Macarron User Manual

Abstract

Macarron is a workflow to systematically annotate and prioritize potentially bioactive (and often unannotated) small molecules in microbial community metabolomic datasets. Macarron prioritizes metabolic features as potentially bioactive in a phenotype/condition of interest using a combination of (a) covariance with annotated metabolites, (b) ecological properties such as abundance with respect to covarying annotated compounds, and (c) differential abundance in the phenotype/condition of interest.

If you have questions, please direct it to: Macarron Forum

Installation

Macarron requires R version 4.2.0 or higher. Install Bioconductor and then install Macarron:

if(!requireNamespace("BiocManager", quietly = TRUE))
    install.packages("BiocManager")
BiocManager::install("Macarron")

Running Macarron

Macarron can be run from the command line or as an R function. Both methods require the same arguments, have the same options, and use the same default settings. The package includes the wrapper Macarron() as well as functions which perform different steps in the Macarron framework.

Input CSV files

Macarron requires 4 comma-separated, appropriately formatted input files. The files and their formatting constraints are described below.

  1. Metabolic features abundances
    • Must contain features in rows and samples in columns.
    • First column must identify features.
  2. Metabolic features annotations
    • Must contain features in rows and annotations in columns.
    • First column must identify features.
    • Second column must contain either HMDB ID or PubChem Compound Identifier (CID).
    • Third column must contain the name of the metabolite.
    • Fourth column must contain a continuous chemical property such as m/z or RT or shift/ppm.
    • Other annotations such as RT, m/z or other identifiers can be listed column 4 onward.
  3. Sample metadata
    • Must contain samples in rows and metadata in columns.
    • First column must identify samples.
    • Second column must contain categorical metadata relevant to prioritization such as phenotypes, exposures or environments.
  4. Chemical taxonomy
    • First column must contain the HMDB ID or PubChem CID. IDs must be consistent between annotation and taxonomy files.
    • Second and third columns must contain chemical subclass and class of the respective metabolite.

If you do not have the chemical taxonomy file, you can generate this file using the annotation dataframe and Macarron utility decorate_ID (see Advanced Topics).

Output Files

By default, all files will be stored in a folder named Macarron_output inside the current working directory. The main prioritization results are stored in prioritized_metabolites_all.csv. Another file, prioritized_metabolites_characterizable.csv is a subset of prioritized_metabolites_all.csv and only contains metabolic features which covary with at least one annotated metabolite. The columns in these output files are:

  • Feature_index: Lists the identifier of the metabolic feature found in column 1 of abundance and annotation files.
  • HMDB_ID (or PubChem ID): Public database identifier from column 2 of annotation file (column 1 of annotation dataframe).
  • Metabolite name: From column 2 of annotation dataframe.
  • mz: The continuous numerical chemical property from column 3 of the annotation dataframe.
  • Priority_score: 1 indicates most prioritized. It is the percentile from the meta-rank of AVA, q-value and effect size.
  • Status: Direction of perturbation (differential abundance) in the phenotype (or environment) of interest compared to reference phenotype.
  • Module: ID of the covariance module a metabolic feature is a member of. Module = 0 indicates a singleton i.e., a metabolic feature that is not assigned to any module.
  • Anchor (of a module): Metabolic feature that has the highest abundance in any phenotype.
  • Related_classes: Chemical taxonomy of the annotated features that covary with a metabolic feature.
  • Covaries_with_standard: 1 (yes) and 0 (no). Column specifies if the metabolic feature covaries with at least one annotated (standard) metabolite.
  • AVA: Abundance versus anchor which is a ratio of the highest abundance (in any phenotype) of a metabolic feature and highest abundance of the covarying anchor. Naturally, the AVA of an anchor metabolite is 1.
  • qvalue: Estimated from multivariate linear model using Maaslin2.
  • effect_size
  • Remaining columns from the annotation dataframe are appended.

Run a demo in R

Using CSV files as inputs

Example (demo) input files can be found under inst/extdata folder of the Macarron source. These files were generated from the PRISM study of stool metabolomes of individuals with inflammatory bowel disease (IBD) and healthy “Control” individuals. Control and IBD are the two phenotypes in this example. Macarron will be applied to prioritize metabolic features with respect to their bioactivity in IBD. Therefore, in this example, the phenotype of interest is “IBD” and the reference phenotype is “Control”. The four input files are demo_abundances.csv, demo_annotations.csv, demo_metadata.csv, and demo_taxonomy.csv.

