29 06:51:24.636147 INFO::Fitting model to feature number 787, F818
## 2025-03-29 06:51:24.638474 INFO::Fitting model to feature number 788, F819
## 2025-03-29 06:51:24.640735 INFO::Fitting model to feature number 789, F820
## 2025-03-29 06:51:24.643034 INFO::Fitting model to feature number 790, F821
## 2025-03-29 06:51:24.645295 INFO::Fitting model to feature number 791, F822
## 2025-03-29 06:51:24.64754 INFO::Fitting model to feature number 792, F823
## 2025-03-29 06:51:24.649797 INFO::Fitting model to feature number 793, F824
## 2025-03-29 06:51:24.652047 INFO::Fitting model to feature number 794, F825
## 2025-03-29 06:51:24.654284 INFO::Fitting model to feature number 795, F826
## 2025-03-29 06:51:24.65652 INFO::Fitting model to feature number 796, F827
## 2025-03-29 06:51:24.658747 INFO::Fitting model to feature number 797, F828
## 2025-03-29 06:51:24.660985 INFO::Fitting model to feature number 798, F829
## 2025-03-29 06:51:24.663247 INFO::Fitting model to feature number 799, F830
## 2025-03-29 06:51:24.665492 INFO::Fitting model to feature number 800, F831
## 2025-03-29 06:51:24.667756 INFO::Fitting model to feature number 801, F832
## 2025-03-29 06:51:24.670054 INFO::Fitting model to feature number 802, F833
## 2025-03-29 06:51:24.672314 INFO::Fitting model to feature number 803, F834
## 2025-03-29 06:51:24.674554 INFO::Fitting model to feature number 804, F835
## 2025-03-29 06:51:24.67681 INFO::Fitting model to feature number 805, F836
## 2025-03-29 06:51:24.679101 INFO::Fitting model to feature number 806, F837
## 2025-03-29 06:51:24.681435 INFO::Fitting model to feature number 807, F838
## 2025-03-29 06:51:24.683677 INFO::Fitting model to feature number 808, F839
## 2025-03-29 06:51:24.685945 INFO::Fitting model to feature number 809, F840
## 2025-03-29 06:51:24.688167 INFO::Fitting model to feature number 810, F841
## 2025-03-29 06:51:24.690397 INFO::Fitting model to feature number 811, F842
## 2025-03-29 06:51:24.692673 INFO::Fitting model to feature number 812, F843
## 2025-03-29 06:51:24.694955 INFO::Fitting model to feature number 813, F844
## 2025-03-29 06:51:24.697206 INFO::Fitting model to feature number 814, F845
## 2025-03-29 06:51:24.699448 INFO::Fitting model to feature number 815, F846
## 2025-03-29 06:51:24.701679 INFO::Fitting model to feature number 816, F847
## 2025-03-29 06:51:24.703944 INFO::Fitting model to feature number 817, F848
## 2025-03-29 06:51:24.706182 INFO::Fitting model to feature number 818, F849
## 2025-03-29 06:51:24.708481 INFO::Fitting model to feature number 819, F850
## 2025-03-29 06:51:24.710716 INFO::Fitting model to feature number 820, F851
## 2025-03-29 06:51:24.712958 INFO::Fitting model to feature number 821, F852
## 2025-03-29 06:51:24.715176 INFO::Fitting model to feature number 822, F853
## 2025-03-29 06:51:24.71742 INFO::Fitting model to feature number 823, F854
## 2025-03-29 06:51:24.719716 INFO::Fitting model to feature number 824, F855
## 2025-03-29 06:51:24.722 INFO::Fitting model to feature number 825, F856
## 2025-03-29 06:51:24.724262 INFO::Fitting model to feature number 826, F857
## 2025-03-29 06:51:24.72649 INFO::Fitting model to feature number 827, F858
## 2025-03-29 06:51:24.728729 INFO::Fitting model to feature number 828, F859
## 2025-03-29 06:51:24.730978 INFO::Fitting model to feature number 829, F860
## 2025-03-29 06:51:24.733219 INFO::Fitting model to feature number 830, F861
## 2025-03-29 06:51:24.735456 INFO::Fitting model to feature number 831, F862
## 2025-03-29 06:51:24.737688 INFO::Fitting model to feature number 832, F863
## 2025-03-29 06:51:24.739947 INFO::Fitting model to feature number 833, F864
## 2025-03-29 06:51:24.74218 INFO::Fitting model to feature number 834, F865
## 2025-03-29 06:51:24.744404 INFO::Fitting model to feature number 835, F866
## 2025-03-29 06:51:24.746633 INFO::Fitting model to feature number 836, F867
## 2025-03-29 06:51:24.748845 INFO::Fitting model to feature number 837, F868
## 2025-03-29 06:51:24.751092 INFO::Fitting model to feature number 838, F869
## 2025-03-29 06:51:24.753329 INFO::Fitting model to feature number 839, F870
## 2025-03-29 06:51:24.755558 INFO::Fitting model to feature number 840, F871
## 2025-03-29 06:51:24.757768 INFO::Fitting model to feature number 841, F872
## 2025-03-29 06:51:24.760001 INFO::Fitting model to feature number 842, F873
## 2025-03-29 06:51:24.762214 INFO::Fitting model to feature number 843, F874
## 2025-03-29 06:51:24.764423 INFO::Fitting model to feature number 844, F875
## 2025-03-29 06:51:24.766644 INFO::Fitting model to feature number 845, F876
## 2025-03-29 06:51:24.768901 INFO::Fitting model to feature number 846, F877
## 2025-03-29 06:51:24.782208 INFO::Fitting model to feature number 847, F878
## 2025-03-29 06:51:24.785275 INFO::Fitting model to feature number 848, F879
## 2025-03-29 06:51:24.787523 INFO::Fitting model to feature number 849, F880
## 2025-03-29 06:51:24.789724 INFO::Fitting model to feature number 850, F881
## 2025-03-29 06:51:24.791972 INFO::Fitting model to feature number 851, F882
## 2025-03-29 06:51:24.794192 INFO::Fitting model to feature number 852, F883
## 2025-03-29 06:51:24.79641 INFO::Fitting model to feature number 853, F884
## 2025-03-29 06:51:24.79863 INFO::Fitting model to feature number 854, F885
## 2025-03-29 06:51:24.800856 INFO::Fitting model to feature number 855, F886
## 2025-03-29 06:51:24.803096 INFO::Fitting model to feature number 856, F887
## 2025-03-29 06:51:24.805318 INFO::Fitting model to feature number 857, F888
## 2025-03-29 06:51:24.80753 INFO::Fitting model to feature number 858, F889
## 2025-03-29 06:51:24.809743 INFO::Fitting model to feature number 859, F890
## 2025-03-29 06:51:24.811999 INFO::Fitting model to feature number 860, F891
## 2025-03-29 06:51:24.814201 INFO::Fitting model to feature number 861, F892
## 2025-03-29 06:51:24.816403 INFO::Fitting model to feature number 862, F893
## 2025-03-29 06:51:24.818637 INFO::Fitting model to feature number 863, F894
## 2025-03-29 06:51:24.820904 INFO::Fitting model to feature number 864, F895
## 2025-03-29 06:51:24.823119 INFO::Fitting model to feature number 865, F896
## 2025-03-29 06:51:24.825319 INFO::Fitting model to feature number 866, F897
## 2025-03-29 06:51:24.82754 INFO::Fitting model to feature number 867, F898
## 2025-03-29 06:51:24.829755 INFO::Fitting model to feature number 868, F899
## 2025-03-29 06:51:24.831979 INFO::Fitting model to feature number 869, F900
## 2025-03-29 06:51:24.938337 INFO::Counting total values for each feature
## 2025-03-29 06:51:25.02105 INFO::Writing filtered data to file Macarron_output/maaslin2_results/features/filtered_data.tsv
## 2025-03-29 06:51:25.075832 INFO::Writing filtered, normalized data to file Macarron_output/maaslin2_results/features/filtered_data_norm.tsv
## 2025-03-29 06:51:25.130446 INFO::Writing filtered, normalized, transformed data to file Macarron_output/maaslin2_results/features/filtered_data_norm_transformed.tsv
## 2025-03-29 06:51:25.184895 INFO::Writing residuals to file Macarron_output/maaslin2_results/fits/residuals.rds
## 2025-03-29 06:51:25.212685 INFO::Writing fitted values to file Macarron_output/maaslin2_results/fits/fitted.rds
## 2025-03-29 06:51:25.235977 INFO::Writing all results to file (ordered by increasing q-values): Macarron_output/maaslin2_results/all_results.tsv
## 2025-03-29 06:51:25.245347 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): Macarron_output/maaslin2_results/significant_results.tsv
## 2025-03-29 06:51:25.249612 INFO::Writing association plots (one for each significant association) to output folder: Macarron_output/maaslin2_results
## 2025-03-29 06:51:25.260403 INFO::Plotting associations from most to least significant, grouped by metadata
## 2025-03-29 06:51:25.261022 INFO::Plotting data for metadata number 1, diagnosis
## 2025-03-29 06:51:25.28838 INFO::Creating boxplot for categorical data, diagnosis vs F504
## 2025-03-29 06:51:25.503589 INFO::Creating boxplot for categorical data, diagnosis vs F859
## 2025-03-29 06:51:25.626539 INFO::Creating boxplot for categorical data, diagnosis vs F533
## 2025-03-29 06:51:25.735396 INFO::Creating boxplot for categorical data, diagnosis vs F587
## 2025-03-29 06:51:25.84663 INFO::Creating boxplot for categorical data, diagnosis vs F584
## 2025-03-29 06:51:25.966961 INFO::Creating boxplot for categorical data, diagnosis vs F197
## 2025-03-29 06:51:26.076659 INFO::Creating boxplot for categorical data, diagnosis vs F380
## 2025-03-29 06:51:26.185693 INFO::Creating boxplot for categorical data, diagnosis vs F829
## 2025-03-29 06:51:26.294797 INFO::Creating boxplot for categorical data, diagnosis vs F664
## 2025-03-29 06:51:26.412949 INFO::Creating boxplot for categorical data, diagnosis vs F93
## 2025-03-29 06:51:26.520294 INFO::Creating boxplot for categorical data, diagnosis vs F15
## 2025-03-29 06:51:26.627611 INFO::Creating boxplot for categorical data, diagnosis vs F881
## 2025-03-29 06:51:26.737093 INFO::Creating boxplot for categorical data, diagnosis vs F806
## 2025-03-29 06:51:26.85292 INFO::Creating boxplot for categorical data, diagnosis vs F78
## 2025-03-29 06:51:26.959538 INFO::Creating boxplot for categorical data, diagnosis vs F189
## 2025-03-29 06:51:27.072606 INFO::Creating boxplot for categorical data, diagnosis vs F369
## 2025-03-29 06:51:27.181818 INFO::Creating boxplot for categorical data, diagnosis vs F623
## 2025-03-29 06:51:27.297478 INFO::Creating boxplot for categorical data, diagnosis vs F710
## 2025-03-29 06:51:27.404917 INFO::Creating boxplot for categorical data, diagnosis vs F851
## 2025-03-29 06:51:27.514461 INFO::Creating boxplot for categorical data, diagnosis vs F257
## 2025-03-29 06:51:27.624614 INFO::Creating boxplot for categorical data, diagnosis vs F330
## 2025-03-29 06:51:27.74117 INFO::Creating boxplot for categorical data, diagnosis vs F344
## 2025-03-29 06:51:27.848254 INFO::Creating boxplot for categorical data, diagnosis vs F696
## 2025-03-29 06:51:27.957633 INFO::Creating boxplot for categorical data, diagnosis vs F741
## 2025-03-29 06:51:28.068504 INFO::Creating boxplot for categorical data, diagnosis vs F509
## 2025-03-29 06:51:28.187265 INFO::Creating boxplot for categorical data, diagnosis vs F479
## 2025-03-29 06:51:28.29539 INFO::Creating boxplot for categorical data, diagnosis vs F550
## 2025-03-29 06:51:28.405656 INFO::Creating boxplot for categorical data, diagnosis vs F640
## 2025-03-29 06:51:28.522561 INFO::Creating boxplot for categorical data, diagnosis vs F281
## 2025-03-29 06:51:28.629585 INFO::Creating boxplot for categorical data, diagnosis vs F80
## 2025-03-29 06:51:28.737388 INFO::Creating boxplot for categorical data, diagnosis vs F285
## 2025-03-29 06:51:28.847667 INFO::Creating boxplot for categorical data, diagnosis vs F531
## 2025-03-29 06:51:28.964955 INFO::Creating boxplot for categorical data, diagnosis vs F737
## 2025-03-29 06:51:29.073443 INFO::Creating boxplot for categorical data, diagnosis vs F875
## 2025-03-29 06:51:29.181747 INFO::Creating boxplot for categorical data, diagnosis vs F864
## 2025-03-29 06:51:29.291096 INFO::Creating boxplot for categorical data, diagnosis vs F379
## 2025-03-29 06:51:29.407892 INFO::Creating boxplot for categorical data, diagnosis vs F190
## 2025-03-29 06:51:29.515522 INFO::Creating boxplot for categorical data, diagnosis vs F4
## 2025-03-29 06:51:29.626159 INFO::Creating boxplot for categorical data, diagnosis vs F591
## 2025-03-29 06:51:29.73598 INFO::Creating boxplot for categorical data, diagnosis vs F773
## 2025-03-29 06:51:29.850759 INFO::Creating boxplot for categorical data, diagnosis vs F283
## 2025-03-29 06:51:29.958404 INFO::Creating boxplot for categorical data, diagnosis vs F233
## 2025-03-29 06:51:30.069758 INFO::Creating boxplot for categorical data, diagnosis vs F420
## 2025-03-29 06:51:30.191391 INFO::Creating boxplot for categorical data, diagnosis vs F5
## 2025-03-29 06:51:30.299448 INFO::Creating boxplot for categorical data, diagnosis vs F137
## 2025-03-29 06:51:30.407074 INFO::Creating boxplot for categorical data, diagnosis vs F215
## 2025-03-29 06:51:30.516657 INFO::Creating boxplot for categorical data, diagnosis vs F489
## 2025-03-29 06:51:30.633483 INFO::Creating boxplot for categorical data, diagnosis vs F220
## 2025-03-29 06:51:30.741445 INFO::Creating boxplot for categorical data, diagnosis vs F691
## 2025-03-29 06:51:30.849966 INFO::Creating boxplot for categorical data, diagnosis vs F381
## 2025-03-29 06:51:30.961246 INFO::Creating boxplot for categorical data, diagnosis vs F539
## 2025-03-29 06:51:31.077782 INFO::Creating boxplot for categorical data, diagnosis vs F490
## 2025-03-29 06:51:31.185532 INFO::Creating boxplot for categorical data, diagnosis vs F832
## 2025-03-29 06:51:31.294583 INFO::Creating boxplot for categorical data, diagnosis vs F396
## 2025-03-29 06:51:31.405538 INFO::Creating boxplot for categorical data, diagnosis vs F528
## 2025-03-29 06:51:31.521299 INFO::Creating boxplot for categorical data, diagnosis vs F234
## 2025-03-29 06:51:31.628437 INFO::Creating boxplot for categorical data, diagnosis vs F178
## 2025-03-29 06:51:31.739122 INFO::Creating boxplot for categorical data, diagnosis vs F761
## 2025-03-29 06:51:31.856854 INFO::Creating boxplot for categorical data, diagnosis vs F2
## 2025-03-29 06:51:31.964397 INFO::Creating boxplot for categorical data, diagnosis vs F260
## 2025-03-29 06:51:32.074019 INFO::Creating boxplot for categorical data, diagnosis vs F734
## 2025-03-29 06:51:32.187211 INFO::Creating boxplot for categorical data, diagnosis vs F429
## 2025-03-29 06:51:32.304359 INFO::Creating boxplot for categorical data, diagnosis vs F630
## 2025-03-29 06:51:32.41256 INFO::Creating boxplot for categorical data, diagnosis vs F817
## 2025-03-29 06:51:32.520602 INFO::Creating boxplot for categorical data, diagnosis vs F847
## 2025-03-29 06:51:32.632116 INFO::Creating boxplot for categorical data, diagnosis vs F896
## 2025-03-29 06:51:32.749057 INFO::Creating boxplot for categorical data, diagnosis vs F81
## 2025-03-29 06:51:32.855257 INFO::Creating boxplot for categorical data, diagnosis vs F110
## 2025-03-29 06:51:32.965569 INFO::Creating boxplot for categorical data, diagnosis vs F3
## 2025-03-29 06:51:33.084244 INFO::Creating boxplot for categorical data, diagnosis vs F33
## 2025-03-29 06:51:33.196079 INFO::Creating boxplot for categorical data, diagnosis vs F270
## 2025-03-29 06:51:33.303937 INFO::Creating boxplot for categorical data, diagnosis vs F278
## 2025-03-29 06:51:33.413819 INFO::Creating boxplot for categorical data, diagnosis vs F264
## 2025-03-29 06:51:33.531007 INFO::Creating boxplot for categorical data, diagnosis vs F90
## 2025-03-29 06:51:33.637668 INFO::Creating boxplot for categorical data, diagnosis vs F403
## 2025-03-29 06:51:33.747215 INFO::Creating boxplot for categorical data, diagnosis vs F727
## 2025-03-29 06:51:33.857923 INFO::Creating boxplot for categorical data, diagnosis vs F394
## 2025-03-29 06:51:33.974361 INFO::Creating boxplot for categorical data, diagnosis vs F800
## 2025-03-29 06:51:34.083341 INFO::Creating boxplot for categorical data, diagnosis vs F439
## 2025-03-29 06:51:34.19425 INFO::Creating boxplot for categorical data, diagnosis vs F554
## 2025-03-29 06:51:34.821755 INFO::Creating boxplot for categorical data, diagnosis vs F559
## 2025-03-29 06:51:34.927299 INFO::Creating boxplot for categorical data, diagnosis vs F548
## 2025-03-29 06:51:35.035008 INFO::Creating boxplot for categorical data, diagnosis vs F794
## 2025-03-29 06:51:35.144615 INFO::Creating boxplot for categorical data, diagnosis vs F45
## 2025-03-29 06:51:35.258673 INFO::Creating boxplot for categorical data, diagnosis vs F158
## 2025-03-29 06:51:35.365349 INFO::Creating boxplot for categorical data, diagnosis vs F477
## 2025-03-29 06:51:35.472441 INFO::Creating boxplot for categorical data, diagnosis vs F1
## 2025-03-29 06:51:35.577808 INFO::Creating boxplot for categorical data, diagnosis vs F862
## 2025-03-29 06:51:35.692653 INFO::Creating boxplot for categorical data, diagnosis vs F803
## 2025-03-29 06:51:35.798056 INFO::Creating boxplot for categorical data, diagnosis vs F751
## 2025-03-29 06:51:35.903713 INFO::Creating boxplot for categorical data, diagnosis vs F98
## 2025-03-29 06:51:36.009823 INFO::Creating boxplot for categorical data, diagnosis vs F22
## 2025-03-29 06:51:36.124636 INFO::Creating boxplot for categorical data, diagnosis vs F625
## 2025-03-29 06:51:36.231181 INFO::Creating boxplot for categorical data, diagnosis vs F206
## 2025-03-29 06:51:36.336483 INFO::Creating boxplot for categorical data, diagnosis vs F779
## 2025-03-29 06:51:36.44173 INFO::Creating boxplot for categorical data, diagnosis vs F532
## 2025-03-29 06:51:36.554008 INFO::Creating boxplot for categorical data, diagnosis vs F676
## 2025-03-29 06:51:36.659952 INFO::Creating boxplot for categorical data, diagnosis vs F644
## 2025-03-29 06:51:36.767067 INFO::Creating boxplot for categorical data, diagnosis vs F7
## 2025-03-29 06:51:36.874055 INFO::Creating boxplot for categorical data, diagnosis vs F596
## 2025-03-29 06:51:36.987583 INFO::Creating boxplot for categorical data, diagnosis vs F250
## 2025-03-29 06:51:37.094196 INFO::Creating boxplot for categorical data, diagnosis vs F462
## 2025-03-29 06:51:37.204823 INFO::Creating boxplot for categorical data, diagnosis vs F516
## 2025-03-29 06:51:37.312166 INFO::Creating boxplot for categorical data, diagnosis vs F659
## 