Package: MEB Type: Package Title: A normalization-invariant minimum enclosing ball method to detect differentially expressed genes for RNA-seq and scRNA-seq data Version: 1.27.0 Author: Yan Zhou, Jiadi Zhu Maintainer: Jiadi Zhu <2160090406@email.szu.edu.cn>, Yan Zhou Description: This package provides a method to identify differential expression genes in the same or different species. Given that non-DE genes have some similarities in features, a scaling-free minimum enclosing ball (SFMEB) model is built to cover those non-DE genes in feature space, then those DE genes, which are enormously different from non-DE genes, being regarded as outliers and rejected outside the ball. The method on this package is described in the article 'A minimum enclosing ball method to detect differential expression genes for RNA-seq data'. The SFMEB method is extended to the scMEB method that considering two or more potential types of cells or unknown labels scRNA-seq dataset DEGs identification. License: GPL-2 Encoding: UTF-8 LazyData: true Depends: R (>= 3.6.0) Suggests: knitr,rmarkdown,BiocStyle VignetteBuilder: knitr RoxygenNote: 7.2.3 Imports: e1071, edgeR, scater, stats, wrswoR, SummarizedExperiment, SingleCellExperiment biocViews: DifferentialExpression, GeneExpression, Normalization, Classification, Sequencing Config/pak/sysreqs: libcairo2-dev libfontconfig1-dev libfreetype6-dev libfribidi-dev libharfbuzz-dev libicu-dev libjpeg-dev libpng-dev libtiff-dev libwebp-dev zlib1g-dev Repository: https://bioc.r-universe.dev Date/Publication: 2026-04-28 12:51:01 UTC RemoteUrl: https://github.com/bioc/MEB RemoteRef: HEAD RemoteSha: 41142955f2be7366da2719a17518fb84d60cb021 NeedsCompilation: no Packaged: 2026-06-18 06:29:54 UTC; root