library(Macarron)
## Loading required package: SummarizedExperiment
## Loading required package: MatrixGenerics
## Loading required package: matrixStats
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## Attaching package: 'MatrixGenerics'
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## Loading required package: GenomicRanges
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prism_abundances <- system.file(
    'extdata','demo_abundances.csv', package="Macarron")
prism_annotations <-system.file(
    'extdata','demo_annotations.csv', package="Macarron")
prism_metadata <-system.file(
    'extdata','demo_metadata.csv', package="Macarron")
mets_taxonomy <-system.file(
    'extdata','demo_taxonomy.csv', package="Macarron")
prism_prioritized <- Macarron::Macarron(input_abundances = prism_abundances,
                                        input_annotations = prism_annotations,
                                        input_metadata = prism_metadata,
                                        input_taxonomy = mets_taxonomy)
## 2024-11-29 08:29:29.910047 INFO::Creating output folder.
## 2024-11-29 08:29:29.919581 INFO::Writing function arguments to log file
## Samples with both abundances and metadata: 102
## 2024-11-29 08:29:30.339076 INFO::Summarized Experiment created.
## 2024-11-29 08:29:30.34009 INFO::Metadata chosen for prevalence filtering: diagnosis
## 869 features pass chosen minimum prevalence threshold of 0.7.
## Calculating pairwise correlations in phenotype: IBD
## 
## Calculating pairwise correlations in phenotype: Control
## Distance matrix with 869 features created.
## 2024-11-29 08:29:33.347804 INFO::Distance matrix with 869 metabolic features created.
## Initiating module detection
## 2024-11-29 08:29:33.348738 INFO::Minimum module size used for this dataset: 10
## Tree constructed
## Evaluating measures of success
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
## 2024-11-29 08:29:34.77846 INFO::Total number of modules detected: 30
## Initiating AVA calculations
## Finding anchors
## Calculating AVA
## Initiating q-value calculations
## [1] "Creating output folder"
## [1] "Creating output feature tables folder"
## [1] "Creating output fits folder"
## [1] "Creating output figures folder"
## 2024-11-29 08:29:36.081026 INFO::Writing function arguments to log file
## 2024-11-29 08:29:36.084783 INFO::Verifying options selected are valid
## 2024-11-29 08:29:36.109929 INFO::Determining format of input files
## 2024-11-29 08:29:36.110501 INFO::Input format is data samples as columns and metadata samples as rows
## 2024-11-29 08:29:36.120746 INFO::Formula for fixed effects: expr ~  diagnosis + age + antibiotics
## 2024-11-29 08:29:36.121682 INFO::Filter data based on min abundance and min prevalence
## 2024-11-29 08:29:36.122136 INFO::Total samples in data: 102
## 2024-11-29 08:29:36.122555 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000
## 2024-11-29 08:29:36.1306 INFO::Total filtered features: 0
## 2024-11-29 08:29:36.131126 INFO::Filtered feature names from abundance and prevalence filtering:
## 2024-11-29 08:29:36.143201 INFO::Total filtered features with variance filtering: 0
## 2024-11-29 08:29:36.143727 INFO::Filtered feature names from variance filtering:
## 2024-11-29 08:29:36.144145 INFO::Running selected normalization method: NONE
## 2024-11-29 08:29:36.144585 INFO::Applying z-score to standardize continuous metadata
## 2024-11-29 08:29:36.157277 INFO::Running selected transform method: NONE
## 2024-11-29 08:29:36.157817 INFO::Running selected analysis method: LM
## 2024-11-29 08:29:36.161027 INFO::Fitting model to feature number 1, F1
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## 2024-11-29 08:29:36.520998 INFO::Fitting model to feature number 159, F165
## 2024-11-29 08:29:36.523307 INFO::Fitting model to feature number 160, F166
## 2024-11-29 08:29:36.52562 INFO::Fitting model to feature number 161, F167
## 2024-11-29 08:29:36.527937 INFO::Fitting model to feature number 162, F168
## 2024-11-29 08:29:36.530256 INFO::Fitting model to feature number 163, F169
## 2024-11-29 08:29:36.53255 INFO::Fitting model to feature number 164, F170
## 2024-11-29 08:29:36.534869 INFO::Fitting model to feature number 165, F171
## 2024-11-29 08:29:36.537166 INFO::Fitting model to feature number 166, F172
## 2024-11-29 08:29:36.53948 INFO::Fitting model to feature number 167, F173
## 2024-11-29 08:29:36.54182 INFO::Fitting model to feature number 168, F174
## 2024-11-29 08:29:36.544121 INFO::Fitting model to feature number 169, F175
## 2024-11-29 08:29:36.546447 INFO::Fitting model to feature number 170, F176
## 2024-11-29 08:29:36.548743 INFO::Fitting model to feature number 171, F177
## 2024-11-29 08:29:36.551072 INFO::Fitting model to feature number 172, F178
## 2024-11-29 08:29:36.553447 INFO::Fitting model to feature number 173, F179
## 2024-11-29 08:29:36.555766 INFO::Fitting model to feature number 174, F180
## 2024-11-29 08:29:36.558105 INFO::Fitting model to feature number 175, F181
## 2024-11-29 08:29:36.560455 INFO::Fitting model to feature number 176, F182
## 2024-11-29 08:29:36.562776 INFO::Fitting model to feature number 177, F183
## 2024-11-29 08:29:36.565053 INFO::Fitting model to feature number 178, F184
## 2024-11-29 08:29:36.567394 INFO::Fitting model to feature number 179, F185
## 2024-11-29 08:29:36.569705 INFO::Fitting model to feature number 180, F186
## 2024-11-29 08:29:36.572021 INFO::Fitting model to feature number 181, F187
## 2024-11-29 08:29:36.574354 INFO::Fitting model to feature number 182, F188
## 2024-11-29 08:29:36.576678 INFO::Fitting model to feature number 183, F189
## 2024-11-29 08:29:36.579001 INFO::Fitting model to feature number 184, F190
## 2024-11-29 08:29:36.581313 INFO::Fitting model to feature number 185, F191
## 2024-11-29 08:29:36.583624 INFO::Fitting model to feature number 186, F192
## 2024-11-29 08:29:36.585968 INFO::Fitting model to feature number 187, F193
## 2024-11-29 08:29:36.588279 INFO::Fitting model to feature number 188, F194
## 2024-11-29 08:29:36.590593 INFO::Fitting model to feature number 189, F195
## 2024-11-29 08:29:36.59289 INFO::Fitting model to feature number 190, F196
## 2024-11-29 08:29:36.5952 INFO::Fitting model to feature number 191, F197
## 2024-11-29 08:29:36.597496 INFO::Fitting model to feature number 192, F198
## 2024-11-29 08:29:36.614836 INFO::Fitting model to feature number 193, F199
## 2024-11-29 08:29:36.617232 INFO::Fitting model to feature number 194, F200
## 2024-11-29 08:29:36.619468 INFO::Fitting model to feature number 195, F201
## 2024-11-29 08:29:36.621678 INFO::Fitting model to feature number 196, F202
## 2024-11-29 08:29:36.623827 INFO::Fitting model to feature number 197, F203
## 2024-11-29 08:29:36.626003 INFO::Fitting model to feature number 198, F204
## 2024-11-29 08:29:36.628178 INFO::Fitting model to feature number 199, F206
## 2024-11-29 08:29:36.630372 INFO::Fitting model to feature number 200, F207
## 2024-11-29 08:29:36.63252 INFO::Fitting model to feature number 201, F208
## 2024-11-29 08:29:36.634705 INFO::Fitting model to feature number 202, F209
## 2024-11-29 08:29:36.636859 INFO::Fitting model to feature number 203, F210
## 2024-11-29 08:29:36.639049 INFO::Fitting model to feature number 204, F211
## 2024-11-29 08:29:36.641212 INFO::Fitting model to feature number 205, F212
## 2024-11-29 08:29:36.643425 INFO::Fitting model to feature number 206, F213
## 2024-11-29 08:29:36.645605 INFO::Fitting model to feature number 207, F214
## 2024-11-29 08:29:36.647754 INFO::Fitting model to feature number 208, F215
## 2024-11-29 08:29:36.649935 INFO::Fitting model to feature number 209, F216
## 2024-11-29 08:29:36.652085 INFO::Fitting model to feature number 210, F217
## 2024-11-29 08:29:36.654256 INFO::Fitting model to feature number 211, F218
## 2024-11-29 08:29:36.656438 INFO::Fitting model to feature number 212, F219
## 2024-11-29 08:29:36.658626 INFO::Fitting model to feature number 213, F220
## 2024-11-29 08:29:36.660838 INFO::Fitting model to feature number 214, F221
## 2024-11-29 08:29:36.663107 INFO::Fitting model to feature number 215, F222
## 2024-11-29 08:29:36.665272 INFO::Fitting model to feature number 216, F223
## 2024-11-29 08:29:36.66796 INFO::Fitting model to feature number 217, F224
## 2024-11-29 08:29:36.670169 INFO::Fitting model to feature number 218, F225
## 2024-11-29 08:29:36.672335 INFO::Fitting model to feature number 219, F226
## 2024-11-29 08:29:36.674541 INFO::Fitting model to feature number 220, F227
## 2024-11-29 08:29:36.676692 INFO::Fitting model to feature number 221, F228
## 2024-11-29 08:29:36.678893 INFO::Fitting model to feature number 222, F229
## 2024-11-29 08:29:36.681061 INFO::Fitting model to feature number 223, F230
## 2024-11-29 08:29:36.683249 INFO::Fitting model to feature number 224, F231
## 2024-11-29 08:29:36.685416 INFO::Fitting model to feature number 225, F232
## 2024-11-29 08:29:36.687638 INFO::Fitting model to feature number 226, F233
## 2024-11-29 08:29:36.689825 INFO::Fitting model to feature number 227, F234
## 2024-11-29 08:29:36.691988 INFO::Fitting model to feature number 228, F235
## 2024-11-29 08:29:36.694186 INFO::Fitting model to feature number 229, F236
## 2024-11-29 08:29:36.696369 INFO::Fitting model to feature number 230, F237
## 2024-11-29 08:29:36.698572 INFO::Fitting model to feature number 231, F238
## 2024-11-29 08:29:36.700739 INFO::Fitting model to feature number 232, F239
## 2024-11-29 08:29:36.70297 INFO::Fitting model to feature number 233, F240
## 2024-11-29 08:29:36.705164 INFO::Fitting model to feature number 234, F241
## 2024-11-29 08:29:36.707388 INFO::Fitting model to feature number 235, F242
## 2024-11-29 08:29:36.709574 INFO::Fitting model to feature number 236, F243
## 2024-11-29 08:29:36.711745 INFO::Fitting model to feature number 237, F244
## 2024-11-29 08:29:36.713951 INFO::Fitting model to feature number 238, F245
## 2024-11-29 08:29:36.716116 INFO::Fitting model to feature number 239, F246
## 2024-11-29 08:29:36.718332 INFO::Fitting model to feature number 240, F247
## 2024-11-29 08:29:36.720484 INFO::Fitting model to feature number 241, F248
## 2024-11-29 08:29:36.722685 INFO::Fitting model to feature number 242, F249
## 2024-11-29 08:29:36.724842 INFO::Fitting model to feature number 243, F250
## 2024-11-29 08:29:36.727022 INFO::Fitting model to feature number 244, F252
## 2024-11-29 08:29:36.729192 INFO::Fitting model to feature number 245, F253
## 2024-11-29 08:29:36.73138 INFO::Fitting model to feature number 246, F254
## 2024-11-29 08:29:36.733578 INFO::Fitting model to feature number 247, F255
## 2024-11-29 08:29:36.735749 INFO::Fitting model to feature number 248, F256
## 2024-11-29 08:29:36.737968 INFO::Fitting model to feature number 249, F257
## 2024-11-29 08:29:36.740188 INFO::Fitting model to feature number 250, F259
## 2024-11-29 08:29:36.742387 INFO::Fitting model to feature number 251, F260
## 2024-11-29 08:29:36.744553 INFO::Fitting model to feature number 252, F261
## 2024-11-29 08:29:36.746731 INFO::Fitting model to feature number 253, F262
## 2024-11-29 08:29:36.748883 INFO::Fitting model to feature number 254, F263
## 2024-11-29 08:29:36.751176 INFO::Fitting model to feature number 255, F264
## 2024-11-29 08:29:36.753357 INFO::Fitting model to feature number 256, F265
## 2024-11-29 08:29:36.755535 INFO::Fitting model to feature number 257, F266
## 2024-11-29 08:29:36.757722 INFO::Fitting model to feature number 258, F267
## 2024-11-29 08:29:36.759867 INFO::Fitting model to feature number 259, F269
## 2024-11-29 08:29:36.762057 INFO::Fitting model to feature number 260, F270
## 2024-11-29 08:29:36.764219 INFO::Fitting model to feature number 261, F271
## 2024-11-29 08:29:36.766426 INFO::Fitting model to feature number 262, F272
## 2024-11-29 08:29:36.768583 INFO::Fitting model to feature number 263, F273
## 2024-11-29 08:29:36.770774 INFO::Fitting model to feature number 264, F274
## 2024-11-29 08:29:36.772912 INFO::Fitting model to feature number 265, F276
## 2024-11-29 08:29:36.775078 INFO::Fitting model to feature number 266, F277
## 2024-11-29 08:29:36.777232 INFO::Fitting model to feature number 267, F278
## 2024-11-29 08:29:36.779426 INFO::Fitting model to feature number 268, F279
## 2024-11-29 08:29:36.781587 INFO::Fitting model to feature number 269, F280
## 2024-11-29 08:29:36.783745 INFO::Fitting model to feature number 270, F281
## 2024-11-29 08:29:36.785918 INFO::Fitting model to feature number 271, F282
## 2024-11-29 08:29:36.788068 INFO::Fitting model to feature number 272, F283
## 2024-11-29 08:29:36.79026 INFO::Fitting model to feature number 273, F284
## 2024-11-29 08:29:36.792392 INFO::Fitting model to feature number 274, F285
## 2024-11-29 08:29:36.79455 INFO::Fitting model to feature number 275, F286
## 2024-11-29 08:29:36.796701 INFO::Fitting model to feature number 276, F287
## 2024-11-29 08:29:36.798878 INFO::Fitting model to feature number 277, F288
## 2024-11-29 08:29:36.800999 INFO::Fitting model to feature number 278, F289
## 2024-11-29 08:29:36.803204 INFO::Fitting model to feature number 279, F290
## 2024-11-29 08:29:36.805349 INFO::Fitting model to feature number 280, F292
## 2024-11-29 08:29:36.807528 INFO::Fitting model to feature number 281, F293
## 2024-11-29 08:29:36.809686 INFO::Fitting model to feature number 282, F294
## 2024-11-29 08:29:36.811818 INFO::Fitting model to feature number 283, F295
## 2024-11-29 08:29:36.813987 INFO::Fitting model to feature number 284, F296
## 2024-11-29 08:29:36.816151 INFO::Fitting model to feature number 285, F297
## 2024-11-29 08:29:36.818342 INFO::Fitting model to feature number 286, F298
## 2024-11-29 08:29:36.820484 INFO::Fitting model to feature number 287, F299
## 2024-11-29 08:29:36.822656 INFO::Fitting model to feature number 288, F300
## 2024-11-29 08:29:36.824799 INFO::Fitting model to feature number 289, F301
## 2024-11-29 08:29:36.827077 INFO::Fitting model to feature number 290, F302
## 2024-11-29 08:29:36.829273 INFO::Fitting model to feature number 291, F303
## 2024-11-29 08:29:36.831458 INFO::Fitting model to feature number 292, F304
## 2024-11-29 08:29:36.833645 INFO::Fitting model to feature number 293, F305
## 2024-11-29 08:29:36.835814 INFO::Fitting model to feature number 294, F306
## 2024-11-29 08:29:36.838024 INFO::Fitting model to feature number 295, F307
## 2024-11-29 08:29:36.840193 INFO::Fitting model to feature number 296, F308
## 2024-11-29 08:29:36.842356 INFO::Fitting model to feature number 297, F309
## 2024-11-29 08:29:36.84453 INFO::Fitting model to feature number 298, F310
## 2024-11-29 08:29:36.846767 INFO::Fitting model to feature number 299, F311
## 2024-11-29 08:29:36.848974 INFO::Fitting model to feature number 300, F312
## 2024-11-29 08:29:36.851176 INFO::Fitting model to feature number 301, F313
## 2024-11-29 08:29:36.853372 INFO::Fitting model to feature number 302, F315
## 2024-11-29 08:29:36.855605 INFO::Fitting model to feature number 303, F316
## 2024-11-29 08:29:36.857819 INFO::Fitting model to feature number 304, F317
## 2024-11-29 08:29:36.859983 INFO::Fitting model to feature number 305, F318
## 2024-11-29 08:29:36.862189 INFO::Fitting model to feature number 306, F319
## 2024-11-29 08:29:36.864356 INFO::Fitting model to feature number 307, F320
## 2024-11-29 08:29:36.866555 INFO::Fitting model to feature number 308, F321
## 2024-11-29 08:29:36.868704 INFO::Fitting model to feature number 309, F322
## 2024-11-29 08:29:36.870894 INFO::Fitting model to feature number 310, F323
## 2024-11-29 08:29:36.873072 INFO::Fitting model to feature number 311, F324
## 2024-11-29 08:29:36.875373 INFO::Fitting model to feature number 312, F325
## 2024-11-29 08:29:36.877622 INFO::Fitting model to feature number 313, F326
## 2024-11-29 08:29:36.879836 INFO::Fitting model to feature number 314, F327
## 2024-11-29 08:29:36.882025 INFO::Fitting model to feature number 315, F328
## 2024-11-29 08:29:36.884187 INFO::Fitting model to feature number 316, F329
## 2024-11-29 08:29:36.886374 INFO::Fitting model to feature number 317, F330
## 2024-11-29 08:29:36.888541 INFO::Fitting model to feature number 318, F331
## 2024-11-29 08:29:36.890732 INFO::Fitting model to feature number 319, F332
## 2024-11-29 08:29:36.892884 INFO::Fitting model to feature number 320, F333
## 2024-11-29 08:29:36.895088 INFO::Fitting model to feature number 321, F334
## 2024-11-29 08:29:36.897256 INFO::Fitting model to feature number 322, F335
## 2024-11-29 08:29:36.89945 INFO::Fitting model to feature number 323, F336
## 2024-11-29 08:29:36.901642 INFO::Fitting model to feature number 324, F337
## 2024-11-29 08:29:36.903795 INFO::Fitting model to feature number 325, F338
## 2024-11-29 08:29:36.905956 INFO::Fitting model to feature number 326, F339
## 2024-11-29 08:29:36.908115 INFO::Fitting model to feature number 327, F340
## 2024-11-29 08:29:36.910316 INFO::Fitting model to feature number 328, F342
## 2024-11-29 08:29:36.912459 INFO::Fitting model to feature number 329, F343
## 2024-11-29 08:29:36.914632 INFO::Fitting model to feature number 330, F344
## 2024-11-29 08:29:36.916785 INFO::Fitting model to feature number 331, F345
## 2024-11-29 08:29:36.918955 INFO::Fitting model to feature number 332, F346
## 2024-11-29 08:29:36.921111 INFO::Fitting model to feature number 333, F347
## 2024-11-29 08:29:36.923299 INFO::Fitting model to feature number 334, F348
## 2024-11-29 08:29:36.925462 INFO::Fitting model to feature number 335, F350
## 2024-11-29 08:29:36.927671 INFO::Fitting model to feature number 336, F351
## 2024-11-29 08:29:36.929882 INFO::Fitting model to feature number 337, F352
## 2024-11-29 08:29:36.932048 INFO::Fitting model to feature number 338, F353
## 2024-11-29 08:29:36.934257 INFO::Fitting model to feature number 339, F355
## 2024-11-29 08:29:36.93642 INFO::Fitting model to feature number 340, F356
## 2024-11-29 08:29:36.93862 INFO::Fitting model to feature number 341, F357
## 2024-11-29 08:29:36.940775 INFO::Fitting model to feature number 342, F358
## 2024-11-29 08:29:36.942958 INFO::Fitting model to feature number 343, F359
## 2024-11-29 08:29:36.945126 INFO::Fitting model to feature number 344, F360
## 2024-11-29 08:29:36.947329 INFO::Fitting model to feature number 345, F361
## 2024-11-29 08:29:36.949489 INFO::Fitting model to feature number 346, F362
## 2024-11-29 08:29:36.951683 INFO::Fitting model to feature number 347, F363
## 2024-11-29 08:29:36.953871 INFO::Fitting model to feature number 348, F364
## 2024-11-29 08:29:36.95604 INFO::Fitting model to feature number 349, F365
## 2024-11-29 08:29:36.958248 INFO::Fitting model to feature number 350, F366
## 2024-11-29 08:29:36.960408 INFO::Fitting model to feature number 351, F367
## 2024-11-29 08:29:36.962596 INFO::Fitting model to feature number 352, F368
## 2024-11-29 08:29:36.964765 INFO::Fitting model to feature number 353, F369
## 2024-11-29 08:29:36.966974 INFO::Fitting model to feature number 354, F370
## 2024-11-29 08:29:36.969139 INFO::Fitting model to feature number 355, F371
## 2024-11-29 08:29:36.971333 INFO::Fitting model to feature number 356, F372
## 2024-11-29 08:29:36.973506 INFO::Fitting model to feature number 357, F373
## 2024-11-29 08:29:36.975701 INFO::Fitting model to feature number 358, F374
## 2024-11-29 08:29:36.977898 INFO::Fitting model to feature number 359, F375
## 2024-11-29 08:29:36.980063 INFO::Fitting model to feature number 360, F376
## 2024-11-29 08:29:36.982323 INFO::Fitting model to feature number 361, F377
## 2024-11-29 08:29:36.984493 INFO::Fitting model to feature number 362, F378
## 2024-11-29 08:29:36.986689 INFO::Fitting model to feature number 363, F379
## 2024-11-29 08:29:36.988877 INFO::Fitting model to feature number 364, F380
## 2024-11-29 08:29:36.991071 INFO::Fitting model to feature number 365, F381
## 2024-11-29 08:29:36.99323 INFO::Fitting model to feature number 366, F382
## 2024-11-29 08:29:36.995422 INFO::Fitting model to feature number 367, F383
## 2024-11-29 08:29:36.997663 INFO::Fitting model to feature number 368, F384
## 2024-11-29 08:29:36.999912 INFO::Fitting model to feature number 369, F386
## 2024-11-29 08:29:37.002124 INFO::Fitting model to feature number 370, F387
## 2024-11-29 08:29:37.004294 INFO::Fitting model to feature number 371, F388
## 2024-11-29 08:29:37.006498 INFO::Fitting model to feature number 372, F389
## 2024-11-29 08:29:37.008669 INFO::Fitting model to feature number 373, F390
## 2024-11-29 08:29:37.010866 INFO::Fitting model to feature number 374, F391
## 2024-11-29 08:29:37.013041 INFO::Fitting model to feature number 375, F392
## 2024-11-29 08:29:37.015233 INFO::Fitting model to feature number 376, F393
## 2024-11-29 08:29:37.017392 INFO::Fitting model to feature number 377, F394
## 2024-11-29 08:29:37.019571 INFO::Fitting model to feature number 378, F395
## 2024-11-29 08:29:37.02175 INFO::Fitting model to feature number 379, F396
## 2024-11-29 08:29:37.023924 INFO::Fitting model to feature number 380, F397
## 2024-11-29 08:29:37.026114 INFO::Fitting model to feature number 381, F398
## 2024-11-29 08:29:37.028295 INFO::Fitting model to feature number 382, F399
## 2024-11-29 08:29:37.030537 INFO::Fitting model to feature number 383, F400
## 2024-11-29 08:29:37.032721 INFO::Fitting model to feature number 384, F401
## 2024-11-29 08:29:37.034929 INFO::Fitting model to feature number 385, F402
## 2024-11-29 08:29:37.037107 INFO::Fitting model to feature number 386, F403
## 2024-11-29 08:29:37.039315 INFO::Fitting model to feature number 387, F404
## 2024-11-29 08:29:37.04163 INFO::Fitting model to feature number 388, F406
## 2024-11-29 08:29:37.043808 INFO::Fitting model to feature number 389, F407
## 2024-11-29 08:29:37.04601 INFO::Fitting model to feature number 390, F408
## 2024-11-29 08:29:37.048178 INFO::Fitting model to feature number 391, F409
## 2024-11-29 08:29:37.050369 INFO::Fitting model to feature number 392, F410
## 2024-11-29 08:29:37.052591 INFO::Fitting model to feature number 393, F411
## 2024-11-29 08:29:37.05481 INFO::Fitting model to feature number 394, F412
## 2024-11-29 08:29:37.056979 INFO::Fitting model to feature number 395, F413
## 2024-11-29 08:29:37.059192 INFO::Fitting model to feature number 396, F414
## 2024-11-29 08:29:37.061364 INFO::Fitting model to feature number 397, F415
## 2024-11-29 08:29:37.063575 INFO::Fitting model to feature number 398, F416
## 2024-11-29 08:29:37.065784 INFO::Fitting model to feature number 399, F417
## 2024-11-29 08:29:37.067967 INFO::Fitting model to feature number 400, F418
## 2024-11-29 08:29:37.070158 INFO::Fitting model to feature number 401, F419
## 2024-11-29 08:29:37.07232 INFO::Fitting model to feature number 402, F420
## 2024-11-29 08:29:37.074521 INFO::Fitting model to feature number 403, F421
## 2024-11-29 08:29:37.076692 INFO::Fitting model to feature number 404, F422
## 2024-11-29 08:29:37.078884 INFO::Fitting model to feature number 405, F423
## 2024-11-29 08:29:37.081056 INFO::Fitting model to feature number 406, F425
## 2024-11-29 08:29:37.083257 INFO::Fitting model to feature number 407, F426
## 2024-11-29 08:29:37.085417 INFO::Fitting model to feature number 408, F428
## 2024-11-29 08:29:37.087858 INFO::Fitting model to feature number 409, F429
## 2024-11-29 08:29:37.090047 INFO::Fitting model to feature number 410, F430
## 2024-11-29 08:29:37.092221 INFO::Fitting model to feature number 411, F431
## 2024-11-29 08:29:37.094412 INFO::Fitting model to feature number 412, F432
## 2024-11-29 08:29:37.096556 INFO::Fitting model to feature number 413, F433
## 2024-11-29 08:29:37.098758 INFO::Fitting model to feature number 414, F434
## 2024-11-29 08:29:37.100912 INFO::Fitting model to feature number 415, F435
## 2024-11-29 08:29:37.103089 INFO::Fitting model to feature number 416, F436
## 2024-11-29 08:29:37.105238 INFO::Fitting model to feature number 417, F437
## 2024-11-29 08:29:37.107448 INFO::Fitting model to feature number 418, F438
## 2024-11-29 08:29:37.109624 INFO::Fitting model to feature number 419, F439
## 2024-11-29 08:29:37.111803 INFO::Fitting model to feature number 420, F440
## 2024-11-29 08:29:37.113994 INFO::Fitting model to feature number 421, F441
## 2024-11-29 08:29:37.116136 INFO::Fitting model to feature number 422, F442
## 2024-11-29 08:29:37.130344 INFO::Fitting model to feature number 423, F443
## 2024-11-29 08:29:37.132569 INFO::Fitting model to feature number 424, F444
## 2024-11-29 08:29:37.134771 INFO::Fitting model to feature number 425, F445
## 2024-11-29 08:29:37.136926 INFO::Fitting model to feature number 426, F446
## 2024-11-29 08:29:37.139084 INFO::Fitting model to feature number 427, F447
## 2024-11-29 08:29:37.141239 INFO::Fitting model to feature number 428, F448
## 2024-11-29 08:29:37.143446 INFO::Fitting model to feature number 429, F449
## 2024-11-29 08:29:37.145622 INFO::Fitting model to feature number 430, F450
## 2024-11-29 08:29:37.147773 INFO::Fitting model to feature number 431, F451
## 2024-11-29 08:29:37.149953 INFO::Fitting model to feature number 432, F452
## 2024-11-29 08:29:37.152091 INFO::Fitting model to feature number 433, F454
## 2024-11-29 08:29:37.154273 INFO::Fitting model to feature number 434, F455
## 2024-11-29 08:29:37.156417 INFO::Fitting model to feature number 435, F456
## 2024-11-29 08:29:37.158612 INFO::Fitting model to feature number 436, F457
## 2024-11-29 08:29:37.160762 INFO::Fitting model to feature number 437, F458
## 2024-11-29 08:29:37.162915 INFO::Fitting model to feature number 438, F459
## 2024-11-29 08:29:37.165038 INFO::Fitting model to feature number 439, F461
## 2024-11-29 08:29:37.167199 INFO::Fitting model to feature number 440, F462
## 2024-11-29 08:29:37.16932 INFO::Fitting model to feature number 441, F463
## 2024-11-29 08:29:37.17151 INFO::Fitting model to feature number 442, F464
## 2024-11-29 08:29:37.173683 INFO::Fitting model to feature number 443, F465
## 2024-11-29 08:29:37.175852 INFO::Fitting model to feature number 444, F466
## 2024-11-29 08:29:37.17802 INFO::Fitting model to feature number 445, F467
## 2024-11-29 08:29:37.180149 INFO::Fitting model to feature number 446, F468
## 2024-11-29 08:29:37.182351 INFO::Fitting model to feature number 447, F469
## 2024-11-29 08:29:37.18451 INFO::Fitting model to feature number 448, F470
## 2024-11-29 08:29:37.186682 INFO::Fitting model to feature number 449, F471
## 2024-11-29 08:29:37.188816 INFO::Fitting model to feature number 450, F474
## 2024-11-29 08:29:37.191012 INFO::Fitting model to feature number 451, F475
## 2024-11-29 08:29:37.193159 INFO::Fitting model to feature number 452, F476
## 2024-11-29 08:29:37.195329 INFO::Fitting model to feature number 453, F477
## 2024-11-29 08:29:37.197479 INFO::Fitting model to feature number 454, F478
## 2024-11-29 08:29:37.199667 INFO::Fitting model to feature number 455, F479
## 2024-11-29 08:29:37.201822 INFO::Fitting model to feature number 456, F480
## 2024-11-29 08:29:37.203981 INFO::Fitting model to feature number 457, F481
## 2024-11-29 08:29:37.206165 INFO::Fitting model to feature number 458, F482
## 2024-11-29 08:29:37.208333 INFO::Fitting model to feature number 459, F483
## 2024-11-29 08:29:37.21052 INFO::Fitting model to feature number 460, F484
## 2024-11-29 08:29:37.212672 INFO::Fitting model to feature number 461, F485
## 2024-11-29 08:29:37.214893 INFO::Fitting model to feature number 462, F486
## 2024-11-29 08:29:37.217101 INFO::Fitting model to feature number 463, F487
## 2024-11-29 08:29:37.219288 INFO::Fitting model to feature number 464, F488
## 2024-11-29 08:29:37.221447 INFO::Fitting model to feature number 465, F489
## 2024-11-29 08:29:37.223646 INFO::Fitting model to feature number 466, F490
## 2024-11-29 08:29:37.225829 INFO::Fitting model to feature number 467, F491
## 2024-11-29 08:29:37.227988 INFO::Fitting model to feature number 468, F492
## 2024-11-29 08:29:37.230187 INFO::Fitting model to feature number 469, F493
## 2024-11-29 08:29:37.232358 INFO::Fitting model to feature number 470, F494
## 2024-11-29 08:29:37.234529 INFO::Fitting model to feature number 471, F495
## 2024-11-29 08:29:37.23667 INFO::Fitting model to feature number 472, F496
## 2024-11-29 08:29:37.23887 INFO::Fitting model to feature number 473, F497
## 2024-11-29 08:29:37.241026 INFO::Fitting model to feature number 474, F498
## 2024-11-29 08:29:37.243194 INFO::Fitting model to feature number 475, F499
## 2024-11-29 08:29:37.24534 INFO::Fitting model to feature number 476, F500
## 2024-11-29 08:29:37.247551 INFO::Fitting model to feature number 477, F501
## 2024-11-29 08:29:37.249764 INFO::Fitting model to feature number 478, F502
## 2024-11-29 08:29:37.251929 INFO::Fitting model to feature number 479, F503
## 2024-11-29 08:29:37.254099 INFO::Fitting model to feature number 480, F504
## 2024-11-29 08:29:37.256259 INFO::Fitting model to feature number 481, F505
## 2024-11-29 08:29:37.258458 INFO::Fitting model to feature number 482, F506
## 2024-11-29 08:29:37.260615 INFO::Fitting model to feature number 483, F507
## 2024-11-29 08:29:37.262784 INFO::Fitting model to feature number 484, F508
## 2024-11-29 08:29:37.264939 INFO::Fitting model to