2025-03-29 06:51:37.425521 INFO::Creating boxplot for categorical data, diagnosis vs F663
## 2025-03-29 06:51:37.531757 INFO::Creating boxplot for categorical data, diagnosis vs F837
## 2025-03-29 06:51:37.637867 INFO::Creating boxplot for categorical data, diagnosis vs F138
## 2025-03-29 06:51:37.752164 INFO::Creating boxplot for categorical data, diagnosis vs F445
## 2025-03-29 06:51:37.85758 INFO::Creating boxplot for categorical data, diagnosis vs F697
## 2025-03-29 06:51:37.96413 INFO::Creating boxplot for categorical data, diagnosis vs F225
## 2025-03-29 06:51:38.071122 INFO::Creating boxplot for categorical data, diagnosis vs F148
## 2025-03-29 06:51:38.185148 INFO::Creating boxplot for categorical data, diagnosis vs F448
## 2025-03-29 06:51:38.291071 INFO::Creating boxplot for categorical data, diagnosis vs F91
## 2025-03-29 06:51:38.397988 INFO::Creating boxplot for categorical data, diagnosis vs F123
## 2025-03-29 06:51:38.504812 INFO::Creating boxplot for categorical data, diagnosis vs F665
## 2025-03-29 06:51:38.617163 INFO::Creating boxplot for categorical data, diagnosis vs F845
## 2025-03-29 06:51:38.724061 INFO::Creating boxplot for categorical data, diagnosis vs F331
## 2025-03-29 06:51:38.831811 INFO::Creating boxplot for categorical data, diagnosis vs F361
## 2025-03-29 06:51:38.939464 INFO::Creating boxplot for categorical data, diagnosis vs F421
## 2025-03-29 06:51:39.053928 INFO::Creating boxplot for categorical data, diagnosis vs F277
## 2025-03-29 06:51:39.161801 INFO::Creating boxplot for categorical data, diagnosis vs F307
## 2025-03-29 06:51:39.273145 INFO::Creating boxplot for categorical data, diagnosis vs F503
## 2025-03-29 06:51:39.380561 INFO::Creating boxplot for categorical data, diagnosis vs F34
## 2025-03-29 06:51:39.494205 INFO::Creating boxplot for categorical data, diagnosis vs F649
## 2025-03-29 06:51:39.601376 INFO::Creating boxplot for categorical data, diagnosis vs F825
## 2025-03-29 06:51:39.707993 INFO::Creating boxplot for categorical data, diagnosis vs F298
## 2025-03-29 06:51:39.823589 INFO::Creating boxplot for categorical data, diagnosis vs F461
## 2025-03-29 06:51:39.930158 INFO::Creating boxplot for categorical data, diagnosis vs F242
## 2025-03-29 06:51:40.03666 INFO::Creating boxplot for categorical data, diagnosis vs F375
## 2025-03-29 06:51:40.143688 INFO::Creating boxplot for categorical data, diagnosis vs F648
## 2025-03-29 06:51:40.260169 INFO::Creating boxplot for categorical data, diagnosis vs F724
## 2025-03-29 06:51:40.366691 INFO::Creating boxplot for categorical data, diagnosis vs F678
## 2025-03-29 06:51:40.47429 INFO::Creating boxplot for categorical data, diagnosis vs F290
## 2025-03-29 06:51:40.583719 INFO::Creating boxplot for categorical data, diagnosis vs F743
## 2025-03-29 06:51:40.698108 INFO::Creating boxplot for categorical data, diagnosis vs F495
## 2025-03-29 06:51:40.804866 INFO::Creating boxplot for categorical data, diagnosis vs F261
## 2025-03-29 06:51:40.911678 INFO::Creating boxplot for categorical data, diagnosis vs F43
## 2025-03-29 06:51:41.026272 INFO::Creating boxplot for categorical data, diagnosis vs F714
## 2025-03-29 06:51:41.134085 INFO::Creating boxplot for categorical data, diagnosis vs F131
## 2025-03-29 06:51:41.240196 INFO::Creating boxplot for categorical data, diagnosis vs F150
## 2025-03-29 06:51:41.347325 INFO::Creating boxplot for categorical data, diagnosis vs F651
## 2025-03-29 06:51:41.463188 INFO::Creating boxplot for categorical data, diagnosis vs F798
## 2025-03-29 06:51:41.568919 INFO::Creating boxplot for categorical data, diagnosis vs F289
## 2025-03-29 06:51:41.67592 INFO::Creating boxplot for categorical data, diagnosis vs F661
## 2025-03-29 06:51:41.783219 INFO::Creating boxplot for categorical data, diagnosis vs F199
## 2025-03-29 06:51:41.896681 INFO::Creating boxplot for categorical data, diagnosis vs F406
## 2025-03-29 06:51:42.003669 INFO::Creating boxplot for categorical data, diagnosis vs F139
## 2025-03-29 06:51:42.112016 INFO::Creating boxplot for categorical data, diagnosis vs F506
## 2025-03-29 06:51:42.227612 INFO::Creating boxplot for categorical data, diagnosis vs F552
## 2025-03-29 06:51:42.334671 INFO::Creating boxplot for categorical data, diagnosis vs F94
## 2025-03-29 06:51:42.441673 INFO::Creating boxplot for categorical data, diagnosis vs F430
## 2025-03-29 06:51:42.548915 INFO::Creating boxplot for categorical data, diagnosis vs F639
## 2025-03-29 06:51:42.662848 INFO::Creating boxplot for categorical data, diagnosis vs F500
## 2025-03-29 06:51:42.769055 INFO::Creating boxplot for categorical data, diagnosis vs F609
## 2025-03-29 06:51:42.875765 INFO::Creating boxplot for categorical data, diagnosis vs F306
## 2025-03-29 06:51:42.983459 INFO::Creating boxplot for categorical data, diagnosis vs F507
## 2025-03-29 06:51:43.098207 INFO::Creating boxplot for categorical data, diagnosis vs F671
## 2025-03-29 06:51:43.204677 INFO::Creating boxplot for categorical data, diagnosis vs F894
## 2025-03-29 06:51:43.312649 INFO::Creating boxplot for categorical data, diagnosis vs F345
## 2025-03-29 06:51:43.459475 INFO::Creating boxplot for categorical data, diagnosis vs F801
## 2025-03-29 06:51:43.571249 INFO::Creating boxplot for categorical data, diagnosis vs F194
## 2025-03-29 06:51:43.680415 INFO::Creating boxplot for categorical data, diagnosis vs F195
## 2025-03-29 06:51:43.789681 INFO::Creating boxplot for categorical data, diagnosis vs F119
## 2025-03-29 06:51:43.911422 INFO::Creating boxplot for categorical data, diagnosis vs F120
## 2025-03-29 06:51:44.02207 INFO::Creating boxplot for categorical data, diagnosis vs F231
## 2025-03-29 06:51:44.130851 INFO::Creating boxplot for categorical data, diagnosis vs F311
## 2025-03-29 06:51:44.238533 INFO::Creating boxplot for categorical data, diagnosis vs F646
## 2025-03-29 06:51:44.36084 INFO::Creating boxplot for categorical data, diagnosis vs F814
## 2025-03-29 06:51:44.469824 INFO::Creating boxplot for categorical data, diagnosis vs F510
## 2025-03-29 06:51:44.578738 INFO::Creating boxplot for categorical data, diagnosis vs F398
## 2025-03-29 06:51:44.687035 INFO::Creating boxplot for categorical data, diagnosis vs F60
## 2025-03-29 06:51:44.808242 INFO::Creating boxplot for categorical data, diagnosis vs F153
## 2025-03-29 06:51:44.918504 INFO::Creating boxplot for categorical data, diagnosis vs F858
## 2025-03-29 06:51:45.02643 INFO::Creating boxplot for categorical data, diagnosis vs F775
## 2025-03-29 06:51:45.135493 INFO::Creating boxplot for categorical data, diagnosis vs F684
## 2025-03-29 06:51:45.260276 INFO::Creating boxplot for categorical data, diagnosis vs F384
## 2025-03-29 06:51:45.371498 INFO::Creating boxplot for categorical data, diagnosis vs F134
## 2025-03-29 06:51:45.47991 INFO::Creating boxplot for categorical data, diagnosis vs F670
## 2025-03-29 06:51:45.589506 INFO::Creating boxplot for categorical data, diagnosis vs F632
## 2025-03-29 06:51:45.713062 INFO::Creating boxplot for categorical data, diagnosis vs F721
## 2025-03-29 06:51:45.822198 INFO::Creating boxplot for categorical data, diagnosis vs F700
## 2025-03-29 06:51:45.930623 INFO::Creating boxplot for categorical data, diagnosis vs F376
## 2025-03-29 06:51:46.04005 INFO::Creating boxplot for categorical data, diagnosis vs F301
## 2025-03-29 06:51:46.162838 INFO::Creating boxplot for categorical data, diagnosis vs F27
## 2025-03-29 06:51:46.269603 INFO::Creating boxplot for categorical data, diagnosis vs F280
## 2025-03-29 06:51:46.378686 INFO::Creating boxplot for categorical data, diagnosis vs F391
## 2025-03-29 06:51:46.498652 INFO::Creating boxplot for categorical data, diagnosis vs F725
## 2025-03-29 06:51:46.609136 INFO::Creating boxplot for categorical data, diagnosis vs F186
## 2025-03-29 06:51:46.71811 INFO::Creating boxplot for categorical data, diagnosis vs F481
## 2025-03-29 06:51:46.82658 INFO::Creating boxplot for categorical data, diagnosis vs F333
## 2025-03-29 06:51:46.947302 INFO::Creating boxplot for categorical data, diagnosis vs F720
## 2025-03-29 06:51:47.056129 INFO::Creating boxplot for categorical data, diagnosis vs F520
## 2025-03-29 06:51:47.167181 INFO::Creating boxplot for categorical data, diagnosis vs F129
## 2025-03-29 06:51:47.27727 INFO::Creating boxplot for categorical data, diagnosis vs F204
## 2025-03-29 06:51:47.399582 INFO::Creating boxplot for categorical data, diagnosis vs F259
## 2025-03-29 06:51:47.507761 INFO::Creating boxplot for categorical data, diagnosis vs F831
## 2025-03-29 06:51:47.617882 INFO::Creating boxplot for categorical data, diagnosis vs F891
## 2025-03-29 06:51:47.726691 INFO::Creating boxplot for categorical data, diagnosis vs F262
## 2025-03-29 06:51:47.848793 INFO::Creating boxplot for categorical data, diagnosis vs F592
## 2025-03-29 06:51:47.956169 INFO::Creating boxplot for categorical data, diagnosis vs F343
## 2025-03-29 06:51:48.065137 INFO::Creating boxplot for categorical data, diagnosis vs F505
## 2025-03-29 06:51:48.187451 INFO::Creating boxplot for categorical data, diagnosis vs F622
## 2025-03-29 06:51:48.299166 INFO::Creating boxplot for categorical data, diagnosis vs F348
## 2025-03-29 06:51:48.407083 INFO::Creating boxplot for categorical data, diagnosis vs F133
## 2025-03-29 06:51:48.516161 INFO::Creating boxplot for categorical data, diagnosis vs F371
## 2025-03-29 06:51:48.638865 INFO::Creating boxplot for categorical data, diagnosis vs F113
## 2025-03-29 06:51:48.746933 INFO::Creating boxplot for categorical data, diagnosis vs F336
## 2025-03-29 06:51:48.8536 INFO::Creating boxplot for categorical data, diagnosis vs F399
## 2025-03-29 06:51:48.96324 INFO::Creating boxplot for categorical data, diagnosis vs F416
## 2025-03-29 06:51:49.086639 INFO::Creating boxplot for categorical data, diagnosis vs F657
## 2025-03-29 06:51:49.1956 INFO::Creating boxplot for categorical data, diagnosis vs F241
## 2025-03-29 06:51:49.303715 INFO::Creating boxplot for categorical data, diagnosis vs F95
## 2025-03-29 06:51:49.413494 INFO::Creating boxplot for categorical data, diagnosis vs F128
## 2025-03-29 06:51:49.536019 INFO::Creating boxplot for categorical data, diagnosis vs F595
## 2025-03-29 06:51:49.644681 INFO::Creating boxplot for categorical data, diagnosis vs F428
## 2025-03-29 06:51:49.753695 INFO::Creating boxplot for categorical data, diagnosis vs F796
## 2025-03-29 06:51:49.875802 INFO::Creating boxplot for categorical data, diagnosis vs F709
## 2025-03-29 06:51:49.985621 INFO::Creating boxplot for categorical data, diagnosis vs F602
## 2025-03-29 06:51:50.094553 INFO::Creating boxplot for categorical data, diagnosis vs F293
## 2025-03-29 06:51:50.204207 INFO::Creating boxplot for categorical data, diagnosis vs F867
## 2025-03-29 06:51:50.326097 INFO::Creating boxplot for categorical data, diagnosis vs F108
## 2025-03-29 06:51:50.433617 INFO::Creating boxplot for categorical data, diagnosis vs F846
## 2025-03-29 06:51:50.541781 INFO::Creating boxplot for categorical data, diagnosis vs F633
## 2025-03-29 06:51:50.650774 INFO::Creating boxplot for categorical data, diagnosis vs F564
## 2025-03-29 06:51:50.773415 INFO::Creating boxplot for categorical data, diagnosis vs F183
## 2025-03-29 06:51:50.881779 INFO::Creating boxplot for categorical data, diagnosis vs F647
## 2025-03-29 06:51:50.993173 INFO::Creating boxplot for categorical data, diagnosis vs F288
## 2025-03-29 06:51:51.115442 INFO::Creating boxplot for categorical data, diagnosis vs F159
## 2025-03-29 06:51:51.225058 INFO::Creating boxplot for categorical data, diagnosis vs F638
## 2025-03-29 06:51:51.332235 INFO::Creating boxplot for categorical data, diagnosis vs F484
## 2025-03-29 06:51:51.440814 INFO::Creating boxplot for categorical data, diagnosis vs F20
## 2025-03-29 06:51:51.563233 INFO::Creating boxplot for categorical data, diagnosis vs F19
## 2025-03-29 06:51:51.669855 INFO::Creating boxplot for categorical data, diagnosis vs F897
## 2025-03-29 06:51:51.780116 INFO::Creating boxplot for categorical data, diagnosis vs F442
## 2025-03-29 06:51:51.899545 INFO::Creating boxplot for categorical data, diagnosis vs F372
## 2025-03-29 06:51:52.01263 INFO::Creating boxplot for categorical data, diagnosis vs F771
## 2025-03-29 06:51:52.119347 INFO::Creating boxplot for categorical data, diagnosis vs F370
## 2025-03-29 06:51:52.228229 INFO::Creating boxplot for categorical data, diagnosis vs F620
## 2025-03-29 06:51:52.37479 INFO::Creating boxplot for categorical data, diagnosis vs F753
## 2025-03-29 06:51:52.485974 INFO::Creating boxplot for categorical data, diagnosis vs F568
## 2025-03-29 06:51:52.595578 INFO::Creating boxplot for categorical data, diagnosis vs F312
## 2025-03-29 06:51:52.704366 INFO::Creating boxplot for categorical data, diagnosis vs F485
## 2025-03-29 06:51:52.831581 INFO::Creating boxplot for categorical data, diagnosis vs F627
## 2025-03-29 06:51:52.94239 INFO::Creating boxplot for categorical data, diagnosis vs F72
## 2025-03-29 06:51:53.05251 INFO::Creating boxplot for categorical data, diagnosis vs F575
## 2025-03-29 06:51:53.16258 INFO::Creating boxplot for categorical data, diagnosis vs F332
## 2025-03-29 06:51:53.291424 INFO::Creating boxplot for categorical data, diagnosis vs F674
## 2025-03-29 06:51:53.404663 INFO::Creating boxplot for categorical data, diagnosis vs F537
## 2025-03-29 06:51:53.51366 INFO::Creating boxplot for categorical data, diagnosis vs F839
## 2025-03-29 06:51:53.623755 INFO::Creating boxplot for categorical data, diagnosis vs F715
## 2025-03-29 06:51:53.751392 INFO::Creating boxplot for categorical data, diagnosis vs F768
## 2025-03-29 06:51:53.861846 INFO::Creating boxplot for categorical data, diagnosis vs F202
## 2025-03-29 06:51:53.972159 INFO::Creating boxplot for categorical data, diagnosis vs F756
## 2025-03-29 06:51:54.080695 INFO::Creating boxplot for categorical data, diagnosis vs F536
## 2025-03-29 06:51:54.210345 INFO::Creating boxplot for categorical data, diagnosis vs F677
## 2025-03-29 06:51:54.322414 INFO::Creating boxplot for categorical data, diagnosis vs F435
## 2025-03-29 06:51:54.431487 INFO::Creating boxplot for categorical data, diagnosis vs F574
## 2025-03-29 06:51:54.553183 INFO::Creating boxplot for categorical data, diagnosis vs F70
## 2025-03-29 06:51:54.669682 INFO::Creating boxplot for categorical data, diagnosis vs F146
## 2025-03-29 06:51:54.779904 INFO::Creating boxplot for categorical data, diagnosis vs F236
## 2025-03-29 06:51:54.890306 INFO::Creating boxplot for categorical data, diagnosis vs F527
## 2025-03-29 06:51:55.017832 INFO::Creating boxplot for categorical data, diagnosis vs F624
## 2025-03-29 06:51:55.129614 INFO::Creating boxplot for categorical data, diagnosis vs F426
## 2025-03-29 06:51:55.240163 INFO::Creating boxplot for categorical data, diagnosis vs F880
## 2025-03-29 06:51:55.349736 INFO::Creating boxplot for categorical data, diagnosis vs F549
## 2025-03-29 06:51:55.479457 INFO::Creating boxplot for categorical data, diagnosis vs F49
## 2025-03-29 06:51:55.591612 INFO::Creating boxplot for categorical data, diagnosis vs F67
## 2025-03-29 06:51:55.701766 INFO::Creating boxplot for categorical data, diagnosis vs F491
## 2025-03-29 06:51:55.814617 INFO::Creating boxplot for categorical data, diagnosis vs F174
## 2025-03-29 06:51:55.943098 INFO::Creating boxplot for categorical data, diagnosis vs F254
## 2025-03-29 06:51:56.054734 INFO::Creating boxplot for categorical data, diagnosis vs F112
## 2025-03-29 06:51:56.163515 INFO::Creating boxplot for categorical data, diagnosis vs F235
## 2025-03-29 06:51:56.28135 INFO::Creating boxplot for categorical data, diagnosis vs F833
## 2025-03-29 06:51:56.405569 INFO::Creating boxplot for categorical data, diagnosis vs F752
## 2025-03-29 06:51:56.517633 INFO::Creating boxplot for categorical data, diagnosis vs F792
## 2025-03-29 06:51:56.627563 INFO::Creating boxplot for categorical data, diagnosis vs F422
## 2025-03-29 06:51:56.754619 INFO::Creating boxplot for categorical data, diagnosis vs F6
## 2025-03-29 06:51:56.866025 INFO::Creating boxplot for categorical data, diagnosis vs F463
## 2025-03-29 06:51:56.974908 INFO::Creating boxplot for categorical data, diagnosis vs F706
## 2025-03-29 06:51:57.08555 INFO::Creating boxplot for categorical data, diagnosis vs F642
## 2025-03-29 06:51:57.215835 INFO::Creating boxplot for categorical data, diagnosis vs F65
## 2025-03-29 06:51:57.32856 INFO::Creating boxplot for categorical data, diagnosis vs F102
## 2025-03-29 06:51:57.437119 INFO::Creating boxplot for categorical data, diagnosis vs F783
## 2025-03-29 06:51:57.546234 INFO::Creating boxplot for categorical data, diagnosis vs F478
## 2025-03-29 06:51:57.673534 INFO::Creating boxplot for categorical data, diagnosis vs F889
## 2025-03-29 06:51:57.785667 INFO::Creating boxplot for categorical data, diagnosis vs F350
## 2025-03-29 06:51:57.893981 INFO::Creating boxplot for categorical data, diagnosis vs F681
## 2025-03-29 06:51:58.015712 INFO::Creating boxplot for categorical data, diagnosis vs F748
## 2025-03-29 06:51:58.134517 INFO::Creating boxplot for categorical data, diagnosis vs F762
## 2025-03-29 06:51:58.243972 INFO::Creating boxplot for categorical data, diagnosis vs F852
## 2025-03-29 06:51:58.354738 INFO::Creating boxplot for categorical data, diagnosis vs F180
## 2025-03-29 06:51:58.48399 INFO::Creating boxplot for categorical data, diagnosis vs F248
## 2025-03-29 06:51:58.594771 INFO::Creating boxplot for categorical data, diagnosis vs F759
## 2025-03-29 06:51:58.702265 INFO::Creating boxplot for categorical data, diagnosis vs F824
## 2025-03-29 06:51:58.812284 INFO::Creating boxplot for categorical data, diagnosis vs F145
## 2025-03-29 06:51:58.943056 INFO::Creating boxplot for categorical data, diagnosis vs F16
## 2025-03-29 06:51:59.05546 INFO::Creating boxplot for categorical data, diagnosis vs F169
## 2025-03-29 06:51:59.171255 INFO::Creating boxplot for categorical data, diagnosis vs F392
## 2025-03-29 06:51:59.296522 INFO::Creating boxplot for categorical data, diagnosis vs F468
## 2025-03-29 06:51:59.416783 INFO::Creating boxplot for categorical data, diagnosis vs F476
## 2025-03-29 06:51:59.528572 INFO::Creating boxplot for categorical data, diagnosis vs F699
## 2025-03-29 06:51:59.638547 INFO::Creating boxplot for categorical data, diagnosis vs F735
## 2025-03-29 06:51:59.766568 INFO::Creating boxplot for categorical data, diagnosis vs F182
## 2025-03-29 06:51:59.879381 INFO::Creating boxplot for categorical data, diagnosis vs F64
## 2025-03-29 06:51:59.987046 INFO::Creating boxplot for categorical data, diagnosis vs F203
## 2025-03-29 06:52:00.099101 INFO::Creating boxplot for categorical data, diagnosis vs F877
## 2025-03-29 06:52:00.227445 INFO::Creating boxplot for categorical data, diagnosis vs F433
## 2025-03-29 06:52:00.339191 INFO::Creating boxplot for categorical data, diagnosis vs F739
## 2025-03-29 06:52:00.452709 INFO::Creating boxplot for categorical data, diagnosis vs F749
## 2025-03-29 06:52:00.577582 INFO::Creating boxplot for categorical data, diagnosis vs F382
## 2025-03-29 06:52:00.690551 INFO::Creating boxplot for categorical data, diagnosis vs F162
## 2025-03-29 06:52:00.800209 INFO::Creating boxplot for categorical data, diagnosis vs F438
## 2025-03-29 06:52:00.911208 INFO::Creating boxplot for categorical data, diagnosis vs F360
## 2025-03-29 06:52:01.043157 INFO::Creating boxplot for categorical data, diagnosis vs F56
## 2025-03-29 06:52:01.156084 INFO::Creating boxplot for categorical data, diagnosis vs F529
## 2025-03-29 06:52:01.26703 INFO::Creating boxplot for categorical data, diagnosis vs F48
## 2025-03-29 06:52:01.422768 INFO::Creating boxplot for categorical data, diagnosis vs F826
## 2025-03-29 06:52:01.54631 INFO::Creating boxplot for categorical data, diagnosis vs F488
## 2025-03-29 06:52:01.660356 INFO::Creating boxplot for categorical data, diagnosis vs F309
## 2025-03-29 06:52:01.774622 INFO::Creating boxplot for categorical data, diagnosis vs F834
## 2025-03-29 06:52:01.90675 INFO::Creating boxplot for categorical data, diagnosis vs F449
## 2025-03-29 06:52:02.02497 INFO::Creating boxplot for categorical data, diagnosis vs F77
## 2025-03-29 06:52:02.139697 INFO::Creating boxplot for categorical data, diagnosis vs F365
## 2025-03-29 06:52:02.255645 INFO::Creating boxplot for categorical data, diagnosis vs F346
## 2025-03-29 06:52:02.38509 INFO::Creating boxplot for categorical data, diagnosis vs F654
## 2025-03-29 06:52:02.499992 INFO::Creating boxplot for categorical data, diagnosis vs F79
## 2025-03-29 06:52:02.611686 INFO::Creating boxplot for categorical data, diagnosis vs F785
## 2025-03-29 06:52:02.722732 INFO::Creating boxplot for categorical data, diagnosis vs F415
## 2025-03-29 06:52:02.848545 INFO::Creating boxplot for categorical data, diagnosis vs F466
## 2025-03-29 06:52:02.962371 INFO::Creating boxplot for categorical data, diagnosis vs F643
## 2025-03-29 06:52:03.075192 INFO::Creating boxplot for categorical data, diagnosis vs F160
## 2025-03-29 06:52:03.18684 INFO::Creating boxplot for categorical data, diagnosis vs F69
## 2025-03-29 06:52:03.315586 INFO::Creating boxplot for categorical data, diagnosis vs F498
## 2025-03-29 06:52:03.428142 INFO::Creating boxplot for categorical data, diagnosis vs F207
## 2025-03-29 06:52:03.542338 INFO::Creating boxplot for categorical data, diagnosis vs F679
## 2025-03-29 06:52:03.651163 INFO::Creating boxplot for categorical data, diagnosis vs F618
## 2025-03-29 06:52:03.778544 INFO::Creating boxplot for categorical data, diagnosis vs F255
## 2025-03-29 06:52:03.891507 INFO::Creating boxplot for categorical data, diagnosis vs F267
## 2025-03-29 06:52:04.006552 INFO::Creating boxplot for categorical data, diagnosis vs F143
## 2025-03-29 06:52:04.127437 INFO::Creating boxplot for categorical data, diagnosis vs F286
## 2025-03-29 06:52:04.245543 INFO::Creating boxplot for categorical data, diagnosis vs F562
## 2025-03-29 06:52:04.358392 INFO::Creating boxplot for categorical data, diagnosis vs F100
## 2025-03-29 06:52:04.472324 INFO::Creating boxplot for categorical data, diagnosis vs F374
## 2025-03-29 06:52:04.600913 INFO::Creating boxplot for categorical data, diagnosis vs F535
## 2025-03-29 06:52:04.714475 INFO::Creating boxplot for categorical data, diagnosis vs F658
## 2025-03-29 06:52:04.826319 INFO::Creating boxplot for categorical data, diagnosis vs F707
## 2025-03-29 06:52:04.936154 INFO::Creating boxplot for categorical data, diagnosis vs F325
## 2025-03-29 06:52:05.064411 INFO::Creating boxplot for categorical data, diagnosis vs F89
## 2025-03-29 06:52:05.177396 INFO::Creating boxplot for categorical data, diagnosis vs F214
## 2025-03-29 06:52:05.289392 INFO::Creating boxplot for categorical data, diagnosis vs F578
## 2025-03-29 06:52:05.400589 INFO::Creating boxplot for categorical data, diagnosis vs F790
## 2025-03-29 06:52:05.528899 INFO::Creating boxplot for categorical data, diagnosis vs F265
## 2025-03-29 06:52:05.641667 INFO::Creating boxplot for categorical data, diagnosis vs F253
## 2025-03-29 06:52:05.753482 INFO::Creating boxplot for categorical data, diagnosis vs F294
## 2025-03-29 06:52:05.872227 INFO::Creating boxplot for categorical data, diagnosis vs F410
## 2025-03-29 06:52:05.993536 INFO::Creating boxplot for categorical data, diagnosis vs F614
## 2025-03-29 06:52:06.105269 INFO::Creating boxplot for categorical data, diagnosis vs F764
## 2025-03-29 06:52:06.217983 INFO::Creating boxplot for categorical data, diagnosis vs F59
## 2025-03-29 06:52:06.344411 INFO::Creating boxplot for categorical data, diagnosis vs F675
## 2025-03-29 06:52:06.457106 INFO::Creating boxplot for categorical data, diagnosis vs F441
## 2025-03-29 06:52:06.571354 INFO::Creating boxplot for categorical data, diagnosis vs F193
## 2025-03-29 06:52:06.680837 INFO::Creating boxplot for categorical data, diagnosis vs F689
## 2025-03-29 06:52:06.80961 INFO::Creating boxplot for categorical data, diagnosis vs F249
## 2025-03-29 06:52:06.921718 INFO::Creating boxplot for categorical data, diagnosis vs F821
## 2025-03-29 06:52:07.035788 INFO::Creating boxplot for categorical data, diagnosis vs F351
## 2025-03-29 06:52:07.146416 INFO::Creating boxplot for categorical data, diagnosis vs F66
## 2025-03-29 06:52:07.278261 INFO::Creating boxplot for categorical data, diagnosis vs F413
## 2025-03-29 06:52:07.391197 INFO::Creating boxplot for categorical data, diagnosis vs F172
## 2025-03-29 06:52:07.503904 INFO::Creating boxplot for categorical data, diagnosis vs F317
## 2025-03-29 06:52:07.631979 INFO::Creating boxplot for categorical data, diagnosis vs F167
## 2025-03-29 06:52:07.746469 INFO::Creating boxplot for categorical data, diagnosis vs F229
## 2025-03-29 06:52:07.858829 INFO::Creating boxplot for categorical data, diagnosis vs F243
## 2025-03-29 06:52:07.971394 INFO::Creating boxplot for categorical data, diagnosis vs F732
## 2025-03-29 06:52:08.100142 INFO::Creating boxplot for categorical data, diagnosis vs F467
## 2025-03-29 06:52:08.212035 INFO::Creating boxplot for categorical data, diagnosis vs F474
## 2025-03-29 06:52:08.32549 INFO::Creating boxplot for categorical data, diagnosis vs F156
## 2025-03-29 06:52:08.436049 INFO::Creating boxplot for categorical data, diagnosis vs F786
## 2025-03-29 06:52:08.564799 INFO::Creating boxplot for categorical data, diagnosis vs F216
## 2025-03-29 06:52:08.676675 INFO::Creating boxplot for categorical data, diagnosis vs F85
## 2025-03-29 06:52:08.788288 INFO::Creating boxplot for categorical data, diagnosis vs F621
## 2025-03-29 06:52:08.914979 INFO::Creating boxplot for categorical data, diagnosis vs F558
## 2025-03-29 06:52:09.028756 INFO::Creating boxplot for categorical data, diagnosis vs F582
## 2025-03-29 06:52:09.140711 INFO::Creating boxplot for categorical data, diagnosis vs F898
## 2025-03-29 06:52:09.252181 INFO::Creating boxplot for categorical data, diagnosis vs F402
## 2025-03-29 06:52:09.38315 INFO::Creating boxplot for categorical data, diagnosis vs F71
## 2025-03-29 06:52:09.495067 INFO::Creating boxplot for categorical data, diagnosis vs F99
## 2025-03-29 06:52:09.610692 INFO::Creating boxplot for categorical data, diagnosis vs F366
## 2025-03-29 06:52:09.731428 INFO::Creating boxplot for categorical data, diagnosis vs F778
## 2025-03-29 06:52:09.847274 INFO::Creating boxplot for categorical data, diagnosis vs F188
## 2025-03-29 06:52:09.959071 INFO::Creating boxplot for categorical data, diagnosis vs F857
## 2025-03-29 06:52:10.06944 INFO::Creating boxplot for categorical data, diagnosis vs F440
## 2025-03-29 06:52:10.19805 INFO::Creating boxplot for categorical data, diagnosis vs F799
## 2025-03-29 06:52:10.310765 INFO::Creating boxplot for categorical data, diagnosis vs F482
## 2025-03-29 06:52:10.421168 INFO::Creating boxplot for categorical data, diagnosis vs F212
## 2025-03-29 06:52:10.530314 INFO::Creating boxplot for categorical data, diagnosis vs F882
## 2025-03-29 06:52:10.687356 INFO::Creating boxplot for categorical data, diagnosis vs F599
## 2025-03-29 06:52:10.80067 INFO::Creating boxplot for categorical data, diagnosis vs F302
## 2025-03-29 06:52:10.913072 INFO::Creating boxplot for categorical data, diagnosis vs F543
## 2025-03-29 06:52:11.034446 INFO::Creating boxplot for categorical data, diagnosis vs F269
## 2025-03-29 06:52:11.162474 INFO::Creating boxplot for categorical data, diagnosis vs F650
## 2025-03-29 06:52:11.275278 INFO::Creating boxplot for categorical data, diagnosis vs F456
## 2025-03-29 06:52:11.388895 INFO::Creating boxplot for categorical data, diagnosis vs F573
## 2025-03-29 06:52:11.517919 INFO::Creating boxplot for categorical data, diagnosis vs F8
## 2025-03-29 06:52:11.638286 INFO::Creating boxplot for categorical data, diagnosis vs F810
## 2025-03-29 06:52:11.750865 INFO::Creating boxplot for categorical data, diagnosis vs F401
## 2025-03-29 06:52:11.865206 INFO::Creating boxplot for categorical data, diagnosis vs F606
## 2025-03-29 06:52:11.997818 INFO::Creating boxplot for categorical data, diagnosis vs F662
## 2025-03-29 06:52:12.111882 INFO::Creating boxplot for categorical data, diagnosis vs F765
## 2025-03-29 06:52:12.223586 INFO::Creating boxplot for categorical data, diagnosis vs F887
## 2025-03-29 06:52:12.337458 INFO::Creating boxplot for categorical data, diagnosis vs F770
## 2025-03-29 06:52:12.469731 INFO::Creating boxplot for categorical data, diagnosis vs F469
## 2025-03-29 06:52:12.584707 INFO::Creating boxplot for categorical data, diagnosis vs F86
## 2025-03-29 06:52:12.699442 INFO::Creating boxplot for categorical data, diagnosis vs F400
## 2025-03-29 06:52:12.812435 INFO::Creating boxplot for categorical data, diagnosis vs F579
## 2025-03-29 06:52:12.947537 INFO::Creating boxplot for categorical data, diagnosis vs F871
## 2025-03-29 06:52:13.060834 INFO::Creating boxplot for categorical data, diagnosis vs F37
## 2025-03-29 06:52:13.174273 INFO::Creating boxplot for categorical data, diagnosis vs F446
## 2025-03-29 06:52:13.287743 INFO::Creating boxplot for categorical data, diagnosis vs F218
## 2025-03-29 06:52:13.423961 INFO::Creating boxplot for categorical data, diagnosis vs F321
## 2025-03-29 06:52:13.536308 INFO::Creating boxplot for categorical data, diagnosis vs F487
## 2025-03-29 06:52:13.655686 INFO::Creating boxplot for categorical data, diagnosis vs F740
## 2025-03-29 06:52:13.786186 INFO::Creating boxplot for categorical data, diagnosis vs F141
## 2025-03-29 06:52:13.902187 INFO::Creating boxplot for categorical data, diagnosis vs F327
## 2025-03-29 06:52:14.014475 INFO::Creating boxplot for categorical data, diagnosis vs F196
## 2025-03-29 06:52:14.130694 INFO::Creating boxplot for categorical data, diagnosis vs F883
## 2025-03-29 06:52:14.264534 INFO::Creating boxplot for categorical data, diagnosis vs F279
## 2025-03-29 06:52:14.379052 INFO::Creating boxplot for categorical data, diagnosis vs F838
## 2025-03-29 06:52:14.492978 INFO::Creating boxplot for categorical data, diagnosis vs F451
## 2025-03-29 06:52:14.612372 INFO::Creating boxplot for categorical data, diagnosis vs F854
## 2025-03-29 06:52:14.748182 INFO::Creating boxplot for categorical data, diagnosis vs F434
## 2025-03-29 06:52:14.861661 INFO::Creating boxplot for categorical data, diagnosis vs F519
## 2025-03-29 06:52:14.973792 INFO::Creating boxplot for categorical data, diagnosis vs F694
## 2025-03-29 06:52:15.087862 INFO::Creating boxplot for categorical data, diagnosis vs F561
## 2025-03-29 06:52:15.225011 INFO::Creating boxplot for categorical data, diagnosis vs F10
## 2025-03-29 06:52:15.338952 INFO::Creating boxplot for categorical data, diagnosis vs F303
## 2025-03-29 06:52:15.453505 INFO::Creating boxplot for categorical data, diagnosis vs F512
## 2025-03-29 06:52:15.587126 INFO::Creating boxplot for categorical data, diagnosis vs F645
## 2025-03-29 06:52:15.701633 INFO::Creating boxplot for categorical data, diagnosis vs F793
## 2025-03-29 06:52:15.815246 INFO::Creating boxplot for categorical data, diagnosis vs F404
## 2025-03-29 06:52:15.928477 INFO::Creating boxplot for categorical data, diagnosis vs F362
## 2025-03-29 06:52:16.06357 INFO::Creating boxplot for categorical data, diagnosis vs F525
## 2025-03-29 06:52:16.176072 INFO::Creating boxplot for categorical data, diagnosis vs F742
## 2025-03-29 06:52:16.289138 INFO::Creating boxplot for categorical data, diagnosis vs F276
## 2025-03-29 06:52:16.402442 INFO::Creating boxplot for categorical data, diagnosis vs F499
## 2025-03-29 06:52:16.537661 INFO::Creating boxplot for categorical data, diagnosis vs F328
## 2025-03-29 06:52:16.659027 INFO::Creating boxplot for categorical data, diagnosis vs F787
## 2025-03-29 06:52:16.773894 INFO::Creating boxplot for categorical data, diagnosis vs F30
## 2025-03-29 06:52:16.905302 INFO::Creating boxplot for categorical data, diagnosis vs F122
## 2025-03-29 06:52:17.023281 INFO::Creating boxplot for categorical data, diagnosis vs F619
## 2025-03-29 06:52:17.137976 INFO::Creating boxplot for categorical data, diagnosis vs F572
## 2025-03-29 06:52:17.252309 INFO::Creating boxplot for categorical data, diagnosis vs F47
## 2025-03-29 06:52:17.387761 INFO::Creating boxplot for categorical data, diagnosis vs F570
## 2025-03-29 06:52:17.499936 INFO::Creating boxplot for categorical data, diagnosis vs F26
## 2025-03-29 06:52:17.613065 INFO::Creating boxplot for categorical data, diagnosis vs F252
## 2025-03-29 06:52:17.727224 INFO::Creating boxplot for categorical data, diagnosis vs F117
## 2025-03-29 06:52:17.862806 INFO::Creating boxplot for categorical data, diagnosis vs F683
## 2025-03-29 06:52:17.975333 INFO::Creating boxplot for categorical data, diagnosis vs F395
## 2025-03-29 06:52:18.089622 INFO::Creating boxplot for categorical data, diagnosis vs F822
## 2025-03-29 06:52:18.222242 INFO::Creating boxplot for categorical data, diagnosis vs F46
## 2025-03-29 06:52:18.334385 INFO::Creating boxplot for categorical data, diagnosis vs F154
## 2025-03-29 06:52:18.44835 INFO::Creating boxplot for categorical data, diagnosis vs F540
## 2025-03-29 06:52:18.562466 INFO::Creating boxplot for categorical data, diagnosis vs F884
## 2025-03-29 06:52:18.701667 INFO::Creating boxplot for categorical data, diagnosis vs F368
## 2025-03-29 06:52:18.81489 INFO::Creating boxplot for categorical data, diagnosis vs F607
## 2025-03-29 06:52:18.929299 INFO::Creating boxplot for categorical data, diagnosis vs F111
## 2025-03-29 06:52:19.055418 INFO::Creating boxplot for categorical data, diagnosis vs F745
## 2025-03-29 06:52:19.180123 INFO::Creating boxplot for categorical data, diagnosis vs F673
## 2025-03-29 06:52:19.294971 INFO::Creating boxplot for categorical data, diagnosis vs F92
## 2025-03-29 06:52:19.408946 INFO::Creating boxplot for categorical data, diagnosis vs F493
## 2025-03-29 06:52:19.545331 INFO::Creating boxplot for categorical data, diagnosis vs F835
## 2025-03-29 06:52:19.660488 INFO::Creating boxplot for categorical data, diagnosis vs F872
## 2025-03-29 06:52:19.77491 INFO::Creating boxplot for categorical data, diagnosis vs F879
## 2025-03-29 06:52:19.885972 INFO::Creating boxplot for categorical data, diagnosis vs F432
## 2025-03-29 06:52:20.052778 INFO::Creating boxplot for categorical data, diagnosis vs F518
## 2025-03-29 06:52:20.165104 INFO::Creating boxplot for categorical data, diagnosis vs F44
## 2025-03-29 06:52:20.279265 INFO::Creating boxplot for categorical data, diagnosis vs F240
## 2025-03-29 06:52:20.406799 INFO::Creating boxplot for categorical data, diagnosis vs F819
## 2025-03-29 06:52:20.529806 INFO::Creating boxplot for categorical data, diagnosis vs F411
## 2025-03-29 06:52:20.644341 INFO::Creating boxplot for categorical data, diagnosis vs F353
## 2025-03-29 06:52:20.762404 INFO::Creating boxplot for categorical data, diagnosis vs F763
## 2025-03-29 06:52:20.89422 INFO::Creating boxplot