feature number 485, F509
## 2024-11-29 08:29:37.267155 INFO::Fitting model to feature number 486, F510
## 2024-11-29 08:29:37.269295 INFO::Fitting model to feature number 487, F511
## 2024-11-29 08:29:37.271469 INFO::Fitting model to feature number 488, F512
## 2024-11-29 08:29:37.27364 INFO::Fitting model to feature number 489, F513
## 2024-11-29 08:29:37.275779 INFO::Fitting model to feature number 490, F514
## 2024-11-29 08:29:37.277957 INFO::Fitting model to feature number 491, F515
## 2024-11-29 08:29:37.280136 INFO::Fitting model to feature number 492, F516
## 2024-11-29 08:29:37.282335 INFO::Fitting model to feature number 493, F517
## 2024-11-29 08:29:37.284489 INFO::Fitting model to feature number 494, F518
## 2024-11-29 08:29:37.286642 INFO::Fitting model to feature number 495, F519
## 2024-11-29 08:29:37.28879 INFO::Fitting model to feature number 496, F520
## 2024-11-29 08:29:37.290984 INFO::Fitting model to feature number 497, F521
## 2024-11-29 08:29:37.29312 INFO::Fitting model to feature number 498, F522
## 2024-11-29 08:29:37.29527 INFO::Fitting model to feature number 499, F523
## 2024-11-29 08:29:37.297405 INFO::Fitting model to feature number 500, F524
## 2024-11-29 08:29:37.299587 INFO::Fitting model to feature number 501, F525
## 2024-11-29 08:29:37.301761 INFO::Fitting model to feature number 502, F526
## 2024-11-29 08:29:37.303902 INFO::Fitting model to feature number 503, F527
## 2024-11-29 08:29:37.306078 INFO::Fitting model to feature number 504, F528
## 2024-11-29 08:29:37.308223 INFO::Fitting model to feature number 505, F529
## 2024-11-29 08:29:37.310378 INFO::Fitting model to feature number 506, F530
## 2024-11-29 08:29:37.312502 INFO::Fitting model to feature number 507, F531
## 2024-11-29 08:29:37.314718 INFO::Fitting model to feature number 508, F532
## 2024-11-29 08:29:37.316909 INFO::Fitting model to feature number 509, F533
## 2024-11-29 08:29:37.319073 INFO::Fitting model to feature number 510, F534
## 2024-11-29 08:29:37.321219 INFO::Fitting model to feature number 511, F535
## 2024-11-29 08:29:37.323414 INFO::Fitting model to feature number 512, F536
## 2024-11-29 08:29:37.325597 INFO::Fitting model to feature number 513, F537
## 2024-11-29 08:29:37.32787 INFO::Fitting model to feature number 514, F539
## 2024-11-29 08:29:37.330112 INFO::Fitting model to feature number 515, F540
## 2024-11-29 08:29:37.332306 INFO::Fitting model to feature number 516, F541
## 2024-11-29 08:29:37.334562 INFO::Fitting model to feature number 517, F543
## 2024-11-29 08:29:37.336762 INFO::Fitting model to feature number 518, F544
## 2024-11-29 08:29:37.338974 INFO::Fitting model to feature number 519, F545
## 2024-11-29 08:29:37.341156 INFO::Fitting model to feature number 520, F546
## 2024-11-29 08:29:37.34335 INFO::Fitting model to feature number 521, F547
## 2024-11-29 08:29:37.345486 INFO::Fitting model to feature number 522, F548
## 2024-11-29 08:29:37.347758 INFO::Fitting model to feature number 523, F549
## 2024-11-29 08:29:37.349945 INFO::Fitting model to feature number 524, F550
## 2024-11-29 08:29:37.352175 INFO::Fitting model to feature number 525, F551
## 2024-11-29 08:29:37.354351 INFO::Fitting model to feature number 526, F552
## 2024-11-29 08:29:37.35649 INFO::Fitting model to feature number 527, F553
## 2024-11-29 08:29:37.358704 INFO::Fitting model to feature number 528, F554
## 2024-11-29 08:29:37.360879 INFO::Fitting model to feature number 529, F555
## 2024-11-29 08:29:37.363328 INFO::Fitting model to feature number 530, F556
## 2024-11-29 08:29:37.365558 INFO::Fitting model to feature number 531, F557
## 2024-11-29 08:29:37.367772 INFO::Fitting model to feature number 532, F558
## 2024-11-29 08:29:37.37 INFO::Fitting model to feature number 533, F559
## 2024-11-29 08:29:37.37219 INFO::Fitting model to feature number 534, F560
## 2024-11-29 08:29:37.374455 INFO::Fitting model to feature number 535, F561
## 2024-11-29 08:29:37.376619 INFO::Fitting model to feature number 536, F562
## 2024-11-29 08:29:37.378805 INFO::Fitting model to feature number 537, F563
## 2024-11-29 08:29:37.380946 INFO::Fitting model to feature number 538, F564
## 2024-11-29 08:29:37.383122 INFO::Fitting model to feature number 539, F566
## 2024-11-29 08:29:37.385332 INFO::Fitting model to feature number 540, F567
## 2024-11-29 08:29:37.387611 INFO::Fitting model to feature number 541, F568
## 2024-11-29 08:29:37.389877 INFO::Fitting model to feature number 542, F569
## 2024-11-29 08:29:37.392118 INFO::Fitting model to feature number 543, F570
## 2024-11-29 08:29:37.394296 INFO::Fitting model to feature number 544, F571
## 2024-11-29 08:29:37.396477 INFO::Fitting model to feature number 545, F572
## 2024-11-29 08:29:37.398683 INFO::Fitting model to feature number 546, F573
## 2024-11-29 08:29:37.400865 INFO::Fitting model to feature number 547, F574
## 2024-11-29 08:29:37.403086 INFO::Fitting model to feature number 548, F575
## 2024-11-29 08:29:37.405253 INFO::Fitting model to feature number 549, F576
## 2024-11-29 08:29:37.407465 INFO::Fitting model to feature number 550, F577
## 2024-11-29 08:29:37.409655 INFO::Fitting model to feature number 551, F578
## 2024-11-29 08:29:37.411819 INFO::Fitting model to feature number 552, F579
## 2024-11-29 08:29:37.414001 INFO::Fitting model to feature number 553, F580
## 2024-11-29 08:29:37.416156 INFO::Fitting model to feature number 554, F581
## 2024-11-29 08:29:37.418583 INFO::Fitting model to feature number 555, F582
## 2024-11-29 08:29:37.421234 INFO::Fitting model to feature number 556, F583
## 2024-11-29 08:29:37.42371 INFO::Fitting model to feature number 557, F584
## 2024-11-29 08:29:37.426112 INFO::Fitting model to feature number 558, F585
## 2024-11-29 08:29:37.428307 INFO::Fitting model to feature number 559, F586
## 2024-11-29 08:29:37.430513 INFO::Fitting model to feature number 560, F587
## 2024-11-29 08:29:37.43266 INFO::Fitting model to feature number 561, F588
## 2024-11-29 08:29:37.434839 INFO::Fitting model to feature number 562, F589
## 2024-11-29 08:29:37.437 INFO::Fitting model to feature number 563, F590
## 2024-11-29 08:29:37.439197 INFO::Fitting model to feature number 564, F591
## 2024-11-29 08:29:37.441364 INFO::Fitting model to feature number 565, F592
## 2024-11-29 08:29:37.443558 INFO::Fitting model to feature number 566, F593
## 2024-11-29 08:29:37.445753 INFO::Fitting model to feature number 567, F594
## 2024-11-29 08:29:37.447935 INFO::Fitting model to feature number 568, F595
## 2024-11-29 08:29:37.450138 INFO::Fitting model to feature number 569, F596
## 2024-11-29 08:29:37.452294 INFO::Fitting model to feature number 570, F597
## 2024-11-29 08:29:37.454469 INFO::Fitting model to feature number 571, F598
## 2024-11-29 08:29:37.45663 INFO::Fitting model to feature number 572, F599
## 2024-11-29 08:29:37.458834 INFO::Fitting model to feature number 573, F600
## 2024-11-29 08:29:37.460989 INFO::Fitting model to feature number 574, F601
## 2024-11-29 08:29:37.463186 INFO::Fitting model to feature number 575, F602
## 2024-11-29 08:29:37.465358 INFO::Fitting model to feature number 576, F603
## 2024-11-29 08:29:37.467552 INFO::Fitting model to feature number 577, F605
## 2024-11-29 08:29:37.469746 INFO::Fitting model to feature number 578, F606
## 2024-11-29 08:29:37.47191 INFO::Fitting model to feature number 579, F607
## 2024-11-29 08:29:37.474102 INFO::Fitting model to feature number 580, F608
## 2024-11-29 08:29:37.476265 INFO::Fitting model to feature number 581, F609
## 2024-11-29 08:29:37.478458 INFO::Fitting model to feature number 582, F610
## 2024-11-29 08:29:37.48062 INFO::Fitting model to feature number 583, F611
## 2024-11-29 08:29:37.482803 INFO::Fitting model to feature number 584, F612
## 2024-11-29 08:29:37.484953 INFO::Fitting model to feature number 585, F613
## 2024-11-29 08:29:37.487151 INFO::Fitting model to feature number 586, F614
## 2024-11-29 08:29:37.489311 INFO::Fitting model to feature number 587, F615
## 2024-11-29 08:29:37.491519 INFO::Fitting model to feature number 588, F616
## 2024-11-29 08:29:37.493728 INFO::Fitting model to feature number 589, F617
## 2024-11-29 08:29:37.495904 INFO::Fitting model to feature number 590, F618
## 2024-11-29 08:29:37.498101 INFO::Fitting model to feature number 591, F619
## 2024-11-29 08:29:37.500263 INFO::Fitting model to feature number 592, F620
## 2024-11-29 08:29:37.502457 INFO::Fitting model to feature number 593, F621
## 2024-11-29 08:29:37.504614 INFO::Fitting model to feature number 594, F622
## 2024-11-29 08:29:37.506797 INFO::Fitting model to feature number 595, F623
## 2024-11-29 08:29:37.508966 INFO::Fitting model to feature number 596, F624
## 2024-11-29 08:29:37.511156 INFO::Fitting model to feature number 597, F625
## 2024-11-29 08:29:37.513333 INFO::Fitting model to feature number 598, F626
## 2024-11-29 08:29:37.515524 INFO::Fitting model to feature number 599, F627
## 2024-11-29 08:29:37.517715 INFO::Fitting model to feature number 600, F628
## 2024-11-29 08:29:37.519884 INFO::Fitting model to feature number 601, F629
## 2024-11-29 08:29:37.522073 INFO::Fitting model to feature number 602, F630
## 2024-11-29 08:29:37.524237 INFO::Fitting model to feature number 603, F631
## 2024-11-29 08:29:37.52645 INFO::Fitting model to feature number 604, F632
## 2024-11-29 08:29:37.52863 INFO::Fitting model to feature number 605, F633
## 2024-11-29 08:29:37.530831 INFO::Fitting model to feature number 606, F634
## 2024-11-29 08:29:37.533003 INFO::Fitting model to feature number 607, F635
## 2024-11-29 08:29:37.535192 INFO::Fitting model to feature number 608, F636
## 2024-11-29 08:29:37.53737 INFO::Fitting model to feature number 609, F637
## 2024-11-29 08:29:37.539569 INFO::Fitting model to feature number 610, F638
## 2024-11-29 08:29:37.541749 INFO::Fitting model to feature number 611, F639
## 2024-11-29 08:29:37.543897 INFO::Fitting model to feature number 612, F640
## 2024-11-29 08:29:37.546091 INFO::Fitting model to feature number 613, F641
## 2024-11-29 08:29:37.548266 INFO::Fitting model to feature number 614, F642
## 2024-11-29 08:29:37.550468 INFO::Fitting model to feature number 615, F643
## 2024-11-29 08:29:37.552696 INFO::Fitting model to feature number 616, F644
## 2024-11-29 08:29:37.554881 INFO::Fitting model to feature number 617, F645
## 2024-11-29 08:29:37.557051 INFO::Fitting model to feature number 618, F646
## 2024-11-29 08:29:37.559242 INFO::Fitting model to feature number 619, F647
## 2024-11-29 08:29:37.561404 INFO::Fitting model to feature number 620, F648
## 2024-11-29 08:29:37.563578 INFO::Fitting model to feature number 621, F649
## 2024-11-29 08:29:37.565765 INFO::Fitting model to feature number 622, F650
## 2024-11-29 08:29:37.56798 INFO::Fitting model to feature number 623, F651
## 2024-11-29 08:29:37.570167 INFO::Fitting model to feature number 624, F652
## 2024-11-29 08:29:37.572328 INFO::Fitting model to feature number 625, F653
## 2024-11-29 08:29:37.574523 INFO::Fitting model to feature number 626, F654
## 2024-11-29 08:29:37.576678 INFO::Fitting model to feature number 627, F655
## 2024-11-29 08:29:37.578932 INFO::Fitting model to feature number 628, F656
## 2024-11-29 08:29:37.581103 INFO::Fitting model to feature number 629, F657
## 2024-11-29 08:29:37.583303 INFO::Fitting model to feature number 630, F658
## 2024-11-29 08:29:37.58547 INFO::Fitting model to feature number 631, F659
## 2024-11-29 08:29:37.587673 INFO::Fitting model to feature number 632, F660
## 2024-11-29 08:29:37.589854 INFO::Fitting model to feature number 633, F661
## 2024-11-29 08:29:37.592005 INFO::Fitting model to feature number 634, F662
## 2024-11-29 08:29:37.594188 INFO::Fitting model to feature number 635, F663
## 2024-11-29 08:29:37.596339 INFO::Fitting model to feature number 636, F664
## 2024-11-29 08:29:37.598532 INFO::Fitting model to feature number 637, F665
## 2024-11-29 08:29:37.6007 INFO::Fitting model to feature number 638, F666
## 2024-11-29 08:29:37.602927 INFO::Fitting model to feature number 639, F667
## 2024-11-29 08:29:37.605101 INFO::Fitting model to feature number 640, F668
## 2024-11-29 08:29:37.607322 INFO::Fitting model to feature number 641, F669
## 2024-11-29 08:29:37.609486 INFO::Fitting model to feature number 642, F670
## 2024-11-29 08:29:37.611706 INFO::Fitting model to feature number 643, F671
## 2024-11-29 08:29:37.613899 INFO::Fitting model to feature number 644, F672
## 2024-11-29 08:29:37.616053 INFO::Fitting model to feature number 645, F673
## 2024-11-29 08:29:37.618243 INFO::Fitting model to feature number 646, F674
## 2024-11-29 08:29:37.620414 INFO::Fitting model to feature number 647, F675
## 2024-11-29 08:29:37.622611 INFO::Fitting model to feature number 648, F676
## 2024-11-29 08:29:37.624769 INFO::Fitting model to feature number 649, F677
## 2024-11-29 08:29:37.626951 INFO::Fitting model to feature number 650, F678
## 2024-11-29 08:29:37.62911 INFO::Fitting model to feature number 651, F679
## 2024-11-29 08:29:37.63128 INFO::Fitting model to feature number 652, F680
## 2024-11-29 08:29:37.64628 INFO::Fitting model to feature number 653, F681
## 2024-11-29 08:29:37.648468 INFO::Fitting model to feature number 654, F682
## 2024-11-29 08:29:37.650659 INFO::Fitting model to feature number 655, F683
## 2024-11-29 08:29:37.65283 INFO::Fitting model to feature number 656, F684
## 2024-11-29 08:29:37.655017 INFO::Fitting model to feature number 657, F685
## 2024-11-29 08:29:37.65719 INFO::Fitting model to feature number 658, F686
## 2024-11-29 08:29:37.659394 INFO::Fitting model to feature number 659, F687
## 2024-11-29 08:29:37.661572 INFO::Fitting model to feature number 660, F688
## 2024-11-29 08:29:37.663738 INFO::Fitting model to feature number 661, F689
## 2024-11-29 08:29:37.665913 INFO::Fitting model to feature number 662, F690
## 2024-11-29 08:29:37.668067 INFO::Fitting model to feature number 663, F691
## 2024-11-29 08:29:37.670265 INFO::Fitting model to feature number 664, F692
## 2024-11-29 08:29:37.672407 INFO::Fitting model to feature number 665, F693
## 2024-11-29 08:29:37.67457 INFO::Fitting model to feature number 666, F694
## 2024-11-29 08:29:37.676704 INFO::Fitting model to feature number 667, F695
## 2024-11-29 08:29:37.678875 INFO::Fitting model to feature number 668, F696
## 2024-11-29 08:29:37.681004 INFO::Fitting model to feature number 669, F697
## 2024-11-29 08:29:37.683157 INFO::Fitting model to feature number 670, F698
## 2024-11-29 08:29:37.685307 INFO::Fitting model to feature number 671, F699
## 2024-11-29 08:29:37.687498 INFO::Fitting model to feature number 672, F700
## 2024-11-29 08:29:37.689664 INFO::Fitting model to feature number 673, F701
## 2024-11-29 08:29:37.691808 INFO::Fitting model to feature number 674, F702
## 2024-11-29 08:29:37.693981 INFO::Fitting model to feature number 675, F704
## 2024-11-29 08:29:37.696124 INFO::Fitting model to feature number 676, F705
## 2024-11-29 08:29:37.698306 INFO::Fitting model to feature number 677, F706
## 2024-11-29 08:29:37.700448 INFO::Fitting model to feature number 678, F707
## 2024-11-29 08:29:37.702623 INFO::Fitting model to feature number 679, F708
## 2024-11-29 08:29:37.704762 INFO::Fitting model to feature number 680, F709
## 2024-11-29 08:29:37.706944 INFO::Fitting model to feature number 681, F710
## 2024-11-29 08:29:37.709102 INFO::Fitting model to feature number 682, F711
## 2024-11-29 08:29:37.711267 INFO::Fitting model to feature number 683, F712
## 2024-11-29 08:29:37.713409 INFO::Fitting model to feature number 684, F713
## 2024-11-29 08:29:37.715594 INFO::Fitting model to feature number 685, F714
## 2024-11-29 08:29:37.717787 INFO::Fitting model to feature number 686, F715
## 2024-11-29 08:29:37.719927 INFO::Fitting model to feature number 687, F716
## 2024-11-29 08:29:37.722165 INFO::Fitting model to feature number 688, F717
## 2024-11-29 08:29:37.724419 INFO::Fitting model to feature number 689, F718
## 2024-11-29 08:29:37.726613 INFO::Fitting model to feature number 690, F719
## 2024-11-29 08:29:37.728778 INFO::Fitting model to feature number 691, F720
## 2024-11-29 08:29:37.730976 INFO::Fitting model to feature number 692, F721
## 2024-11-29 08:29:37.733139 INFO::Fitting model to feature number 693, F722
## 2024-11-29 08:29:37.735326 INFO::Fitting model to feature number 694, F723
## 2024-11-29 08:29:37.737478 INFO::Fitting model to feature number 695, F724
## 2024-11-29 08:29:37.739656 INFO::Fitting model to feature number 696, F725
## 2024-11-29 08:29:37.741865 INFO::Fitting model to feature number 697, F726
## 2024-11-29 08:29:37.744018 INFO::Fitting model to feature number 698, F727
## 2024-11-29 08:29:37.746227 INFO::Fitting model to feature number 699, F728
## 2024-11-29 08:29:37.748392 INFO::Fitting model to feature number 700, F729
## 2024-11-29 08:29:37.750568 INFO::Fitting model to feature number 701, F730
## 2024-11-29 08:29:37.752719 INFO::Fitting model to feature number 702, F731
## 2024-11-29 08:29:37.754895 INFO::Fitting model to feature number 703, F732
## 2024-11-29 08:29:37.757051 INFO::Fitting model to feature number 704, F733
## 2024-11-29 08:29:37.759241 INFO::Fitting model to feature number 705, F734
## 2024-11-29 08:29:37.761391 INFO::Fitting model to feature number 706, F735
## 2024-11-29 08:29:37.763567 INFO::Fitting model to feature number 707, F736
## 2024-11-29 08:29:37.765747 INFO::Fitting model to feature number 708, F737
## 2024-11-29 08:29:37.767895 INFO::Fitting model to feature number 709, F739
## 2024-11-29 08:29:37.770061 INFO::Fitting model to feature number 710, F740
## 2024-11-29 08:29:37.772217 INFO::Fitting model to feature number 711, F741
## 2024-11-29 08:29:37.774381 INFO::Fitting model to feature number 712, F742
## 2024-11-29 08:29:37.776525 INFO::Fitting model to feature number 713, F743
## 2024-11-29 08:29:37.778705 INFO::Fitting model to feature number 714, F744
## 2024-11-29 08:29:37.780876 INFO::Fitting model to feature number 715, F745
## 2024-11-29 08:29:37.7831 INFO::Fitting model to feature number 716, F746
## 2024-11-29 08:29:37.785262 INFO::Fitting model to feature number 717, F747
## 2024-11-29 08:29:37.787438 INFO::Fitting model to feature number 718, F748
## 2024-11-29 08:29:37.789587 INFO::Fitting model to feature number 719, F749
## 2024-11-29 08:29:37.791733 INFO::Fitting model to feature number 720, F750
## 2024-11-29 08:29:37.793932 INFO::Fitting model to feature number 721, F751
## 2024-11-29 08:29:37.796081 INFO::Fitting model to feature number 722, F752
## 2024-11-29 08:29:37.798277 INFO::Fitting model to feature number 723, F753
## 2024-11-29 08:29:37.800419 INFO::Fitting model to feature number 724, F754
## 2024-11-29 08:29:37.802601 INFO::Fitting model to feature number 725, F755
## 2024-11-29 08:29:37.804738 INFO::Fitting model to feature number 726, F756
## 2024-11-29 08:29:37.806918 INFO::Fitting model to feature number 727, F757
## 2024-11-29 08:29:37.809071 INFO::Fitting model to feature number 728, F758
## 2024-11-29 08:29:37.811246 INFO::Fitting model to feature number 729, F759
## 2024-11-29 08:29:37.813376 INFO::Fitting model to feature number 730, F760
## 2024-11-29 08:29:37.815534 INFO::Fitting model to feature number 731, F761
## 2024-11-29 08:29:37.817707 INFO::Fitting model to feature number 732, F762
## 2024-11-29 08:29:37.819846 INFO::Fitting model to feature number 733, F763
## 2024-11-29 08:29:37.822013 INFO::Fitting model to feature number 734, F764
## 2024-11-29 08:29:37.824151 INFO::Fitting model to feature number 735, F765
## 2024-11-29 08:29:37.826306 INFO::Fitting model to feature number 736, F766
## 2024-11-29 08:29:37.828535 INFO::Fitting model to feature number 737, F767
## 2024-11-29 08:29:37.830767 INFO::Fitting model to feature number 738, F768
## 2024-11-29 08:29:37.832929 INFO::Fitting model to feature number 739, F769
## 2024-11-29 08:29:37.835104 INFO::Fitting model to feature number 740, F770
## 2024-11-29 08:29:37.837242 INFO::Fitting model to feature number 741, F771
## 2024-11-29 08:29:37.839415 INFO::Fitting model to feature number 742, F772
## 2024-11-29 08:29:37.841591 INFO::Fitting model to feature number 743, F773
## 2024-11-29 08:29:37.843788 INFO::Fitting model to feature number 744, F774
## 2024-11-29 08:29:37.845978 INFO::Fitting model to feature number 745, F775
## 2024-11-29 08:29:37.848177 INFO::Fitting model to feature number 746, F776
## 2024-11-29 08:29:37.850363 INFO::Fitting model to feature number 747, F777
## 2024-11-29 08:29:37.852518 INFO::Fitting model to feature number 748, F778
## 2024-11-29 08:29:37.854766 INFO::Fitting model to feature number 749, F779
## 2024-11-29 08:29:37.856952 INFO::Fitting model to feature number 750, F780
## 2024-11-29 08:29:37.859137 INFO::Fitting model to feature number 751, F781
## 2024-11-29 08:29:37.8613 INFO::Fitting model to feature number 752, F782
## 2024-11-29 08:29:37.863501 INFO::Fitting model to feature number 753, F783
## 2024-11-29 08:29:37.865709 INFO::Fitting model to feature number 754, F784
## 2024-11-29 08:29:37.867888 INFO::Fitting model to feature number 755, F785
## 2024-11-29 08:29:37.870064 INFO::Fitting model to feature number 756, F786
## 2024-11-29 08:29:37.872242 INFO::Fitting model to feature number 757, F787
## 2024-11-29 08:29:37.874449 INFO::Fitting model to feature number 758, F788
## 2024-11-29 08:29:37.87665 INFO::Fitting model to feature number 759, F789
## 2024-11-29 08:29:37.878868 INFO::Fitting model to feature number 760, F790
## 2024-11-29 08:29:37.881078 INFO::Fitting model to feature number 761, F791
## 2024-11-29 08:29:37.883305 INFO::Fitting model to feature number 762, F792
## 2024-11-29 08:29:37.885475 INFO::Fitting model to feature number 763, F793
## 2024-11-29 08:29:37.887714 INFO::Fitting model to feature number 764, F794
## 2024-11-29 08:29:37.889911 INFO::Fitting model to feature number 765, F795
## 2024-11-29 08:29:37.892067 INFO::Fitting model to feature number 766, F796
## 2024-11-29 08:29:37.894238 INFO::Fitting model to feature number 767, F797
## 2024-11-29 08:29:37.896397 INFO::Fitting model to feature number 768, F798
## 2024-11-29 08:29:37.898582 INFO::Fitting model to feature number 769, F799
## 2024-11-29 08:29:37.900764 INFO::Fitting model to feature number 770, F800
## 2024-11-29 08:29:37.903037 INFO::Fitting model to feature number 771, F801
## 2024-11-29 08:29:37.905266 INFO::Fitting model to feature number 772, F802
## 2024-11-29 08:29:37.907475 INFO::Fitting model to feature number 773, F803
## 2024-11-29 08:29:37.909674 INFO::Fitting model to feature number 774, F804
## 2024-11-29 08:29:37.911844 INFO::Fitting model to feature number 775, F805
## 2024-11-29 08:29:37.914016 INFO::Fitting model to feature number 776, F806
## 2024-11-29 08:29:37.916184 INFO::Fitting model to feature number 777, F808
## 2024-11-29 08:29:37.918384 INFO::Fitting model to feature number 778, F809
## 2024-11-29 08:29:37.92055 INFO::Fitting model to feature number 779, F810
## 2024-11-29 08:29:37.922744 INFO::Fitting model to feature number 780, F811
## 2024-11-29 08:29:37.924906 INFO::Fitting model to feature number 781, F812
## 2024-11-29 08:29:37.927106 INFO::Fitting model to feature number 782, F813
## 2024-11-29 08:29:37.929269 INFO::Fitting model to feature number 783, F814
## 2024-11-29 08:29:37.931444 INFO::Fitting model to feature number 784, F815
## 2024-11-29 08:29:37.933606 INFO::Fitting model to feature number 785, F816
## 2024-11-29 08:29:37.935781 INFO::Fitting model to feature number 786, F817
## 2024-11-29 08:29:37.937991 INFO::Fitting model to feature number 787, F818
## 2024-11-29 08:29:37.940152 INFO::Fitting model to feature number 788, F819
## 2024-11-29 08:29:37.942323 INFO::Fitting model to feature number 789, F820
## 2024-11-29 08:29:37.944477 INFO::Fitting model to feature number 790, F821
## 2024-11-29 08:29:37.94664 INFO::Fitting model to feature number 791, F822
## 2024-11-29 08:29:37.948839 INFO::Fitting model to feature number 792, F823
## 2024-11-29 08:29:37.951064 INFO::Fitting model to feature number 793, F824
## 2024-11-29 08:29:37.953238 INFO::Fitting model to feature number 794, F825
## 2024-11-29 08:29:37.955439 INFO::Fitting model to feature number 795, F826
## 2024-11-29 08:29:37.957624 INFO::Fitting model to feature number 796, F827
## 2024-11-29 08:29:37.959785 INFO::Fitting model to feature number 797, F828
## 2024-11-29 08:29:37.961974 INFO::Fitting model to feature number 798, F829
## 2024-11-29 08:29:37.964127 INFO::Fitting model to feature number 799, F830
## 2024-11-29 08:29:37.966301 INFO::Fitting model to feature number 800, F831
## 2024-11-29 08:29:37.968451 INFO::Fitting model to feature number 801, F832
## 2024-11-29 08:29:37.970627 INFO::Fitting model to feature number 802, F833
## 2024-11-29 08:29:37.972784 INFO::Fitting model to feature number 803, F834
## 2024-11-29 08:29:37.974971 INFO::Fitting model to feature number 804, F835
## 2024-11-29 08:29:37.977147 INFO::Fitting model to feature number 805, F836
## 2024-11-29 08:29:37.979337 INFO::Fitting model to feature number 806, F837
## 2024-11-29 08:29:37.981554 INFO::Fitting model to feature number 807, F838
## 2024-11-29 08:29:37.983725 INFO::Fitting model to feature number 808, F839
## 2024-11-29 08:29:37.985966 INFO::Fitting model to feature number 809, F840
## 2024-11-29 08:29:37.988143 INFO::Fitting model to feature number 810, F841
## 2024-11-29 08:29:37.99034 INFO::Fitting model to feature number 811, F842
## 2024-11-29 08:29:37.992486 INFO::Fitting model to feature number 812, F843
## 2024-11-29 08:29:37.994673 INFO::Fitting model to feature number 813, F844
## 2024-11-29 08:29:37.996828 INFO::Fitting model to feature number 814, F845
## 2024-11-29 08:29:37.999047 INFO::Fitting model to feature number 815, F846
## 2024-11-29 08:29:38.00121 INFO::Fitting model to feature number 816, F847
## 2024-11-29 08:29:38.003392 INFO::Fitting model to feature number 817, F848
## 2024-11-29 08:29:38.00557 INFO::Fitting model to feature number 818, F849
## 2024-11-29 08:29:38.007756 INFO::Fitting model to feature number 819, F850
## 2024-11-29 08:29:38.009943 INFO::Fitting model to feature number 820, F851
## 2024-11-29 08:29:38.012104 INFO::Fitting model to feature number 821, F852
## 2024-11-29 08:29:38.014296 INFO::Fitting model to feature number 822, F853
## 2024-11-29 08:29:38.016455 INFO::Fitting model to feature number 823, F854
## 2024-11-29 08:29:38.018647 INFO::Fitting model to feature number 824, F855
## 2024-11-29 08:29:38.020812 INFO::Fitting model to feature number 825, F856
## 2024-11-29 08:29:38.023005 INFO::Fitting model to feature number 826, F857
## 2024-11-29 08:29:38.025174 INFO::Fitting model to feature number 827, F858
## 2024-11-29 08:29:38.02737 INFO::Fitting model to feature number 828, F859
## 2024-11-29 08:29:38.029569 INFO::Fitting model to feature number 829, F860
## 2024-11-29 08:29:38.031744 INFO::Fitting model to feature number 830, F861
## 2024-11-29 08:29:38.033937 INFO::Fitting model to feature number 831, F862
## 2024-11-29 08:29:38.036113 INFO::Fitting model to feature number 832, F863
## 2024-11-29 08:29:38.038317 INFO::Fitting model to feature number 833, F864
## 2024-11-29 08:29:38.040632 INFO::Fitting model to feature number 834, F865
## 2024-11-29 08:29:38.043357 INFO::Fitting model to feature number 835, F866
## 2024-11-29 08:29:38.04582 INFO::Fitting model to feature number 836, F867
## 2024-11-29 08:29:38.048058 INFO::Fitting model to feature number 837, F868
## 2024-11-29 08:29:38.050294 INFO::Fitting model to feature number 838, F869
## 2024-11-29 08:29:38.052528 INFO::Fitting model to feature number 839, F870
## 2024-11-29 08:29:38.054736 INFO::Fitting model to feature number 840, F871
## 2024-11-29 08:29:38.056967 INFO::Fitting model to feature number 841, F872
## 2024-11-29 08:29:38.059205 INFO::Fitting model to feature number 842, F873
## 2024-11-29 08:29:38.061417 INFO::Fitting model to feature number 843, F874
## 2024-11-29 08:29:38.06362 INFO::Fitting model to feature number 844, F875
## 2024-11-29 08:29:38.065826 INFO::Fitting model to feature number 845, F876
## 2024-11-29 08:29:38.06802 INFO::Fitting model to feature number 846, F877
## 2024-11-29 08:29:38.070223 INFO::Fitting model to feature number 847, F878
## 2024-11-29 08:29:38.07238 INFO::Fitting model to feature number 848, F879
## 2024-11-29 08:29:38.074589 INFO::Fitting model to feature number 849, F880
## 2024-11-29 08:29:38.076752 INFO::Fitting model to feature number 850, F881
## 2024-11-29 08:29:38.078961 INFO::Fitting model to feature number 851, F882
## 2024-11-29 08:29:38.08113 INFO::Fitting model to feature number 852, F883
## 2024-11-29 08:29:38.083325 INFO::Fitting model to feature number 853, F884
## 2024-11-29 08:29:38.085501 INFO::Fitting model to feature number 854, F885
## 2024-11-29 08:29:38.08771 INFO::Fitting model to feature number 855, F886
## 2024-11-29 08:29:38.089891 INFO::Fitting model to feature number 856, F887
## 2024-11-29 08:29:38.092059 INFO::Fitting model to feature number 857, F888
## 2024-11-29 08:29:38.094248 INFO::Fitting model to feature number 858, F889
## 2024-11-29 08:29:38.09642 INFO::Fitting model to feature number 859, F890