for categorical data, diagnosis vs F97
## 2025-03-29 06:52:21.007656 INFO::Creating boxplot for categorical data, diagnosis vs F40
## 2025-03-29 06:52:21.12267 INFO::Creating boxplot for categorical data, diagnosis vs F652
## 2025-03-29 06:52:21.238671 INFO::Creating boxplot for categorical data, diagnosis vs F789
## 2025-03-29 06:52:21.373473 INFO::Creating boxplot for categorical data, diagnosis vs F25
## 2025-03-29 06:52:21.486626 INFO::Creating boxplot for categorical data, diagnosis vs F256
## 2025-03-29 06:52:21.600678 INFO::Creating boxplot for categorical data, diagnosis vs F423
## 2025-03-29 06:52:21.72201 INFO::Creating boxplot for categorical data, diagnosis vs F594
## 2025-03-29 06:52:21.85647 INFO::Creating boxplot for categorical data, diagnosis vs F201
## 2025-03-29 06:52:21.969857 INFO::Creating boxplot for categorical data, diagnosis vs F813
## 2025-03-29 06:52:22.085772 INFO::Creating boxplot for categorical data, diagnosis vs F653
## 2025-03-29 06:52:22.199404 INFO::Creating boxplot for categorical data, diagnosis vs F524
## 2025-03-29 06:52:22.331541 INFO::Creating boxplot for categorical data, diagnosis vs F777
## 2025-03-29 06:52:22.445501 INFO::Creating boxplot for categorical data, diagnosis vs F226
## 2025-03-29 06:52:22.560561 INFO::Creating boxplot for categorical data, diagnosis vs F227
## 2025-03-29 06:52:22.68726 INFO::Creating boxplot for categorical data, diagnosis vs F521
## 2025-03-29 06:52:22.807855 INFO::Creating boxplot for categorical data, diagnosis vs F14
## 2025-03-29 06:52:22.920356 INFO::Creating boxplot for categorical data, diagnosis vs F310
## 2025-03-29 06:52:23.037924 INFO::Creating boxplot for categorical data, diagnosis vs F452
## 2025-03-29 06:52:23.172307 INFO::Creating boxplot for categorical data, diagnosis vs F52
## 2025-03-29 06:52:23.287904 INFO::Creating boxplot for categorical data, diagnosis vs F53
## 2025-03-29 06:52:23.406183 INFO::Creating boxplot for categorical data, diagnosis vs F844
## 2025-03-29 06:52:23.523284 INFO::Creating boxplot for categorical data, diagnosis vs F31
## 2025-03-29 06:52:23.658224 INFO::Creating boxplot for categorical data, diagnosis vs F795
## 2025-03-29 06:52:23.77359 INFO::Creating boxplot for categorical data, diagnosis vs F766
## 2025-03-29 06:52:23.887759 INFO::Creating boxplot for categorical data, diagnosis vs F342
## 2025-03-29 06:52:24.002427 INFO::Creating boxplot for categorical data, diagnosis vs F408
## 2025-03-29 06:52:24.137468 INFO::Creating boxplot for categorical data, diagnosis vs F282
## 2025-03-29 06:52:24.250136 INFO::Creating boxplot for categorical data, diagnosis vs F508
## 2025-03-29 06:52:24.369099 INFO::Creating boxplot for categorical data, diagnosis vs F805
## 2025-03-29 06:52:24.499814 INFO::Creating boxplot for categorical data, diagnosis vs F337
## 2025-03-29 06:52:24.617683 INFO::Creating boxplot for categorical data, diagnosis vs F820
## 2025-03-29 06:52:24.732435 INFO::Creating boxplot for categorical data, diagnosis vs F593
## 2025-03-29 06:52:24.850961 INFO::Creating boxplot for categorical data, diagnosis vs F701
## 2025-03-29 06:52:24.985316 INFO::Creating boxplot for categorical data, diagnosis vs F459
## 2025-03-29 06:52:25.099885 INFO::Creating boxplot for categorical data, diagnosis vs F305
## 2025-03-29 06:52:25.215168 INFO::Creating boxplot for categorical data, diagnosis vs F142
## 2025-03-29 06:52:25.329955 INFO::Creating boxplot for categorical data, diagnosis vs F534
## 2025-03-29 06:52:25.467111 INFO::Creating boxplot for categorical data, diagnosis vs F135
## 2025-03-29 06:52:25.582037 INFO::Creating boxplot for categorical data, diagnosis vs F702
## 2025-03-29 06:52:25.697631 INFO::Creating boxplot for categorical data, diagnosis vs F776
## 2025-03-29 06:52:25.828908 INFO::Creating boxplot for categorical data, diagnosis vs F295
## 2025-03-29 06:52:25.948263 INFO::Creating boxplot for categorical data, diagnosis vs F355
## 2025-03-29 06:52:26.061641 INFO::Creating boxplot for categorical data, diagnosis vs F797
## 2025-03-29 06:52:26.177767 INFO::Creating boxplot for categorical data, diagnosis vs F13
## 2025-03-29 06:52:26.310712 INFO::Creating boxplot for categorical data, diagnosis vs F356
## 2025-03-29 06:52:26.425747 INFO::Creating boxplot for categorical data, diagnosis vs F359
## 2025-03-29 06:52:26.539006 INFO::Creating boxplot for categorical data, diagnosis vs F121
## 2025-03-29 06:52:26.653009 INFO::Creating boxplot for categorical data, diagnosis vs F850
## 2025-03-29 06:52:26.790799 INFO::Creating boxplot for categorical data, diagnosis vs F899
## 2025-03-29 06:52:26.904144 INFO::Creating boxplot for categorical data, diagnosis vs F628
## 2025-03-29 06:52:27.018482 INFO::Creating boxplot for categorical data, diagnosis vs F843
## 2025-03-29 06:52:27.149005 INFO::Creating boxplot for categorical data, diagnosis vs F107
## 2025-03-29 06:52:27.263984 INFO::Creating boxplot for categorical data, diagnosis vs F287
## 2025-03-29 06:52:27.378278 INFO::Creating boxplot for categorical data, diagnosis vs F165
## 2025-03-29 06:52:27.491026 INFO::Creating boxplot for categorical data, diagnosis vs F557
## 2025-03-29 06:52:27.623746 INFO::Creating boxplot for categorical data, diagnosis vs F127
## 2025-03-29 06:52:27.736791 INFO::Creating boxplot for categorical data, diagnosis vs F299
## 2025-03-29 06:52:27.852294 INFO::Creating boxplot for categorical data, diagnosis vs F497
## 2025-03-29 06:52:27.966275 INFO::Creating boxplot for categorical data, diagnosis vs F711
## 2025-03-29 06:52:28.10059 INFO::Creating boxplot for categorical data, diagnosis vs F319
## 2025-03-29 06:52:28.212472 INFO::Creating boxplot for categorical data, diagnosis vs F271
## 2025-03-29 06:52:28.326232 INFO::Creating boxplot for categorical data, diagnosis vs F157
## 2025-03-29 06:52:28.457006 INFO::Creating boxplot for categorical data, diagnosis vs F560
## 2025-03-29 06:52:28.57169 INFO::Creating boxplot for categorical data, diagnosis vs F680
## 2025-03-29 06:52:28.685804 INFO::Creating boxplot for categorical data, diagnosis vs F580
## 2025-03-29 06:52:28.803796 INFO::Creating boxplot for categorical data, diagnosis vs F152
## 2025-03-29 06:52:28.936231 INFO::Creating boxplot for categorical data, diagnosis vs F12
## 2025-03-29 06:52:29.049835 INFO::Creating boxplot for categorical data, diagnosis vs F324
## 2025-03-29 06:52:29.166361 INFO::Creating boxplot for categorical data, diagnosis vs F893
## 2025-03-29 06:52:29.808474 INFO::Creating boxplot for categorical data, diagnosis vs F318
## 2025-03-29 06:52:29.915425 INFO::Creating boxplot for categorical data, diagnosis vs F784
## 2025-03-29 06:52:30.021702 INFO::Creating boxplot for categorical data, diagnosis vs F567
## 2025-03-29 06:52:30.128969 INFO::Creating boxplot for categorical data, diagnosis vs F457
## 2025-03-29 06:52:30.243056 INFO::Creating boxplot for categorical data, diagnosis vs F708
## 2025-03-29 06:52:30.349436 INFO::Creating boxplot for categorical data, diagnosis vs F669
## 2025-03-29 06:52:30.455605 INFO::Creating boxplot for categorical data, diagnosis vs F87
## 2025-03-29 06:52:31.913828 INFO::Plotting data for metadata number 2, antibiotics
## 2025-03-29 06:52:31.915065 INFO::Creating boxplot for categorical data, antibiotics vs F663
## 2025-03-29 06:52:32.028017 INFO::Creating boxplot for categorical data, antibiotics vs F838
## 2025-03-29 06:52:32.142348 INFO::Creating boxplot for categorical data, antibiotics vs F764
## 2025-03-29 06:52:32.257251 INFO::Creating boxplot for categorical data, antibiotics vs F880
## 2025-03-29 06:52:32.377773 INFO::Creating boxplot for categorical data, antibiotics vs F751
## 2025-03-29 06:52:32.491496 INFO::Creating boxplot for categorical data, antibiotics vs F288
## 2025-03-29 06:52:32.605099 INFO::Creating boxplot for categorical data, antibiotics vs F65
## 2025-03-29 06:52:32.726125 INFO::Creating boxplot for categorical data, antibiotics vs F742
## 2025-03-29 06:52:32.839884 INFO::Creating boxplot for categorical data, antibiotics vs F528
## 2025-03-29 06:52:32.958279 INFO::Creating boxplot for categorical data, antibiotics vs F790
## 2025-03-29 06:52:33.073013 INFO::Creating boxplot for categorical data, antibiotics vs F777
## 2025-03-29 06:52:33.194285 INFO::Creating boxplot for categorical data, antibiotics vs F178
## 2025-03-29 06:52:33.30822 INFO::Creating boxplot for categorical data, antibiotics vs F139
## 2025-03-29 06:52:33.422201 INFO::Creating boxplot for categorical data, antibiotics vs F202
## 2025-03-29 06:52:33.544717 INFO::Creating boxplot for categorical data, antibiotics vs F220
## 2025-03-29 06:52:33.658984 INFO::Creating boxplot for categorical data, antibiotics vs F397
## 2025-03-29 06:52:33.773424 INFO::Creating boxplot for categorical data, antibiotics vs F882
## 2025-03-29 06:52:33.891988 INFO::Creating boxplot for categorical data, antibiotics vs F446
## 2025-03-29 06:52:34.013062 INFO::Creating boxplot for categorical data, antibiotics vs F418
## 2025-03-29 06:52:34.129861 INFO::Creating boxplot for categorical data, antibiotics vs F133
## 2025-03-29 06:52:34.244091 INFO::Creating boxplot for categorical data, antibiotics vs F696
## 2025-03-29 06:52:34.366705 INFO::Creating boxplot for categorical data, antibiotics vs F548
## 2025-03-29 06:52:34.480995 INFO::Creating boxplot for categorical data, antibiotics vs F536
## 2025-03-29 06:52:34.595698 INFO::Creating boxplot for categorical data, antibiotics vs F194
## 2025-03-29 06:52:34.711318 INFO::Creating boxplot for categorical data, antibiotics vs F34
## 2025-03-29 06:52:34.832792 INFO::Creating boxplot for categorical data, antibiotics vs F153
## 2025-03-29 06:52:34.952227 INFO::Creating boxplot for categorical data, antibiotics vs F400
## 2025-03-29 06:52:35.067492 INFO::Creating boxplot for categorical data, antibiotics vs F794
## 2025-03-29 06:52:35.189788 INFO::Creating boxplot for categorical data, antibiotics vs F396
## 2025-03-29 06:52:35.303887 INFO::Creating boxplot for categorical data, antibiotics vs F182
## 2025-03-29 06:52:35.419211 INFO::Creating boxplot for categorical data, antibiotics vs F719
## 2025-03-29 06:52:35.534993 INFO::Creating boxplot for categorical data, antibiotics vs F109
## 2025-03-29 06:52:35.655726 INFO::Creating boxplot for categorical data, antibiotics vs F180
## 2025-03-29 06:52:35.769559 INFO::Creating boxplot for categorical data, antibiotics vs F552
## 2025-03-29 06:52:35.883708 INFO::Creating boxplot for categorical data, antibiotics vs F789
## 2025-03-29 06:52:36.011022 INFO::Creating boxplot for categorical data, antibiotics vs F893
## 2025-03-29 06:52:36.127737 INFO::Creating boxplot for categorical data, antibiotics vs F834
## 2025-03-29 06:52:36.242641 INFO::Creating boxplot for categorical data, antibiotics vs F889
## 2025-03-29 06:52:36.358776 INFO::Creating boxplot for categorical data, antibiotics vs F143
## 2025-03-29 06:52:36.479103 INFO::Creating boxplot for categorical data, antibiotics vs F224
## 2025-03-29 06:52:36.594436 INFO::Creating boxplot for categorical data, antibiotics vs F5
## 2025-03-29 06:52:36.708454 INFO::Creating boxplot for categorical data, antibiotics vs F873
## 2025-03-29 06:52:36.83222 INFO::Creating boxplot for categorical data, antibiotics vs F452
## 2025-03-29 06:52:36.952738 INFO::Creating boxplot for categorical data, antibiotics vs F681
## 2025-03-29 06:52:37.066487 INFO::Creating boxplot for categorical data, antibiotics vs F468
## 2025-03-29 06:52:37.189925 INFO::Creating boxplot for categorical data, antibiotics vs F731
## 2025-03-29 06:52:37.305947 INFO::Creating boxplot for categorical data, antibiotics vs F479
## 2025-03-29 06:52:37.420336 INFO::Creating boxplot for categorical data, antibiotics vs F520
## 2025-03-29 06:52:37.538829 INFO::Creating boxplot for categorical data, antibiotics vs F649
## 2025-03-29 06:52:37.661274 INFO::Creating boxplot for categorical data, antibiotics vs F259
## 2025-03-29 06:52:37.776413 INFO::Creating boxplot for categorical data, antibiotics vs F186
## 2025-03-29 06:52:37.891708 INFO::Creating boxplot for categorical data, antibiotics vs F312
## 2025-03-29 06:52:38.018128 INFO::Creating boxplot for categorical data, antibiotics vs F477
## 2025-03-29 06:52:38.133514 INFO::Creating boxplot for categorical data, antibiotics vs F4
## 2025-03-29 06:52:38.248976 INFO::Creating boxplot for categorical data, antibiotics vs F632
## 2025-03-29 06:52:38.372209 INFO::Creating boxplot for categorical data, antibiotics vs F31
## 2025-03-29 06:52:38.486801 INFO::Creating boxplot for categorical data, antibiotics vs F184
## 2025-03-29 06:52:38.601936 INFO::Creating boxplot for categorical data, antibiotics vs F7
## 2025-03-29 06:52:38.716263 INFO::Creating boxplot for categorical data, antibiotics vs F213
## 2025-03-29 06:52:38.877118 INFO::Creating boxplot for categorical data, antibiotics vs F691
## 2025-03-29 06:52:38.993694 INFO::Creating boxplot for categorical data, antibiotics vs F828
## 2025-03-29 06:52:39.110506 INFO::Creating boxplot for categorical data, antibiotics vs F831
## 2025-03-29 06:52:39.23948 INFO::Creating boxplot for categorical data, antibiotics vs F315
## 2025-03-29 06:52:39.358775 INFO::Creating boxplot for categorical data, antibiotics vs F159
## 2025-03-29 06:52:39.473214 INFO::Creating boxplot for categorical data, antibiotics vs F331
## 2025-03-29 06:52:39.59134 INFO::Creating boxplot for categorical data, antibiotics vs F757
## 2025-03-29 06:52:39.721709 INFO::Creating boxplot for categorical data, antibiotics vs F167
## 2025-03-29 06:52:39.83998 INFO::Creating boxplot for categorical data, antibiotics vs F85
## 2025-03-29 06:52:39.956745 INFO::Creating boxplot for categorical data, antibiotics vs F80
## 2025-03-29 06:52:40.073557 INFO::Creating boxplot for categorical data, antibiotics vs F105
## 2025-03-29 06:52:40.204281 INFO::Creating boxplot for categorical data, antibiotics vs F674
## 2025-03-29 06:52:40.319649 INFO::Creating boxplot for categorical data, antibiotics vs F50
## 2025-03-29 06:52:40.436328 INFO::Creating boxplot for categorical data, antibiotics vs F164
## 2025-03-29 06:52:40.564299 INFO::Creating boxplot for categorical data, antibiotics vs F840
## 2025-03-29 06:52:40.682334 INFO::Creating boxplot for categorical data, antibiotics vs F232
## 2025-03-29 06:52:40.798763 INFO::Creating boxplot for categorical data, antibiotics vs F872
## 2025-03-29 06:52:40.917107 INFO::Creating boxplot for categorical data, antibiotics vs F54
## 2025-03-29 06:52:41.05003 INFO::Creating boxplot for categorical data, antibiotics vs F365
## 2025-03-29 06:52:41.16686 INFO::Creating boxplot for categorical data, antibiotics vs F499
## 2025-03-29 06:52:41.283537 INFO::Creating boxplot for categorical data, antibiotics vs F510
## 2025-03-29 06:52:41.413673 INFO::Creating boxplot for categorical data, antibiotics vs F716
## 2025-03-29 06:52:41.531479 INFO::Creating boxplot for categorical data, antibiotics vs F454
## 2025-03-29 06:52:41.647788 INFO::Creating boxplot for categorical data, antibiotics vs F52
## 2025-03-29 06:52:41.764898 INFO::Creating boxplot for categorical data, antibiotics vs F273
## 2025-03-29 06:52:41.895992 INFO::Creating boxplot for categorical data, antibiotics vs F474
## 2025-03-29 06:52:42.014958 INFO::Creating boxplot for categorical data, antibiotics vs F267
## 2025-03-29 06:52:42.131349 INFO::Creating boxplot for categorical data, antibiotics vs F253
## 2025-03-29 06:52:42.26026 INFO::Creating boxplot for categorical data, antibiotics vs F247
## 2025-03-29 06:52:42.378099 INFO::Creating boxplot for categorical data, antibiotics vs F708
## 2025-03-29 06:52:42.493317 INFO::Creating boxplot for categorical data, antibiotics vs F438
## 2025-03-29 06:52:42.610059 INFO::Creating boxplot for categorical data, antibiotics vs F450
## 2025-03-29 06:52:42.740233 INFO::Creating boxplot for categorical data, antibiotics vs F666
## 2025-03-29 06:52:42.856028 INFO::Creating boxplot for categorical data, antibiotics vs F720
## 2025-03-29 06:52:42.971481 INFO::Creating boxplot for categorical data, antibiotics vs F48
## 2025-03-29 06:52:43.10312 INFO::Creating boxplot for categorical data, antibiotics vs F371
## 2025-03-29 06:52:43.220941 INFO::Creating boxplot for categorical data, antibiotics vs F423
## 2025-03-29 06:52:43.33877 INFO::Creating boxplot for categorical data, antibiotics vs F190
## 2025-03-29 06:52:43.463048 INFO::Creating boxplot for categorical data, antibiotics vs F351
## 2025-03-29 06:52:43.585557 INFO::Creating boxplot for categorical data, antibiotics vs F394
## 2025-03-29 06:52:43.699153 INFO::Creating boxplot for categorical data, antibiotics vs F581
## 2025-03-29 06:52:43.816636 INFO::Creating boxplot for categorical data, antibiotics vs F276
## 2025-03-29 06:52:43.94861 INFO::Creating boxplot for categorical data, antibiotics vs F608
## 2025-03-29 06:52:44.071602 INFO::Creating boxplot for categorical data, antibiotics vs F28
## 2025-03-29 06:52:44.189127 INFO::Creating boxplot for categorical data, antibiotics vs F805
## 2025-03-29 06:52:44.317595 INFO::Creating boxplot for categorical data, antibiotics vs F249
## 2025-03-29 06:52:44.436539 INFO::Creating boxplot for categorical data, antibiotics vs F776
## 2025-03-29 06:52:44.551787 INFO::Creating boxplot for categorical data, antibiotics vs F755
## 2025-03-29 06:52:44.669435 INFO::Creating boxplot for categorical data, antibiotics vs F68
## 2025-03-29 06:52:44.801163 INFO::Creating boxplot for categorical data, antibiotics vs F78
## 2025-03-29 06:52:44.916561 INFO::Creating boxplot for categorical data, antibiotics vs F381
## 2025-03-29 06:52:45.039149 INFO::Creating boxplot for categorical data, antibiotics vs F644
## 2025-03-29 06:52:45.170135 INFO::Creating boxplot for categorical data, antibiotics vs F358
## 2025-03-29 06:52:45.287403 INFO::Creating boxplot for categorical data, antibiotics vs F344
## 2025-03-29 06:52:45.401996 INFO::Creating boxplot for categorical data, antibiotics vs F209
## 2025-03-29 06:52:45.519915 INFO::Creating boxplot for categorical data, antibiotics vs F898
## 2025-03-29 06:52:45.650541 INFO::Creating boxplot for categorical data, antibiotics vs F51
## 2025-03-29 06:52:45.766362 INFO::Creating boxplot for categorical data, antibiotics vs F149
## 2025-03-29 06:52:45.883276 INFO::Creating boxplot for categorical data, antibiotics vs F108
## 2025-03-29 06:52:46.013025 INFO::Creating boxplot for categorical data, antibiotics vs F255
## 2025-03-29 06:52:46.129134 INFO::Creating boxplot for categorical data, antibiotics vs F823
## 2025-03-29 06:52:46.246135 INFO::Creating boxplot for categorical data, antibiotics vs F864
## 2025-03-29 06:52:46.375221 INFO::Creating boxplot for categorical data, antibiotics vs F214
## 2025-03-29 06:52:46.493349 INFO::Creating boxplot for categorical data, antibiotics vs F76
## 2025-03-29 06:52:46.610299 INFO::Creating boxplot for categorical data, antibiotics vs F575
## 2025-03-29 06:52:46.728103 INFO::Creating boxplot for categorical data, antibiotics vs F13
## 2025-03-29 06:52:46.857222 INFO::Creating boxplot for categorical data, antibiotics vs F389
## 2025-03-29 06:52:46.972511 INFO::Creating boxplot for categorical data, antibiotics vs F556
## 2025-03-29 06:52:47.095761 INFO::Creating boxplot for categorical data, antibiotics vs F49
## 2025-03-29 06:52:47.226106 INFO::Creating boxplot for categorical data, antibiotics vs F436
## 2025-03-29 06:52:47.342523 INFO::Creating boxplot for categorical data, antibiotics vs F378
## 2025-03-29 06:52:47.459612 INFO::Creating boxplot for categorical data, antibiotics vs F682
## 2025-03-29 06:52:47.616753 INFO::Creating boxplot for categorical data, antibiotics vs F47
## 2025-03-29 06:52:47.736035 INFO::Creating boxplot for categorical data, antibiotics vs F429
## 2025-03-29 06:52:47.853179 INFO::Creating boxplot for categorical data, antibiotics vs F588
## 2025-03-29 06:52:47.971402 INFO::Creating boxplot for categorical data, antibiotics vs F616
## 2025-03-29 06:52:48.10939 INFO::Creating boxplot for categorical data, antibiotics vs F323
## 2025-03-29 06:52:48.22906 INFO::Creating boxplot for categorical data, antibiotics vs F409
## 2025-03-29 06:52:48.346389 INFO::Creating boxplot for categorical data, antibiotics vs F326
## 2025-03-29 06:52:48.47841 INFO::Creating boxplot for categorical data, antibiotics vs F698
## 2025-03-29 06:52:48.602862 INFO::Creating boxplot for categorical data, antibiotics vs F567
## 2025-03-29 06:52:48.720451 INFO::Creating boxplot for categorical data, antibiotics vs F179
## 2025-03-29 06:52:48.839207 INFO::Creating boxplot for categorical data, antibiotics vs F787
## 2025-03-29 06:52:48.975563 INFO::Creating boxplot for categorical data, antibiotics vs F79
## 2025-03-29 06:52:49.101099 INFO::Creating boxplot for categorical data, antibiotics vs F335
## 2025-03-29 06:52:49.219782 INFO::Creating boxplot for categorical data, antibiotics vs F576
## 2025-03-29 06:52:49.34872 INFO::Creating boxplot for categorical data, antibiotics vs F667
## 2025-03-29 06:52:49.476418 INFO::Creating boxplot for categorical data, antibiotics vs F694
## 2025-03-29 06:52:49.595771 INFO::Creating boxplot for categorical data, antibiotics vs F297
## 2025-03-29 06:52:49.713776 INFO::Creating boxplot for categorical data, antibiotics vs F569
## 2025-03-29 06:52:49.851431 INFO::Creating boxplot for categorical data, antibiotics vs F138
## 2025-03-29 06:52:49.971115 INFO::Creating boxplot for categorical data, antibiotics vs F611
## 2025-03-29 06:52:50.088933 INFO::Creating boxplot for categorical data, antibiotics vs F810
## 2025-03-29 06:52:50.220213 INFO::Creating boxplot for categorical data, antibiotics vs F746
## 2025-03-29 06:52:50.347297 INFO::Creating boxplot for categorical data, antibiotics vs F23
## 2025-03-29 06:52:50.466349 INFO::Creating boxplot for categorical data, antibiotics vs F135
## 2025-03-29 06:52:50.584358 INFO::Creating boxplot for categorical data, antibiotics vs F411
## 2025-03-29 06:52:50.720749 INFO::Creating boxplot for categorical data, antibiotics vs F489
## 2025-03-29 06:52:50.839501 INFO::Creating boxplot for categorical data, antibiotics vs F492
## 2025-03-29 06:52:50.957838 INFO::Creating boxplot for categorical data, antibiotics vs F844
## 2025-03-29 06:52:51.091947 INFO::Creating boxplot for categorical data, antibiotics vs F586
## 2025-03-29 06:52:51.219823 INFO::Creating boxplot for categorical data, antibiotics vs F11
## 2025-03-29 06:52:51.338275 INFO::Creating boxplot for categorical data, antibiotics vs F900
## 2025-03-29 06:52:51.456997 INFO::Creating boxplot for categorical data, antibiotics vs F21
## 2025-03-29 06:52:51.595266 INFO::Creating boxplot for categorical data, antibiotics vs F736
## 2025-03-29 06:52:51.714327 INFO::Creating boxplot for categorical data, antibiotics vs F408
## 2025-03-29 06:52:51.831356 INFO::Creating boxplot for categorical data, antibiotics vs F788
## 2025-03-29 06:52:51.967675 INFO::Creating boxplot for categorical data, antibiotics vs F66
## 2025-03-29 06:52:52.087965 INFO::Creating boxplot for categorical data, antibiotics vs F493
## 2025-03-29 06:52:52.206191 INFO::Creating boxplot for categorical data, antibiotics vs F343
## 2025-03-29 06:52:52.324137 INFO::Creating boxplot for categorical data, antibiotics vs F352
## 2025-03-29 06:52:52.461246 INFO::Creating boxplot for categorical data, antibiotics vs F677
## 2025-03-29 06:52:52.578993 INFO::Creating boxplot for categorical data, antibiotics vs F816
## 2025-03-29 06:52:52.69679 INFO::Creating boxplot for categorical data, antibiotics vs F457
## 2025-03-29 06:52:52.832688 INFO::Creating boxplot for categorical data, antibiotics vs F330
## 2025-03-29 06:52:52.951967 INFO::Creating boxplot for categorical data, antibiotics vs F293
## 2025-03-29 06:52:53.06814 INFO::Creating boxplot for categorical data, antibiotics vs F725
## 2025-03-29 06:52:53.187031 INFO::Creating boxplot for categorical data, antibiotics vs F813
## 2025-03-29 06:52:53.325421 INFO::Creating boxplot for categorical data, antibiotics vs F295
## 2025-03-29 06:52:53.44492 INFO::Creating boxplot for categorical data, antibiotics vs F656
## 2025-03-29 06:52:53.563828 INFO::Creating boxplot for categorical data, antibiotics vs F669
## 2025-03-29 06:52:53.699522 INFO::Creating boxplot for categorical data, antibiotics vs F15
## 2025-03-29 06:52:53.817263 INFO::Creating boxplot for categorical data, antibiotics vs F419
## 2025-03-29 06:52:53.934023 INFO::Creating boxplot for categorical data, antibiotics vs F701
## 2025-03-29 06:52:54.069726 INFO::Creating boxplot for categorical data, antibiotics vs F176
## 2025-03-29 06:52:54.192739 INFO::Creating boxplot for categorical data, antibiotics vs F203
## 2025-03-29 06:52:54.308944 INFO::Creating boxplot for categorical data, antibiotics vs F501
## 2025-03-29 06:52:54.427567 INFO::Creating boxplot for categorical data, antibiotics vs F772
## 2025-03-29 06:52:54.563339 INFO::Creating boxplot for categorical data, antibiotics vs F488
## 2025-03-29 06:52:54.681632 INFO::Creating boxplot for categorical data, antibiotics vs F600
## 2025-03-29 06:52:54.799307 INFO::Creating boxplot for categorical data, antibiotics vs F768
## 2025-03-29 06:52:54.935519 INFO::Creating boxplot for categorical data, antibiotics vs F432
## 2025-03-29 06:52:55.055633 INFO::Creating boxplot for categorical data, antibiotics vs F26
## 2025-03-29 06:52:55.173066 INFO::Creating boxplot for categorical data, antibiotics vs F189
## 2025-03-29 06:52:55.302377 INFO::Creating boxplot for categorical data, antibiotics vs F200
## 2025-03-29 06:52:55.428544 INFO::Creating boxplot for categorical data, antibiotics vs F121
## 2025-03-29 06:52:55.546414 INFO::Creating boxplot for categorical data, antibiotics vs F624
## 2025-03-29 06:52:55.665657 INFO::Creating boxplot for categorical data, antibiotics vs F855
## 2025-03-29 06:52:55.803499 INFO::Creating boxplot for categorical data, antibiotics vs F380
## 2025-03-29 06:52:55.920889 INFO::Creating boxplot for categorical data, antibiotics vs F734
## 2025-03-29 06:52:56.038938 INFO::Creating boxplot for categorical data, antibiotics vs F16
## 2025-03-29 06:52:56.176782 INFO::Creating boxplot for categorical data, antibiotics vs F602
## 2025-03-29 06:52:56.297627 INFO::Creating boxplot for categorical data, antibiotics vs F210
## 2025-03-29 06:52:56.413148 INFO::Creating boxplot for categorical data, antibiotics vs F217
## 2025-03-29 06:52:56.580252 INFO::Creating boxplot for categorical data, antibiotics vs F640
## 2025-03-29 06:52:56.702014 INFO::Creating boxplot for categorical data, antibiotics vs F631
## 2025-03-29 06:52:56.824231 INFO::Creating boxplot for categorical data, antibiotics vs F32
## 2025-03-29 06:52:56.94433 INFO::Creating boxplot for categorical data, antibiotics vs F322
## 2025-03-29 06:52:57.082713 INFO::Creating boxplot for categorical data, antibiotics vs F476
## 2025-03-29 06:52:57.205039 INFO::Creating boxplot for categorical data, antibiotics vs F265
## 2025-03-29 06:52:57.326964 INFO::Creating boxplot for categorical data, antibiotics vs F283
## 2025-03-29 06:52:57.453227 INFO::Creating boxplot for categorical data, antibiotics vs F316
## 2025-03-29 06:52:57.583312 INFO::Creating boxplot for categorical data, antibiotics vs F465
## 2025-03-29 06:52:57.703943 INFO::Creating boxplot for categorical data, antibiotics vs F24
## 2025-03-29 06:52:57.824625 INFO::Creating boxplot for categorical data, antibiotics vs F38
## 2025-03-29 06:52:57.961537 INFO::Creating boxplot for categorical data, antibiotics vs F82
## 2025-03-29 06:52:58.081123 INFO::Creating boxplot for categorical data, antibiotics vs F86
## 2025-03-29 06:52:58.203141 INFO::Creating boxplot for categorical data, antibiotics vs F270
## 2025-03-29 06:52:58.320424 INFO::Creating boxplot for categorical data, antibiotics vs F485
## 2025-03-29 06:52:58.457778 INFO::Creating boxplot for categorical data, antibiotics vs F486
## 2025-03-29 06:52:58.578807 INFO::Creating boxplot for categorical data, antibiotics vs F399
## 2025-03-29 06:52:58.698857 INFO::Creating boxplot for categorical data, antibiotics vs F573
## 2025-03-29 06:52:58.834272 INFO::Creating boxplot for categorical data, antibiotics vs F877
## 2025-03-29 06:52:58.954608 INFO::Creating boxplot for categorical data, antibiotics vs F709
## 2025-03-29 06:52:59.075395 INFO::Creating boxplot for categorical data, antibiotics vs F227
## 2025-03-29 06:52:59.200352 INFO::Creating boxplot for categorical data, antibiotics vs F553
## 2025-03-29 06:52:59.337905 INFO::Creating boxplot for categorical data, antibiotics vs F123
## 2025-03-29 06:52:59.457383 INFO::Creating boxplot for categorical data, antibiotics vs F118
## 2025-03-29 06:52:59.578594 INFO::Creating boxplot for categorical data, antibiotics vs F605
## 2025-03-29 06:52:59.715158 INFO::Creating boxplot for categorical data, antibiotics vs F619
## 2025-03-29 06:52:59.836408 INFO::Creating boxplot for categorical data, antibiotics vs F830
## 2025-03-29 06:52:59.957508 INFO::Creating boxplot for categorical data, antibiotics vs F837
## 2025-03-29 06:53:00.076552 INFO::Creating boxplot for categorical data, antibiotics vs F12
## 2025-03-29 06:53:00.214071 INFO::Creating boxplot for categorical data, antibiotics vs F623
## 2025-03-29 06:53:00.337159 INFO::Creating boxplot for categorical data, antibiotics vs F806
## 2025-03-29 06:53:00.455389 INFO::Creating boxplot for categorical data, antibiotics vs F353
## 2025-03-29 06:53:00.591657 INFO::Creating boxplot for categorical data, antibiotics vs F829
## 2025-03-29 06:53:00.71239 INFO::Creating boxplot for categorical data, antibiotics vs F289
## 2025-03-29 06:53:00.83158 INFO::Creating boxplot for categorical data, antibiotics vs F93
## 2025-03-29 06:53:00.958625 INFO::Creating boxplot for categorical data, antibiotics vs F379
## 2025-03-29 06:53:01.087654 INFO::Creating boxplot for categorical data, antibiotics vs F370
## 2025-03-29 06:53:01.207752 INFO::Creating boxplot for categorical data, antibiotics vs F360
## 2025-03-29 06:53:01.32749 INFO::Creating boxplot for categorical data, antibiotics vs F710
## 2025-03-29 06:53:01.463357 INFO::Creating boxplot for categorical data, antibiotics vs F388
## 2025-03-29 06:53:01.583861 INFO::Creating boxplot for categorical data, antibiotics vs F796
## 2025-03-29 06:53:01.703832 INFO::Creating boxplot for categorical data, antibiotics vs F174
## 2025-03-29 06:53:01.836811 INFO::Creating boxplot for categorical data, antibiotics vs F601
## 2025-03-29 06:53:01.957541 INFO::Creating boxplot for categorical data, antibiotics vs F775
## 2025-03-29 06:53:02.077961 INFO::Creating boxplot for categorical data, antibiotics vs F836
## 2025-03-29 06:53:02.197118 INFO::Creating boxplot for categorical data, antibiotics vs F192
## 2025-03-29 06:53:02.334888 INFO::Creating boxplot for categorical data, antibiotics vs F463
## 2025-03-29 06:53:02.454646 INFO::Creating boxplot for categorical data, antibiotics vs F57
## 2025-03-29 06:53:02.574883 INFO::Creating boxplot for categorical data, antibiotics vs F658
## 2025-03-29 06:53:02.710159 INFO::Creating boxplot for categorical data, antibiotics vs F596
## 2025-03-29 06:53:02.82917 INFO::Creating boxplot for categorical data, antibiotics vs F218
## 2025-03-29 06:53:02.949279 INFO::Creating boxplot for categorical data, antibiotics vs F104
## 2025-03-29 06:53:03.069534 INFO::Creating boxplot for categorical data, antibiotics vs F466
## 2025-03-29 06:53:03.208867 INFO::Creating boxplot for categorical data, antibiotics vs F737
## 2025-03-29 06:53:03.327833 INFO::Creating boxplot for categorical data, antibiotics vs F487
## 2025-03-29 06:53:03.446487 INFO::Creating boxplot for categorical data, antibiotics vs F369
## 2025-03-29 06:53:03.583573 INFO::Creating boxplot for categorical data, antibiotics vs F584
## 2025-03-29 06:53:03.702894 INFO::Creating boxplot for categorical data, antibiotics vs F166
## 2025-03-29 06:53:03.823151 INFO::Creating boxplot for categorical data, antibiotics vs F822
## 2025-03-29 06:53:03.959602 INFO::Creating boxplot for categorical data, antibiotics vs F416
## 2025-03-29 06:53:04.081376 INFO::Creating boxplot for categorical data, antibiotics vs F70
## 2025-03-29 06:53:04.203117 INFO::Creating boxplot for categorical data, antibiotics vs F243
## 2025-03-29 06:53:04.323606 INFO::Creating boxplot for categorical data, antibiotics vs F498
## 2025-03-29 06:53:04.462182 INFO::Creating boxplot for categorical data, antibiotics vs F272
## 2025-03-29 06:53:04.582576 INFO::Creating boxplot for categorical data, antibiotics vs F846
## 2025-03-29 06:53:04.701346 INFO::Creating boxplot for categorical data, antibiotics vs F881
## 2025-03-29 06:53:04.837131 INFO::Creating boxplot for categorical data, antibiotics vs F280
## 2025-03-29 06:53:04.957345 INFO::Creating boxplot for categorical data, antibiotics vs F761
## 2025-03-29 06:53:05.076066 INFO::Creating boxplot for categorical data, antibiotics vs F781
## 2025-03-29 06:53:05.211622 INFO::Creating boxplot for categorical data, antibiotics vs F697
## 2025-03-29 06:53:05.333732 INFO::Creating boxplot for categorical data, antibiotics vs F890
## 2025-03-29 06:53:05.454041 INFO::Creating boxplot for categorical data, antibiotics vs F197
## 2025-03-29 06:53:05.572544 INFO::Creating boxplot for categorical data, antibiotics vs F826
## 2025-03-29 06:53:05.738502 INFO::Creating boxplot for categorical data, antibiotics vs F641
## 2025-03-29 06:53:05.860027 INFO::Creating boxplot for categorical data, antibiotics vs F700
## 2025-03-29 06:53:05.980335 INFO::Creating boxplot for categorical data, antibiotics vs F531
## 2025-03-29 06:53:06.122972 INFO::Creating boxplot for categorical data, antibiotics vs F660
## 2025-03-29 06:53:06.24436 INFO::Creating boxplot for categorical data, antibiotics vs F257
## 2025-03-29 06:53:06.365466 INFO::Creating boxplot for categorical data, antibiotics vs F136
## 2025-03-29 06:53:06.487015 INFO::Creating boxplot for categorical data, antibiotics vs F875
## 2025-03-29 06:53:06.629827 INFO::Creating boxplot for categorical data, antibiotics vs F160
## 2025-03-29 06:53:06.751112 INFO::Creating boxplot for categorical data, antibiotics vs F782
## 2025-03-29 06:53:06.873993 INFO::Creating boxplot for categorical data, antibiotics vs F642
## 2025-03-29 06:53:07.012068 INFO::Creating boxplot for categorical data, antibiotics vs F730
## 2025-03-29 06:53:07.136698 INFO::Creating boxplot for categorical data, antibiotics vs F679
## 2025-03-29 06:53:07.256359 INFO::Creating boxplot for categorical data, antibiotics vs F713
## 2025-03-29 06:53:07.379124 INFO::Creating boxplot for categorical data, antibiotics vs F821
## 2025-03-29 06:53:07.522255 INFO::Creating boxplot for categorical data, antibiotics vs F443
## 2025-03-29 06:53:07.643963 INFO::Creating boxplot for categorical data, antibiotics vs F729
## 2025-03-29 06:53:07.767395 INFO::Creating boxplot for categorical data, antibiotics