## 2024-11-29 08:29:38.098629 INFO::Fitting model to feature number 860, F891
## 2024-11-29 08:29:38.10081 INFO::Fitting model to feature number 861, F892
## 2024-11-29 08:29:38.102998 INFO::Fitting model to feature number 862, F893
## 2024-11-29 08:29:38.105158 INFO::Fitting model to feature number 863, F894
## 2024-11-29 08:29:38.107364 INFO::Fitting model to feature number 864, F895
## 2024-11-29 08:29:38.109574 INFO::Fitting model to feature number 865, F896
## 2024-11-29 08:29:38.111737 INFO::Fitting model to feature number 866, F897
## 2024-11-29 08:29:38.113926 INFO::Fitting model to feature number 867, F898
## 2024-11-29 08:29:38.116092 INFO::Fitting model to feature number 868, F899
## 2024-11-29 08:29:38.118287 INFO::Fitting model to feature number 869, F900
## 2024-11-29 08:29:38.234645 INFO::Counting total values for each feature
## 2024-11-29 08:29:38.310226 INFO::Writing filtered data to file Macarron_output/maaslin2_results/features/filtered_data.tsv
## 2024-11-29 08:29:38.366389 INFO::Writing filtered, normalized data to file Macarron_output/maaslin2_results/features/filtered_data_norm.tsv
## 2024-11-29 08:29:38.422217 INFO::Writing filtered, normalized, transformed data to file Macarron_output/maaslin2_results/features/filtered_data_norm_transformed.tsv
## 2024-11-29 08:29:38.477804 INFO::Writing residuals to file Macarron_output/maaslin2_results/fits/residuals.rds
## 2024-11-29 08:29:38.50565 INFO::Writing fitted values to file Macarron_output/maaslin2_results/fits/fitted.rds
## 2024-11-29 08:29:38.528878 INFO::Writing all results to file (ordered by increasing q-values): Macarron_output/maaslin2_results/all_results.tsv
## 2024-11-29 08:29:38.538332 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): Macarron_output/maaslin2_results/significant_results.tsv
## 2024-11-29 08:29:38.542608 INFO::Writing association plots (one for each significant association) to output folder: Macarron_output/maaslin2_results
## 2024-11-29 08:29:38.553277 INFO::Plotting associations from most to least significant, grouped by metadata
## 2024-11-29 08:29:38.55392 INFO::Plotting data for metadata number 1, diagnosis
## 2024-11-29 08:29:38.580681 INFO::Creating boxplot for categorical data, diagnosis vs F504
## 2024-11-29 08:29:38.768502 INFO::Creating boxplot for categorical data, diagnosis vs F859
## 2024-11-29 08:29:38.903415 INFO::Creating boxplot for categorical data, diagnosis vs F533
## 2024-11-29 08:29:39.009455 INFO::Creating boxplot for categorical data, diagnosis vs F587
## 2024-11-29 08:29:39.118085 INFO::Creating boxplot for categorical data, diagnosis vs F584
## 2024-11-29 08:29:39.224067 INFO::Creating boxplot for categorical data, diagnosis vs F197
## 2024-11-29 08:29:39.336882 INFO::Creating boxplot for categorical data, diagnosis vs F380
## 2024-11-29 08:29:39.441999 INFO::Creating boxplot for categorical data, diagnosis vs F829
## 2024-11-29 08:29:39.547559 INFO::Creating boxplot for categorical data, diagnosis vs F664
## 2024-11-29 08:29:39.701465 INFO::Creating boxplot for categorical data, diagnosis vs F93
## 2024-11-29 08:29:39.808373 INFO::Creating boxplot for categorical data, diagnosis vs F15
## 2024-11-29 08:29:39.91519 INFO::Creating boxplot for categorical data, diagnosis vs F881
## 2024-11-29 08:29:40.022979 INFO::Creating boxplot for categorical data, diagnosis vs F806
## 2024-11-29 08:29:40.14179 INFO::Creating boxplot for categorical data, diagnosis vs F78
## 2024-11-29 08:29:40.246501 INFO::Creating boxplot for categorical data, diagnosis vs F189
## 2024-11-29 08:29:40.352379 INFO::Creating boxplot for categorical data, diagnosis vs F369
## 2024-11-29 08:29:40.457577 INFO::Creating boxplot for categorical data, diagnosis vs F623
## 2024-11-29 08:29:40.570735 INFO::Creating boxplot for categorical data, diagnosis vs F710
## 2024-11-29 08:29:40.67578 INFO::Creating boxplot for categorical data, diagnosis vs F851
## 2024-11-29 08:29:40.78195 INFO::Creating boxplot for categorical data, diagnosis vs F257
## 2024-11-29 08:29:40.890078 INFO::Creating boxplot for categorical data, diagnosis vs F330
## 2024-11-29 08:29:41.004554 INFO::Creating boxplot for categorical data, diagnosis vs F344
## 2024-11-29 08:29:41.111271 INFO::Creating boxplot for categorical data, diagnosis vs F696
## 2024-11-29 08:29:41.216708 INFO::Creating boxplot for categorical data, diagnosis vs F741
## 2024-11-29 08:29:41.330576 INFO::Creating boxplot for categorical data, diagnosis vs F509
## 2024-11-29 08:29:41.436762 INFO::Creating boxplot for categorical data, diagnosis vs F479
## 2024-11-29 08:29:41.542993 INFO::Creating boxplot for categorical data, diagnosis vs F550
## 2024-11-29 08:29:41.650229 INFO::Creating boxplot for categorical data, diagnosis vs F640
## 2024-11-29 08:29:41.763815 INFO::Creating boxplot for categorical data, diagnosis vs F281
## 2024-11-29 08:29:41.868507 INFO::Creating boxplot for categorical data, diagnosis vs F80
## 2024-11-29 08:29:41.973653 INFO::Creating boxplot for categorical data, diagnosis vs F285
## 2024-11-29 08:29:42.080194 INFO::Creating boxplot for categorical data, diagnosis vs F531
## 2024-11-29 08:29:42.195227 INFO::Creating boxplot for categorical data, diagnosis vs F737
## 2024-11-29 08:29:42.300311 INFO::Creating boxplot for categorical data, diagnosis vs F875
## 2024-11-29 08:29:42.406773 INFO::Creating boxplot for categorical data, diagnosis vs F864
## 2024-11-29 08:29:42.52135 INFO::Creating boxplot for categorical data, diagnosis vs F379
## 2024-11-29 08:29:42.626807 INFO::Creating boxplot for categorical data, diagnosis vs F190
## 2024-11-29 08:29:42.734356 INFO::Creating boxplot for categorical data, diagnosis vs F4
## 2024-11-29 08:29:42.842984 INFO::Creating boxplot for categorical data, diagnosis vs F591
## 2024-11-29 08:29:42.959897 INFO::Creating boxplot for categorical data, diagnosis vs F773
## 2024-11-29 08:29:43.064434 INFO::Creating boxplot for categorical data, diagnosis vs F283
## 2024-11-29 08:29:43.175191 INFO::Creating boxplot for categorical data, diagnosis vs F233
## 2024-11-29 08:29:43.281416 INFO::Creating boxplot for categorical data, diagnosis vs F420
## 2024-11-29 08:29:43.39566 INFO::Creating boxplot for categorical data, diagnosis vs F5
## 2024-11-29 08:29:43.502476 INFO::Creating boxplot for categorical data, diagnosis vs F137
## 2024-11-29 08:29:43.60878 INFO::Creating boxplot for categorical data, diagnosis vs F215
## 2024-11-29 08:29:43.72478 INFO::Creating boxplot for categorical data, diagnosis vs F489
## 2024-11-29 08:29:43.829951 INFO::Creating boxplot for categorical data, diagnosis vs F220
## 2024-11-29 08:29:43.9366 INFO::Creating boxplot for categorical data, diagnosis vs F691
## 2024-11-29 08:29:44.042852 INFO::Creating boxplot for categorical data, diagnosis vs F381
## 2024-11-29 08:29:44.159784 INFO::Creating boxplot for categorical data, diagnosis vs F539
## 2024-11-29 08:29:44.263511 INFO::Creating boxplot for categorical data, diagnosis vs F490
## 2024-11-29 08:29:44.368858 INFO::Creating boxplot for categorical data, diagnosis vs F832
## 2024-11-29 08:29:44.476026 INFO::Creating boxplot for categorical data, diagnosis vs F396
## 2024-11-29 08:29:44.589432 INFO::Creating boxplot for categorical data, diagnosis vs F528
## 2024-11-29 08:29:44.694936 INFO::Creating boxplot for categorical data, diagnosis vs F234
## 2024-11-29 08:29:44.80462 INFO::Creating boxplot for categorical data, diagnosis vs F178
## 2024-11-29 08:29:44.919633 INFO::Creating boxplot for categorical data, diagnosis vs F761
## 2024-11-29 08:29:45.027337 INFO::Creating boxplot for categorical data, diagnosis vs F2
## 2024-11-29 08:29:45.14002 INFO::Creating boxplot for categorical data, diagnosis vs F260
## 2024-11-29 08:29:45.247062 INFO::Creating boxplot for categorical data, diagnosis vs F734
## 2024-11-29 08:29:45.362475 INFO::Creating boxplot for categorical data, diagnosis vs F429
## 2024-11-29 08:29:45.467849 INFO::Creating boxplot for categorical data, diagnosis vs F630
## 2024-11-29 08:29:45.576421 INFO::Creating boxplot for categorical data, diagnosis vs F817
## 2024-11-29 08:29:45.692524 INFO::Creating boxplot for categorical data, diagnosis vs F847
## 2024-11-29 08:29:45.808661 INFO::Creating boxplot for categorical data, diagnosis vs F896
## 2024-11-29 08:29:45.915521 INFO::Creating boxplot for categorical data, diagnosis vs F81
## 2024-11-29 08:29:46.02111 INFO::Creating boxplot for categorical data, diagnosis vs F110
## 2024-11-29 08:29:46.135486 INFO::Creating boxplot for categorical data, diagnosis vs F3
## 2024-11-29 08:29:46.243051 INFO::Creating boxplot for categorical data, diagnosis vs F33
## 2024-11-29 08:29:46.350824 INFO::Creating boxplot for categorical data, diagnosis vs F270
## 2024-11-29 08:29:46.467115 INFO::Creating boxplot for categorical data, diagnosis vs F278
## 2024-11-29 08:29:46.571499 INFO::Creating boxplot for categorical data, diagnosis vs F264
## 2024-11-29 08:29:46.676073 INFO::Creating boxplot for categorical data, diagnosis vs F90
## 2024-11-29 08:29:46.781307 INFO::Creating boxplot for categorical data, diagnosis vs F403
## 2024-11-29 08:29:46.895572 INFO::Creating boxplot for categorical data, diagnosis vs F727
## 2024-11-29 08:29:47.000791 INFO::Creating boxplot for categorical data, diagnosis vs F394
## 2024-11-29 08:29:47.109946 INFO::Creating boxplot for categorical data, diagnosis vs F800
## 2024-11-29 08:29:47.232716 INFO::Creating boxplot for categorical data, diagnosis vs F439
## 2024-11-29 08:29:47.339562 INFO::Creating boxplot for categorical data, diagnosis vs F554
## 2024-11-29 08:29:47.44512 INFO::Creating boxplot for categorical data, diagnosis vs F559
## 2024-11-29 08:29:47.550636 INFO::Creating boxplot for categorical data, diagnosis vs F548
## 2024-11-29 08:29:47.665343 INFO::Creating boxplot for categorical data, diagnosis vs F794
## 2024-11-29 08:29:47.771477 INFO::Creating boxplot for categorical data, diagnosis vs F45
## 2024-11-29 08:29:47.877596 INFO::Creating boxplot for categorical data, diagnosis vs F158
## 2024-11-29 08:29:48.019464 INFO::Creating boxplot for categorical data, diagnosis vs F477
## 2024-11-29 08:29:48.133426 INFO::Creating boxplot for categorical data, diagnosis vs F1
## 2024-11-29 08:29:48.240821 INFO::Creating boxplot for categorical data, diagnosis vs F862
## 2024-11-29 08:29:48.346459 INFO::Creating boxplot for categorical data, diagnosis vs F803
## 2024-11-29 08:29:48.467026 INFO::Creating boxplot for categorical data, diagnosis vs F751
## 2024-11-29 08:29:48.575928 INFO::Creating boxplot for categorical data, diagnosis vs F98
## 2024-11-29 08:29:48.682642 INFO::Creating boxplot for categorical data, diagnosis vs F22
## 2024-11-29 08:29:48.790296 INFO::Creating boxplot for categorical data, diagnosis vs F625
## 2024-11-29 08:29:48.912363 INFO::Creating boxplot for categorical data, diagnosis vs F206
## 2024-11-29 08:29:49.019211 INFO::Creating boxplot for categorical data, diagnosis vs F779
## 2024-11-29 08:29:49.125972 INFO::Creating boxplot for categorical data, diagnosis vs F532
## 2024-11-29 08:29:49.24003 INFO::Creating boxplot for categorical data, diagnosis vs F676
## 2024-11-29 08:29:49.362319 INFO::Creating boxplot for categorical data, diagnosis vs F644
## 2024-11-29 08:29:49.469296 INFO::Creating boxplot for categorical data, diagnosis vs F7
## 2024-11-29 08:29:49.576024 INFO::Creating boxplot for categorical data, diagnosis vs F596
## 2024-11-29 08:29:49.697105 INFO::Creating boxplot for categorical data, diagnosis vs F250
## 2024-11-29 08:29:49.805794 INFO::Creating boxplot for categorical data, diagnosis vs F462
## 2024-11-29 08:29:49.910833 INFO::Creating boxplot for categorical data, diagnosis vs F516
## 2024-11-29 08:29:50.017329 INFO::Creating boxplot for categorical data, diagnosis vs F659
## 2024-11-29 08:29:50.141183 INFO::Creating boxplot for categorical data, diagnosis vs F663
## 2024-11-29 08:29:50.253323 INFO::Creating boxplot for categorical data, diagnosis vs F837
## 2024-11-29 08:29:50.359789 INFO::Creating boxplot for categorical data, diagnosis vs F138
## 2024-11-29 08:29:50.466534 INFO::Creating boxplot for categorical data, diagnosis vs F445
## 2024-11-29 08:29:50.587829 INFO::Creating boxplot for categorical data, diagnosis vs F697
## 2024-11-29 08:29:50.694319 INFO::Creating boxplot for categorical data, diagnosis vs F225
## 2024-11-29 08:29:50.803702 INFO::Creating boxplot for categorical data, diagnosis vs F148
## 2024-11-29 08:29:50.921048 INFO::Creating boxplot for categorical data, diagnosis vs F448
## 2024-11-29 08:29:51.033455 INFO::Creating boxplot for categorical data, diagnosis vs F91
## 2024-11-29 08:29:51.13997 INFO::Creating boxplot for categorical data, diagnosis vs F123
## 2024-11-29 08:29:51.251799 INFO::Creating boxplot for categorical data, diagnosis vs F665
## 2024-11-29 08:29:51.373835 INFO::Creating boxplot for categorical data, diagnosis vs F845
## 2024-11-29 08:29:51.480647 INFO::Creating boxplot for categorical data, diagnosis vs F331
## 2024-11-29 08:29:51.587593 INFO::Creating boxplot for categorical data, diagnosis vs F361
## 2024-11-29 08:29:51.694463 INFO::Creating boxplot for categorical data, diagnosis vs F421
## 2024-11-29 08:29:51.820495 INFO::Creating boxplot for categorical data, diagnosis vs F277
## 2024-11-29 08:29:51.927566 INFO::Creating boxplot for categorical data, diagnosis vs F307
## 2024-11-29 08:29:52.033808 INFO::Creating boxplot for categorical data, diagnosis vs F503
## 2024-11-29 08:29:52.156671 INFO::Creating boxplot for categorical data, diagnosis vs F34
## 2024-11-29 08:29:52.266936 INFO::Creating boxplot for categorical data, diagnosis vs F649
## 2024-11-29 08:29:52.375551 INFO::Creating boxplot for categorical data, diagnosis vs F825
## 2024-11-29 08:29:52.483125 INFO::Creating boxplot for categorical data, diagnosis vs F298
## 2024-11-29 08:29:52.608222 INFO::Creating boxplot for categorical data, diagnosis vs F461
## 2024-11-29 08:29:52.714539 INFO::Creating boxplot for categorical data, diagnosis vs F242
## 2024-11-29 08:29:52.821875 INFO::Creating boxplot for categorical data, diagnosis vs F375
## 2024-11-29 08:29:52.930916 INFO::Creating boxplot for categorical data, diagnosis vs F648
## 2024-11-29 08:29:53.054847 INFO::Creating boxplot for categorical data, diagnosis vs F724
## 2024-11-29 08:29:53.160734 INFO::Creating boxplot for categorical data, diagnosis vs F678
## 2024-11-29 08:29:53.270582 INFO::Creating boxplot for categorical data, diagnosis vs F290
## 2024-11-29 08:29:53.39821 INFO::Creating boxplot for categorical data, diagnosis vs F743
## 2024-11-29 08:29:53.507421 INFO::Creating boxplot for categorical data, diagnosis vs F495
## 2024-11-29 08:29:53.616002 INFO::Creating boxplot for categorical data, diagnosis vs F261
## 2024-11-29 08:29:53.726296 INFO::Creating boxplot for categorical data, diagnosis vs F43
## 2024-11-29 08:29:53.850627 INFO::Creating boxplot for categorical data, diagnosis vs F714
## 2024-11-29 08:29:53.959463 INFO::Creating boxplot for categorical data, diagnosis vs F131
## 2024-11-29 08:29:54.067622 INFO::Creating boxplot for categorical data, diagnosis vs F150
## 2024-11-29 08:29:54.190893 INFO::Creating boxplot for categorical data, diagnosis vs F651
## 2024-11-29 08:29:54.304012 INFO::Creating boxplot for categorical data, diagnosis vs F798
## 2024-11-29 08:29:54.409806 INFO::Creating boxplot for categorical data, diagnosis vs F289
## 2024-11-29 08:29:54.517372 INFO::Creating boxplot for categorical data, diagnosis vs F661
## 2024-11-29 08:29:54.641965 INFO::Creating boxplot for categorical data, diagnosis vs F199
## 2024-11-29 08:29:54.746951 INFO::Creating boxplot for categorical data, diagnosis vs F406
## 2024-11-29 08:29:54.856529 INFO::Creating boxplot for categorical data, diagnosis vs F139
## 2024-11-29 08:29:54.981108 INFO::Creating boxplot for categorical data, diagnosis vs F506
## 2024-11-29 08:29:55.088061 INFO::Creating boxplot for categorical data, diagnosis vs F552
## 2024-11-29 08:29:55.194506 INFO::Creating boxplot for categorical data, diagnosis vs F94
## 2024-11-29 08:29:55.306456 INFO::Creating boxplot for categorical data, diagnosis vs F430
## 2024-11-29 08:29:55.432424 INFO::Creating boxplot for categorical data, diagnosis vs F639
## 2024-11-29 08:29:55.539124 INFO::Creating boxplot for categorical data, diagnosis vs F500
## 2024-11-29 08:29:55.645861 INFO::Creating boxplot for categorical data, diagnosis vs F609
## 2024-11-29 08:29:55.76852 INFO::Creating boxplot for categorical data, diagnosis vs F306
## 2024-11-29 08:29:55.876211 INFO::Creating boxplot for categorical data, diagnosis vs F507
## 2024-11-29 08:29:55.982039 INFO::Creating boxplot for categorical data, diagnosis vs F671
## 2024-11-29 08:29:56.089661 INFO::Creating boxplot for categorical data, diagnosis vs F894
## 2024-11-29 08:29:56.21261 INFO::Creating boxplot for categorical data, diagnosis vs F345
## 2024-11-29 08:29:56.32314 INFO::Creating boxplot for categorical data, diagnosis vs F801
## 2024-11-29 08:29:56.430775 INFO::Creating boxplot for categorical data, diagnosis vs F194
## 2024-11-29 08:29:57.075439 INFO::Creating boxplot for categorical data, diagnosis vs F195
## 2024-11-29 08:29:57.179041 INFO::Creating boxplot for categorical data, diagnosis vs F119
## 2024-11-29 08:29:57.281329 INFO::Creating boxplot for categorical data, diagnosis vs F120
## 2024-11-29 08:29:57.388235 INFO::Creating boxplot for categorical data, diagnosis vs F231
## 2024-11-29 08:29:57.502871 INFO::Creating boxplot for categorical data, diagnosis vs F311
## 2024-11-29 08:29:57.608294 INFO::Creating boxplot for categorical data, diagnosis vs F646
## 2024-11-29 08:29:57.712247 INFO::Creating boxplot for categorical data, diagnosis vs F814
## 2024-11-29 08:29:57.817199 INFO::Creating boxplot for categorical data, diagnosis vs F510
## 2024-11-29 08:29:57.931626 INFO::Creating boxplot for categorical data, diagnosis vs F398
## 2024-11-29 08:29:58.034462 INFO::Creating boxplot for categorical data, diagnosis vs F60
## 2024-11-29 08:29:58.138039 INFO::Creating boxplot for categorical data, diagnosis vs F153
## 2024-11-29 08:29:58.244072 INFO::Creating boxplot for categorical data, diagnosis vs F858
## 2024-11-29 08:29:58.35978 INFO::Creating boxplot for categorical data, diagnosis vs F775
## 2024-11-29 08:29:58.462862 INFO::Creating boxplot for categorical data, diagnosis vs F684
## 2024-11-29 08:29:58.566193 INFO::Creating boxplot for categorical data, diagnosis vs F384
## 2024-11-29 08:29:58.677323 INFO::Creating boxplot for categorical data, diagnosis vs F134
## 2024-11-29 08:29:58.780215 INFO::Creating boxplot for categorical data, diagnosis vs F670
## 2024-11-29 08:29:58.883835 INFO::Creating boxplot for categorical data, diagnosis vs F632
## 2024-11-29 08:29:58.990522 INFO::Creating boxplot for categorical data, diagnosis vs F721
## 2024-11-29 08:29:59.101805 INFO::Creating boxplot for categorical data, diagnosis vs F700
## 2024-11-29 08:29:59.205942 INFO::Creating boxplot for categorical data, diagnosis vs F376
## 2024-11-29 08:29:59.309654 INFO::Creating boxplot for categorical data, diagnosis vs F301
## 2024-11-29 08:29:59.415603 INFO::Creating boxplot for categorical data, diagnosis vs F27
## 2024-11-29 08:29:59.524884 INFO::Creating boxplot for categorical data, diagnosis vs F280
## 2024-11-29 08:29:59.631065 INFO::Creating boxplot for categorical data, diagnosis vs F391
## 2024-11-29 08:29:59.736046 INFO::Creating boxplot for categorical data, diagnosis vs F725
## 2024-11-29 08:29:59.847423 INFO::Creating boxplot for categorical data, diagnosis vs F186
## 2024-11-29 08:29:59.953552 INFO::Creating boxplot for categorical data, diagnosis vs F481
## 2024-11-29 08:30:00.05759 INFO::Creating boxplot for categorical data, diagnosis vs F333
## 2024-11-29 08:30:00.165212 INFO::Creating boxplot for categorical data, diagnosis vs F720
## 2024-11-29 08:30:00.275757 INFO::Creating boxplot for categorical data, diagnosis vs F520
## 2024-11-29 08:30:00.384203 INFO::Creating boxplot for categorical data, diagnosis vs F129
## 2024-11-29 08:30:00.492975 INFO::Creating boxplot for categorical data, diagnosis vs F204
## 2024-11-29 08:30:00.599493 INFO::Creating boxplot for categorical data, diagnosis vs F259
## 2024-11-29 08:30:00.709864 INFO::Creating boxplot for categorical data, diagnosis vs F831
## 2024-11-29 08:30:00.814599 INFO::Creating boxplot for categorical data, diagnosis vs F891
## 2024-11-29 08:30:00.921151 INFO::Creating boxplot for categorical data, diagnosis vs F262
## 2024-11-29 08:30:01.034226 INFO::Creating boxplot for categorical data, diagnosis vs F592
## 2024-11-29 08:30:01.137422 INFO::Creating boxplot for categorical data, diagnosis vs F343
## 2024-11-29 08:30:01.240622 INFO::Creating boxplot for categorical data, diagnosis vs F505
## 2024-11-29 08:30:01.347115 INFO::Creating boxplot for categorical data, diagnosis vs F622
## 2024-11-29 08:30:01.46061 INFO::Creating boxplot for categorical data, diagnosis vs F348
## 2024-11-29 08:30:01.563833 INFO::Creating boxplot for categorical data, diagnosis vs F133
## 2024-11-29 08:30:01.669814 INFO::Creating boxplot for categorical data, diagnosis vs F371
## 2024-11-29 08:30:01.778969 INFO::Creating boxplot for categorical data, diagnosis vs F113
## 2024-11-29 08:30:01.889922 INFO::Creating boxplot for categorical data, diagnosis vs F336
## 2024-11-29 08:30:01.993386 INFO::Creating boxplot for categorical data, diagnosis vs F399
## 2024-11-29 08:30:02.098168 INFO::Creating boxplot for categorical data, diagnosis vs F416
## 2024-11-29 08:30:02.211133 INFO::Creating boxplot for categorical data, diagnosis vs F657
## 2024-11-29 08:30:02.315253 INFO::Creating boxplot for categorical data, diagnosis vs F241
## 2024-11-29 08:30:02.421129 INFO::Creating boxplot for categorical data, diagnosis vs F95
## 2024-11-29 08:30:02.526871 INFO::Creating boxplot for categorical data, diagnosis vs F128
## 2024-11-29 08:30:02.638417 INFO::Creating boxplot for categorical data, diagnosis vs F595
## 2024-11-29 08:30:02.743456 INFO::Creating boxplot for categorical data, diagnosis vs F428
## 2024-11-29 08:30:02.848588 INFO::Creating boxplot for categorical data, diagnosis vs F796
## 2024-11-29 08:30:02.966115 INFO::Creating boxplot for categorical data, diagnosis vs F709
## 2024-11-29 08:30:03.072105 INFO::Creating boxplot for categorical data, diagnosis vs F602
## 2024-11-29 08:30:03.176966 INFO::Creating boxplot for categorical data, diagnosis vs F293
## 2024-11-29 08:30:03.282061 INFO::Creating boxplot for categorical data, diagnosis vs F867
## 2024-11-29 08:30:03.394781 INFO::Creating boxplot for categorical data, diagnosis vs F108
## 2024-11-29 08:30:03.497797 INFO::Creating boxplot for categorical data, diagnosis vs F846
## 2024-11-29 08:30:03.602168 INFO::Creating boxplot for categorical data, diagnosis vs F633
## 2024-11-29 08:30:03.707941 INFO::Creating boxplot for categorical data, diagnosis vs F564
## 2024-11-29 08:30:03.823314 INFO::Creating boxplot for categorical data, diagnosis vs F183
## 2024-11-29 08:30:03.930297 INFO::Creating boxplot for categorical data, diagnosis vs F647
## 2024-11-29 08:30:04.037375 INFO::Creating boxplot for categorical data, diagnosis vs F288
## 2024-11-29 08:30:04.149318 INFO::Creating boxplot for categorical data, diagnosis vs F159
## 2024-11-29 08:30:04.253759 INFO::Creating boxplot for categorical data, diagnosis vs F638
## 2024-11-29 08:30:04.358129 INFO::Creating boxplot for categorical data, diagnosis vs F484
## 2024-11-29 08:30:04.463879 INFO::Creating boxplot for categorical data, diagnosis vs F20
## 2024-11-29 08:30:04.575392 INFO::Creating boxplot for categorical data, diagnosis vs F19
## 2024-11-29 08:30:04.677859 INFO::Creating boxplot for categorical data, diagnosis vs F897
## 2024-11-29 08:30:04.784519 INFO::Creating boxplot for categorical data, diagnosis vs F442
## 2024-11-29 08:30:04.899638 INFO::Creating boxplot for categorical data, diagnosis vs F372
## 2024-11-29 08:30:05.003042 INFO::Creating boxplot for categorical data, diagnosis vs F771
## 2024-11-29 08:30:05.10691 INFO::Creating boxplot for categorical data, diagnosis vs F370
## 2024-11-29 08:30:05.212087 INFO::Creating boxplot for categorical data, diagnosis vs F620
## 2024-11-29 08:30:05.352172 INFO::Creating boxplot for categorical data, diagnosis vs F753
## 2024-11-29 08:30:05.458795 INFO::Creating boxplot for categorical data, diagnosis vs F568
## 2024-11-29 08:30:05.564289 INFO::Creating boxplot for categorical data, diagnosis vs F312
## 2024-11-29 08:30:05.682351 INFO::Creating boxplot for categorical data, diagnosis vs F485
## 2024-11-29 08:30:05.792338 INFO::Creating boxplot for categorical data, diagnosis vs F627
## 2024-11-29 08:30:05.899324 INFO::Creating boxplot for categorical data, diagnosis vs F72
## 2024-11-29 08:30:06.005721 INFO::Creating boxplot for categorical data, diagnosis vs F575
## 2024-11-29 08:30:06.125924 INFO::Creating boxplot for categorical data, diagnosis vs F332
## 2024-11-29 08:30:06.234065 INFO::Creating boxplot for categorical data, diagnosis vs F674
## 2024-11-29 08:30:06.340248 INFO::Creating boxplot for categorical data, diagnosis vs F537
## 2024-11-29 08:30:06.448383 INFO::Creating boxplot for categorical data, diagnosis vs F839
## 2024-11-29 08:30:06.570225 INFO::Creating boxplot for categorical data, diagnosis vs F715
## 2024-11-29 08:30:06.675298 INFO::Creating boxplot for categorical data, diagnosis vs F768
## 2024-11-29 08:30:06.779742 INFO::Creating boxplot for categorical data, diagnosis vs F202
## 2024-11-29 08:30:06.889339 INFO::Creating boxplot for categorical data, diagnosis vs F756
## 2024-11-29 08:30:07.009978 INFO::Creating boxplot for categorical data, diagnosis vs F536
## 2024-11-29 08:30:07.115836 INFO::Creating boxplot for categorical data, diagnosis vs F677
## 2024-11-29 08:30:07.22021 INFO::Creating boxplot for categorical data, diagnosis vs F435
## 2024-11-29 08:30:07.340415 INFO::Creating boxplot for categorical data, diagnosis vs F574
## 2024-11-29 08:30:07.448352 INFO::Creating boxplot for categorical data, diagnosis vs F70
## 2024-11-29 08:30:07.553655 INFO::Creating boxplot for categorical data, diagnosis vs F146
## 2024-11-29 08:30:07.659411 INFO::Creating boxplot for categorical data, diagnosis vs F236
## 2024-11-29 08:30:07.780741 INFO::Creating boxplot for categorical data, diagnosis vs F527
## 2024-11-29 08:30:07.890347 INFO::Creating boxplot for categorical data, diagnosis vs F624
## 2024-11-29 08:30:07.998393 INFO::Creating boxplot for categorical data, diagnosis vs F426
## 2024-11-29 08:30:08.106771 INFO::Creating boxplot for categorical data, diagnosis vs F880
## 2024-11-29 08:30:08.228164 INFO::Creating boxplot for categorical data, diagnosis vs F549
## 2024-11-29 08:30:08.333663 INFO::Creating boxplot for categorical data, diagnosis vs F49
## 2024-11-29 08:30:08.439684 INFO::Creating boxplot for categorical data, diagnosis vs F67
## 2024-11-29 08:30:08.560534 INFO::Creating boxplot for categorical data, diagnosis vs F491
## 2024-11-29 08:30:08.670661 INFO::Creating boxplot for categorical data, diagnosis vs F174
## 2024-11-29 08:30:08.774337 INFO::Creating boxplot for categorical data, diagnosis vs F254
## 2024-11-29 08:30:08.884585 INFO::Creating boxplot for categorical data, diagnosis vs F112
## 2024-11-29 08:30:09.008293 INFO::Creating boxplot for categorical data, diagnosis vs F235
## 2024-11-29 08:30:09.114994 INFO::Creating boxplot for categorical data, diagnosis vs F833
## 2024-11-29 08:30:09.220474 INFO::Creating boxplot for categorical data, diagnosis vs F752
## 2024-11-29 08:30:09.326573 INFO::Creating boxplot for categorical data, diagnosis vs F792
## 2024-11-29 08:30:09.453238 INFO::Creating boxplot for categorical data, diagnosis vs F422
## 2024-11-29 08:30:09.558534 INFO::Creating boxplot for categorical data, diagnosis vs F6
## 2024-11-29 08:30:09.663782 INFO::Creating boxplot for categorical data, diagnosis vs F463
## 2024-11-29 08:30:09.783285 INFO::Creating boxplot for categorical data, diagnosis vs F706
## 2024-11-29 08:30:09.893108 INFO::Creating boxplot for categorical data, diagnosis vs F642
## 2024-11-29 08:30:10.001311 INFO::Creating boxplot for categorical data, diagnosis vs F65
## 2024-11-29 08:30:10.111887 INFO::Creating boxplot for categorical data, diagnosis vs F102
## 2024-11-29 08:30:10.232671 INFO::Creating boxplot for categorical data, diagnosis vs F783
## 2024-11-29 08:30:10.336345 INFO::Creating boxplot for categorical data, diagnosis vs F478
## 2024-11-29 08:30:10.445028 INFO::Creating boxplot for categorical data, diagnosis vs F889
## 2024-11-29 08:30:10.5644 INFO::Creating boxplot for categorical data, diagnosis vs F350
## 2024-11-29 08:30:10.674121 INFO::Creating boxplot for categorical data, diagnosis vs F681
## 2024-11-29 08:30:10.777385 INFO::Creating boxplot for categorical data, diagnosis vs F748
## 2024-11-29 08:30:10.883254 INFO::Creating boxplot for categorical data, diagnosis vs F762
## 2024-11-29 08:30:11.004188 INFO::Creating boxplot for categorical data, diagnosis vs F852
## 2024-11-29 08:30:11.110575 INFO::Creating boxplot for categorical data, diagnosis