vs F25
## 2025-03-29 06:53:07.90528 INFO::Creating boxplot for categorical data, antibiotics vs F338
## 2025-03-29 06:53:08.032335 INFO::Creating boxplot for categorical data, antibiotics vs F647
## 2025-03-29 06:53:08.154395 INFO::Creating boxplot for categorical data, antibiotics vs F817
## 2025-03-29 06:53:08.275075 INFO::Creating boxplot for categorical data, antibiotics vs F535
## 2025-03-29 06:53:08.420137 INFO::Creating boxplot for categorical data, antibiotics vs F634
## 2025-03-29 06:53:08.542682 INFO::Creating boxplot for categorical data, antibiotics vs F533
## 2025-03-29 06:53:08.663454 INFO::Creating boxplot for categorical data, antibiotics vs F808
## 2025-03-29 06:53:08.805197 INFO::Creating boxplot for categorical data, antibiotics vs F571
## 2025-03-29 06:53:08.928154 INFO::Creating boxplot for categorical data, antibiotics vs F529
## 2025-03-29 06:53:09.050494 INFO::Creating boxplot for categorical data, antibiotics vs F827
## 2025-03-29 06:53:09.172229 INFO::Creating boxplot for categorical data, antibiotics vs F107
## 2025-03-29 06:53:09.314236 INFO::Creating boxplot for categorical data, antibiotics vs F515
## 2025-03-29 06:53:09.43515 INFO::Creating boxplot for categorical data, antibiotics vs F305
## 2025-03-29 06:53:09.558307 INFO::Creating boxplot for categorical data, antibiotics vs F662
## 2025-03-29 06:53:09.700361 INFO::Creating boxplot for categorical data, antibiotics vs F310
## 2025-03-29 06:53:09.822078 INFO::Creating boxplot for categorical data, antibiotics vs F430
## 2025-03-29 06:53:09.942101 INFO::Creating boxplot for categorical data, antibiotics vs F173
## 2025-03-29 06:53:10.063492 INFO::Creating boxplot for categorical data, antibiotics vs F820
## 2025-03-29 06:53:10.207956 INFO::Creating boxplot for categorical data, antibiotics vs F743
## 2025-03-29 06:53:10.328097 INFO::Creating boxplot for categorical data, antibiotics vs F63
## 2025-03-29 06:53:10.451956 INFO::Creating boxplot for categorical data, antibiotics vs F215
## 2025-03-29 06:53:10.593198 INFO::Creating boxplot for categorical data, antibiotics vs F216
## 2025-03-29 06:53:10.714026 INFO::Creating boxplot for categorical data, antibiotics vs F245
## 2025-03-29 06:53:10.837379 INFO::Creating boxplot for categorical data, antibiotics vs F862
## 2025-03-29 06:53:10.966362 INFO::Creating boxplot for categorical data, antibiotics vs F541
## 2025-03-29 06:53:11.101356 INFO::Creating boxplot for categorical data, antibiotics vs F558
## 2025-03-29 06:53:11.222377 INFO::Creating boxplot for categorical data, antibiotics vs F633
## 2025-03-29 06:53:11.343912 INFO::Creating boxplot for categorical data, antibiotics vs F94
## 2025-03-29 06:53:11.48686 INFO::Creating boxplot for categorical data, antibiotics vs F574
## 2025-03-29 06:53:11.606366 INFO::Creating boxplot for categorical data, antibiotics vs F238
## 2025-03-29 06:53:11.728214 INFO::Creating boxplot for categorical data, antibiotics vs F815
## 2025-03-29 06:53:11.86842 INFO::Creating boxplot for categorical data, antibiotics vs F587
## 2025-03-29 06:53:11.990402 INFO::Creating boxplot for categorical data, antibiotics vs F464
## 2025-03-29 06:53:12.111799 INFO::Creating boxplot for categorical data, antibiotics vs F590
## 2025-03-29 06:53:12.233126 INFO::Creating boxplot for categorical data, antibiotics vs F124
## 2025-03-29 06:53:12.378834 INFO::Creating boxplot for categorical data, antibiotics vs F664
## 2025-03-29 06:53:12.498735 INFO::Creating boxplot for categorical data, antibiotics vs F100
## 2025-03-29 06:53:12.622075 INFO::Creating boxplot for categorical data, antibiotics vs F744
## 2025-03-29 06:53:12.765005 INFO::Creating boxplot for categorical data, antibiotics vs F444
## 2025-03-29 06:53:12.886912 INFO::Creating boxplot for categorical data, antibiotics vs F597
## 2025-03-29 06:53:13.008905 INFO::Creating boxplot for categorical data, antibiotics vs F650
## 2025-03-29 06:53:13.14532 INFO::Creating boxplot for categorical data, antibiotics vs F147
## 2025-03-29 06:53:13.271415 INFO::Creating boxplot for categorical data, antibiotics vs F363
## 2025-03-29 06:53:13.397774 INFO::Creating boxplot for categorical data, antibiotics vs F521
## 2025-03-29 06:53:13.518939 INFO::Creating boxplot for categorical data, antibiotics vs F412
## 2025-03-29 06:53:13.661821 INFO::Creating boxplot for categorical data, antibiotics vs F279
## 2025-03-29 06:53:13.783163 INFO::Creating boxplot for categorical data, antibiotics vs F225
## 2025-03-29 06:53:13.903129 INFO::Creating boxplot for categorical data, antibiotics vs F10
## 2025-03-29 06:53:14.047838 INFO::Creating boxplot for categorical data, antibiotics vs F481
## 2025-03-29 06:53:14.168976 INFO::Creating boxplot for categorical data, antibiotics vs F861
## 2025-03-29 06:53:14.290484 INFO::Creating boxplot for categorical data, antibiotics vs F888
## 2025-03-29 06:53:14.433073 INFO::Creating boxplot for categorical data, antibiotics vs F156
## 2025-03-29 06:53:14.559082 INFO::Creating boxplot for categorical data, antibiotics vs F857
## 2025-03-29 06:53:14.680367 INFO::Creating boxplot for categorical data, antibiotics vs F509
## 2025-03-29 06:53:14.800903 INFO::Creating boxplot for categorical data, antibiotics vs F244
## 2025-03-29 06:53:14.976777 INFO::Creating boxplot for categorical data, antibiotics vs F514
## 2025-03-29 06:53:15.097256 INFO::Creating boxplot for categorical data, antibiotics vs F196
## 2025-03-29 06:53:15.221475 INFO::Creating boxplot for categorical data, antibiotics vs F304
## 2025-03-29 06:53:15.367575 INFO::Creating boxplot for categorical data, antibiotics vs F833
## 2025-03-29 06:53:15.494792 INFO::Creating boxplot for categorical data, antibiotics vs F294
## 2025-03-29 06:53:15.61504 INFO::Creating boxplot for categorical data, antibiotics vs F550
## 2025-03-29 06:53:15.73648 INFO::Creating boxplot for categorical data, antibiotics vs F869
## 2025-03-29 06:53:15.879368 INFO::Creating boxplot for categorical data, antibiotics vs F364
## 2025-03-29 06:53:16.000924 INFO::Creating boxplot for categorical data, antibiotics vs F583
## 2025-03-29 06:53:16.124497 INFO::Creating boxplot for categorical data, antibiotics vs F441
## 2025-03-29 06:53:16.269057 INFO::Creating boxplot for categorical data, antibiotics vs F595
## 2025-03-29 06:53:16.391443 INFO::Creating boxplot for categorical data, antibiotics vs F35
## 2025-03-29 06:53:16.514245 INFO::Creating boxplot for categorical data, antibiotics vs F630
## 2025-03-29 06:53:16.637593 INFO::Creating boxplot for categorical data, antibiotics vs F401
## 2025-03-29 06:53:16.780526 INFO::Creating boxplot for categorical data, antibiotics vs F287
## 2025-03-29 06:53:16.901341 INFO::Creating boxplot for categorical data, antibiotics vs F250
## 2025-03-29 06:53:17.023478 INFO::Creating boxplot for categorical data, antibiotics vs F239
## 2025-03-29 06:53:17.165702 INFO::Creating boxplot for categorical data, antibiotics vs F88
## 2025-03-29 06:53:17.287929 INFO::Creating boxplot for categorical data, antibiotics vs F752
## 2025-03-29 06:53:17.410399 INFO::Creating boxplot for categorical data, antibiotics vs F539
## 2025-03-29 06:53:17.536054 INFO::Creating boxplot for categorical data, antibiotics vs F69
## 2025-03-29 06:53:17.676715 INFO::Creating boxplot for categorical data, antibiotics vs F126
## 2025-03-29 06:53:17.797521 INFO::Creating boxplot for categorical data, antibiotics vs F362
## 2025-03-29 06:53:17.921495 INFO::Creating boxplot for categorical data, antibiotics vs F753
## 2025-03-29 06:53:18.06476 INFO::Creating boxplot for categorical data, antibiotics vs F469
## 2025-03-29 06:53:18.187228 INFO::Creating boxplot for categorical data, antibiotics vs F14
## 2025-03-29 06:53:18.30894 INFO::Creating boxplot for categorical data, antibiotics vs F803
## 2025-03-29 06:53:18.430891 INFO::Creating boxplot for categorical data, antibiotics vs F814
## 2025-03-29 06:53:18.57372 INFO::Creating boxplot for categorical data, antibiotics vs F449
## 2025-03-29 06:53:18.694746 INFO::Creating boxplot for categorical data, antibiotics vs F494
## 2025-03-29 06:53:18.817458 INFO::Creating boxplot for categorical data, antibiotics vs F439
## 2025-03-29 06:53:18.959573 INFO::Creating boxplot for categorical data, antibiotics vs F686
## 2025-03-29 06:53:19.082289 INFO::Creating boxplot for categorical data, antibiotics vs F591
## 2025-03-29 06:53:19.204089 INFO::Creating boxplot for categorical data, antibiotics vs F735
## 2025-03-29 06:53:19.32507 INFO::Creating boxplot for categorical data, antibiotics vs F111
## 2025-03-29 06:53:19.469071 INFO::Creating boxplot for categorical data, antibiotics vs F346
## 2025-03-29 06:53:19.590696 INFO::Creating boxplot for categorical data, antibiotics vs F29
## 2025-03-29 06:53:19.715307 INFO::Creating boxplot for categorical data, antibiotics vs F376
## 2025-03-29 06:53:19.857326 INFO::Creating boxplot for categorical data, antibiotics vs F414
## 2025-03-29 06:53:19.978891 INFO::Creating boxplot for categorical data, antibiotics vs F555
## 2025-03-29 06:53:20.102106 INFO::Creating boxplot for categorical data, antibiotics vs F517
## 2025-03-29 06:53:20.238567 INFO::Creating boxplot for categorical data, antibiotics vs F544
## 2025-03-29 06:53:20.366693 INFO::Creating boxplot for categorical data, antibiotics vs F339
## 2025-03-29 06:53:20.490986 INFO::Creating boxplot for categorical data, antibiotics vs F689
## 2025-03-29 06:53:20.615194 INFO::Creating boxplot for categorical data, antibiotics vs F391
## 2025-03-29 06:53:20.756383 INFO::Creating boxplot for categorical data, antibiotics vs F502
## 2025-03-29 06:53:20.877712 INFO::Creating boxplot for categorical data, antibiotics vs F298
## 2025-03-29 06:53:21.002744 INFO::Creating boxplot for categorical data, antibiotics vs F337
## 2025-03-29 06:53:21.146506 INFO::Creating boxplot for categorical data, antibiotics vs F773
## 2025-03-29 06:53:21.268039 INFO::Creating boxplot for categorical data, antibiotics vs F592
## 2025-03-29 06:53:21.389986 INFO::Creating boxplot for categorical data, antibiotics vs F307
## 2025-03-29 06:53:21.526395 INFO::Creating boxplot for categorical data, antibiotics vs F115
## 2025-03-29 06:53:21.65914 INFO::Creating boxplot for categorical data, antibiotics vs F739
## 2025-03-29 06:53:21.780618 INFO::Creating boxplot for categorical data, antibiotics vs F433
## 2025-03-29 06:53:21.903757 INFO::Creating boxplot for categorical data, antibiotics vs F384
## 2025-03-29 06:53:22.046785 INFO::Creating boxplot for categorical data, antibiotics vs F750
## 2025-03-29 06:53:22.169113 INFO::Creating boxplot for categorical data, antibiotics vs F762
## 2025-03-29 06:53:22.291201 INFO::Creating boxplot for categorical data, antibiotics vs F277
## 2025-03-29 06:53:22.432329 INFO::Creating boxplot for categorical data, antibiotics vs F871
## 2025-03-29 06:53:22.553711 INFO::Creating boxplot for categorical data, antibiotics vs F839
## 2025-03-29 06:53:22.675727 INFO::Creating boxplot for categorical data, antibiotics vs F127
## 2025-03-29 06:53:22.805073 INFO::Creating boxplot for categorical data, antibiotics vs F554
## 2025-03-29 06:53:22.937084 INFO::Creating boxplot for categorical data, antibiotics vs F676
## 2025-03-29 06:53:23.057078 INFO::Creating boxplot for categorical data, antibiotics vs F568
## 2025-03-29 06:53:23.178429 INFO::Creating boxplot for categorical data, antibiotics vs F137
## 2025-03-29 06:53:23.319465 INFO::Creating boxplot for categorical data, antibiotics vs F131
## 2025-03-29 06:53:23.440681 INFO::Creating boxplot for categorical data, antibiotics vs F60
## 2025-03-29 06:53:23.562991 INFO::Creating boxplot for categorical data, antibiotics vs F98
## 2025-03-29 06:53:23.703789 INFO::Creating boxplot for categorical data, antibiotics vs F672
## 2025-03-29 06:53:23.827471 INFO::Creating boxplot for categorical data, antibiotics vs F530
## 2025-03-29 06:53:23.949637 INFO::Creating boxplot for categorical data, antibiotics vs F809
## 2025-03-29 06:53:24.60312 INFO::Creating boxplot for categorical data, antibiotics vs F894
## 2025-03-29 06:53:24.719026 INFO::Creating boxplot for categorical data, antibiotics vs F22
## 2025-03-29 06:53:24.833576 INFO::Creating boxplot for categorical data, antibiotics vs F818
## 2025-03-29 06:53:24.947379 INFO::Creating boxplot for categorical data, antibiotics vs F559
## 2025-03-29 06:53:25.069663 INFO::Creating boxplot for categorical data, antibiotics vs F741
## 2025-03-29 06:53:25.183514 INFO::Creating boxplot for categorical data, antibiotics vs F398
## 2025-03-29 06:53:25.296451 INFO::Creating boxplot for categorical data, antibiotics vs F357
## 2025-03-29 06:53:25.413259 INFO::Creating boxplot for categorical data, antibiotics vs F119
## 2025-03-29 06:53:25.534606 INFO::Creating boxplot for categorical data, antibiotics vs F426
## 2025-03-29 06:53:25.649029 INFO::Creating boxplot for categorical data, antibiotics vs F204
## 2025-03-29 06:53:25.761949 INFO::Creating boxplot for categorical data, antibiotics vs F851
## 2025-03-29 06:53:25.883113 INFO::Creating boxplot for categorical data, antibiotics vs F657
## 2025-03-29 06:53:25.995993 INFO::Creating boxplot for categorical data, antibiotics vs F801
## 2025-03-29 06:53:26.110561 INFO::Creating boxplot for categorical data, antibiotics vs F754
## 2025-03-29 06:53:26.22602 INFO::Creating boxplot for categorical data, antibiotics vs F859
## 2025-03-29 06:53:26.347499 INFO::Creating boxplot for categorical data, antibiotics vs F480
## 2025-03-29 06:53:26.461511 INFO::Creating boxplot for categorical data, antibiotics vs F507
## 2025-03-29 06:53:26.574965 INFO::Creating boxplot for categorical data, antibiotics vs F207
## 2025-03-29 06:53:28.085049 INFO::Plotting data for metadata number 3, age
## 2025-03-29 06:53:28.0863 INFO::Creating scatter plot for continuous data, age vs F340
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:28.237892 INFO::Creating scatter plot for continuous data, age vs F603
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:28.413556 INFO::Creating scatter plot for continuous data, age vs F356
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:28.535751 INFO::Creating scatter plot for continuous data, age vs F181
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:28.649656 INFO::Creating scatter plot for continuous data, age vs F177
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:28.778239 INFO::Creating scatter plot for continuous data, age vs F390
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:28.898585 INFO::Creating scatter plot for continuous data, age vs F743
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:29.011141 INFO::Creating scatter plot for continuous data, age vs F491
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:29.142041 INFO::Creating scatter plot for continuous data, age vs F436
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:29.254094 INFO::Creating scatter plot for continuous data, age vs F219
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:29.366157 INFO::Creating scatter plot for continuous data, age vs F483
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:29.496712 INFO::Creating scatter plot for continuous data, age vs F878
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:29.618545 INFO::Creating scatter plot for continuous data, age vs F876
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:29.739397 INFO::Creating scatter plot for continuous data, age vs F211
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:29.869307 INFO::Creating scatter plot for continuous data, age vs F732
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:29.989254 INFO::Creating scatter plot for continuous data, age vs F222
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:30.111722 INFO::Creating scatter plot for continuous data, age vs F688
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:30.24079 INFO::Creating scatter plot for continuous data, age vs F170
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:30.361122 INFO::Creating scatter plot for continuous data, age vs F431
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:30.482935 INFO::Creating scatter plot for continuous data, age vs F174
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:30.605141 INFO::Creating scatter plot for continuous data, age vs F17
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:30.718325 INFO::Creating scatter plot for continuous data, age vs F334
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:30.840008 INFO::Creating scatter plot for continuous data, age vs F835
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:30.960713 INFO::Creating scatter plot for continuous data, age vs F223
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:31.083921 INFO::Creating scatter plot for continuous data, age vs F383
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:31.197212 INFO::Creating scatter plot for continuous data, age vs F623
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:31.325921 INFO::Creating scatter plot for continuous data, age vs F329
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:31.448719 INFO::Creating scatter plot for continuous data, age vs F395
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:31.578177 INFO::Creating scatter plot for continuous data, age vs F528
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:31.702977 INFO::Creating scatter plot for continuous data, age vs F13