vs F180
## 2024-11-29 08:30:11.215843 INFO::Creating boxplot for categorical data, diagnosis vs F248
## 2024-11-29 08:30:11.32132 INFO::Creating boxplot for categorical data, diagnosis vs F759
## 2024-11-29 08:30:11.44336 INFO::Creating boxplot for categorical data, diagnosis vs F824
## 2024-11-29 08:30:11.548501 INFO::Creating boxplot for categorical data, diagnosis vs F145
## 2024-11-29 08:30:11.654284 INFO::Creating boxplot for categorical data, diagnosis vs F16
## 2024-11-29 08:30:11.775392 INFO::Creating boxplot for categorical data, diagnosis vs F169
## 2024-11-29 08:30:11.882426 INFO::Creating boxplot for categorical data, diagnosis vs F392
## 2024-11-29 08:30:11.987638 INFO::Creating boxplot for categorical data, diagnosis vs F468
## 2024-11-29 08:30:12.096816 INFO::Creating boxplot for categorical data, diagnosis vs F476
## 2024-11-29 08:30:12.219747 INFO::Creating boxplot for categorical data, diagnosis vs F699
## 2024-11-29 08:30:12.324301 INFO::Creating boxplot for categorical data, diagnosis vs F735
## 2024-11-29 08:30:12.429835 INFO::Creating boxplot for categorical data, diagnosis vs F182
## 2024-11-29 08:30:12.552962 INFO::Creating boxplot for categorical data, diagnosis vs F64
## 2024-11-29 08:30:12.658574 INFO::Creating boxplot for categorical data, diagnosis vs F203
## 2024-11-29 08:30:12.762227 INFO::Creating boxplot for categorical data, diagnosis vs F877
## 2024-11-29 08:30:12.867951 INFO::Creating boxplot for categorical data, diagnosis vs F433
## 2024-11-29 08:30:12.993648 INFO::Creating boxplot for categorical data, diagnosis vs F739
## 2024-11-29 08:30:13.10089 INFO::Creating boxplot for categorical data, diagnosis vs F749
## 2024-11-29 08:30:13.208297 INFO::Creating boxplot for categorical data, diagnosis vs F382
## 2024-11-29 08:30:13.328361 INFO::Creating boxplot for categorical data, diagnosis vs F162
## 2024-11-29 08:30:13.43588 INFO::Creating boxplot for categorical data, diagnosis vs F438
## 2024-11-29 08:30:13.54158 INFO::Creating boxplot for categorical data, diagnosis vs F360
## 2024-11-29 08:30:13.649125 INFO::Creating boxplot for categorical data, diagnosis vs F56
## 2024-11-29 08:30:13.800572 INFO::Creating boxplot for categorical data, diagnosis vs F529
## 2024-11-29 08:30:13.911388 INFO::Creating boxplot for categorical data, diagnosis vs F48
## 2024-11-29 08:30:14.019767 INFO::Creating boxplot for categorical data, diagnosis vs F826
## 2024-11-29 08:30:14.144877 INFO::Creating boxplot for categorical data, diagnosis vs F488
## 2024-11-29 08:30:14.257764 INFO::Creating boxplot for categorical data, diagnosis vs F309
## 2024-11-29 08:30:14.36764 INFO::Creating boxplot for categorical data, diagnosis vs F834
## 2024-11-29 08:30:14.478129 INFO::Creating boxplot for categorical data, diagnosis vs F449
## 2024-11-29 08:30:14.602026 INFO::Creating boxplot for categorical data, diagnosis vs F77
## 2024-11-29 08:30:14.712384 INFO::Creating boxplot for categorical data, diagnosis vs F365
## 2024-11-29 08:30:14.820115 INFO::Creating boxplot for categorical data, diagnosis vs F346
## 2024-11-29 08:30:14.928003 INFO::Creating boxplot for categorical data, diagnosis vs F654
## 2024-11-29 08:30:15.048628 INFO::Creating boxplot for categorical data, diagnosis vs F79
## 2024-11-29 08:30:15.157541 INFO::Creating boxplot for categorical data, diagnosis vs F785
## 2024-11-29 08:30:15.263385 INFO::Creating boxplot for categorical data, diagnosis vs F415
## 2024-11-29 08:30:15.368546 INFO::Creating boxplot for categorical data, diagnosis vs F466
## 2024-11-29 08:30:15.491641 INFO::Creating boxplot for categorical data, diagnosis vs F643
## 2024-11-29 08:30:15.601955 INFO::Creating boxplot for categorical data, diagnosis vs F160
## 2024-11-29 08:30:15.718408 INFO::Creating boxplot for categorical data, diagnosis vs F69
## 2024-11-29 08:30:15.837672 INFO::Creating boxplot for categorical data, diagnosis vs F498
## 2024-11-29 08:30:15.950333 INFO::Creating boxplot for categorical data, diagnosis vs F207
## 2024-11-29 08:30:16.059083 INFO::Creating boxplot for categorical data, diagnosis vs F679
## 2024-11-29 08:30:16.164331 INFO::Creating boxplot for categorical data, diagnosis vs F618
## 2024-11-29 08:30:16.286628 INFO::Creating boxplot for categorical data, diagnosis vs F255
## 2024-11-29 08:30:16.39671 INFO::Creating boxplot for categorical data, diagnosis vs F267
## 2024-11-29 08:30:16.504523 INFO::Creating boxplot for categorical data, diagnosis vs F143
## 2024-11-29 08:30:16.611228 INFO::Creating boxplot for categorical data, diagnosis vs F286
## 2024-11-29 08:30:16.731075 INFO::Creating boxplot for categorical data, diagnosis vs F562
## 2024-11-29 08:30:16.839085 INFO::Creating boxplot for categorical data, diagnosis vs F100
## 2024-11-29 08:30:16.947386 INFO::Creating boxplot for categorical data, diagnosis vs F374
## 2024-11-29 08:30:17.068725 INFO::Creating boxplot for categorical data, diagnosis vs F535
## 2024-11-29 08:30:17.178382 INFO::Creating boxplot for categorical data, diagnosis vs F658
## 2024-11-29 08:30:17.284909 INFO::Creating boxplot for categorical data, diagnosis vs F707
## 2024-11-29 08:30:17.3902 INFO::Creating boxplot for categorical data, diagnosis vs F325
## 2024-11-29 08:30:17.510118 INFO::Creating boxplot for categorical data, diagnosis vs F89
## 2024-11-29 08:30:17.619972 INFO::Creating boxplot for categorical data, diagnosis vs F214
## 2024-11-29 08:30:17.725858 INFO::Creating boxplot for categorical data, diagnosis vs F578
## 2024-11-29 08:30:17.832502 INFO::Creating boxplot for categorical data, diagnosis vs F790
## 2024-11-29 08:30:17.954257 INFO::Creating boxplot for categorical data, diagnosis vs F265
## 2024-11-29 08:30:18.064126 INFO::Creating boxplot for categorical data, diagnosis vs F253
## 2024-11-29 08:30:18.170933 INFO::Creating boxplot for categorical data, diagnosis vs F294
## 2024-11-29 08:30:18.292621 INFO::Creating boxplot for categorical data, diagnosis vs F410
## 2024-11-29 08:30:18.450112 INFO::Creating boxplot for categorical data, diagnosis vs F614
## 2024-11-29 08:30:18.557671 INFO::Creating boxplot for categorical data, diagnosis vs F764
## 2024-11-29 08:30:18.668336 INFO::Creating boxplot for categorical data, diagnosis vs F59
## 2024-11-29 08:30:18.789379 INFO::Creating boxplot for categorical data, diagnosis vs F675
## 2024-11-29 08:30:18.901296 INFO::Creating boxplot for categorical data, diagnosis vs F441
## 2024-11-29 08:30:19.011369 INFO::Creating boxplot for categorical data, diagnosis vs F193
## 2024-11-29 08:30:19.130745 INFO::Creating boxplot for categorical data, diagnosis vs F689
## 2024-11-29 08:30:19.240676 INFO::Creating boxplot for categorical data, diagnosis vs F249
## 2024-11-29 08:30:19.347214 INFO::Creating boxplot for categorical data, diagnosis vs F821
## 2024-11-29 08:30:19.455236 INFO::Creating boxplot for categorical data, diagnosis vs F351
## 2024-11-29 08:30:19.57806 INFO::Creating boxplot for categorical data, diagnosis vs F66
## 2024-11-29 08:30:19.69069 INFO::Creating boxplot for categorical data, diagnosis vs F413
## 2024-11-29 08:30:19.797834 INFO::Creating boxplot for categorical data, diagnosis vs F172
## 2024-11-29 08:30:19.92093 INFO::Creating boxplot for categorical data, diagnosis vs F317
## 2024-11-29 08:30:20.03482 INFO::Creating boxplot for categorical data, diagnosis vs F167
## 2024-11-29 08:30:20.146672 INFO::Creating boxplot for categorical data, diagnosis vs F229
## 2024-11-29 08:30:20.2547 INFO::Creating boxplot for categorical data, diagnosis vs F243
## 2024-11-29 08:30:20.380569 INFO::Creating boxplot for categorical data, diagnosis vs F732
## 2024-11-29 08:30:20.491209 INFO::Creating boxplot for categorical data, diagnosis vs F467
## 2024-11-29 08:30:20.597786 INFO::Creating boxplot for categorical data, diagnosis vs F474
## 2024-11-29 08:30:20.71945 INFO::Creating boxplot for categorical data, diagnosis vs F156
## 2024-11-29 08:30:20.833039 INFO::Creating boxplot for categorical data, diagnosis vs F786
## 2024-11-29 08:30:20.942612 INFO::Creating boxplot for categorical data, diagnosis vs F216
## 2024-11-29 08:30:21.051912 INFO::Creating boxplot for categorical data, diagnosis vs F85
## 2024-11-29 08:30:21.175643 INFO::Creating boxplot for categorical data, diagnosis vs F621
## 2024-11-29 08:30:21.28421 INFO::Creating boxplot for categorical data, diagnosis vs F558
## 2024-11-29 08:30:21.389846 INFO::Creating boxplot for categorical data, diagnosis vs F582
## 2024-11-29 08:30:21.495783 INFO::Creating boxplot for categorical data, diagnosis vs F898
## 2024-11-29 08:30:21.619225 INFO::Creating boxplot for categorical data, diagnosis vs F402
## 2024-11-29 08:30:21.72821 INFO::Creating boxplot for categorical data, diagnosis vs F71
## 2024-11-29 08:30:21.836221 INFO::Creating boxplot for categorical data, diagnosis vs F99
## 2024-11-29 08:30:21.9628 INFO::Creating boxplot for categorical data, diagnosis vs F366
## 2024-11-29 08:30:22.074036 INFO::Creating boxplot for categorical data, diagnosis vs F778
## 2024-11-29 08:30:22.181737 INFO::Creating boxplot for categorical data, diagnosis vs F188
## 2024-11-29 08:30:22.32411 INFO::Creating boxplot for categorical data, diagnosis vs F857
## 2024-11-29 08:30:22.445141 INFO::Creating boxplot for categorical data, diagnosis vs F440
## 2024-11-29 08:30:22.559747 INFO::Creating boxplot for categorical data, diagnosis vs F799
## 2024-11-29 08:30:22.670533 INFO::Creating boxplot for categorical data, diagnosis vs F482
## 2024-11-29 08:30:22.794803 INFO::Creating boxplot for categorical data, diagnosis vs F212
## 2024-11-29 08:30:22.903455 INFO::Creating boxplot for categorical data, diagnosis vs F882
## 2024-11-29 08:30:23.015645 INFO::Creating boxplot for categorical data, diagnosis vs F599
## 2024-11-29 08:30:23.127357 INFO::Creating boxplot for categorical data, diagnosis vs F302
## 2024-11-29 08:30:23.25546 INFO::Creating boxplot for categorical data, diagnosis vs F543
## 2024-11-29 08:30:23.367619 INFO::Creating boxplot for categorical data, diagnosis vs F269
## 2024-11-29 08:30:23.480116 INFO::Creating boxplot for categorical data, diagnosis vs F650
## 2024-11-29 08:30:23.590178 INFO::Creating boxplot for categorical data, diagnosis vs F456
## 2024-11-29 08:30:23.71902 INFO::Creating boxplot for categorical data, diagnosis vs F573
## 2024-11-29 08:30:23.831342 INFO::Creating boxplot for categorical data, diagnosis vs F8
## 2024-11-29 08:30:23.94396 INFO::Creating boxplot for categorical data, diagnosis vs F810
## 2024-11-29 08:30:24.06878 INFO::Creating boxplot for categorical data, diagnosis vs F401
## 2024-11-29 08:30:24.181921 INFO::Creating boxplot for categorical data, diagnosis vs F606
## 2024-11-29 08:30:24.29033 INFO::Creating boxplot for categorical data, diagnosis vs F662
## 2024-11-29 08:30:24.399921 INFO::Creating boxplot for categorical data, diagnosis vs F765
## 2024-11-29 08:30:24.528613 INFO::Creating boxplot for categorical data, diagnosis vs F887
## 2024-11-29 08:30:24.641334 INFO::Creating boxplot for categorical data, diagnosis vs F770
## 2024-11-29 08:30:24.749342 INFO::Creating boxplot for categorical data, diagnosis vs F469
## 2024-11-29 08:30:24.857754 INFO::Creating boxplot for categorical data, diagnosis vs F86
## 2024-11-29 08:30:24.991031 INFO::Creating boxplot for categorical data, diagnosis vs F400
## 2024-11-29 08:30:25.102171 INFO::Creating boxplot for categorical data, diagnosis vs F579
## 2024-11-29 08:30:25.211391 INFO::Creating boxplot for categorical data, diagnosis vs F871
## 2024-11-29 08:30:25.334813 INFO::Creating boxplot for categorical data, diagnosis vs F37
## 2024-11-29 08:30:25.446362 INFO::Creating boxplot for categorical data, diagnosis vs F446
## 2024-11-29 08:30:25.557877 INFO::Creating boxplot for categorical data, diagnosis vs F218
## 2024-11-29 08:30:25.66789 INFO::Creating boxplot for categorical data, diagnosis vs F321
## 2024-11-29 08:30:25.794335 INFO::Creating boxplot for categorical data, diagnosis vs F487
## 2024-11-29 08:30:25.904736 INFO::Creating boxplot for categorical data, diagnosis vs F740
## 2024-11-29 08:30:26.015249 INFO::Creating boxplot for categorical data, diagnosis vs F141
## 2024-11-29 08:30:26.122117 INFO::Creating boxplot for categorical data, diagnosis vs F327
## 2024-11-29 08:30:26.249268 INFO::Creating boxplot for categorical data, diagnosis vs F196
## 2024-11-29 08:30:26.359469 INFO::Creating boxplot for categorical data, diagnosis vs F883
## 2024-11-29 08:30:26.469165 INFO::Creating boxplot for categorical data, diagnosis vs F279
## 2024-11-29 08:30:26.599711 INFO::Creating boxplot for categorical data, diagnosis vs F838
## 2024-11-29 08:30:26.712881 INFO::Creating boxplot for categorical data, diagnosis vs F451
## 2024-11-29 08:30:26.822723 INFO::Creating boxplot for categorical data, diagnosis vs F854
## 2024-11-29 08:30:26.932455 INFO::Creating boxplot for categorical data, diagnosis vs F434
## 2024-11-29 08:30:27.06276 INFO::Creating boxplot for categorical data, diagnosis vs F519
## 2024-11-29 08:30:27.1726 INFO::Creating boxplot for categorical data, diagnosis vs F694
## 2024-11-29 08:30:27.28324 INFO::Creating boxplot for categorical data, diagnosis vs F561
## 2024-11-29 08:30:27.404469 INFO::Creating boxplot for categorical data, diagnosis vs F10
## 2024-11-29 08:30:27.521942 INFO::Creating boxplot for categorical data, diagnosis vs F303
## 2024-11-29 08:30:27.631579 INFO::Creating boxplot for categorical data, diagnosis vs F512
## 2024-11-29 08:30:27.741614 INFO::Creating boxplot for categorical data, diagnosis vs F645
## 2024-11-29 08:30:27.868556 INFO::Creating boxplot for categorical data, diagnosis vs F793
## 2024-11-29 08:30:27.981361 INFO::Creating boxplot for categorical data, diagnosis vs F404
## 2024-11-29 08:30:28.092096 INFO::Creating boxplot for categorical data, diagnosis vs F362
## 2024-11-29 08:30:28.201128 INFO::Creating boxplot for categorical data, diagnosis vs F525
## 2024-11-29 08:30:28.331025 INFO::Creating boxplot for categorical data, diagnosis vs F742
## 2024-11-29 08:30:28.441373 INFO::Creating boxplot for categorical data, diagnosis vs F276
## 2024-11-29 08:30:28.551056 INFO::Creating boxplot for categorical data, diagnosis vs F499
## 2024-11-29 08:30:28.681666 INFO::Creating boxplot for categorical data, diagnosis vs F328
## 2024-11-29 08:30:28.796915 INFO::Creating boxplot for categorical data, diagnosis vs F787
## 2024-11-29 08:30:28.906665 INFO::Creating boxplot for categorical data, diagnosis vs F30
## 2024-11-29 08:30:29.016755 INFO::Creating boxplot for categorical data, diagnosis vs F122
## 2024-11-29 08:30:29.147462 INFO::Creating boxplot for categorical data, diagnosis vs F619
## 2024-11-29 08:30:29.259285 INFO::Creating boxplot for categorical data, diagnosis vs F572
## 2024-11-29 08:30:29.369223 INFO::Creating boxplot for categorical data, diagnosis vs F47
## 2024-11-29 08:30:29.498047 INFO::Creating boxplot for categorical data, diagnosis vs F570
## 2024-11-29 08:30:29.608666 INFO::Creating boxplot for categorical data, diagnosis vs F26
## 2024-11-29 08:30:29.719724 INFO::Creating boxplot for categorical data, diagnosis vs F252
## 2024-11-29 08:30:29.83068 INFO::Creating boxplot for categorical data, diagnosis vs F117
## 2024-11-29 08:30:29.960427 INFO::Creating boxplot for categorical data, diagnosis vs F683
## 2024-11-29 08:30:30.07173 INFO::Creating boxplot for categorical data, diagnosis vs F395
## 2024-11-29 08:30:30.181676 INFO::Creating boxplot for categorical data, diagnosis vs F822
## 2024-11-29 08:30:30.310195 INFO::Creating boxplot for categorical data, diagnosis vs F46
## 2024-11-29 08:30:30.420414 INFO::Creating boxplot for categorical data, diagnosis vs F154
## 2024-11-29 08:30:30.530983 INFO::Creating boxplot for categorical data, diagnosis vs F540
## 2024-11-29 08:30:30.641478 INFO::Creating boxplot for categorical data, diagnosis vs F884
## 2024-11-29 08:30:30.771681 INFO::Creating boxplot for categorical data, diagnosis vs F368
## 2024-11-29 08:30:30.885081 INFO::Creating boxplot for categorical data, diagnosis vs F607
## 2024-11-29 08:30:30.997238 INFO::Creating boxplot for categorical data, diagnosis vs F111
## 2024-11-29 08:30:31.157847 INFO::Creating boxplot for categorical data, diagnosis vs F745
## 2024-11-29 08:30:31.268897 INFO::Creating boxplot for categorical data, diagnosis vs F673
## 2024-11-29 08:30:31.380432 INFO::Creating boxplot for categorical data, diagnosis vs F92
## 2024-11-29 08:30:31.494812 INFO::Creating boxplot for categorical data, diagnosis vs F493
## 2024-11-29 08:30:31.624059 INFO::Creating boxplot for categorical data, diagnosis vs F835
## 2024-11-29 08:30:31.738621 INFO::Creating boxplot for categorical data, diagnosis vs F872
## 2024-11-29 08:30:31.85017 INFO::Creating boxplot for categorical data, diagnosis vs F879
## 2024-11-29 08:30:31.97233 INFO::Creating boxplot for categorical data, diagnosis vs F432
## 2024-11-29 08:30:32.087835 INFO::Creating boxplot for categorical data, diagnosis vs F518
## 2024-11-29 08:30:32.196462 INFO::Creating boxplot for categorical data, diagnosis vs F44
## 2024-11-29 08:30:32.306763 INFO::Creating boxplot for categorical data, diagnosis vs F240
## 2024-11-29 08:30:32.4323 INFO::Creating boxplot for categorical data, diagnosis vs F819
## 2024-11-29 08:30:32.545442 INFO::Creating boxplot for categorical data, diagnosis vs F411
## 2024-11-29 08:30:32.65713 INFO::Creating boxplot for categorical data, diagnosis vs F353
## 2024-11-29 08:30:32.769009 INFO::Creating boxplot for categorical data, diagnosis vs F763
## 2024-11-29 08:30:32.899377 INFO::Creating boxplot for categorical data, diagnosis vs F97
## 2024-11-29 08:30:33.010744 INFO::Creating boxplot for categorical data, diagnosis vs F40
## 2024-11-29 08:30:33.122603 INFO::Creating boxplot for categorical data, diagnosis vs F652
## 2024-11-29 08:30:33.242139 INFO::Creating boxplot for categorical data, diagnosis vs F789
## 2024-11-29 08:30:33.362485 INFO::Creating boxplot for categorical data, diagnosis vs F25
## 2024-11-29 08:30:33.472262 INFO::Creating boxplot for categorical data, diagnosis vs F256
## 2024-11-29 08:30:33.584616 INFO::Creating boxplot for categorical data, diagnosis vs F423
## 2024-11-29 08:30:33.713147 INFO::Creating boxplot for categorical data, diagnosis vs F594
## 2024-11-29 08:30:33.82475 INFO::Creating boxplot for categorical data, diagnosis vs F201
## 2024-11-29 08:30:33.93557 INFO::Creating boxplot for categorical data, diagnosis vs F813
## 2024-11-29 08:30:34.050425 INFO::Creating boxplot for categorical data, diagnosis vs F653
## 2024-11-29 08:30:34.17781 INFO::Creating boxplot for categorical data, diagnosis vs F524
## 2024-11-29 08:30:34.286792 INFO::Creating boxplot for categorical data, diagnosis vs F777
## 2024-11-29 08:30:34.399334 INFO::Creating boxplot for categorical data, diagnosis vs F226
## 2024-11-29 08:30:34.52614 INFO::Creating boxplot for categorical data, diagnosis vs F227
## 2024-11-29 08:30:34.639955 INFO::Creating boxplot for categorical data, diagnosis vs F521
## 2024-11-29 08:30:34.75405 INFO::Creating boxplot for categorical data, diagnosis vs F14
## 2024-11-29 08:30:34.86767 INFO::Creating boxplot for categorical data, diagnosis vs F310
## 2024-11-29 08:30:34.999835 INFO::Creating boxplot for categorical data, diagnosis vs F452
## 2024-11-29 08:30:35.112502 INFO::Creating boxplot for categorical data, diagnosis vs F52
## 2024-11-29 08:30:35.22344 INFO::Creating boxplot for categorical data, diagnosis vs F53
## 2024-11-29 08:30:35.33476 INFO::Creating boxplot for categorical data, diagnosis vs F844
## 2024-11-29 08:30:35.462598 INFO::Creating boxplot for categorical data, diagnosis vs F31
## 2024-11-29 08:30:35.572997 INFO::Creating boxplot for categorical data, diagnosis vs F795
## 2024-11-29 08:30:35.683955 INFO::Creating boxplot for categorical data, diagnosis vs F766
## 2024-11-29 08:30:35.812423 INFO::Creating boxplot for categorical data, diagnosis vs F342
## 2024-11-29 08:30:35.926549 INFO::Creating boxplot for categorical data, diagnosis vs F408
## 2024-11-29 08:30:36.039814 INFO::Creating boxplot for categorical data, diagnosis vs F282
## 2024-11-29 08:30:36.150898 INFO::Creating boxplot for categorical data, diagnosis vs F508
## 2024-11-29 08:30:36.279482 INFO::Creating boxplot for categorical data, diagnosis vs F805
## 2024-11-29 08:30:36.39153 INFO::Creating boxplot for categorical data, diagnosis vs F337
## 2024-11-29 08:30:36.505047 INFO::Creating boxplot for categorical data, diagnosis vs F820
## 2024-11-29 08:30:36.632726 INFO::Creating boxplot for categorical data, diagnosis vs F593
## 2024-11-29 08:30:36.746832 INFO::Creating boxplot for categorical data, diagnosis vs F701
## 2024-11-29 08:30:36.858898 INFO::Creating boxplot for categorical data, diagnosis vs F459
## 2024-11-29 08:30:36.969187 INFO::Creating boxplot for categorical data, diagnosis vs F305
## 2024-11-29 08:30:37.102679 INFO::Creating boxplot for categorical data, diagnosis vs F142
## 2024-11-29 08:30:37.213394 INFO::Creating boxplot for categorical data, diagnosis vs F534
## 2024-11-29 08:30:37.324449 INFO::Creating boxplot for categorical data, diagnosis vs F135
## 2024-11-29 08:30:37.452329 INFO::Creating boxplot for categorical data, diagnosis vs F702
## 2024-11-29 08:30:37.565769 INFO::Creating boxplot for categorical data, diagnosis vs F776
## 2024-11-29 08:30:37.67862 INFO::Creating boxplot for categorical data, diagnosis vs F295
## 2024-11-29 08:30:37.793163 INFO::Creating boxplot for categorical data, diagnosis vs F355
## 2024-11-29 08:30:37.919365 INFO::Creating boxplot for categorical data, diagnosis vs F797
## 2024-11-29 08:30:38.031947 INFO::Creating boxplot for categorical data, diagnosis vs F13
## 2024-11-29 08:30:38.144467 INFO::Creating boxplot for categorical data, diagnosis vs F356
## 2024-11-29 08:30:38.275855 INFO::Creating boxplot for categorical data, diagnosis vs F359
## 2024-11-29 08:30:38.389586 INFO::Creating boxplot for categorical data, diagnosis vs F121
## 2024-11-29 08:30:38.500616 INFO::Creating boxplot for categorical data, diagnosis vs F850
## 2024-11-29 08:30:38.611726 INFO::Creating boxplot for categorical data, diagnosis vs F899
## 2024-11-29 08:30:38.741739 INFO::Creating boxplot for categorical data, diagnosis vs F628
## 2024-11-29 08:30:38.851419 INFO::Creating boxplot for categorical data, diagnosis vs F843
## 2024-11-29 08:30:38.96227 INFO::Creating boxplot for categorical data, diagnosis vs F107
## 2024-11-29 08:30:39.090139 INFO::Creating boxplot for categorical data, diagnosis vs F287
## 2024-11-29 08:30:39.205629 INFO::Creating boxplot for categorical data, diagnosis vs F165
## 2024-11-29 08:30:39.31603 INFO::Creating boxplot for categorical data, diagnosis vs F557
## 2024-11-29 08:30:39.428871 INFO::Creating boxplot for categorical data, diagnosis vs F127
## 2024-11-29 08:30:39.557126 INFO::Creating boxplot for categorical data, diagnosis vs F299
## 2024-11-29 08:30:39.668374 INFO::Creating boxplot for categorical data, diagnosis vs F497
## 2024-11-29 08:30:39.781136 INFO::Creating boxplot for categorical data, diagnosis vs F711
## 2024-11-29 08:30:39.941273 INFO::Creating boxplot for categorical data, diagnosis vs F319
## 2024-11-29 08:30:40.054076 INFO::Creating boxplot for categorical data, diagnosis vs F271
## 2024-11-29 08:30:40.166712 INFO::Creating boxplot for categorical data, diagnosis vs F157
## 2024-11-29 08:30:40.279433 INFO::Creating boxplot for categorical data, diagnosis vs F560
## 2024-11-29 08:30:40.419918 INFO::Creating boxplot for categorical data, diagnosis vs F680
## 2024-11-29 08:30:40.531825 INFO::Creating boxplot for categorical data, diagnosis vs F580
## 2024-11-29 08:30:40.643535 INFO::Creating boxplot for categorical data, diagnosis vs F152
## 2024-11-29 08:30:40.75677 INFO::Creating boxplot for categorical data, diagnosis vs F12
## 2024-11-29 08:30:40.891173 INFO::Creating boxplot for categorical data, diagnosis vs F324
## 2024-11-29 08:30:41.002983 INFO::Creating boxplot for categorical data, diagnosis vs F893
## 2024-11-29 08:30:41.118165 INFO::Creating boxplot for categorical data, diagnosis vs F318
## 2024-11-29 08:30:41.257362 INFO::Creating boxplot for categorical data, diagnosis vs F784
## 2024-11-29 08:30:41.371297 INFO::Creating boxplot for categorical data, diagnosis vs F567
## 2024-11-29 08:30:41.484561 INFO::Creating boxplot for categorical data, diagnosis vs F457
## 2024-11-29 08:30:41.599089 INFO::Creating boxplot for categorical data, diagnosis vs F708
## 2024-11-29 08:30:41.734907 INFO::Creating boxplot for categorical data, diagnosis vs F669
## 2024-11-29 08:30:41.846537 INFO::Creating boxplot for categorical data, diagnosis vs F87
## 2024-11-29 08:30:43.40137 INFO::Plotting data for metadata number 2, antibiotics
## 2024-11-29 08:30:43.40273 INFO::Creating boxplot for categorical data, antibiotics vs F663
## 2024-11-29 08:30:43.520868 INFO::Creating boxplot for categorical data, antibiotics vs F838
## 2024-11-29 08:30:43.638136 INFO::Creating boxplot for categorical data, antibiotics vs F764
## 2024-11-29 08:30:43.769634 INFO::Creating boxplot for categorical data, antibiotics vs F880
## 2024-11-29 08:30:43.901221 INFO::Creating boxplot for categorical data, antibiotics vs F751
## 2024-11-29 08:30:44.019991 INFO::Creating boxplot for categorical data, antibiotics vs F288
## 2024-11-29 08:30:44.140438 INFO::Creating boxplot for categorical data, antibiotics vs F65
## 2024-11-29 08:30:44.283418 INFO::Creating boxplot for categorical data, antibiotics vs F742
## 2024-11-29 08:30:44.402501 INFO::Creating boxplot for categorical data, antibiotics vs F528
## 2024-11-29 08:30:44.522375 INFO::Creating boxplot for categorical data, antibiotics vs F790
## 2024-11-29 08:30:44.663844 INFO::Creating boxplot for categorical data, antibiotics vs F777
## 2024-11-29 08:30:44.783711 INFO::Creating boxplot for categorical data, antibiotics vs F178
## 2024-11-29 08:30:44.902962 INFO::Creating boxplot for categorical data, antibiotics vs F139
## 2024-11-29 08:30:45.023151 INFO::Creating boxplot for categorical data, antibiotics vs F202
## 2024-11-29 08:30:45.166582 INFO::Creating boxplot for categorical data, antibiotics vs F220
## 2024-11-29 08:30:45.285919 INFO::Creating boxplot for categorical data, antibiotics vs F397
## 2024-11-29 08:30:45.408624 INFO::Creating boxplot for categorical data, antibiotics vs F882
## 2024-11-29 08:30:45.551278 INFO::Creating boxplot for categorical data, antibiotics vs F446
## 2024-11-29 08:30:45.669114 INFO::Creating boxplot for categorical data, antibiotics vs F418
## 2024-11-29 08:30:45.787368 INFO::Creating boxplot for categorical data, antibiotics vs F133
## 2024-11-29 08:30:45.93877 INFO::Creating boxplot for categorical data, antibiotics vs F696
## 2024-11-29 08:30:46.060037 INFO::Creating boxplot for categorical data, antibiotics vs F548
## 2024-11-29 08:30:46.180566 INFO::Creating boxplot for categorical data, antibiotics vs F536
## 2024-11-29 08:30:46.299577 INFO::Creating boxplot for categorical data, antibiotics vs F194
## 2024-11-29 08:30:46.441723 INFO::Creating boxplot for categorical data, antibiotics vs F34
## 2024-11-29 08:30:46.56062 INFO::Creating boxplot for categorical data, antibiotics vs F153
## 2024-11-29 08:30:46.679965 INFO::Creating boxplot for categorical data, antibiotics vs F400
## 2024-11-29 08:30:46.823127 INFO::Creating boxplot for categorical data, antibiotics vs F794
## 2024-11-29 08:30:46.942099 INFO::Creating boxplot for categorical data, antibiotics vs F396
## 2024-11-29 08:30:47.061613 INFO::Creating boxplot for categorical data, antibiotics vs F182
## 2024-11-29 08:30:47.203923 INFO::Creating boxplot for categorical data, antibiotics vs F719
## 2024-11-29 08:30:47.324296 INFO::Creating boxplot for categorical data, antibiotics vs F109
## 2024-11-29 08:30:47.446177 INFO::Creating boxplot for categorical data, antibiotics vs F180
## 2024-11-29 08:30:47.583225 INFO::Creating boxplot for categorical data, antibiotics vs F552
## 2024-11-29 08:30:47.70861 INFO::Creating boxplot for categorical data, antibiotics vs F789
## 2024-11-29 08:30:47.828896 INFO::Creating boxplot for categorical data, antibiotics vs F893
## 2024-11-29 08:30:47.950959 INFO::Creating boxplot for categorical data, antibiotics vs F834
## 2024-11-29 08:30:48.096156 INFO::Creating boxplot for categorical data, antibiotics vs F889
## 2024-11-29 08:30:48.215505 INFO::Creating boxplot for categorical data, antibiotics vs F143
## 2024-11-29 08:30:48.334568 INFO::Creating boxplot for categorical data, antibiotics vs F224
## 2024-11-29 08:30:48.477219 INFO::Creating boxplot for categorical data, antibiotics vs F5
## 2024-11-29 08:30:48.595779 INFO::Creating boxplot for categorical data, antibiotics vs F873
## 2024-11-29 08:30:48.716081 INFO::Creating boxplot for categorical data, antibiotics vs F452
## 2024-11-29 08:30:48.861249 INFO::Creating boxplot for categorical data, antibiotics vs F681
## 2024-11-29 08:30:48.978983 INFO::Creating boxplot for categorical data, antibiotics vs F468
## 2024-11-29 08:30:49.100639 INFO::Creating boxplot for categorical data, antibiotics vs F731
## 2024-11-29 08:30:49.780204 INFO::Creating boxplot for categorical data, antibiotics vs F479
## 2024-11-29 08:30:49.893054 INFO::Creating boxplot for categorical data, antibiotics vs F520
## 2024-11-29 08:30:50.005313 INFO::Creating boxplot for categorical data, antibiotics vs F649
## 2024-11-29 08:30:50.123039 INFO::Creating boxplot for categorical data, antibiotics vs F259
## 2024-11-29 08:30:50.243205 INFO::Creating boxplot for categorical data, antibiotics vs F186
## 2024-11-29 08:30:50.354772 INFO::Creating boxplot for categorical data, antibiotics vs F312
## 2024-11-29 08:30:50.468338 INFO::Creating boxplot for categorical data, antibiotics vs F477
## 2024-11-29 08:30:50.59244 INFO::Creating boxplot for categorical data, antibiotics vs F4
## 2024-11-29 08:30:50.705331 INFO::Creating boxplot for categorical data, antibiotics vs F632
## 2024-11-29 08:30:50.816391 INFO::Creating boxplot for categorical data, antibiotics vs F31
## 2024-11-29 08:30:50.930893 INFO::Creating boxplot for categorical data, antibiotics vs F184
## 2024-11-29 08:30:51.051538 INFO::Creating boxplot for categorical data, antibiotics vs F7
## 2024-11-29 08:30:51.162607 INFO::Creating boxplot for categorical data, antibiotics vs F213
## 2024-11-29 08:30:51.27459 INFO::Creating boxplot for categorical data, antibiotics vs F691
## 2024-11-29 08:30:51.393262 INFO::Creating boxplot for categorical data, antibiotics vs F828
## 2024-11-29 08:30:51.504152 INFO::Creating boxplot for categorical data, antibiotics vs F831
## 2024-11-29 08:30:51.617462 INFO::Creating boxplot for categorical data, antibiotics vs F315
## 2024-11-29 08:30:51.729845 INFO::Creating boxplot for categorical data, antibiotics vs F159
## 2024-11-29 08:30:51.847322 INFO::Creating boxplot for categorical data, antibiotics vs F331
## 2024-11-29 08:30:51.960209 INFO::Creating boxplot for categorical data, antibiotics vs F757
## 2024-11-29 08:30:52.073543 INFO::Creating boxplot for categorical data, antibiotics vs F167
## 2024-11-29 08:30:52.196165 INFO::Creating boxplot for categorical data, antibiotics vs F85
## 2024-11-29 08:30:52.307161 INFO::Creating boxplot for categorical data, antibiotics vs F80
## 2024-11-29 08:30:52.419342 INFO::Creating boxplot for categorical data, antibiotics vs F105
## 2024-11-29 08:30:52.54012 INFO::Creating boxplot for categorical data, antibiotics vs F674
## 2024-11-29 08:30:52.651198 INFO::Creating boxplot for categorical data, antibiotics vs F50
## 2024-11-29 08:30:52.763147 INFO::Creating boxplot for categorical data, antibiotics vs F164
## 2024-11-29 08:30:52.879957 INFO::Creating boxplot for categorical data, antibiotics vs F840
## 2024-11-29 08:30:53.000469 INFO::Creating boxplot for categorical data, antibiotics vs F232
## 2024-11-29 08:30:53.113753 INFO::Creating boxplot for categorical data, antibiotics vs F872
## 2024-11-29 08:30:53.227324 INFO::Creating boxplot for categorical data, antibiotics vs F54
## 2024-11-29 08:30:53.349237 INFO::Creating boxplot for categorical data, antibiotics vs F365
## 2024-11-29 08:30:53.461701 INFO::Creating boxplot for categorical data, antibiotics vs F499
## 2024-11-29 08:30:53.574033 INFO::Creating boxplot for categorical data, antibiotics vs F510
## 2024-11-29 08:30:53.69147 INFO::Creating boxplot for categorical data, antibiotics vs F716
## 2024-11-29 08:30:53.810644 INFO::Creating boxplot for categorical data, antibiotics vs F454
## 2024-11-29 08:30:53.923985 INFO::Creating boxplot for categorical data, antibiotics vs F52
## 2024-11-29 08:30:54.040321 INFO::Creating boxplot for categorical data, antibiotics vs F273
## 2024-11-29 08:30:54.161764 INFO::Creating boxplot for categorical data, antibiotics vs F474
## 2024-11-29 08:30:54.273027 INFO::Creating boxplot for categorical data, antibiotics vs F267
## 2024-11-29 08:30:54.384887 INFO::Creating boxplot for categorical data, antibiotics vs F253
## 2024-11-29 08:30:54.505921 INFO::Creating boxplot for categorical data, antibiotics vs F247
## 2024-11-29 08:30:54.61754 INFO::Creating boxplot for categorical data, antibiotics vs F708
## 2024-11-29 08:30:54.72848 INFO::Creating boxplot for categorical data, antibiotics vs F438
## 2024-11-29 08:30:54.840397 INFO::Creating boxplot for categorical data, antibiotics vs F450
## 2024-11-29 08:30:54.964809 INFO::Creating boxplot for categorical data, antibiotics vs F666
## 2024-11-29 08:30:55.078737 INFO::Creating boxplot for categorical data, antibiotics vs F720
## 2024-11-29 08:30:55.193243 INFO::Creating boxplot for categorical data, antibiotics vs F48
## 2024-11-29 08:30:55.315496 INFO::Creating boxplot for categorical data, antibiotics vs F371
## 2024-11-29 08:30:55.427903 INFO::Creating boxplot for categorical data, antibiotics vs F423
## 2024-11-29 08:30:55.541896 INFO::Creating boxplot for categorical data, antibiotics vs F190
## 2024-11-29 08:30:55.662414 INFO::Creating boxplot for categorical data, antibiotics vs F351
## 2024-11-29 08:30:55.776166 INFO::Creating boxplot for categorical data, antibiotics vs F394
## 2024-11-29 08:30:55.886157 INFO::Creating boxplot for categorical data, antibiotics vs F581
## 2024-11-29 08:30:56.000802 INFO::Creating boxplot for categorical data, antibiotics vs F276
## 2024-11-29 08:30:56.121259 INFO::Creating boxplot for categorical data, antibiotics vs F608
## 2024-11-29 08:30:56.233306 INFO::Creating boxplot for categorical data, antibiotics vs F28
## 2024-11-29 08:30:56.347556 INFO::Creating boxplot for categorical data, antibiotics vs F805
## 2024-11-29 08:30:56.467882 INFO::Creating boxplot for categorical data, antibiotics vs F249
## 2024-11-29 08:30:56.578856 INFO::Creating boxplot for categorical data, antibiotics vs F776
## 2024-11-29 08:30:56.690336 INFO::Creating boxplot for categorical data, antibiotics vs F755
## 2024-11-29 08:30:56.811337 INFO::Creating boxplot for categorical data, antibiotics vs F68
## 2024-11-29 08:30:56.927375 INFO::Creating boxplot for categorical data, antibiotics vs F78
## 2024-11-29 08:30:57.040426 INFO::Creating boxplot for categorical data, antibiotics vs F381
## 2024-11-29 08:30:57.162273 INFO::Creating boxplot for categorical data, antibiotics vs F644
## 2024-11-29 08:30:57.274367 INFO::Creating boxplot for categorical data, antibiotics vs F358
## 2024-11-29 08:30:57.385845 INFO::Creating boxplot for categorical data, antibiotics vs F344
## 2024-11-29 08:30:57.498181 INFO::Creating boxplot for categorical data, antibiotics vs F209
## 2024-11-29 08:30:57.617366 INFO::Creating boxplot for categorical data, antibiotics vs F898
## 2024-11-29 08:30:57.729868 INFO::Creating boxplot for categorical data, antibiotics vs F51
## 2024-11-29 08:30:57.84588 INFO::Creating boxplot for categorical data, antibiotics vs F149
## 2024-11-29 08:30:57.997018 INFO::Creating boxplot for categorical data, antibiotics vs F108
## 2024-11-29 08:30:58.112823 INFO::Creating boxplot for categorical data, antibiotics vs F255
## 2024-11-29 08:30:58.227173 INFO::Creating boxplot for categorical data, antibiotics vs F823
## 2024-11-29 08:30:58.351546 INFO::Creating boxplot for categorical data, antibiotics vs F864
## 2024-11-29 08:30:58.47129 INFO::Creating boxplot for categorical data, antibiotics vs F214
## 2024-11-29 08:30:58.584089 INFO::Creating boxplot for categorical data, antibiotics vs F76
## 2024-11-29 08:30:58.697594 INFO::Creating boxplot for categorical data, antibiotics vs F575
## 2024-11-29 08:30:58.826882 INFO::Creating boxplot for categorical data, antibiotics vs F13
## 2024-11-29 08:30:58.940197 INFO::Creating boxplot for categorical data, antibiotics vs F389
## 2024-11-29 08:30:59.058287 INFO::Creating boxplot for categorical data, antibiotics vs F556
## 2024-11-29 08:30:59.187043 INFO::Creating boxplot for categorical data, antibiotics vs F49
## 2024-11-29 08:30:59.305384 INFO::Creating boxplot for categorical data, antibiotics vs F436
## 2024-11-29 08:30:59.418147 INFO::Creating boxplot for categorical data, antibiotics vs F378
## 2024-11-29 08:30:59.533313 INFO::Creating boxplot for categorical data, antibiotics vs F682
## 2024-11-29 08:30:59.66611 INFO::Creating boxplot for categorical data, antibiotics vs F47
## 2024-11-29 08:30:59.780296 INFO::Creating boxplot for categorical data, antibiotics vs F429
## 2024-11-29 08:30:59.894859 INFO::Creating boxplot for categorical data, antibiotics vs F588
## 2024-11-29 08:31:00.027338 INFO::Creating boxplot for categorical data, antibiotics vs F616
## 2024-11-29 08:31:00.146788 INFO::Creating boxplot for categorical data, antibiotics vs F323
## 2024-11-29 08:31:00.259798 INFO::Creating boxplot for categorical data, antibiotics vs F409
## 2024-11-29 08:31:00.375298 INFO::Creating boxplot for categorical data, antibiotics vs F326
## 2024-11-29 08:31:00.510363 INFO::Creating boxplot for categorical data, antibiotics vs F698
## 2024-11-29 08:31:00.624554 INFO::Creating boxplot for categorical data, antibiotics vs F567
## 2024-11-29 08:31:00.737409 INFO::Creating boxplot for categorical data, antibiotics vs F179
## 2024-11-29 08:31:00.869331 INFO::Creating boxplot for categorical data, antibiotics vs F787
## 2024-11-29 08:31:00.984232 INFO::Creating boxplot for categorical data, antibiotics vs F79
## 2024-11-29 08:31:01.097484 INFO::Creating boxplot for categorical data, antibiotics vs F335
## 2024-11-29 08:31:01.226513 INFO::Creating boxplot for categorical data, antibiotics vs F576
## 2024-11-29 08:31:01.347843 INFO::Creating boxplot for categorical data, antibiotics vs F667
## 2024-11-29 08:31:01.46019 INFO::Creating boxplot for categorical data, antibiotics vs F694
## 2024-11-29 08:31:01.574169 INFO::Creating boxplot for categorical data, antibiotics vs F297
## 2024-11-29 08:31:01.704088 INFO::Creating boxplot for categorical data, antibiotics vs F569
## 2024-11-29 08:31:01.819314 INFO::Creating boxplot for categorical data, antibiotics vs F138
## 2024-11-29 08:31:01.932952 INFO::Creating boxplot for categorical data, antibiotics vs F611
## 2024-11-29 08:31:02.06913 INFO::Creating boxplot for categorical data, antibiotics vs F810
## 2024-11-29 08:31:02.184853 INFO::Creating boxplot for categorical data, antibiotics vs F746
## 2024-11-29 08:31:02.297743 INFO::Creating boxplot for categorical data, antibiotics vs F23
## 2024-11-29 08:31:02.415742 INFO::Creating boxplot for categorical data, antibiotics vs F135
## 2024-11-29 08:31:02.547718 INFO::Creating boxplot for categorical data, antibiotics vs F411
## 2024-11-29 08:31:02.660851 INFO::Creating boxplot for categorical data, antibiotics vs F489
## 2024-11-29 08:31:02.77442 INFO::Creating boxplot for categorical data, antibiotics vs F492
## 2024-11-29 08:31:02.904775 INFO::Creating boxplot for categorical data, antibiotics vs F844
## 2024-11-29 08:31:03.020109 INFO::Creating boxplot for categorical data, antibiotics vs F586
## 2024-11-29 08:31:03.13429 INFO::Creating boxplot for categorical data, antibiotics vs F11
## 2024-11-29 08:31:03.264712 INFO::Creating boxplot for categorical data, antibiotics vs F900
## 2024-11-29 08:31:03.381185 INFO::Creating boxplot for categorical data, antibiotics vs F21
## 2024-11-29 08:31:03.494791 INFO::Creating boxplot for categorical data, antibiotics vs F736
## 2024-11-29 08:31:03.619704 INFO::Creating boxplot for categorical data, antibiotics vs F408
## 2024-11-29 08:31:03.739606 INFO::Creating boxplot for categorical data, antibiotics vs F788
## 2024-11-29 08:31:03.85141 INFO::Creating boxplot for categorical data, antibiotics vs F66
## 2024-11-29 08:31:03.964887 INFO::Creating boxplot for categorical data, antibiotics vs F493
## 2024-11-29 08:31:04.09988 INFO::Creating boxplot for categorical data, antibiotics vs F343
## 2024-11-29 08:31:04.215359 INFO::Creating boxplot for categorical data, antibiotics vs F352
## 2024-11-29 08:31:04.32983 INFO::Creating boxplot for categorical data, antibiotics vs F677
## 2024-11-29 08:31:04.459702 INFO::Creating boxplot for categorical data, antibiotics vs F816
## 2024-11-29 08:31:04.574357 INFO::Creating boxplot for categorical data, antibiotics vs F457
## 2024-11-29 08:31:04.686919 INFO::Creating boxplot for categorical data, antibiotics vs F330
## 2024-11-29 08:31:04.816024 INFO::Creating boxplot for categorical data, antibiotics vs F293
## 2024-11-29 08:31:04.931425 INFO::Creating boxplot for categorical data, antibiotics vs F725
## 2024-11-29 08:31:05.043395 INFO::Creating boxplot for categorical data, antibiotics vs F813
## 2024-11-29 08:31:05.161344 INFO::Creating boxplot for categorical data, antibiotics vs F295
## 2024-11-29 08:31:05.294524 INFO::Creating boxplot for categorical data, antibiotics vs F656
## 2024-11-29 08:31:05.409472 INFO::Creating boxplot for categorical data, antibiotics vs F669
## 2024-11-29 08:31:05.526323 INFO::Creating boxplot for categorical data, antibiotics vs F15
## 2024-11-29 08:31:05.658406 INFO::Creating boxplot for categorical data, antibiotics vs F419
## 2024-11-29 08:31:05.771361 INFO::Creating boxplot for categorical data, antibiotics vs F701
## 2024-11-29 08:31:05.883886 INFO::Creating boxplot for categorical data, antibiotics vs F176
## 2024-11-29 08:31:06.017164 INFO::Creating boxplot for categorical data, antibiotics vs F203
## 2024-11-29 08:31:06.13641 INFO::Creating boxplot for categorical data, antibiotics vs F501
## 2024-11-29 08:31:06.253135 INFO::Creating boxplot for categorical data, antibiotics vs F772
## 2024-11-29 08:31:06.420203 INFO::Creating boxplot for categorical data, antibiotics vs F488
## 2024-11-29 08:31:06.540284 INFO::Creating boxplot for categorical data, antibiotics vs F600
## 2024-11-29 08:31:06.659069 INFO::Creating boxplot for categorical data, antibiotics vs F768
## 2024-11-29 08:31:06.775187 INFO::Creating boxplot for categorical data, antibiotics vs F432
## 2024-11-29 08:31:06.907504 INFO::Creating boxplot for categorical data, antibiotics vs F26
## 2024-11-29 08:31:07.025139 INFO::Creating boxplot for categorical data, antibiotics vs F189
## 2024-11-29 08:31:07.140848 INFO::Creating boxplot for categorical data, antibiotics vs F200
## 2024-11-29 08:31:07.272632 INFO::Creating boxplot for categorical data, antibiotics vs F121
## 2024-11-29 08:31:07.392047 INFO::Creating boxplot for categorical data, antibiotics vs F624
## 2024-11-29 08:31:07.509557 INFO::Creating boxplot for categorical data, antibiotics vs F855
## 2024-11-29 08:31:07.624913 INFO::Creating boxplot for categorical data, antibiotics vs F380
## 2024-11-29 08:31:07.755308 INFO::Creating boxplot for categorical data, antibiotics vs F734
## 2024-11-29 08:31:07.872604 INFO::Creating boxplot for categorical data, antibiotics vs F16
## 2024-11-29 08:31:07.987144 INFO::Creating boxplot for categorical data, antibiotics vs F602
## 2024-11-29 08:31:08.122193 INFO::Creating boxplot for categorical data, antibiotics vs F210
## 2024-11-29 08:31:08.243388 INFO::Creating boxplot for categorical data, antibiotics vs F217
## 2024-11-29 08:31:08.360183 INFO::Creating boxplot for categorical data, antibiotics vs F640
## 2024-11-29 08:31:08.474091 INFO::Creating boxplot for categorical data, antibiotics vs F631
## 2024-11-29 08:31:08.606997 INFO::Creating boxplot for categorical data, antibiotics vs F32
## 2024-11-29 08:31:08.722709 INFO::Creating boxplot for categorical data, antibiotics vs F322
## 2024-11-29 08:31:08.835776 INFO::Creating boxplot for categorical data, antibiotics vs F476
## 2024-11-29 08:31:08.970151 INFO::Creating boxplot for categorical data, antibiotics vs F265
## 2024-11-29 08:31:09.094193 INFO::Creating boxplot for categorical data, antibiotics vs F283
## 2024-11-29 08:31:09.208717 INFO::Creating boxplot for categorical data, antibiotics vs F316
## 2024-11-29 08:31:09.338872 INFO::Creating boxplot for categorical data, antibiotics vs F465
## 2024-11-29 08:31:09.457801 INFO::Creating boxplot for categorical data, antibiotics vs F24
## 2024-11-29 08:31:09.574939 INFO::Creating boxplot for categorical data, antibiotics vs F38
## 2024-11-29 08:31:09.692976 INFO::Creating boxplot for categorical data, antibiotics vs F82
## 2024-11-29 08:31:09.821398 INFO::Creating boxplot for categorical data, antibiotics vs F86
## 2024-11-29 08:31:09.938091 INFO::Creating boxplot for categorical data, antibiotics vs F270
## 2024-11-29 08:31:10.052372 INFO::Creating boxplot for categorical data, antibiotics vs F485
## 2024-11-29 08:31:10.18603 INFO::Creating boxplot for categorical data, antibiotics vs F486
## 2024-11-29 08:31:10.307275 INFO::Creating boxplot for categorical data, antibiotics vs F399
## 2024-11-29 08:31:10.421937 INFO::Creating boxplot for categorical data, antibiotics vs F573
## 2024-11-29 08:31:10.537282 INFO::Creating boxplot for categorical data, antibiotics vs F877
## 2024-11-29 08:31:10.66914 INFO::Creating boxplot for categorical data, antibiotics vs F709
## 2024-11-29 08:31:10.786224 INFO::Creating boxplot for categorical data, antibiotics vs F227
## 2024-11-29 08:31:10.900719 INFO::Creating boxplot for categorical data, antibiotics vs F553
## 2024-11-29 08:31:11.028994 INFO::Creating boxplot for categorical data, antibiotics vs F123
## 2024-11-29 08:31:11.149244 INFO::Creating boxplot for categorical data, antibiotics vs F118
## 2024-11-29 08:31:11.263939 INFO::Creating boxplot for categorical data, antibiotics vs F605
## 2024-11-29 08:31:11.392833 INFO::Creating boxplot for categorical data, antibiotics vs F619
## 2024-11-29 08:31:11.511292 INFO::Creating boxplot for categorical data, antibiotics vs F830
## 2024-11-29 08:31:11.625535 INFO::Creating boxplot for categorical data, antibiotics vs F837
## 2024-11-29 08:31:11.739711 INFO::Creating boxplot for categorical data, antibiotics vs F12
## 2024-11-29 08:31:11.869386 INFO::Creating boxplot for categorical data, antibiotics vs F623
## 2024-11-29 08:31:11.983333 INFO::Creating boxplot for categorical data, antibiotics vs F806
## 2024-11-29 08:31:12.097244 INFO::Creating boxplot for categorical data, antibiotics vs F353
## 2024-11-29 08:31:12.227378 INFO::Creating boxplot for categorical data, antibiotics vs F829
## 2024-11-29 08:31:12.345712 INFO::Creating boxplot for categorical data, antibiotics vs F289
## 2024-11-29 08:31:12.461555 INFO::Creating boxplot for categorical data, antibiotics vs F93
## 2024-11-29 08:31:12.590948 INFO::Creating boxplot for categorical data, antibiotics vs F379
## 2024-11-29 08:31:12.708785 INFO::Creating boxplot for categorical data, antibiotics vs F370
## 2024-11-29 08:31:12.82314 INFO::Creating boxplot for categorical data, antibiotics vs F360
## 2024-11-29 08:31:12.937807 INFO::Creating boxplot for categorical data, antibiotics vs F710
## 2024-11-29 08:31:13.070281 INFO::Creating boxplot for categorical data, antibiotics vs F388
## 2024-11-29 08:31:13.192029 INFO::Creating boxplot for categorical data, antibiotics vs F796
## 2024-11-29 08:31:13.307849 INFO::Creating boxplot for categorical data, antibiotics vs F174
## 2024-11-29 08:31:13.437743 INFO::Creating boxplot for categorical data, antibiotics vs F601
## 2024-11-29 08:31:13.553107 INFO::Creating boxplot for categorical data, antibiotics vs F775
## 2024-11-29 08:31:13.667066 INFO::Creating boxplot for categorical data, antibiotics vs F836
## 2024-11-29 08:31:13.79724 INFO::Creating boxplot for categorical data, antibiotics vs F192
## 2024-11-29 08:31:13.912728 INFO::Creating boxplot for categorical data, antibiotics vs F463
## 2024-11-29 08:31:14.024872 INFO::Creating boxplot for categorical data, antibiotics vs F57
## 2024-11-29 08:31:14.155674 INFO::Creating boxplot for categorical data, antibiotics vs F658
## 2024-11-29 08:31:14.272726 INFO::Creating boxplot for categorical data, antibiotics vs F596
## 2024-11-29 08:31:14.388027 INFO::Creating boxplot for categorical data, antibiotics vs F218
## 2024-11-29 08:31:14.505029 INFO::Creating boxplot for categorical data, antibiotics vs F104
## 2024-11-29 08:31:14.638878 INFO::Creating boxplot for categorical data, antibiotics vs F466
## 2024-11-29 08:31:14.754567 INFO::Creating boxplot for categorical data, antibiotics vs F737
## 2024-11-29 08:31:14.867648 INFO::Creating boxplot for categorical data, antibiotics vs F487
## 2024-11-29 08:31:15.02523 INFO::Creating boxplot for categorical data, antibiotics vs F369
## 2024-11-29 08:31:15.147848 INFO::Creating boxplot for categorical data, antibiotics vs F584
## 2024-11-29 08:31:15.263994 INFO::Creating boxplot for categorical data, antibiotics vs F166
## 2024-11-29 08:31:15.398581 INFO::Creating boxplot for categorical data, antibiotics vs F822
## 2024-11-29 08:31:15.518543 INFO::Creating boxplot for categorical data, antibiotics vs F416
## 2024-11-29 08:31:15.643137 INFO::Creating boxplot for categorical data, antibiotics vs F70
## 2024-11-29 08:31:15.760521 INFO::Creating boxplot for categorical data, antibiotics vs F243
## 2024-11-29 08:31:15.89822 INFO::Creating boxplot for categorical data, antibiotics vs F498
## 2024-11-29 08:31:16.016109 INFO::Creating boxplot for categorical data, antibiotics vs F272
## 2024-11-29 08:31:16.134023 INFO::Creating boxplot for categorical data, antibiotics vs F846
## 2024-11-29 08:31:16.275314 INFO::Creating boxplot for categorical data, antibiotics vs F881
## 2024-11-29 08:31:16.393032 INFO::Creating boxplot for categorical data, antibiotics vs F280
## 2024-11-29 08:31:16.513626 INFO::Creating boxplot for categorical data, antibiotics vs F761
## 2024-11-29 08:31:16.629508 INFO::Creating boxplot for categorical data, antibiotics vs F781
## 2024-11-29 08:31:16.767226 INFO::Creating boxplot for categorical data, antibiotics vs F697
## 2024-11-29 08:31:16.884948 INFO::Creating boxplot for categorical data, antibiotics vs F890
## 2024-11-29 08:31:17.001988 INFO::Creating boxplot for categorical data, antibiotics vs F197
## 2024-11-29 08:31:17.138186 INFO::Creating boxplot for categorical data, antibiotics vs F826
## 2024-11-29 08:31:17.257866 INFO::Creating boxplot for categorical data, antibiotics vs F641
## 2024-11-29 08:31:17.377305 INFO::Creating boxplot for categorical data, antibiotics vs F700
## 2024-11-29 08:31:17.493185 INFO::Creating boxplot for categorical data, antibiotics vs F531
## 2024-11-29 08:31:17.630279 INFO::Creating boxplot for categorical data, antibiotics vs F660
## 2024-11-29 08:31:17.747689 INFO::Creating boxplot for categorical data, antibiotics vs F257
## 2024-11-29 08:31:17.863114 INFO::Creating boxplot for categorical data, antibiotics vs F136
## 2024-11-29 08:31:18.000055 INFO::Creating boxplot for categorical data, antibiotics vs F875
## 2024-11-29 08:31:18.118745 INFO::Creating boxplot for categorical data, antibiotics vs F160
## 2024-11-29 08:31:18.241421 INFO::Creating boxplot for categorical data, antibiotics vs F782
## 2024-11-29 08:31:18.375664 INFO::Creating boxplot for categorical data, antibiotics vs F642
## 2024-11-29 08:31:18.505046 INFO::Creating boxplot for categorical data, antibiotics vs F730
## 2024-11-29 08:31:18.62407 INFO::Creating boxplot for categorical data, antibiotics vs F679
## 2024-11-29 08:31:18.742393 INFO::Creating boxplot for categorical data, antibiotics vs F713
## 2024-11-29 08:31:18.881315 INFO::Creating boxplot for categorical data, antibiotics vs F821
## 2024-11-29 08:31:19.00188 INFO::Creating boxplot for categorical data, antibiotics vs F443
## 2024-11-29 08:31:19.12147 INFO::Creating boxplot for categorical data, antibiotics vs F729
## 2024-11-29 08:31:19.264363 INFO::Creating boxplot for categorical data, antibiotics vs F25
## 2024-11-29 08:31:19.384963 INFO::Creating boxplot for categorical data, antibiotics vs F338
## 2024-11-29 08:31:19.502917 INFO::Creating boxplot for categorical data, antibiotics vs F647
## 2024-11-29 08:31:19.635064 INFO::Creating boxplot for categorical data, antibiotics vs F817
## 2024-11-29 08:31:19.756951 INFO::Creating boxplot for categorical data, antibiotics vs F535
## 2024-11-29 08:31:19.874159 INFO::Creating boxplot for categorical data, antibiotics vs F634
## 2024-11-29 08:31:19.992416 INFO::Creating boxplot for categorical data, antibiotics vs F533
## 2024-11-29 08:31:20.130813 INFO::Creating boxplot for categorical data, antibiotics vs F808
## 2024-11-29 08:31:20.25116 INFO::Creating boxplot for categorical data, antibiotics vs F571
## 2024-11-29 08:31:20.367405 INFO::Creating boxplot for categorical data, antibiotics vs F529
## 2024-11-29 08:31:20.506496 INFO::Creating boxplot for categorical data, antibiotics vs F827
## 2024-11-29 08:31:20.625706 INFO::Creating boxplot for categorical data, antibiotics vs F107
## 2024-11-29 08:31:20.742583 INFO::Creating boxplot for categorical data, antibiotics vs F515
## 2024-11-29 08:31:20.875861 INFO::Creating boxplot for categorical data, antibiotics vs F305
## 2024-11-29 08:31:20.996502 INFO::Creating boxplot for categorical data, antibiotics vs F662
## 2024-11-29 08:31:21.113491 INFO::Creating boxplot for categorical data, antibiotics vs F310
## 2024-11-29 08:31:21.230905 INFO::Creating boxplot for categorical data, antibiotics vs F430
## 2024-11-29 08:31:21.36708 INFO::Creating boxplot for categorical data, antibiotics vs F173
## 2024-11-29 08:31:21.484526 INFO::Creating boxplot for categorical data, antibiotics vs F820
## 2024-11-29 08:31:21.600626 INFO::Creating boxplot for categorical data, antibiotics vs F743
## 2024-11-29 08:31:21.737033 INFO::Creating boxplot for categorical data, antibiotics vs F63
## 2024-11-29 08:31:21.85477 INFO::Creating boxplot for categorical data, antibiotics vs F215
## 2024-11-29 08:31:21.970437 INFO::Creating boxplot for categorical data, antibiotics vs F216
## 2024-11-29 08:31:22.106305 INFO::Creating boxplot for categorical data, antibiotics vs F245
## 2024-11-29 08:31:22.227665 INFO::Creating boxplot for categorical data, antibiotics vs F862
## 2024-11-29 08:31:22.343338 INFO::Creating boxplot for categorical data, antibiotics vs F541
## 2024-11-29 08:31:22.471421 INFO::Creating boxplot for categorical data, antibiotics vs F558
## 2024-11-29 08:31:22.596689 INFO::Creating boxplot for categorical data, antibiotics vs F633
## 2024-11-29 08:31:22.716761 INFO::Creating boxplot for categorical data, antibiotics vs F94
## 2024-11-29 08:31:22.833818 INFO::Creating boxplot for categorical data, antibiotics vs F574
## 2024-11-29 08:31:22.972817 INFO::Creating boxplot for categorical data, antibiotics vs F238
## 2024-11-29 08:31:23.091725 INFO::Creating boxplot for categorical data, antibiotics vs F815
## 2024-11-29 08:31:23.208548 INFO::Creating boxplot for categorical data, antibiotics vs F587
## 2024-11-29 08:31:23.345974 INFO::Creating boxplot for categorical data, antibiotics vs F464
## 2024-11-29 08:31:23.463836 INFO::Creating boxplot for categorical data, antibiotics vs F590
## 2024-11-29 08:31:23.579948 INFO::Creating boxplot for categorical data, antibiotics vs F124
## 2024-11-29 08:31:23.749473 INFO::Creating boxplot for categorical data, antibiotics vs F664
## 2024-11-29 08:31:23.867781 INFO::Creating boxplot for categorical data, antibiotics vs F100
## 2024-11-29 08:31:23.991023 INFO::Creating boxplot for categorical data, antibiotics vs F744
## 2024-11-29 08:31:24.114719 INFO::Creating boxplot for categorical data, antibiotics vs F444
## 2024-11-29 08:31:24.255792 INFO::Creating boxplot for categorical data, antibiotics vs F597
## 2024-11-29 08:31:24.377999 INFO::Creating boxplot for categorical data, antibiotics vs F650
## 2024-11-29 08:31:24.497808 INFO::Creating boxplot for categorical data, antibiotics vs F147
## 2024-11-29 08:31:24.633129 INFO::Creating boxplot for categorical data, antibiotics vs F363
## 2024-11-29 08:31:24.753493 INFO::Creating boxplot for categorical data, antibiotics vs F521
## 2024-11-29 08:31:24.874202 INFO::Creating boxplot for categorical data, antibiotics vs F412
## 2024-11-29 08:31:24.992792 INFO::Creating boxplot for categorical data, antibiotics vs F279
## 2024-11-29 08:31:25.133662 INFO::Creating boxplot for categorical data, antibiotics vs F225
## 2024-11-29 08:31:25.255459 INFO::Creating boxplot for categorical data, antibiotics vs F10
## 2024-11-29 08:31:25.378785 INFO::Creating boxplot for categorical data, antibiotics vs F481
## 2024-11-29 08:31:25.516175 INFO::Creating boxplot for categorical data, antibiotics vs F861
## 2024-11-29 08:31:25.635812 INFO::Creating boxplot for categorical data, antibiotics vs F888
## 2024-11-29 08:31:25.75612 INFO::Creating boxplot for categorical data, antibiotics vs F156
## 2024-11-29 08:31:25.890636 INFO::Creating boxplot for categorical data, antibiotics vs F857
## 2024-11-29 08:31:26.01093 INFO::Creating boxplot for categorical data, antibiotics vs F509
## 2024-11-29 08:31:26.127584 INFO::Creating boxplot for categorical data, antibiotics vs F244
## 2024-11-29 08:31:26.245601 INFO::Creating boxplot for categorical data, antibiotics vs F514
## 2024-11-29 08:31:26.383134 INFO::Creating boxplot for categorical data, antibiotics vs F196
## 2024-11-29 08:31:26.50465 INFO::Creating boxplot for categorical data, antibiotics vs F304
## 2024-11-29 08:31:26.626103 INFO::Creating boxplot for categorical data, antibiotics vs F833
## 2024-11-29 08:31:26.765432 INFO::Creating boxplot for categorical data, antibiotics vs F294
## 2024-11-29 08:31:26.886527 INFO::Creating boxplot for categorical data, antibiotics