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:31.814102 INFO::Creating scatter plot for continuous data, age vs F36
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:31.925525 INFO::Creating scatter plot for continuous data, age vs F285
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:32.054997 INFO::Creating scatter plot for continuous data, age vs F404
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:32.166915 INFO::Creating scatter plot for continuous data, age vs F894
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:32.286908 INFO::Creating scatter plot for continuous data, age vs F300
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:32.416132 INFO::Creating scatter plot for continuous data, age vs F32
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:32.535755 INFO::Creating scatter plot for continuous data, age vs F24
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:32.656295 INFO::Creating scatter plot for continuous data, age vs F97
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:32.778029 INFO::Creating scatter plot for continuous data, age vs F849
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:32.891899 INFO::Creating scatter plot for continuous data, age vs F185
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:33.01185 INFO::Creating scatter plot for continuous data, age vs F513
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:33.183009 INFO::Creating scatter plot for continuous data, age vs F296
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:33.305799 INFO::Creating scatter plot for continuous data, age vs F471
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:33.429689 INFO::Creating scatter plot for continuous data, age vs F793
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:33.567691 INFO::Creating scatter plot for continuous data, age vs F402
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:33.697532 INFO::Creating scatter plot for continuous data, age vs F541
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:33.818047 INFO::Creating scatter plot for continuous data, age vs F496
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:33.942719 INFO::Creating scatter plot for continuous data, age vs F386
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:34.056442 INFO::Creating scatter plot for continuous data, age vs F594
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:34.178405 INFO::Creating scatter plot for continuous data, age vs F704
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:34.304805 INFO::Creating scatter plot for continuous data, age vs F330
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:34.429802 INFO::Creating scatter plot for continuous data, age vs F197
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:34.551027 INFO::Creating scatter plot for continuous data, age vs F735
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:34.686719 INFO::Creating scatter plot for continuous data, age vs F481
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:34.801602 INFO::Creating scatter plot for continuous data, age vs F635
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:34.923363 INFO::Creating scatter plot for continuous data, age vs F687
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:35.056181 INFO::Creating scatter plot for continuous data, age vs F652
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:35.182761 INFO::Creating scatter plot for continuous data, age vs F651
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:35.303923 INFO::Creating scatter plot for continuous data, age vs F82
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:35.417405 INFO::Creating scatter plot for continuous data, age vs F7
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:35.545442 INFO::Creating scatter plot for continuous data, age vs F866
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:35.667156 INFO::Creating scatter plot for continuous data, age vs F593
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:35.781571 INFO::Creating scatter plot for continuous data, age vs F733
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:35.908388 INFO::Creating scatter plot for continuous data, age vs F684
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:36.029119 INFO::Creating scatter plot for continuous data, age vs F410
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:36.144296 INFO::Creating scatter plot for continuous data, age vs F224
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:36.280003 INFO::Creating scatter plot for continuous data, age vs F722
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:36.400692 INFO::Creating scatter plot for continuous data, age vs F856
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:36.51473 INFO::Creating scatter plot for continuous data, age vs F680
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:36.641463 INFO::Creating scatter plot for continuous data, age vs F19
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:36.763335 INFO::Creating scatter plot for continuous data, age vs F860
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:36.876302 INFO::Creating scatter plot for continuous data, age vs F859
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:37.011846 INFO::Creating scatter plot for continuous data, age vs F522
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:37.135828 INFO::Creating scatter plot for continuous data, age vs F372
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:37.257002 INFO::Creating scatter plot for continuous data, age vs F899
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:37.38461 INFO::Creating scatter plot for continuous data, age vs F782
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:37.506737 INFO::Creating scatter plot for continuous data, age vs F839
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:37.628584 INFO::Creating scatter plot for continuous data, age vs F827
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:37.76391 INFO::Creating scatter plot for continuous data, age vs F817
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:37.885364 INFO::Creating scatter plot for continuous data, age vs F345
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:37.998024 INFO::Creating scatter plot for continuous data, age vs F127
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:38.135024 INFO::Creating scatter plot for continuous data, age vs F749
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:38.255812 INFO::Creating scatter plot for continuous data, age vs F877
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:38.375983 INFO::Creating scatter plot for continuous data, age vs F150
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:38.511617 INFO::Creating scatter plot for continuous data, age vs F752
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:38.623742 INFO::Creating scatter plot for continuous data, age vs F848
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:38.738084 INFO::Creating scatter plot for continuous data, age vs F809
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:38.875458 INFO::Creating scatter plot for continuous data, age vs F751
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:38.988081 INFO::Creating scatter plot for continuous data, age vs F15
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:39.101607 INFO::Creating scatter plot for continuous data, age vs F521
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:39.229638 INFO::Creating scatter plot for continuous data, age vs F842
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:39.351189 INFO::Creating scatter plot for continuous data, age vs F319
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:39.471978 INFO::Creating scatter plot for continuous data, age vs F96
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:39.607825 INFO::Creating scatter plot for continuous data, age vs F171
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:39.733819 INFO::Creating scatter plot for continuous data, age vs F241
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:39.846966 INFO::Creating scatter plot for continuous data, age vs F582
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:39.974904 INFO::Creating scatter plot for continuous data, age vs F822
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:40.088303 INFO::Creating scatter plot for continuous data, age vs F748
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:40.201203 INFO::Creating scatter plot for continuous data, age vs F147
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:40.336221 INFO::Creating scatter plot for continuous data, age vs F16
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:40.44866 INFO::Creating scatter plot for continuous data, age vs F212
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:40.569559 INFO::Creating scatter plot for continuous data, age vs F718
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:40.705867 INFO::Creating scatter plot for continuous data, age vs F663
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:40.819791 INFO::Creating scatter plot for continuous data, age vs F690
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:40.943437 INFO::Creating scatter plot for continuous data, age vs F865
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:41.098833 INFO::Creating scatter plot for continuous data, age vs F421
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:41.215071 INFO::Creating scatter plot for continuous data, age vs F110
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:41.336959 INFO::Creating scatter plot for continuous data, age vs F857
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:41.479936 INFO::Creating scatter plot for continuous data, age vs F84
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:41.604238 INFO::Creating scatter plot for continuous data, age vs F123
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:41.71657 INFO::Creating scatter plot for continuous data, age vs F566
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:41.84167 INFO::Creating scatter plot for continuous data, age vs F370
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:41.967689 INFO::Creating scatter plot for continuous data, age vs F65
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:42.082249 INFO::Creating scatter plot for continuous data, age vs F119
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:42.196196 INFO::Creating scatter plot for continuous data, age vs F263
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:42.329949 INFO::Creating scatter plot for continuous data, age vs F630
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:42.453836 INFO::Creating scatter plot for continuous data, age vs F628
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:42.568077 INFO::Creating scatter plot for continuous data, age vs F711
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:42.71022 INFO::Creating scatter plot for continuous data, age vs F152
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:42.83895 INFO::Creating scatter plot for continuous data, age vs F324
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:42.961786 INFO::Creating scatter plot for continuous data, age vs F575
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:43.096544 INFO::Creating scatter plot for continuous data, age vs F699
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:43.221191 INFO::Creating scatter plot for continuous data, age vs F846
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:43.343245 INFO::Creating scatter plot for continuous data, age vs F380
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:43.484582 INFO::Creating scatter plot for continuous data, age vs F172
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:43.609299 INFO::Creating scatter plot for continuous data, age vs F504
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:43.722708 INFO::Creating scatter plot for continuous data, age vs F34
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:43.860291 INFO::Creating scatter plot for continuous data, age vs F199
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:43.985207 INFO::Creating scatter plot for continuous data, age vs F198
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:44.107235 INFO::Creating scatter plot for continuous data, age vs F479
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:44.250128 INFO::Creating scatter plot for continuous data, age vs F673
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:44.368615 INFO::Creating scatter plot for continuous data, age vs F508
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:44.490234 INFO::Creating scatter plot for continuous data, age vs F337
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:44.634782 INFO::Creating scatter plot for continuous data, age vs F737
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:44.759638 INFO::Creating scatter plot for continuous data, age vs F609
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:44.883399 INFO::Creating scatter plot for continuous data, age vs F40
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:45.018147 INFO::Creating scatter plot for continuous data, age vs F821
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:45.144716 INFO::Creating scatter plot for continuous data, age vs F643
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:45.256821 INFO::Creating scatter plot for continuous data, age vs F759
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:45.387221 INFO::Creating scatter plot for continuous data, age vs F417
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:45.518866 INFO::Creating scatter plot for continuous data, age vs F58
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:45.641032 INFO::Creating scatter plot for continuous data, age vs F267
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:45.785132 INFO::Creating scatter plot for continuous data, age vs F101
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:45.901511 INFO::Creating scatter plot for continuous data, age vs F890
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:46.024419 INFO::Creating scatter plot for continuous data, age vs F655
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:46.169154 INFO::Creating scatter plot for continuous data, age vs F95
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:46.285336 INFO::Creating scatter plot for continuous data, age vs F775
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:46.398925 INFO::Creating scatter plot for continuous data, age vs F93
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:46.539347 INFO::Creating scatter plot for continuous data, age vs F353
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:46.658736 INFO::Creating scatter plot for continuous data, age vs F480
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:46.780917 INFO::Creating scatter plot for continuous data, age vs F567
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:46.924754 INFO::Creating scatter plot for continuous data, age vs F871
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:47.050799 INFO::Creating scatter plot for continuous data, age vs F295
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:47.165356 INFO::Creating scatter plot for continuous data, age vs F459
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:47.307916 INFO::Creating scatter plot for continuous data, age vs F812
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:47.432488 INFO::Creating scatter plot for continuous data, age vs F146
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:47.544565 INFO::Creating scatter plot for continuous data, age vs F239
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:47.687028 INFO::Creating scatter plot for continuous data, age vs F754
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:47.810786 INFO::Creating scatter plot for continuous data, age vs F443
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:47.92376 INFO::Creating scatter plot for continuous data, age vs F5
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:48.067193 INFO::Creating scatter plot for continuous data, age vs F864
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-29 06:53:48.184064 INFO::Creating scatter plot for continuous data, age vs F477
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:48.304963 INFO::Creating scatter plot for continuous data, age vs F571
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-29 06:53:48.446917 INFO::Creating scatter plot for continuous data, age vs F715
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Initiating effect size calculations
## 
## Calculating mean abundance in: IBD
## 
## Calculating mean abundance in: Control
## 
## Calculating effect size in: IBD
## 
## Initiating prioritization
## 
## Calculating meta-rank and prioritizing metabolic features
## 2025-03-29 06:53:50.121593 INFO::Writing all prioritized metabolites to file: Macarron_output/prioritized_metabolites_all.csv
## 2025-03-29 06:53:50.126933 INFO::Writing characterizable prioritized metabolites to file: Macarron_output/prioritized_metabolites_characterizable.csv
## 2025-03-29 06:53:50.141318 INFO::Writing highly prioritized metabolites in IBD to file: Macarron_output/highly_prioritized_per_module_in_IBD.csv

Using dataframes as inputs

abundances_df = read.csv(file = prism_abundances, row.names = 1) # setting features as rownames
annotations_df = read.csv(file = prism_annotations, row.names = 1) # setting features as rownames
metadata_df = read.csv(file = prism_metadata, row.names = 1) # setting samples as rownames 
taxonomy_df = read.csv(file = mets_taxonomy)

# Running Macarron
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
                                        input_annotations = annotations_df,
                                        input_metadata = metadata_df,
                                        input_taxonomy = taxonomy_df)

Running Macarron as individual functions

The Macarron::Macarron() function is a wrapper for the Macarron framework. Users can also apply individual functions on the input dataframes to achieve same results as the wrapper with the added benefit of storing output from each function for other analyses. There are seven steps:

# Step 1: Storing input data in a summarized experiment object
prism_mbx <- prepInput(input_abundances = abundances_df,
                       input_annotations = annotations_df,
                       input_metadata = metadata_df)

# Step 2: Creating a distance matrix from pairwise correlations in abundances of metabolic features
prism_w <- makeDisMat(se = prism_mbx)

# Step 3: Finding covariance modules
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df)
# The output is a list containing two dataframes- module assignments and measures of success
# if evaluateMOS=TRUE. To write modules to a separate dataframe, do:
prism_module_assignments <- prism_modules[[1]]
prism_modules_mos <- prism_modules[[2]]

# Step 4: Calculating AVA
prism_ava <- calAVA(se = prism_mbx,
                    mod.assn = prism_modules)

# Step 5: Calculating q-value
prism_qval <- calQval(se = prism_mbx,
                      mod.assn = prism_modules)

# Step 6: Calculating effect size
prism_es <- calES(se = prism_mbx,
                   mac.qval = prism_qval)

# Step 7: Prioritizing metabolic features
prism_prioritized <- prioritize(se = prism_mbx,
                                mod.assn = prism_modules,
                                mac.ava = prism_ava,
                                mac.qval = prism_qval,
                                mac.es = prism_es)
# The output is a list containing two dataframes- all prioritized metabolic features and
# only characterizable metabolic features.
all_prioritized <- prism_prioritized[[1]]
char_prioritized <- prism_prioritized[[2]]

# Step 8 (optional): View only the highly prioritized metabolic features in each module
prism_highly_prioritized <- showBest(prism_prioritized)

Session info from running the demo in R can be displayed with the following command.

sessionInfo()
## R version 4.4.3 (2025-02-28)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=C              
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] Macarron_1.11.0             SummarizedExperiment_1.37.0
##  [3] Biobase_2.67.0              GenomicRanges_1.59.1       
##  [5] GenomeInfoDb_1.43.4         IRanges_2.41.3             
##  [7] S4Vectors_0.45.4            BiocGenerics_0.53.6        
##  [9] generics_0.1.3              MatrixGenerics_1.19.1      
## [11] matrixStats_1.5.0           BiocStyle_2.35.0           
## 
## loaded via a namespace (and not attached):
##   [1] mnormt_2.1.1            DBI_1.2.3               pbapply_1.7-2          
##   [4] gridExtra_2.3           rlang_1.1.5             magrittr_2.0.3         
##   [7] compiler_4.4.3          RSQLite_2.3.9           mgcv_1.9-1             
##  [10] png_0.1-8               vctrs_0.6.5             stringr_1.5.1          
##  [13] pkgconfig_2.0.3         crayon_1.5.3            fastmap_1.2.0          
##  [16] backports_1.5.0         XVector_0.47.2          labeling_0.4.3         
##  [19] rmarkdown_2.29          preprocessCore_1.69.0   UCSC.utils_1.3.1       
##  [22] bit_4.6.0               xfun_0.51               cachem_1.1.0           
##  [25] jsonlite_2.0.0          blob_1.2.4              DelayedArray_0.33.6    
##  [28] BiocParallel_1.41.2     psych_2.5.3             Maaslin2_1.21.0        
##  [31] parallel_4.4.3          cluster_2.1.8.1         biglm_0.9-3            
##  [34] R6_2.6.1                RColorBrewer_1.1-3      bslib_0.9.0            
##  [37] stringi_1.8.7           rpart_4.1.24            jquerylib_0.1.4        
##  [40] Rcpp_1.0.14             iterators_1.0.14        knitr_1.50             
##  [43] WGCNA_1.73              base64enc_0.1-3         Matrix_1.7-3           
##  [46] splines_4.4.3           nnet_7.3-20             tidyselect_1.2.1       
##  [49] rstudioapi_0.17.1       abind_1.4-8             yaml_2.3.10            
##  [52] doParallel_1.0.17       codetools_0.2-20        plyr_1.8.9             
##  [55] lattice_0.22-6          tibble_3.2.1            withr_3.0.2            
##  [58] KEGGREST_1.47.0         evaluate_1.0.3          foreign_0.8-89         
##  [61] survival_3.8-3          getopt_1.20.4           Biostrings_2.75.4      
##  [64] pillar_1.10.1           BiocManager_1.30.25     checkmate_2.3.2        
##  [67] foreach_1.5.2           pcaPP_2.0-5             ggplot2_3.5.1          
##  [70] munsell_0.5.1           scales_1.3.0            glue_1.8.0             
##  [73] Hmisc_5.2-3             maketools_1.3.2         tools_4.4.3            
##  [76] robustbase_0.99-4-1     sys_3.4.3               data.table_1.17.0      
##  [79] mvtnorm_1.3-3           buildtools_1.0.0        fastcluster_1.2.6      
##  [82] grid_4.4.3              optparse_1.7.5          impute_1.81.0          
##  [85] AnnotationDbi_1.69.0    colorspace_2.1-1        nlme_3.1-167           
##  [88] GenomeInfoDbData_1.2.13 htmlTable_2.4.3         Formula_1.2-5          
##  [91] cli_3.6.4               S4Arrays_1.7.3          dplyr_1.1.4            
##  [94] DEoptimR_1.1-3-1        gtable_0.3.6            hash_2.2.6.3           
##  [97] logging_0.10-108        dynamicTreeCut_1.63-1   sass_0.4.9             
## [100] digest_0.6.37           SparseArray_1.7.7       farver_2.1.2           
## [103] htmlwidgets_1.6.4       memoise_2.0.1           htmltools_0.5.8.1      
## [106] lifecycle_1.0.4         httr_1.4.7              GO.db_3.20.0           
## [109] bit64_4.6.0-1

Advanced Topics

Generating the input chemical taxonomy file

The input taxonomy dataframe can be generated using the input metabolic features annotation dataframe using Macarron::decorateID(). This function annotates an HMDB ID or a PubChem CID with the chemical class and subclass of the metabolite.

taxonomy_df <- decorateID(input_annotations = annotations_df)
write.csv(taxonomy_df, file="demo_taxonomy.csv", row.names = FALSE)

Accessory output files

Macarron.log

A record of all chosen parameters and steps that were followed during execution.

modules_measures_of_success.csv

This file provides information about the properties of covariance modules used in the analysis. By default, modules are generated using a minimum module size (MMS) (argument: min_module_size) equal to cube root of the total number of prevalent metabolic features. Macarron evaluates 9 measures of success (MOS) that collectively capture the “correctness” and chemical homogeneity of the modules. The MOS are as follows:

  • Total modules: Number of modules.
  • Singletons: Number of metabolic features that were not assigned to any module at MMS.
  • % Annotated modules: Percentage of modules that contained at least one annotated metabolic feature.
  • % Consistent assignments: Percentage of times the same metabolic feature was assigned to the same module e.g. if three metabolic features represent glucose, they should all be in the same module. This percentage must be high.
  • Max classes per module: The highest number of chemical classes observed in any module. This is evaluated using the chemical taxonomy of covarying annotated features.
  • 90p classes per module: 90th percentile of classes per module; captures the chemical homogeneity of the modules.
  • Max subclasses per module: The highest number of chemical subclasses observed in any module.
  • 90p subclasses per module: 90th percentile of subclasses per module; captures the chemical homogeneity of the modules.
  • % Features in HAM: Macarron first finds homogeneously annoted modules (HAMs): These are modules in which >75% annotated features have the same chemical class indicating that they are chemically homogeneous. It then calculates how many features the HAMs account for.

Maaslin2 results

This folder contains the Maaslin2 log file (maaslin2.log), significant associations found by Maaslin2 (significant_results.tsv) and the linear model residuals file (residuals.rds). For more information, see Maaslin2.

Changing defaults

Filtering metabolic features based on prevalence

Ideally, at least 50% metabolic features must be retained after prevalence filtering. By default, Macarron uses the union of metabolic features observed (non-zero abundance) in at least 70% samples of any phenotype for further analysis. This prevalence threshold may be high for some metabolomics datasets and can be changed using the min_prevalence argument.

prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
                                        input_annotations = annotations_df,
                                        input_metadata = metadata_df,
                                        input_taxonomy = taxonomy_df,
                                        min_prevalence = 0.5)
# or
prism_w <- makeDisMat(se = prism_mbx,
                      min_prevalence = 0.5)

Minimum module size

By default, cube root of the total number of prevalent features is used as the minimum module size (MMS) (argument: min_module_size) for module detection and generation. We expect this to work for most real world datasets. To determine if the modules are optimal for further analysis, Macarron evaluates several measures of success (MOS) as described above. In addition to evaluating MOS for modules generated using the default MMS, Macarron also evaluates MOS for MMS values that are larger (MMS+5, MMS+10) and smaller (MMS-5, MMS-10) than the default MMS. If you find that the MOS improve with larger or smaller MMS, you may change the default accordingly. For more details about module detection, please see WGCNA and dynamicTreeCut.

# See MOS of modules generated using default
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df)
prism_modules_mos <- prism_modules[[2]]
View(prism_modules_mos)

# Change MMS
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df,
                            min_module_size = 10)

Specifying fixed effects, random effects and reference

Macarron uses Maaslin2 for determining the q-value of differential abundance in a phenotype of interest. For default execution, the phenotype of interest must be a category in column 1 of the metadata dataframe e.g. IBD in diagnosis in the demo. This is also the column that is picked by the metadata_variable argument for identifying the main phenotypes/conditions in any dataset (see Macarron.log file). Further, in the default execution, all columns in the metadata table are considered as fixed effects and the alphabetically first categorical variable in each covariate with two categories is considered as the reference. Maaslin2 requires reference categories to be explicitly defined for all categorical metadata with more than two categories. Defaults can be changed with the arguments fixed_effects, random_effects and reference. In the demo example, fixed effects and reference can be defined as follows:

prism_qval <- calQval(se = prism_mbx,
                      mod.assn = prism_modules,
                      metadata_variable = "diagnosis",
                      fixed_effects = c("diagnosis","age","antibiotics"),
                      reference = c("diagnosis,Control";"antibiotics,No"))

Command line invocation

The package source contains a script MacarronCMD.R in inst/scripts to invoke Macarron in the command line using Rscript. The inst/scripts folder also contains a README file that comprehensively documents the usage of the script.