vs F550
## 2024-11-29 08:31:27.005327 INFO::Creating boxplot for categorical data, antibiotics vs F869
## 2024-11-29 08:31:27.125688 INFO::Creating boxplot for categorical data, antibiotics vs F364
## 2024-11-29 08:31:27.266269 INFO::Creating boxplot for categorical data, antibiotics vs F583
## 2024-11-29 08:31:27.38662 INFO::Creating boxplot for categorical data, antibiotics vs F441
## 2024-11-29 08:31:27.508143 INFO::Creating boxplot for categorical data, antibiotics vs F595
## 2024-11-29 08:31:27.646216 INFO::Creating boxplot for categorical data, antibiotics vs F35
## 2024-11-29 08:31:27.765496 INFO::Creating boxplot for categorical data, antibiotics vs F630
## 2024-11-29 08:31:27.885691 INFO::Creating boxplot for categorical data, antibiotics vs F401
## 2024-11-29 08:31:28.021779 INFO::Creating boxplot for categorical data, antibiotics vs F287
## 2024-11-29 08:31:28.142946 INFO::Creating boxplot for categorical data, antibiotics vs F250
## 2024-11-29 08:31:28.262741 INFO::Creating boxplot for categorical data, antibiotics vs F239
## 2024-11-29 08:31:28.382774 INFO::Creating boxplot for categorical data, antibiotics vs F88
## 2024-11-29 08:31:28.520343 INFO::Creating boxplot for categorical data, antibiotics vs F752
## 2024-11-29 08:31:28.638677 INFO::Creating boxplot for categorical data, antibiotics vs F539
## 2024-11-29 08:31:28.755761 INFO::Creating boxplot for categorical data, antibiotics vs F69
## 2024-11-29 08:31:28.891528 INFO::Creating boxplot for categorical data, antibiotics vs F126
## 2024-11-29 08:31:29.012487 INFO::Creating boxplot for categorical data, antibiotics vs F362
## 2024-11-29 08:31:29.133089 INFO::Creating boxplot for categorical data, antibiotics vs F753
## 2024-11-29 08:31:29.269738 INFO::Creating boxplot for categorical data, antibiotics vs F469
## 2024-11-29 08:31:29.392008 INFO::Creating boxplot for categorical data, antibiotics vs F14
## 2024-11-29 08:31:29.511186 INFO::Creating boxplot for categorical data, antibiotics vs F803
## 2024-11-29 08:31:29.628981 INFO::Creating boxplot for categorical data, antibiotics vs F814
## 2024-11-29 08:31:29.765477 INFO::Creating boxplot for categorical data, antibiotics vs F449
## 2024-11-29 08:31:29.884285 INFO::Creating boxplot for categorical data, antibiotics vs F494
## 2024-11-29 08:31:30.002072 INFO::Creating boxplot for categorical data, antibiotics vs F439
## 2024-11-29 08:31:30.140973 INFO::Creating boxplot for categorical data, antibiotics vs F686
## 2024-11-29 08:31:30.259119 INFO::Creating boxplot for categorical data, antibiotics vs F591
## 2024-11-29 08:31:30.379762 INFO::Creating boxplot for categorical data, antibiotics vs F735
## 2024-11-29 08:31:30.515672 INFO::Creating boxplot for categorical data, antibiotics vs F111
## 2024-11-29 08:31:30.634568 INFO::Creating boxplot for categorical data, antibiotics vs F346
## 2024-11-29 08:31:30.752486 INFO::Creating boxplot for categorical data, antibiotics vs F29
## 2024-11-29 08:31:30.884893 INFO::Creating boxplot for categorical data, antibiotics vs F376
## 2024-11-29 08:31:31.008902 INFO::Creating boxplot for categorical data, antibiotics vs F414
## 2024-11-29 08:31:31.128622 INFO::Creating boxplot for categorical data, antibiotics vs F555
## 2024-11-29 08:31:31.24646 INFO::Creating boxplot for categorical data, antibiotics vs F517
## 2024-11-29 08:31:31.386591 INFO::Creating boxplot for categorical data, antibiotics vs F544
## 2024-11-29 08:31:31.505028 INFO::Creating boxplot for categorical data, antibiotics vs F339
## 2024-11-29 08:31:31.623564 INFO::Creating boxplot for categorical data, antibiotics vs F689
## 2024-11-29 08:31:31.763578 INFO::Creating boxplot for categorical data, antibiotics vs F391
## 2024-11-29 08:31:31.88115 INFO::Creating boxplot for categorical data, antibiotics vs F502
## 2024-11-29 08:31:31.999591 INFO::Creating boxplot for categorical data, antibiotics vs F298
## 2024-11-29 08:31:32.137687 INFO::Creating boxplot for categorical data, antibiotics vs F337
## 2024-11-29 08:31:32.257239 INFO::Creating boxplot for categorical data, antibiotics vs F773
## 2024-11-29 08:31:32.376259 INFO::Creating boxplot for categorical data, antibiotics vs F592
## 2024-11-29 08:31:32.539018 INFO::Creating boxplot for categorical data, antibiotics vs F307
## 2024-11-29 08:31:32.663597 INFO::Creating boxplot for categorical data, antibiotics vs F115
## 2024-11-29 08:31:32.78123 INFO::Creating boxplot for categorical data, antibiotics vs F739
## 2024-11-29 08:31:32.901552 INFO::Creating boxplot for categorical data, antibiotics vs F433
## 2024-11-29 08:31:33.065511 INFO::Creating boxplot for categorical data, antibiotics vs F384
## 2024-11-29 08:31:33.187809 INFO::Creating boxplot for categorical data, antibiotics vs F750
## 2024-11-29 08:31:33.308129 INFO::Creating boxplot for categorical data, antibiotics vs F762
## 2024-11-29 08:31:33.452024 INFO::Creating boxplot for categorical data, antibiotics vs F277
## 2024-11-29 08:31:33.572903 INFO::Creating boxplot for categorical data, antibiotics vs F871
## 2024-11-29 08:31:33.691875 INFO::Creating boxplot for categorical data, antibiotics vs F839
## 2024-11-29 08:31:33.813258 INFO::Creating boxplot for categorical data, antibiotics vs F127
## 2024-11-29 08:31:33.95546 INFO::Creating boxplot for categorical data, antibiotics vs F554
## 2024-11-29 08:31:34.073052 INFO::Creating boxplot for categorical data, antibiotics vs F676
## 2024-11-29 08:31:34.192378 INFO::Creating boxplot for categorical data, antibiotics vs F568
## 2024-11-29 08:31:34.339117 INFO::Creating boxplot for categorical data, antibiotics vs F137
## 2024-11-29 08:31:34.459579 INFO::Creating boxplot for categorical data, antibiotics vs F131
## 2024-11-29 08:31:34.578322 INFO::Creating boxplot for categorical data, antibiotics vs F60
## 2024-11-29 08:31:34.698284 INFO::Creating boxplot for categorical data, antibiotics vs F98
## 2024-11-29 08:31:34.842617 INFO::Creating boxplot for categorical data, antibiotics vs F672
## 2024-11-29 08:31:34.963202 INFO::Creating boxplot for categorical data, antibiotics vs F530
## 2024-11-29 08:31:35.082907 INFO::Creating boxplot for categorical data, antibiotics vs F809
## 2024-11-29 08:31:35.229831 INFO::Creating boxplot for categorical data, antibiotics vs F894
## 2024-11-29 08:31:35.350523 INFO::Creating boxplot for categorical data, antibiotics vs F22
## 2024-11-29 08:31:35.470438 INFO::Creating boxplot for categorical data, antibiotics vs F818
## 2024-11-29 08:31:35.607773 INFO::Creating boxplot for categorical data, antibiotics vs F559
## 2024-11-29 08:31:35.733556 INFO::Creating boxplot for categorical data, antibiotics vs F741
## 2024-11-29 08:31:35.85176 INFO::Creating boxplot for categorical data, antibiotics vs F398
## 2024-11-29 08:31:35.972566 INFO::Creating boxplot for categorical data, antibiotics vs F357
## 2024-11-29 08:31:36.119822 INFO::Creating boxplot for categorical data, antibiotics vs F119
## 2024-11-29 08:31:36.237719 INFO::Creating boxplot for categorical data, antibiotics vs F426
## 2024-11-29 08:31:36.357163 INFO::Creating boxplot for categorical data, antibiotics vs F204
## 2024-11-29 08:31:36.500367 INFO::Creating boxplot for categorical data, antibiotics vs F851
## 2024-11-29 08:31:36.617963 INFO::Creating boxplot for categorical data, antibiotics vs F657
## 2024-11-29 08:31:36.736757 INFO::Creating boxplot for categorical data, antibiotics vs F801
## 2024-11-29 08:31:36.868746 INFO::Creating boxplot for categorical data, antibiotics vs F754
## 2024-11-29 08:31:37.002182 INFO::Creating boxplot for categorical data, antibiotics vs F859
## 2024-11-29 08:31:37.119591 INFO::Creating boxplot for categorical data, antibiotics vs F480
## 2024-11-29 08:31:37.241575 INFO::Creating boxplot for categorical data, antibiotics vs F507
## 2024-11-29 08:31:37.391824 INFO::Creating boxplot for categorical data, antibiotics vs F207
## 2024-11-29 08:31:39.009264 INFO::Plotting data for metadata number 3, age
## 2024-11-29 08:31:39.010531 INFO::Creating scatter plot for continuous data, age vs F340
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:39.172811 INFO::Creating scatter plot for continuous data, age vs F603
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:39.3833 INFO::Creating scatter plot for continuous data, age vs F356
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:39.512373 INFO::Creating scatter plot for continuous data, age vs F181
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:39.629454 INFO::Creating scatter plot for continuous data, age vs F177
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:39.78014 INFO::Creating scatter plot for continuous data, age vs F390
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:39.905299 INFO::Creating scatter plot for continuous data, age vs F743
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:40.021209 INFO::Creating scatter plot for continuous data, age vs F491
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:40.174576 INFO::Creating scatter plot for continuous data, age vs F436
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:40.291561 INFO::Creating scatter plot for continuous data, age vs F219
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:40.411992 INFO::Creating scatter plot for continuous data, age vs F483
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:40.56593 INFO::Creating scatter plot for continuous data, age vs F878
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:40.691498 INFO::Creating scatter plot for continuous data, age vs F876
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:40.818321 INFO::Creating scatter plot for continuous data, age vs F211
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:40.970693 INFO::Creating scatter plot for continuous data, age vs F732
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:41.098127 INFO::Creating scatter plot for continuous data, age vs F222
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:41.240935 INFO::Creating scatter plot for continuous data, age vs F688
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:41.379577 INFO::Creating scatter plot for continuous data, age vs F170
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:41.507723 INFO::Creating scatter plot for continuous data, age vs F431
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:42.199505 INFO::Creating scatter plot for continuous data, age vs F174
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:42.308609 INFO::Creating scatter plot for continuous data, age vs F17
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:42.418825 INFO::Creating scatter plot for continuous data, age vs F334
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:42.550371 INFO::Creating scatter plot for continuous data, age vs F835
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:42.661144 INFO::Creating scatter plot for continuous data, age vs F223
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:42.779696 INFO::Creating scatter plot for continuous data, age vs F383
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:42.896823 INFO::Creating scatter plot for continuous data, age vs F623
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:43.012584 INFO::Creating scatter plot for continuous data, age vs F329
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:43.131817 INFO::Creating scatter plot for continuous data, age vs F395
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:43.258487 INFO::Creating scatter plot for continuous data, age vs F528
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:43.369721 INFO::Creating scatter plot for continuous data, age vs F13
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:43.486078 INFO::Creating scatter plot for continuous data, age vs F36
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:43.596994 INFO::Creating scatter plot for continuous data, age vs F285
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:43.722705 INFO::Creating scatter plot for continuous data, age vs F404
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:43.831498 INFO::Creating scatter plot for continuous data, age vs F894
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:43.950343 INFO::Creating scatter plot for continuous data, age vs F300
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:44.075793 INFO::Creating scatter plot for continuous data, age vs F32
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:44.1929 INFO::Creating scatter plot for continuous data, age vs F24
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:44.310592 INFO::Creating scatter plot for continuous data, age vs F97
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:44.427335 INFO::Creating scatter plot for continuous data, age vs F849
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:44.539766 INFO::Creating scatter plot for continuous data, age vs F185
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:44.65884 INFO::Creating scatter plot for continuous data, age vs F513
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:44.783149 INFO::Creating scatter plot for continuous data, age vs F296
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:44.900573 INFO::Creating scatter plot for continuous data, age vs F471
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:45.019062 INFO::Creating scatter plot for continuous data, age vs F793
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:45.14445 INFO::Creating scatter plot for continuous data, age vs F402
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:45.262043 INFO::Creating scatter plot for continuous data, age vs F541
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:45.380938 INFO::Creating scatter plot for continuous data, age vs F496
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:45.503941 INFO::Creating scatter plot for continuous data, age vs F386
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:45.614468 INFO::Creating scatter plot for continuous data, age vs F594
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:45.73309 INFO::Creating scatter plot for continuous data, age vs F704
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:45.859187 INFO::Creating scatter plot for continuous data, age vs F330
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:45.976409 INFO::Creating scatter plot for continuous data, age vs F197
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:46.094263 INFO::Creating scatter plot for continuous data, age vs F735
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:46.219226 INFO::Creating scatter plot for continuous data, age vs F481
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:46.371499 INFO::Creating scatter plot for continuous data, age vs F635
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:46.5142 INFO::Creating scatter plot for continuous data, age vs F687
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:46.640227 INFO::Creating scatter plot for continuous data, age vs F652
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:46.757659 INFO::Creating scatter plot for continuous data, age vs F651
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:46.884688 INFO::Creating scatter plot for continuous data, age vs F82
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:46.992868 INFO::Creating scatter plot for continuous data, age vs F7
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:47.101091 INFO::Creating scatter plot for continuous data, age vs F866
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:47.228353 INFO::Creating scatter plot for continuous data, age vs F593
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:47.33818 INFO::Creating scatter plot for continuous data, age vs F733
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:47.448102 INFO::Creating scatter plot for continuous data, age vs F684
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:47.583043 INFO::Creating scatter plot for continuous data, age vs F410
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:47.694035 INFO::Creating scatter plot for continuous data, age vs F224
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:47.811868 INFO::Creating scatter plot for continuous data, age vs F722
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:47.938485 INFO::Creating scatter plot for continuous data, age vs F856
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:48.047485 INFO::Creating scatter plot for continuous data, age vs F680
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:48.159688 INFO::Creating scatter plot for continuous data, age vs F19
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:48.287988 INFO::Creating scatter plot for continuous data, age vs F860
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:48.396904 INFO::Creating scatter plot for continuous data, age vs F859
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:48.51457 INFO::Creating scatter plot for continuous data, age vs F522
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:48.643976 INFO::Creating scatter plot for continuous data, age vs F372
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:48.760943 INFO::Creating scatter plot for continuous data, age vs F899
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:48.869769 INFO::Creating scatter plot for continuous data, age vs F782
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:48.996066 INFO::Creating scatter plot for continuous data, age vs F839
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:49.112929 INFO::Creating scatter plot for continuous data, age vs F827
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:49.231564 INFO::Creating scatter plot for continuous data, age vs F817
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:49.360006 INFO::Creating scatter plot for continuous data, age vs F345
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:49.471115 INFO::Creating scatter plot for continuous data, age vs F127
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:49.596811 INFO::Creating scatter plot for continuous data, age vs F749
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:49.757758 INFO::Creating scatter plot for continuous data, age vs F877
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:49.876531 INFO::Creating scatter plot for continuous data, age vs F150
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:49.995537 INFO::Creating scatter plot for continuous data, age vs F752
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:50.123887 INFO::Creating scatter plot for continuous data, age vs F848
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:50.237458 INFO::Creating scatter plot for continuous data, age vs F809
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:50.356422 INFO::Creating scatter plot for continuous data, age vs F751
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:50.483531 INFO::Creating scatter plot for continuous data, age vs F15
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:50.600677 INFO::Creating scatter plot for continuous data, age vs F521
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:50.711994 INFO::Creating scatter plot for continuous data, age vs F842
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:50.847398 INFO::Creating scatter plot for continuous data, age vs F319
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:50.967806 INFO::Creating scatter plot for continuous data, age vs F96
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:51.086577 INFO::Creating scatter plot for continuous data, age vs F171
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:51.22251 INFO::Creating scatter plot for continuous data, age vs F241
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:51.333981 INFO::Creating scatter plot for continuous data, age vs F582
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:51.44348 INFO::Creating scatter plot for continuous data, age vs F822
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:51.573824 INFO::Creating scatter plot for continuous data, age vs F748
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:51.687068 INFO::Creating scatter plot for continuous data, age vs F147
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:51.807844 INFO::Creating scatter plot for continuous data, age vs F16
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:51.932276 INFO::Creating scatter plot for continuous data, age vs F212
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:52.056405 INFO::Creating scatter plot for continuous data, age vs F718
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:52.175081 INFO::Creating scatter plot for continuous data, age vs F663
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:52.29784 INFO::Creating scatter plot for continuous data, age vs F690
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:52.424886 INFO::Creating scatter plot for continuous data, age vs F865
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:52.53687 INFO::Creating scatter plot for continuous data, age vs F421
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:52.650846 INFO::Creating scatter plot for continuous data, age vs F110
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:52.788329 INFO::Creating scatter plot for continuous data, age vs F857
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:52.90597 INFO::Creating scatter plot for continuous data, age vs F84
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:53.040465 INFO::Creating scatter plot for continuous data, age vs F123
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:53.15524 INFO::Creating scatter plot for continuous data, age vs F566
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:53.264644 INFO::Creating scatter plot for continuous data, age vs F370
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:53.376807 INFO::Creating scatter plot for continuous data, age vs F65
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:53.505886 INFO::Creating scatter plot for continuous data, age vs F119
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:53.621693 INFO::Creating scatter plot for continuous data, age vs F263
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:53.733102 INFO::Creating scatter plot for continuous data, age vs F630
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:53.871427 INFO::Creating scatter plot for continuous data, age vs F628
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:53.983382 INFO::Creating scatter plot for continuous data, age vs F711
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:54.103811 INFO::Creating scatter plot for continuous data, age vs F152
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:54.23981 INFO::Creating scatter plot for continuous data, age vs F324
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:54.358465 INFO::Creating scatter plot for continuous data, age vs F575
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:54.470351 INFO::Creating scatter plot for continuous data, age vs F699
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:54.608158 INFO::Creating scatter plot for continuous data, age vs F846
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:54.726903 INFO::Creating scatter plot for continuous data, age vs F380
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:54.862875 INFO::Creating scatter plot for continuous data, age vs F172
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:54.985279 INFO::Creating scatter plot for continuous data, age vs F504
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:55.096152 INFO::Creating scatter plot for continuous data, age vs F34
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:55.223269 INFO::Creating scatter plot for continuous data, age vs F199
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:55.345049 INFO::Creating scatter plot for continuous data, age vs F198
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:55.467081 INFO::Creating scatter plot for continuous data, age vs F479
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:55.609791 INFO::Creating scatter plot for continuous data, age vs F673
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:55.723198 INFO::Creating scatter plot for continuous data, age vs F508
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:55.842343 INFO::Creating scatter plot for continuous data, age vs F337
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:55.981673 INFO::Creating scatter plot for continuous data, age vs F737
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:56.102008 INFO::Creating scatter plot for continuous data, age vs F609
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:56.220845 INFO::Creating scatter plot for continuous data, age vs F40
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:56.349334 INFO::Creating scatter plot for continuous data, age vs F821
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:56.469661 INFO::Creating scatter plot for continuous data, age vs F643
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:56.582321 INFO::Creating scatter plot for continuous data, age vs F759
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:56.71412 INFO::Creating scatter plot for continuous data, age vs F417
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:56.83504 INFO::Creating scatter plot for continuous data, age vs F58
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:56.955696 INFO::Creating scatter plot for continuous data, age vs F267
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:57.093441 INFO::Creating scatter plot for continuous data, age vs F101
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:57.204367 INFO::Creating scatter plot for continuous data, age vs F890
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:57.32514 INFO::Creating scatter plot for continuous data, age vs F655
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:57.49676 INFO::Creating scatter plot for continuous data, age vs F95
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:57.611501 INFO::Creating scatter plot for continuous data, age vs F775
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:57.731307 INFO::Creating scatter plot for continuous data, age vs F93
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:57.870857 INFO::Creating scatter plot for continuous data, age vs F353
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:57.987222 INFO::Creating scatter plot for continuous data, age vs F480
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:58.111022 INFO::Creating scatter plot for continuous data, age vs F567
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:58.249196 INFO::Creating scatter plot for continuous data, age vs F871
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:58.371646 INFO::Creating scatter plot for continuous data, age vs F295
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:58.486785 INFO::Creating scatter plot for continuous data, age vs F459
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:58.624086 INFO::Creating scatter plot for continuous data, age vs F812
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:58.747301 INFO::Creating scatter plot for continuous data, age vs F146
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:58.858823 INFO::Creating scatter plot for continuous data, age vs F239
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:58.996808 INFO::Creating scatter plot for continuous data, age vs F754
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:59.119197 INFO::Creating scatter plot for continuous data, age vs F443
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:59.23108 INFO::Creating scatter plot for continuous data, age vs F5
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:59.370151 INFO::Creating scatter plot for continuous data, age vs F864
## `geom_smooth()` using formula = 'y ~ x'
## 2024-11-29 08:31:59.484415 INFO::Creating scatter plot for continuous data, age vs F477
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:59.606275 INFO::Creating scatter plot for continuous data, age vs F571
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-11-29 08:31:59.749696 INFO::Creating scatter plot for continuous data, age vs F715
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Initiating effect size calculations
## 
## Calculating mean abundance in: IBD
## 
## Calculating mean abundance in: Control
## 
## Calculating effect size in: IBD
## 
## Initiating prioritization
## 
## Calculating meta-rank and prioritizing metabolic features
## 2024-11-29 08:32:01.373049 INFO::Writing all prioritized metabolites to file: Macarron_output/prioritized_metabolites_all.csv
## 2024-11-29 08:32:01.378564 INFO::Writing characterizable prioritized metabolites to file: Macarron_output/prioritized_metabolites_characterizable.csv
## 2024-11-29 08:32:01.392828 INFO::Writing highly prioritized metabolites in IBD to file: Macarron_output/highly_prioritized_per_module_in_IBD.csv

Using dataframes as inputs

abundances_df = read.csv(file = prism_abundances, row.names = 1) # setting features as rownames
annotations_df = read.csv(file = prism_annotations, row.names = 1) # setting features as rownames
metadata_df = read.csv(file = prism_metadata, row.names = 1) # setting samples as rownames 
taxonomy_df = read.csv(file = mets_taxonomy)

# Running Macarron
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
                                        input_annotations = annotations_df,
                                        input_metadata = metadata_df,
                                        input_taxonomy = taxonomy_df)

Running Macarron as individual functions

The Macarron::Macarron() function is a wrapper for the Macarron framework. Users can also apply individual functions on the input dataframes to achieve same results as the wrapper with the added benefit of storing output from each function for other analyses. There are seven steps:

# Step 1: Storing input data in a summarized experiment object
prism_mbx <- prepInput(input_abundances = abundances_df,
                       input_annotations = annotations_df,
                       input_metadata = metadata_df)

# Step 2: Creating a distance matrix from pairwise correlations in abundances of metabolic features
prism_w <- makeDisMat(se = prism_mbx)

# Step 3: Finding covariance modules
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df)
# The output is a list containing two dataframes- module assignments and measures of success
# if evaluateMOS=TRUE. To write modules to a separate dataframe, do:
prism_module_assignments <- prism_modules[[1]]
prism_modules_mos <- prism_modules[[2]]

# Step 4: Calculating AVA
prism_ava <- calAVA(se = prism_mbx,
                    mod.assn = prism_modules)

# Step 5: Calculating q-value
prism_qval <- calQval(se = prism_mbx,
                      mod.assn = prism_modules)

# Step 6: Calculating effect size
prism_es <- calES(se = prism_mbx,
                   mac.qval = prism_qval)

# Step 7: Prioritizing metabolic features
prism_prioritized <- prioritize(se = prism_mbx,
                                mod.assn = prism_modules,
                                mac.ava = prism_ava,
                                mac.qval = prism_qval,
                                mac.es = prism_es)
# The output is a list containing two dataframes- all prioritized metabolic features and
# only characterizable metabolic features.
all_prioritized <- prism_prioritized[[1]]
char_prioritized <- prism_prioritized[[2]]

# Step 8 (optional): View only the highly prioritized metabolic features in each module
prism_highly_prioritized <- showBest(prism_prioritized)

Session info from running the demo in R can be displayed with the following command.

sessionInfo()
## R version 4.4.2 (2024-10-31)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=C              
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] Macarron_1.11.0             SummarizedExperiment_1.37.0
##  [3] Biobase_2.67.0              GenomicRanges_1.59.1       
##  [5] GenomeInfoDb_1.43.2         IRanges_2.41.1             
##  [7] S4Vectors_0.45.2            BiocGenerics_0.53.3        
##  [9] generics_0.1.3              MatrixGenerics_1.19.0      
## [11] matrixStats_1.4.1           BiocStyle_2.35.0           
## 
## loaded via a namespace (and not attached):
##   [1] mnormt_2.1.1            DBI_1.2.3               pbapply_1.7-2          
##   [4] gridExtra_2.3           rlang_1.1.4             magrittr_2.0.3         
##   [7] compiler_4.4.2          RSQLite_2.3.8           mgcv_1.9-1             
##  [10] png_0.1-8               vctrs_0.6.5             stringr_1.5.1          
##  [13] pkgconfig_2.0.3         crayon_1.5.3            fastmap_1.2.0          
##  [16] backports_1.5.0         XVector_0.47.0          labeling_0.4.3         
##  [19] utf8_1.2.4              rmarkdown_2.29          preprocessCore_1.69.0  
##  [22] UCSC.utils_1.3.0        bit_4.5.0               xfun_0.49              
##  [25] zlibbioc_1.52.0         cachem_1.1.0            jsonlite_1.8.9         
##  [28] blob_1.2.4              DelayedArray_0.33.2     BiocParallel_1.41.0    
##  [31] psych_2.4.6.26          Maaslin2_1.21.0         parallel_4.4.2         
##  [34] cluster_2.1.6           biglm_0.9-3             R6_2.5.1               
##  [37] RColorBrewer_1.1-3      stringi_1.8.4           bslib_0.8.0            
##  [40] rpart_4.1.23            jquerylib_0.1.4         Rcpp_1.0.13-1          
##  [43] iterators_1.0.14        knitr_1.49              WGCNA_1.73             
##  [46] base64enc_0.1-3         Matrix_1.7-1            splines_4.4.2          
##  [49] nnet_7.3-19             tidyselect_1.2.1        rstudioapi_0.17.1      
##  [52] abind_1.4-8             yaml_2.3.10             doParallel_1.0.17      
##  [55] codetools_0.2-20        plyr_1.8.9              lattice_0.22-6         
##  [58] tibble_3.2.1            withr_3.0.2             KEGGREST_1.47.0        
##  [61] evaluate_1.0.1          foreign_0.8-87          survival_3.7-0         
##  [64] getopt_1.20.4           Biostrings_2.75.1       pillar_1.9.0           
##  [67] BiocManager_1.30.25     checkmate_2.3.2         foreach_1.5.2          
##  [70] pcaPP_2.0-5             ggplot2_3.5.1           munsell_0.5.1          
##  [73] scales_1.3.0            glue_1.8.0              Hmisc_5.2-0            
##  [76] maketools_1.3.1         tools_4.4.2             robustbase_0.99-4-1    
##  [79] sys_3.4.3               data.table_1.16.2       mvtnorm_1.3-2          
##  [82] buildtools_1.0.0        fastcluster_1.2.6       grid_4.4.2             
##  [85] optparse_1.7.5          impute_1.81.0           AnnotationDbi_1.69.0   
##  [88] colorspace_2.1-1        nlme_3.1-166            GenomeInfoDbData_1.2.13
##  [91] htmlTable_2.4.3         Formula_1.2-5           cli_3.6.3              
##  [94] fansi_1.0.6             S4Arrays_1.7.1          dplyr_1.1.4            
##  [97] DEoptimR_1.1-3-1        gtable_0.3.6            hash_2.2.6.3           
## [100] logging_0.10-108        dynamicTreeCut_1.63-1   sass_0.4.9             
## [103] digest_0.6.37           SparseArray_1.7.2       farver_2.1.2           
## [106] htmlwidgets_1.6.4       memoise_2.0.1           htmltools_0.5.8.1      
## [109] lifecycle_1.0.4         httr_1.4.7              GO.db_3.20.0           
## [112] bit64_4.5.2

Advanced Topics

Generating the input chemical taxonomy file

The input taxonomy dataframe can be generated using the input metabolic features annotation dataframe using Macarron::decorateID(). This function annotates an HMDB ID or a PubChem CID with the chemical class and subclass of the metabolite.

taxonomy_df <- decorateID(input_annotations = annotations_df)
write.csv(taxonomy_df, file="demo_taxonomy.csv", row.names = FALSE)

Accessory output files

Macarron.log

A record of all chosen parameters and steps that were followed during execution.

modules_measures_of_success.csv

This file provides information about the properties of covariance modules used in the analysis. By default, modules are generated using a minimum module size (MMS) (argument: min_module_size) equal to cube root of the total number of prevalent metabolic features. Macarron evaluates 9 measures of success (MOS) that collectively capture the “correctness” and chemical homogeneity of the modules. The MOS are as follows:

  • Total modules: Number of modules.
  • Singletons: Number of metabolic features that were not assigned to any module at MMS.
  • % Annotated modules: Percentage of modules that contained at least one annotated metabolic feature.
  • % Consistent assignments: Percentage of times the same metabolic feature was assigned to the same module e.g. if three metabolic features represent glucose, they should all be in the same module. This percentage must be high.
  • Max classes per module: The highest number of chemical classes observed in any module. This is evaluated using the chemical taxonomy of covarying annotated features.
  • 90p classes per module: 90th percentile of classes per module; captures the chemical homogeneity of the modules.
  • Max subclasses per module: The highest number of chemical subclasses observed in any module.
  • 90p subclasses per module: 90th percentile of subclasses per module; captures the chemical homogeneity of the modules.
  • % Features in HAM: Macarron first finds homogeneously annoted modules (HAMs): These are modules in which >75% annotated features have the same chemical class indicating that they are chemically homogeneous. It then calculates how many features the HAMs account for.

Maaslin2 results

This folder contains the Maaslin2 log file (maaslin2.log), significant associations found by Maaslin2 (significant_results.tsv) and the linear model residuals file (residuals.rds). For more information, see Maaslin2.

Changing defaults

Filtering metabolic features based on prevalence

Ideally, at least 50% metabolic features must be retained after prevalence filtering. By default, Macarron uses the union of metabolic features observed (non-zero abundance) in at least 70% samples of any phenotype for further analysis. This prevalence threshold may be high for some metabolomics datasets and can be changed using the min_prevalence argument.

prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
                                        input_annotations = annotations_df,
                                        input_metadata = metadata_df,
                                        input_taxonomy = taxonomy_df,
                                        min_prevalence = 0.5)
# or
prism_w <- makeDisMat(se = prism_mbx,
                      min_prevalence = 0.5)

Minimum module size

By default, cube root of the total number of prevalent features is used as the minimum module size (MMS) (argument: min_module_size) for module detection and generation. We expect this to work for most real world datasets. To determine if the modules are optimal for further analysis, Macarron evaluates several measures of success (MOS) as described above. In addition to evaluating MOS for modules generated using the default MMS, Macarron also evaluates MOS for MMS values that are larger (MMS+5, MMS+10) and smaller (MMS-5, MMS-10) than the default MMS. If you find that the MOS improve with larger or smaller MMS, you may change the default accordingly. For more details about module detection, please see WGCNA and dynamicTreeCut.

# See MOS of modules generated using default
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df)
prism_modules_mos <- prism_modules[[2]]
View(prism_modules_mos)

# Change MMS
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df,
                            min_module_size = 10)

Specifying fixed effects, random effects and reference

Macarron uses Maaslin2 for determining the q-value of differential abundance in a phenotype of interest. For default execution, the phenotype of interest must be a category in column 1 of the metadata dataframe e.g. IBD in diagnosis in the demo. This is also the column that is picked by the metadata_variable argument for identifying the main phenotypes/conditions in any dataset (see Macarron.log file). Further, in the default execution, all columns in the metadata table are considered as fixed effects and the alphabetically first categorical variable in each covariate with two categories is considered as the reference. Maaslin2 requires reference categories to be explicitly defined for all categorical metadata with more than two categories. Defaults can be changed with the arguments fixed_effects, random_effects and reference. In the demo example, fixed effects and reference can be defined as follows:

prism_qval <- calQval(se = prism_mbx,
                      mod.assn = prism_modules,
                      metadata_variable = "diagnosis",
                      fixed_effects = c("diagnosis","age","antibiotics"),
                      reference = c("diagnosis,Control";"antibiotics,No"))

Command line invocation

The package source contains a script MacarronCMD.R in inst/scripts to invoke Macarron in the command line using Rscript. The inst/scripts folder also contains a README file that comprehensively documents the usage of the script.